{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:04:35Z","timestamp":1788818675707,"version":"build-2803163510"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PN-III-P1-1.1-PD-2021-0225"],"award-info":[{"award-number":["PN-III-P1-1.1-PD-2021-0225"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-82088-1","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T08:01:09Z","timestamp":1733385669000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Enhancement of chlorpromazine efficacy in breast cancer treatment by 266\u00a0nm laser irradiation"],"prefix":"10.1038","volume":"14","author":[{"given":"Ana Maria","family":"Udrea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Staicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Smarandache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionut Relu","family":"Andrei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalina Andreea","family":"Badea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Speranta","family":"Avram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihail Lucian","family":"Pascu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra Angela","family":"Pirvulescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Balas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"issue":"1","key":"82088_CR1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12943-023-01805-y","volume":"22","author":"F Ye","year":"2023","unstructured":"Ye, F. et al. Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer. Mol. Cancer 22 (1), 105 (2023).","journal-title":"Mol. Cancer"},{"key":"82088_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","volume":"66","author":"M Arnold","year":"2022","unstructured":"Arnold, M. et al. Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast 66, 15\u201323 (2022).","journal-title":"Breast"},{"issue":"2","key":"82088_CR3","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3390\/immuno3020013","volume":"3","author":"M Vasileiou","year":"2023","unstructured":"Vasileiou, M., Papageorgiou, S. & Nguyen, N. P. Current advancements and future perspectives of immunotherapy in breast cancer treatment. Immuno 3 (2), 195\u2013216 (2023).","journal-title":"Immuno"},{"issue":"12","key":"82088_CR4","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.3390\/biomedicines9121785","volume":"9","author":"N Vlachos","year":"2021","unstructured":"Vlachos, N., Lampros, M., Voulgaris, S. & Alexiou, G. A. Repurposing antipsychotics for cancer treatment. Biomedicines 9 (12), 1785 (2021).","journal-title":"Biomedicines"},{"issue":"8","key":"82088_CR5","doi-asserted-by":"publisher","first-page":"e0235676","DOI":"10.1371\/journal.pone.0235676","volume":"15","author":"A Badran","year":"2020","unstructured":"Badran, A. et al. Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro. Pizzo SV, editor. PLoS ONE 15 (8), e0235676 (2020).","journal-title":"PLoS ONE"},{"issue":"9","key":"82088_CR6","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1002\/2211-5463.12699","volume":"9","author":"H Lee","year":"2019","unstructured":"Lee, H., Kang, S., Sonn, J. K. & Lim, Y. Dopamine receptor D 2 activation suppresses the radiosensitizing effect of aripiprazole via activation of AMPK. FEBS Open. Bio 9 (9), 1580\u20131588 (2019).","journal-title":"FEBS Open. Bio"},{"issue":"14","key":"82088_CR7","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.18632\/oncotarget.28010","volume":"12","author":"P Kamgar-Dayhoff","year":"2021","unstructured":"Kamgar-Dayhoff, P. & Brelidze, T. I. Multifaceted effect of chlorpromazine in cancer: Implications for cancer treatment. Oncotarget 12 (14), 1406\u20131426 (2021).","journal-title":"Oncotarget"},{"key":"82088_CR8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.cbi.2019.01.033","volume":"302","author":"CE Yang","year":"2019","unstructured":"Yang, C. E. et al. The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chemico-Biol. Interact. 