{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T05:29:31Z","timestamp":1738387771685,"version":"3.35.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-82227-8","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T03:34:35Z","timestamp":1735356875000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel biomarker of COVID-19: MMP8 emerged by integrated bulk RNAseq and single-cell sequencing"],"prefix":"10.1038","volume":"14","author":[{"given":"Zhenguo","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunda","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"issue":"1","key":"82227_CR1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41374-021-00663-w","volume":"102","author":"Y Zhou","year":"2022","unstructured":"Zhou, Y., Zhang, L., Xie, Y. H. & Wu, J. Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics. Lab. Invest. 102(1), 4\u201313 (2022).","journal-title":"Lab. Invest."},{"issue":"5","key":"82227_CR2","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.chest.2020.12.026","volume":"159","author":"V Kaul","year":"2021","unstructured":"Kaul, V. et al. Medical Education during the COVID-19 pandemic. Chest 159(5), 1949\u20131960 (2021).","journal-title":"Chest"},{"key":"82227_CR3","doi-asserted-by":"crossref","unstructured":"Sharma, A., Ahmad Farouk, I. & Lal, S. K. COVID-19: a review on the novel coronavirus disease evolution, transmission, detection, control and prevention. Viruses 13(2). (2021).","DOI":"10.3390\/v13020202"},{"issue":"2","key":"82227_CR4","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3892\/etm.2017.4684","volume":"14","author":"X Yu","year":"2017","unstructured":"Yu, X. et al. Sivelestat sodium hydrate improves post-traumatic knee osteoarthritis through nuclear factor-\u03baB in a rat model. Exp. Ther. Med. 14(2), 1531\u20131537 (2017).","journal-title":"Exp. Ther. Med."},{"issue":"10","key":"82227_CR5","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.21037\/jtd-22-1309","volume":"14","author":"R Zhang","year":"2022","unstructured":"Zhang, R. et al. Myocardial protective effect of sivelestat sodium in rat models with sepsis-induced myocarditis. J. Thorac. Dis. 14(10), 4003\u20134011 (2022).","journal-title":"J. Thorac. Disease"},{"issue":"3","key":"82227_CR6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00540-017-2327-1","volume":"31","author":"M Kishimoto","year":"2017","unstructured":"Kishimoto, M. et al. Sivelestat sodium and mortality in pneumonia patients requiring mechanical ventilation: propensity score analysis of a Japanese nationwide database. J. Anesth. 31(3), 405\u2013412 (2017).","journal-title":"J. Anesth."},{"issue":"8","key":"82227_CR7","first-page":"1259","volume":"43","author":"M Luo","year":"2023","unstructured":"Luo, M. et al. Sivelestat sodium for treatment of patients with COVID-19-associated acute respiratory distress syndrome in intensive care unit: a single-center retrospective cohort study. Nan Fang Yi Ke da xue xue bao = J. South. Med. Univ. 43(8), 1259\u20131267 (2023).","journal-title":"Nan Fang Yi Ke da xue xue bao = J. South. Med. Univ."},{"key":"82227_CR8","doi-asserted-by":"crossref","first-page":"147702","DOI":"10.1016\/j.gene.2023.147702","volume":"884","author":"J Weng","year":"2023","unstructured":"Weng, J. et al. Sivelestat sodium alleviated lipopolysaccharide-induced acute lung injury by improving endoplasmic reticulum stress. Gene 884, 147702 (2023).","journal-title":"Gene"},{"key":"82227_CR9","doi-asserted-by":"crossref","first-page":"113924","DOI":"10.1016\/j.bios.2021.113924","volume":"200","author":"M Zandi","year":"2022","unstructured":"Zandi, M. & Fani, M. Target genes used for biosensor development in COVID-19 diagnosis. Biosens. Bioelectron. 200, 113924 (2022).","journal-title":"Biosens. Bioelectron."