{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:57:57Z","timestamp":1790722677482,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-82051-0","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T21:52:31Z","timestamp":1735336351000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Seasonal variations and environmental influences on dry eye operations in Japan"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5819-1126","authenticated-orcid":false,"given":"Yoshiaki","family":"Kabata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Terauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"82051_CR1","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1056\/NEJMra1407936","volume":"378","author":"JA Clayton","year":"2018","unstructured":"Clayton, J. A. Dry eye. N. Engl. J. Med. 378, 2212\u20132223 (2018).","journal-title":"N. Engl. J. Med."},{"key":"82051_CR2","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/ICU.0b013e32833a8c15","volume":"21","author":"NJ Friedman","year":"2010","unstructured":"Friedman, N. J. Impact of dry eye disease and treatment on quality of life. Curr. Opin. Ophthalmol. 21, 310 (2010).","journal-title":"Curr. Opin. Ophthalmol."},{"key":"82051_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtos.2023.04.007","volume":"29","author":"M Alves","year":"2023","unstructured":"Alves, M. et al. TFOS lifestyle report: Impact of environmental conditions on the ocular surface. Ocul. Surf. 29, 1\u201352 (2023).","journal-title":"Ocul. Surf."},{"key":"82051_CR4","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"F Stapleton","year":"2017","unstructured":"Stapleton, F. et al. TFOS DEWS II epidemiology report. Ocul. Surf. 15, 334\u2013365 (2017).","journal-title":"Ocul. Surf."},{"key":"82051_CR5","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1001\/jamaophthalmol.2016.0139","volume":"134","author":"SH Hwang","year":"2016","unstructured":"Hwang, S. H. et al. Potential importance of ozone in the association between outdoor air pollution and dry eye disease in South Korea. JAMA Ophthalmol. 134, 503\u2013510 (2016).","journal-title":"JAMA Ophthalmol."},{"key":"82051_CR6","doi-asserted-by":"crossref","unstructured":"R, P., S, V. S. & Bhukya, R. Assessment of seasonal variations in dry eye syndrome prevalence among office workers. Asian Journal of Medical Sciences 15, 100\u2013105 (2024).","DOI":"10.3126\/ajms.v15i9.66957"},{"key":"82051_CR7","doi-asserted-by":"publisher","first-page":"3809","DOI":"10.2147\/OPTH.S442567","volume":"17","author":"M Ayaki","year":"2023","unstructured":"Ayaki, M. & Negishi, K. Seasonality of tear meniscus volume and dry eye-related symptoms \u2013 a cross-sectional retrospective cohort study. Clin. Ophthalmol. 17, 3809\u20133816 (2023).","journal-title":"Clin. Ophthalmol."},{"key":"82051_CR8","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/cei.12759","volume":"184","author":"M Guzm\u00e1n","year":"2016","unstructured":"Guzm\u00e1n, M. et al. Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease. Clin. Exp. Immunol. 184, 248\u2013256 (2016).","journal-title":"Clin. Exp. Immunol."},{"key":"82051_CR9","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.ajo.2005.10.057","volume":"141","author":"JP McCulley","year":"2006","unstructured":"McCulley, J. P., Aronowicz, J. D., Uchiyama, E., Shine, W. E. & Butovich, I. A. Correlations in a change in aqueous tear evaporation with a change in relative humidity and the impact. Am. J. Ophthalmol. 141, 758\u2013760 (2006).","journal-title":"Am. J. Ophthalmol."},{"key":"82051_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1097\/ICO.0b013e31826671ab","volume":"32","author":"AA Abusharha","year":"2013","unstructured":"Abusharha, A. A. & Pearce, E. I. The effect of low humidity on the human tear film. Cornea 32, 429 (2013).","journal-title":"Cornea"},{"key":"82051_CR11","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3341\/kjo.2023.0077","volume":"37","author":"M-S Song","year":"2023","unstructured":"Song, M.-S., Lee, Y., Paik, H. J. & Kim, D. H. A comprehensive analysis of the influence of temperature and humidity on dry eye disease. Korean J. Ophthalmol. 37, 501\u2013509 (2023).","journal-title":"Korean J. Ophthalmol."},{"key":"82051_CR12","unstructured":"Team, W. H. O. O. and E. H. WHO Air quality guidelines for particulate matter, ozone, nitrogen dioxide and sulfur dioxide\u202f: global update 2005\u202f: summary of risk assessment. Lignes directrices OMS relatives \u00e0 la qualit\u00e9 de l\u2019air\u202f: particules, ozone, dioxyde d\u2019azote et dioxyde de soufre\u202f: mise \u00e0 jour mondiale 2005\u202f: synth\u00e8se de l\u2019\u00e9valuation des risques (2006)."