302, 28\u201335 (2019).","journal-title":"Chemico-Biol. Interact."},{"issue":"18","key":"82088_CR9","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.4161\/cc.8.18.9623","volume":"8","author":"JL Riffell","year":"2009","unstructured":"Riffell, J. L., Zimmerman, C., Khong, A., McHardy, L. M. & Roberge, M. Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation. Cell. Cycle 8 (18), 3025\u20133038 (2009).","journal-title":"Cell. Cycle"},{"issue":"1","key":"82088_CR10","doi-asserted-by":"publisher","first-page":"18043","DOI":"10.1038\/s41598-020-74752-z","volume":"10","author":"T Tozar","year":"2020","unstructured":"Tozar, T. et al. Anti-staphylococcal activity and mode of action of thioridazine photoproducts. Sci. Rep. 10 (1), 18043 (2020).","journal-title":"Sci. Rep."},{"key":"82088_CR11","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.micpath.2019.02.012","volume":"129","author":"T Tozar","year":"2019","unstructured":"Tozar, T. et al. In vitro antimicrobial efficacy of laser exposed chlorpromazine against Gram-positive bacteria in planktonic and biofilm growth state. Microb. Pathog. 129, 250\u2013256 (2019).","journal-title":"Microb. Pathog."},{"key":"82088_CR12","doi-asserted-by":"publisher","first-page":"111997","DOI":"10.1016\/j.jphotobiol.2020.111997","volume":"211","author":"AM Udrea","year":"2020","unstructured":"Udrea, A. M., Avram, S., Nistorescu, S., Pascu, M. L. & Romanitan, M. O. Laser irradiated phenothiazines: new potential treatment for COVID-19 explored by molecular docking. J. Photochem. Photobiol., B 211, 111997 (2020).","journal-title":"J. Photochem. Photobiol., B"},{"issue":"S256","key":"82088_CR13","doi-asserted-by":"publisher","first-page":"j1755","DOI":"10.1111\/j.1755-3768.2016.0363","volume":"94","author":"A Popa Cherecheanu","year":"2016","unstructured":"Popa Cherecheanu, A. et al. Application of laser radiation exposed Chlorpromazine for the treatment of pseudotumours induced in rabbit eyes. Acta Ophthalmol. 94 (S256), j1755\u2013376820160363 (2016).","journal-title":"Acta Ophthalmol."},{"key":"82088_CR14","doi-asserted-by":"crossref","unstructured":"Tozar, T., Smarandache, A., Pascu, M. L., Staicu, A. & Pirvulescu, R. A. Laser modified phenothiazines and hydantoins: Photo-products characterisation and application on animal eyes pseudo-tumours. Lett. Drug Des. Discovery 15 (6), 687\u2013697 (2018).","DOI":"10.2174\/1570180814666170914115415"},{"issue":"5","key":"82088_CR15","first-page":"051002","volume":"20","author":"T Alexandru","year":"2015","unstructured":"Alexandru, T. et al. Characterization of mixtures of compounds produced in chlorpromazine aqueous solutions by ultraviolet laser irradiation: their applications in antimicrobial assays. J. Biomed. Opt. 20 (5), 051002\u2013051002 (2015).","journal-title":"J. Biomed. Opt."},{"key":"82088_CR16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ejps.2015.09.017","volume":"81","author":"IR Andrei","year":"2016","unstructured":"Andrei, I. R. et al. Chlorpromazine transformation by exposure to ultraviolet laser beams in droplet and bulk. Eur. J. Pharm. Sci. 81, 27\u201335 (2016).","journal-title":"Eur. J. Pharm. Sci."},{"issue":"D1","key":"82088_CR17","doi-asserted-by":"publisher","first-page":"D1102","DOI":"10.1093\/nar\/gky1033","volume":"47","author":"S Kim","year":"2019","unstructured":"Kim, S. et al. PubChem 2019 update: Improved access to chemical data. Nucleic Acids Res. 47 (D1), D1102\u2013D1109 (2019).","journal-title":"Nucleic Acids Res."},{"key":"82088_CR18","unstructured":"Dassault Syst\u00e8mes BIOVIA, [Discovery Studio], [19.1.0.18287], San Diego: Dassault Syst\u00e8mes, (2019)."