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It has been linked to numerous health hazards that range from asthma to irritation of the eye to contact dermatitis. <jats:italic>Citrullus colocynthis<\/jats:italic> (C.C.) is utilized as a supplement to combat a range of health-related problems. This study aimed to assess the effectiveness of locally applied <jats:italic>Citrullus colocynthis<\/jats:italic> extract and <jats:italic>Citrullus colocynthis<\/jats:italic> loaded with <jats:italic>ZnONPs<\/jats:italic> against dermatitis caused by the disinfectant <jats:italic>glutaraldehyde<\/jats:italic> (2%).The female mice were divided into five groups (G1, G2, G3, G4, and G5). Group 1 was used as a control. The other 4 groups (2,3,4,and 5) were sprayed with 2% <jats:italic>GLU<\/jats:italic> (2 mg\/kg body weight), and the other groups (3,4,and 5) were subjected to local application of natural products (<jats:italic>Citrullus colocynthis<\/jats:italic> extract cream, <jats:italic>ZnONP<\/jats:italic> cream, and <jats:italic>Citrullus colocynthis<\/jats:italic> loaded on <jats:italic>ZnONP<\/jats:italic> cream), respectively. Each experimental animal was followed for 5 days per week for 30 days.Our findings revealed that GLU-induced dermatitis via the upregulation of TNF-\u03b1, IL-1b, NFkb 1, and ptgs2 mRNA expression and the downregulation of TGFB1 mRNA expression caused oxidative stress and altered the biochemical markers and histological appearance. However, these effects were improved by <jats:italic>the ZnONPs<\/jats:italic>, <jats:italic>C.C.<\/jats:italic> extract, and <jats:italic>C.C.-ZnONPs<\/jats:italic>.Local application of <jats:italic>Citrullus colocynthis ZnONPs<\/jats:italic> and <jats:italic>ZnONPs<\/jats:italic> had preventive effects against <jats:italic>GLU<\/jats:italic>-induced dermatitis through the suppression of oxidative stress and inflammatory markers and the enhancement of antioxidants.<\/jats:p>","DOI":"10.1038\/s41598-024-82066-7","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T18:19:21Z","timestamp":1736446761000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["New insight into the protective effect of Citrullus colocynthis loaded with ZnONP cream on glutaraldehyde-induced dermatitis in health care workers"],"prefix":"10.1038","volume":"15","author":[{"given":"Walaa A.","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa A.","family":"Moselhy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlam G.","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadallah","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"82066_CR1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jhin.2023.06.029","volume":"139","author":"C Sottani","year":"2023","unstructured":"Sottani, C. et al. 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