},{"key":"82051_CR13","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jtos.2024.01.009","volume":"32","author":"M Guo","year":"2024","unstructured":"Guo, M. et al. Association between systemic medication use and severity of dry eye signs and symptoms in the DRy eye assessment and management (DREAM) study. Ocul. Surf. 32, 112\u2013119 (2024).","journal-title":"Ocul. Surf."},{"key":"82051_CR14","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1136\/bjo.86.9.1031","volume":"86","author":"D Liu","year":"2002","unstructured":"Liu, D. & Sadhan, Y. Surgical punctal occlusion: a prospective study. Br. J. Ophthalmol. 86, 1031\u20131034 (2002).","journal-title":"Br. J. Ophthalmol."},{"key":"82051_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1136\/bjophthalmol-2018-313267","volume":"103","author":"A-M Ervin","year":"2019","unstructured":"Ervin, A.-M., Law, A. & Pucker, A. D. Punctal occlusion for dry eye syndrome: summary of a Cochrane systematic review. Br. J. Ophthalmol. 103, 301\u2013306 (2019).","journal-title":"Br. J. Ophthalmol."},{"key":"82051_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006775.pub3","author":"A-M Ervin","year":"2017","unstructured":"Ervin, A.-M., Law, A. & Pucker, A. D. Punctal occlusion for dry eye syndrome. Cochrane Database Syst. Rev. https:\/\/doi.org\/10.1002\/14651858.CD006775.pub3 (2017).","journal-title":"Cochrane Database Syst. Rev."},{"key":"82051_CR17","doi-asserted-by":"publisher","first-page":"21046","DOI":"10.1038\/s41598-022-25557-9","volume":"12","author":"JR Eidet","year":"2022","unstructured":"Eidet, J. R., Chen, X., R\u00e6der, S., Badian, R. A. & Utheim, T. P. Seasonal variations in presenting symptoms and signs of dry eye disease in Norway. Sci. Rep. 12, 21046 (2022).","journal-title":"Sci. Rep."},{"key":"82051_CR18","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1016\/j.ophtha.2015.02.013","volume":"122","author":"N Kumar","year":"2015","unstructured":"Kumar, N., Feuer, W., Lanza, N. L. & Galor, A. Seasonal Variation in Dry Eye. Ophthalmology 122, 1727\u20131729 (2015).","journal-title":"Ophthalmology"},{"key":"82051_CR19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1159\/000027401","volume":"213","author":"P Versura","year":"1999","unstructured":"Versura, P., Profazio, V., Cellini, M., Torreggiani, A. & Caramazza, R. Eye discomfort and air pollution. Ophthalmologica 213, 103\u2013109 (1999).","journal-title":"Ophthalmologica"},{"key":"82051_CR20","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/aos.12985","volume":"94","author":"G van Setten","year":"2016","unstructured":"van Setten, G., Labetoulle, M., Baudouin, C. & Rolando, M. Evidence of seasonality and effects of psychrometry in dry eye disease. Acta Ophthalmol. 94, 499\u2013506 (2016).","journal-title":"Acta Ophthalmol."},{"key":"82051_CR21","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/BF00404705","volume":"233","author":"T Hikichi","year":"1995","unstructured":"Hikichi, T. et al. Prevalence of dry eye in Japanese eye centers. Graefes Arch. Clin. Exp. Ophthalmol. 233, 555\u2013558 (1995).","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"82051_CR22","doi-asserted-by":"publisher","first-page":"e02433","DOI":"10.1128\/spectrum.02433-22","volume":"11","author":"T Beck-Friis","year":"2023","unstructured":"Beck-Friis, T. et al. Outdoor absolute humidity predicts the start of norovirus GII epidemics. Microbiol. Spectr. 11, e02433-e2522 (2023).","journal-title":"Microbiol. Spectr."},{"key":"82051_CR23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12199-021-01030-3","volume":"26","author":"S Chen","year":"2021","unstructured":"Chen, S. et al. The role of absolute humidity in respiratory mortality in Guangzhou, a hot and wet city of South China. Environ. Health Prev. Med. 26, 109 (2021).","journal-title":"Environ. Health Prev. Med."},{"key":"82051_CR24","doi-asserted-by":"publisher","first-page":"e02426","DOI":"10.1128\/AEM.02426-18","volume":"85","author":"A Peci","year":"2019","unstructured":"Peci, A. et al. Effects of absolute humidity, relative humidity, temperature, and wind speed on influenza activity in Toronto, Ontario, Canada. Appl. Environ. Microbiol. 85, e02426-e2518 (2019).","journal-title":"Appl. Environ. Microbiol."