},{"issue":"1","key":"82088_CR19","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1758-2946-3-33","volume":"3","author":"NM O\u2019Boyle","year":"2011","unstructured":"O\u2019Boyle, N. M. et al. Open Babel: an open chemical toolbox. J. Cheminform. 3 (1), 33 (2011).","journal-title":"J. Cheminform."},{"issue":"1","key":"82088_CR20","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina, A., Michielin, O. & Zoete, V. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci. Rep. 7 (1), 42717 (2017).","journal-title":"Sci. Rep."},{"issue":"W1","key":"82088_CR21","doi-asserted-by":"publisher","first-page":"W257","DOI":"10.1093\/nar\/gky318","volume":"46","author":"P Banerjee","year":"2018","unstructured":"Banerjee, P., Eckert, A. O., Schrey, A. K. & Preissner, R. ProTox-II: A webserver for the prediction of toxicity of chemicals. Nucleic Acids Res. 46 (W1), W257\u2013W263 (2018).","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"82088_CR22","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.3390\/pharmaceutics15041194","volume":"15","author":"M Balas","year":"2023","unstructured":"Balas, M. et al. Photodynamic activity of TMPyP4\/TiO2 complex under blue light in human melanoma cells: Potential for Cancer-selective therapy. Pharmaceutics 15 (4), 1194 (2023).","journal-title":"Pharmaceutics"},{"key":"82088_CR23","doi-asserted-by":"publisher","unstructured":"Parson, W. W. Modern Optical Spectroscopy: With Exercises and Examples from Biophysics and Biochemistry. (Berlin, Heidelberg: Springer Berlin Heidelberg; 2015).Accessed 26 Jan 2024. Available from: https:\/\/doi.org\/10.1007\/978-3-662-46777-0 (2015).","DOI":"10.1007\/978-3-662-46777-0"},{"issue":"2","key":"82088_CR24","doi-asserted-by":"publisher","first-page":"e55767","DOI":"10.1371\/journal.pone.0055767","volume":"8","author":"ML Pascu","year":"2013","unstructured":"Pascu, M. L. et al. Exposure of chlorpromazine to 266 nm laser beam generates new species with antibacterial properties: contributions to development of a new process for drug discovery. PLOS ONE. 8 (2), e55767 (2013).","journal-title":"PLOS ONE"},{"key":"82088_CR25","unstructured":"Gupta, R. R. (ed) Phenothiazines and 1,4- Benzothiazines: Chemical and Biomedical Aspects, 992 (Elsevier, 1988)."},{"issue":"2","key":"82088_CR26","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1006\/abio.2000.4876","volume":"287","author":"BS Berlett","year":"2000","unstructured":"Berlett, B. S., Levine, R. L. & Stadtman, E. R. Use of isosbestic point wavelength shifts to estimate the fraction of a precursor that is converted to a given product. Anal. Biochem. 287 (2), 329\u2013333 (2000).","journal-title":"Anal. Biochem."},{"key":"82088_CR27","doi-asserted-by":"crossref","unstructured":"Smarandache A, Militaru A, Goker H, Pascu A, Pascu ML. Laser methods for pharmaceutical pollutants removal. Schiopu P, Tamas R, editors. Proc SPIE. 2012 Nov 1;8411:84111E.","DOI":"10.1117\/12.966414"},{"issue":"9","key":"82088_CR28","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1039\/an9851001117","volume":"110","author":"AA Fasanmade","year":"1985","unstructured":"Fasanmade, A. A. & Fell, A. F. Determination of chlorpromazine and its sulphoxide in pharmaceutical dosage forms by third-order derivative ultraviolet spectroscopy. Analyst 110 (9), 1117 (1985).","journal-title":"Analyst"},{"key":"82088_CR29","doi-asserted-by":"crossref","unstructured":"Mizuno, K. Photochemistry of aromatic compounds. in Photochemistry [Internet] (eds Albini, A.., & Protti, S.) 116\u201368 (Cambridge: Royal Society of Chemistry, 2018). Accessed Feb 28 2024. http:\/\/ebook.rsc.org\/?DOI=10.1039\/9781788013598-00116","DOI":"10.1039\/9781788013598-00116"},{"issue":"7","key":"82088_CR30","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3390\/catal9070627","volume":"9","author":"A