},{"key":"82227_CR10","doi-asserted-by":"crossref","unstructured":"Lim, W. Y., Lan, B. L. & Ramakrishnan, N. Emerging biosensors to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review. Biosensors 11(11). (2021).","DOI":"10.3390\/bios11110434"},{"key":"82227_CR11","doi-asserted-by":"crossref","first-page":"593223","DOI":"10.3389\/fphys.2021.593223","volume":"12","author":"M Lopes-Pacheco","year":"2021","unstructured":"Lopes-Pacheco, M. et al. Pathogenesis of multiple organ injury in COVID-19 and potential therapeutic strategies. Front. Physiol. 12, 593223 (2021).","journal-title":"Front. Physiol."},{"issue":"3","key":"82227_CR12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1515\/cclm-2021-1021","volume":"60","author":"A Vianello","year":"2022","unstructured":"Vianello, A. et al. The pathogenesis, epidemiology and biomarkers of susceptibility of pulmonary fibrosis in COVID-19 survivors. Clin. Chem. Lab. Med. 60(3), 307\u2013316 (2022).","journal-title":"Clin. Chem. Lab. Med."},{"issue":"5","key":"82227_CR13","doi-asserted-by":"crossref","first-page":"e0251819","DOI":"10.1371\/journal.pone.0251819","volume":"16","author":"E Cione","year":"2021","unstructured":"Cione, E. et al. Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury. PLoS One. 16(5), e0251819 (2021).","journal-title":"PLoS One"},{"issue":"6","key":"82227_CR14","first-page":"e15462","volume":"13","author":"G Topp","year":"2021","unstructured":"Topp, G. et al. Biomarkers predictive of extubation and survival of COVID-19 patients. Cureus 13(6), e15462 (2021).","journal-title":"Cureus"},{"issue":"10","key":"82227_CR15","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1002\/jmv.27184","volume":"93","author":"H Alay","year":"2021","unstructured":"Alay, H. & Laloglu, E. The role of angiopoietin-2 and surfactant protein-D levels in SARS-CoV-2-related lung injury: a prospective, observational, cohort study. J. Med. Virol. 93(10), 6008\u20136015 (2021).","journal-title":"J. Med. Virol."},{"issue":"7","key":"82227_CR16","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/s41591-020-0944-y","volume":"26","author":"AJ Wilk","year":"2020","unstructured":"Wilk, A. J. et al. A single-cell atlas of the peripheral immune response in patients with severe COVID-19. Nat. Med. 26(7), 1070\u20131076 (2020).","journal-title":"Nat. Med."},{"key":"82227_CR17","doi-asserted-by":"crossref","first-page":"848582","DOI":"10.3389\/fimmu.2022.848582","volume":"13","author":"D Primorac","year":"2022","unstructured":"Primorac, D. et al. Adaptive immune responses and immunity to SARS-CoV-2. Front. Immunol. 13, 848582 (2022).","journal-title":"Front. Immunol."},{"issue":"1","key":"82227_CR18","doi-asserted-by":"crossref","first-page":"e0360021","DOI":"10.1128\/mbio.03600-21","volume":"13","author":"L Zhao","year":"2021","unstructured":"Zhao, L. et al. Gasdermin D inhibits coronavirus infection by promoting the noncanonical secretion of beta interferon. mBio 13(1), e0360021 (2021).","journal-title":"mBio"},{"issue":"5","key":"82227_CR19","doi-asserted-by":"crossref","first-page":"e0234221","DOI":"10.1128\/mBio.02342-21","volume":"12","author":"Y Luo","year":"2021","unstructured":"Luo, Y. et al. Identification of ZDHHC17 as a potential drug target for swine acute diarrhea syndrome coronavirus infection. mBio 12(5), e0234221 (2021).","journal-title":"mBio"},{"key":"82227_CR20","doi-asserted-by":"crossref","unstructured":"Mostafa, H. H. et al. Metagenomic next-generation sequencing of nasopharyngeal specimens collected from confirmed and suspect COVID-19 patients. mBio 11(6). (2020).","DOI":"10.1128\/mBio.01969-20"},{"key":"82227_CR21","doi-asserted-by":"crossref","first-page":"632490","DOI":"10.3389\/fcimb.2021.632490","volume":"11","author":"X Chen","year":"2021","unstructured":"Chen, X. et al. Next-generation sequencing reveals the progression of COVID-19. Front. Cell. Infect. Microbiol. 