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Mass dog vaccination (MDV) is key to controlling dog rabies, requiring 70% coverage in the susceptible dog population to eliminate rabies deaths. MDV campaigns must achieve geographical homogeneity of coverage. Although rabies elimination is feasible, operation challenges exist, especially in hard-to-reach areas. We conducted geospatial modelling to identify geographical factors affecting MDV success in terms of campaign completeness and vaccination coverage across 25 districts in south-eastern Tanzania. From October 2016 to January 2017, about 81,000 dogs were vaccinated in 1,379 (68%) villages within these districts. Multivariable regression analysis revealed that land cover, residence, poverty, and elevation were associated with campaign completeness. The odds of achieving completeness in croplands were 1.75 times higher compared to forests. Vaccination coverage was influenced by residence, area, poverty index, and elevation, with urban areas having lower odds of achieving coverage compared to rural areas. Coverage probabilities exceeding 70% were lower on islands, highlands, urban areas, and areas bordering protected areas. As the 2030 deadline for \"zero dog-mediated human rabies deaths\" approaches, operational and logistical challenges in MDV campaigns persist. Our data provide insights into MDV success and failure, guiding future control efforts to improve their effectiveness.<\/jats:p>","DOI":"10.1038\/s41598-024-82085-4","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T03:08:25Z","timestamp":1735355305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Understanding and overcoming geographical barriers for scaling up dog vaccinations against rabies"],"prefix":"10.1038","volume":"14","author":[{"given":"Maganga","family":"Sambo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Hampson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C. 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