Arimi","year":"2019","unstructured":"Arimi, A., Dillert, R., Dr\u00e4ger, G. & Bahnemann, D. W. Light-Induced reactions of Chlorpromazine in the Presence of a heterogeneous photocatalyst: Formation of a long-lasting Sulfoxide. Catalysts 9 (7), 627 (2019).","journal-title":"Catalysts"},{"issue":"1\u20133","key":"82088_CR31","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.molstruc.2008.01.025","volume":"888","author":"R Joshi","year":"2008","unstructured":"Joshi, R., Ghanty, T. K. & Mukherjee, T. Reactions and structural investigation of chlorpromazine radical cation. J. Mol. Struct. 888 (1\u20133), 401\u2013408 (2008).","journal-title":"J. Mol. Struct."},{"key":"82088_CR32","unstructured":"Socrates, G. Infrared and Raman Characteristic Group Frequencies: Tables and Charts. 3. ed., repr. as paperback, 347 (Chichester: Wiley, 2010)."},{"issue":"7","key":"82088_CR33","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.3390\/antiox11071371","volume":"11","author":"O Voronova","year":"2022","unstructured":"Voronova, O., Zhuravkov, S., Korotkova, E., Artamonov, A. & Plotnikov, E. Antioxidant properties of new phenothiazine derivatives. Antioxidants 11 (7), 1371 (2022).","journal-title":"Antioxidants"},{"issue":"15","key":"82088_CR34","doi-asserted-by":"publisher","first-page":"5912","DOI":"10.1021\/jo0706980","volume":"72","author":"E Baciocchi","year":"2007","unstructured":"Baciocchi, E., Del Giacco, T., Lanzalunga, O., Lapi, A. & Raponi, D. The singlet oxygen oxidation of chlorpromazine and some phenothiazine derivatives. Products and reaction mechanisms. J. Org. Chem. 72 (15), 5912\u20135915 (2007).","journal-title":"J. Org. Chem."},{"issue":"2","key":"82088_CR35","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1007\/s11356-016-7727-5","volume":"24","author":"J Trawi\u0144ski","year":"2017","unstructured":"Trawi\u0144ski, J. & Skibi\u0144ski, R. Studies on photodegradation process of psychotropic drugs: A review. Environ. Sci. Pollut Res. 24 (2), 1152\u20131199 (2017).","journal-title":"Environ. Sci. Pollut Res."},{"issue":"4","key":"82088_CR36","first-page":"537","volume":"19","author":"T Tozar","year":"2018","unstructured":"Tozar, T. & Pascu, M. L. Time stability of laser exposed phenothiazines aqueous solutions in view of antimicrobial research. Proc. Rom Acad. Ser. A-Math Phys. 19 (4), 537\u2013544 (2018).","journal-title":"Proc. Rom Acad. Ser. A-Math Phys."},{"key":"82088_CR37","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.actaastro.2021.08.038","volume":"189","author":"\u00c1 Simon","year":"2021","unstructured":"Simon, \u00c1. et al. Photoactive chlorpromazine and promazine drugs exposed to hypergravity conditions after interaction with UV laser radiation. Acta Astronaut. 189, 260\u2013268 (2021).","journal-title":"Acta Astronaut."},{"key":"82088_CR38","doi-asserted-by":"crossref","unstructured":"Anagnostis, S., Khehra, N. & Parmar, M. S. Chlorpromazine. in Encyclopedia of Toxicology [Internet]. 995\u20131002 (Elsevier, 2024). Accessed 1 Nov 2024.https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780128243152006485","DOI":"10.1016\/B978-0-12-824315-2.00648-5"},{"key":"82088_CR39","doi-asserted-by":"publisher","first-page":"635472","DOI":"10.3389\/fonc.2021.635472","volume":"11","author":"S Matteoni","year":"2021","unstructured":"Matteoni, S. et al. Anticancer properties of the antipsychotic drug chlorpromazine and its synergism with temozolomide in restraining human glioblastoma proliferation in vitro. Front. Oncol. 11, 635472 (2021).","journal-title":"Front. Oncol."},{"issue":"8","key":"82088_CR40","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1097\/CAD.0b013e32832ec041","volume":"20","author":"CW Yde","year":"2009","unstructured":"Yde, C. W. et al. The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells. Anti-Cancer Drugs. 