},{"key":"82051_CR25","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.epidem.2015.06.002","volume":"13","author":"PQ Thai","year":"2015","unstructured":"Thai, P. Q. et al. Seasonality of absolute humidity explains seasonality of influenza-like illness in Vietnam. Epidemics 13, 65\u201373 (2015).","journal-title":"Epidemics"},{"key":"82051_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1167\/tvst.9.5.25","volume":"9","author":"EJ Berg","year":"2020","unstructured":"Berg, E. J. et al. Climatic and environmental correlates of dry eye disease severity: A report from the dry eye assessment and management (DREAM) study. Transl. Vis. Sci. Technol. 9, 25 (2020).","journal-title":"Transl. Vis. Sci. Technol."},{"key":"82051_CR27","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1167\/iovs.04-1326","volume":"46","author":"S Barabino","year":"2005","unstructured":"Barabino, S. et al. The controlled-environment chamber: a new mouse model of dry eye. Invest. Ophthalmol. Vis. Sci. 46, 2766\u20132771 (2005).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"82051_CR28","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.ajo.2014.01.001","volume":"157","author":"A L\u00f3pez-Miguel","year":"2014","unstructured":"L\u00f3pez-Miguel, A. et al. Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions. Am. J. Ophthalmol. 157, 788-798.e2 (2014).","journal-title":"Am. J. Ophthalmol."},{"key":"82051_CR29","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.envres.2010.03.003","volume":"110","author":"P Novaes","year":"2010","unstructured":"Novaes, P. et al. The effects of chronic exposure to traffic derived air pollution on the ocular surface. Environ. Res. 110, 372\u2013374 (2010).","journal-title":"Environ. Res."},{"key":"82051_CR30","doi-asserted-by":"publisher","first-page":"6860","DOI":"10.3390\/ijerph18136860","volume":"18","author":"C-J Chung","year":"2021","unstructured":"Chung, C.-J. et al. Exposure to ambient NO2 increases the risk of dry eye syndrome in females: An 11-year population-based study. Int. J. Environ. Res. Public Health 18, 6860 (2021).","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"82051_CR31","doi-asserted-by":"publisher","first-page":"117001","DOI":"10.1016\/j.atmosenv.2019.117001","volume":"218","author":"J Song","year":"2019","unstructured":"Song, J. et al. Short-term exposure to nitrogen dioxide pollution and the risk of eye and adnexa diseases in Xinxiang, China. Atmos. Environ. 218, 117001 (2019).","journal-title":"Atmos. Environ."},{"key":"82051_CR32","doi-asserted-by":"publisher","unstructured":"Traffic-derived Air Pollution and Lung Function Growth | American Journal of Respiratory and Critical Care Medicine. https:\/\/www.atsjournals.org\/doi\/full\/https:\/\/doi.org\/10.1164\/rccm.201210-1892ED.","DOI":"10.1164\/rccm.201210-1892ED"},{"key":"82051_CR33","unstructured":"The impact of the congestion charging scheme on air quality in London. Part 2. Analysis of the oxidative potential of particulate matter. - Abstract - Europe PMC. https:\/\/europepmc.org\/article\/med\/21830497."},{"key":"82051_CR34","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jtos.2020.04.005","volume":"19","author":"J Vehof","year":"2021","unstructured":"Vehof, J., Snieder, H., Jansonius, N. & Hammond, C. J. Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands. Ocular Surf. 19, 83\u201393 (2021).","journal-title":"Ocular Surf."},{"key":"82051_CR35","unstructured":"NDB Open Data Japan. https:\/\/www.stat.go.jp\/data\/jinsui\/riyou.html."},{"key":"82051_CR36","unstructured":"Japan Meteorological Agency database. https:\/\/www.jma.go.jp\/jma\/menu\/menureport.html."},{"key":"82051_CR37","unstructured":"Environmental Observatory. https:\/\/tenbou.nies.go.jp\/download\/changelog.html."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82051-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82051-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82051-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T22:08:33Z","timestamp":1735337313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82051-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["82051"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-82051-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5007533\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"31 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Ethical review of Jikei University School of Medicine was exempt because we used a public database for analysis, and the data contained no identifiable personal information.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"30962"}}