20 (8), 723\u2013735 (2009).","journal-title":"Anti-Cancer Drugs"},{"key":"82088_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/645460","volume":"2012","author":"DG Deavall","year":"2012","unstructured":"Deavall, D. G., Martin, E. A., Horner, J. M. & Roberts, R. Drug-Induced oxidative stress and toxicity. J. Toxicol. 2012, 1\u201313 (2012).","journal-title":"J. Toxicol."},{"issue":"10","key":"82088_CR42","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1111\/cas.15068","volume":"112","author":"H Nakamura","year":"2021","unstructured":"Nakamura, H. & Takada, K. Reactive oxygen species in cancer: current findings and future directions. Cancer Sci. 112 (10), 3945\u20133952 (2021).","journal-title":"Cancer Sci."},{"issue":"4","key":"82088_CR43","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1002\/hep.26160","volume":"57","author":"S Anth\u00e9rieu","year":"2013","unstructured":"Anth\u00e9rieu, S. et al. Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells. Hepatology 57 (4), 1518\u20131529 (2013).","journal-title":"Hepatology"},{"issue":"1","key":"82088_CR44","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1186\/s13046-021-02144-w","volume":"40","author":"S Matteoni","year":"2021","unstructured":"Matteoni, S. et al. Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response. J. Exp. Clin. Cancer Res. 40 (1), 347 (2021).","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"82088_CR45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s12032-024-02323-7","volume":"41","author":"S Harris","year":"2024","unstructured":"Harris, S., Nagarajan, P. & Kim, K. The cytotoxic effects of prazosin, chlorpromazine, and haloperidol on hepatocellular carcinoma and immortalized non-tumor liver cells. Med. Oncol. 41 (4), 87 (2024).","journal-title":"Med. Oncol."},{"key":"82088_CR46","doi-asserted-by":"publisher","first-page":"634849","DOI":"10.3389\/fcell.2020.634849","volume":"8","author":"W Ren","year":"2021","unstructured":"Ren, W., Zhao, W., Cao, L. & Huang, J. Involvement of the Actin Machinery in programmed cell death. Front. Cell. Dev. Biol. 8, 634849 (2021).","journal-title":"Front. Cell. Dev. Biol."},{"issue":"5","key":"82088_CR47","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3892\/or.2023.8637","volume":"50","author":"S Kwon","year":"2023","unstructured":"Kwon, S., Han, S. & Kim, K. Differential response of MDA\u2013MB\u2013231 breast cancer and MCF10A normal breast cells to cytoskeletal disruption. Oncol. Rep. 50 (5), 200 (2023).","journal-title":"Oncol. Rep."},{"issue":"1","key":"82088_CR48","doi-asserted-by":"publisher","first-page":"34657","DOI":"10.1038\/srep34657","volume":"6","author":"A Colin","year":"2016","unstructured":"Colin, A., Bonnemay, L., Gayrard, C., Gautier, J. & Gueroui, Z. Triggering signaling pathways using F-actin self-organization. Sci. Rep. 6 (1), 34657 (2016).","journal-title":"Sci. Rep."},{"key":"82088_CR49","doi-asserted-by":"publisher","first-page":"0080","DOI":"10.34133\/research.0080","volume":"6","author":"X Ji","year":"2023","unstructured":"Ji, X. et al. Intermittent F-actin perturbations by magnetic fields inhibit breast Cancer metastasis. Research 6, 0080 (2023).","journal-title":"Research"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82088-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82088-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82088-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T10:53:01Z","timestamp":1733395981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82088-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["82088"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-82088-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]},"assertion":[{"value":"12 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30329"}}