11, 632490 (2021).","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"5","key":"82227_CR22","doi-asserted-by":"crossref","first-page":"e430","DOI":"10.1002\/ctm2.430","volume":"11","author":"P Wang","year":"2021","unstructured":"Wang, P. et al. Identification of potential vaccine targets for COVID-19 by combining single-cell and bulk TCR sequencing. Clin. Transl Med. 11(5), e430 (2021).","journal-title":"Clin. Transl Med."},{"issue":"1","key":"82227_CR23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41368-021-00146-0","volume":"13","author":"X Li","year":"2021","unstructured":"Li, X. & Wang, C. Y. From bulk, single-cell to spatial RNA sequencing. Int. J. Oral Sci. 13(1), 36 (2021).","journal-title":"Int. J. Oral Sci."},{"issue":"11","key":"82227_CR24","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1002\/1878-0261.13190","volume":"16","author":"T Wang","year":"2022","unstructured":"Wang, T. et al. Integrating bulk and single-cell RNA sequencing reveals cellular heterogeneity and immune infiltration in hepatocellular carcinoma. Mol. Oncol. 16(11), 2195\u20132213 (2022).","journal-title":"Mol. Oncol."},{"issue":"1","key":"82227_CR25","doi-asserted-by":"crossref","first-page":"lqad020","DOI":"10.1093\/nargab\/lqad020","volume":"5","author":"Y Lefol","year":"2023","unstructured":"Lefol, Y. et al. TiSA: TimeSeriesAnalysis-a pipeline for the analysis of longitudinal transcriptomics data. NAR Genom Bioinform. 5(1), lqad020 (2023).","journal-title":"NAR Genom Bioinform"},{"issue":"7","key":"82227_CR26","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43(7), e47 (2015).","journal-title":"Nucleic Acids Res."},{"key":"82227_CR27","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 9, 559 (2008).","journal-title":"BMC Bioinform."},{"issue":"3","key":"82227_CR28","first-page":"100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu, T. et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innov. (Camb). 2(3), 100141 (2021).","journal-title":"Innov. (Camb)"},{"issue":"1","key":"82227_CR29","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41467-021-21702-6","volume":"12","author":"P Bost","year":"2021","unstructured":"Bost, P. et al. Deciphering the state of immune silence in fatal COVID-19 patients. Nat. Commun. 12(1), 1428 (2021).","journal-title":"Nat. Commun."},{"issue":"5","key":"82227_CR30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","volume":"33","author":"R Satija","year":"2015","unstructured":"Satija, R., Farrell, J. A., Gennert, D., Schier, A. F. & Regev, A. Spatial reconstruction of single-cell gene expression data. Nat. Biotechnol. 33(5), 495\u2013502 (2015).","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"82227_CR31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran, D. et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat. Immunol. 20(2), 163\u2013172 (2019).","journal-title":"Nat. Immunol."},{"issue":"D1","key":"82227_CR32","doi-asserted-by":"crossref","first-page":"D870","DOI":"10.1093\/nar\/gkac947","volume":"51","author":"C Hu","year":"2023","unstructured":"Hu, C. et al. CellMarker 2.0: an updated database of manually curated cell markers in human\/mouse and web tools based on scRNA-seq data. Nucleic Acids Res. 51(D1), D870\u2013D876 (2023).","journal-title":"Nucleic Acids Res."},{"issue":"6359","key":"82227_CR33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.aan6828","volume":"358","author":"MJT Stubbington","year":"2017","unstructured":"Stubbington, M. J. T., Rozenblatt-Rosen, O., Regev, A. & Teichmann, S. A. Single-cell transcriptomics to explore the immune system in health and disease. Science 358(6359), 58\u201363 (2017).","journal-title":"Science"},{"issue":"1","key":"82227_CR34","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell-cell communication using CellChat. Nat. Commun. 12(1), 1088 (2021).","journal-title":"Nat. Commun."},{"key":"82227_CR35","doi-asserted-by":"crossref","unstructured":"Kijima, Y. et al. Suspected pneumonia caused by coronavirus disease 2019 after kidney transplantation: a case report. Transplant. Proc. 54(6):1547\u20131550. (2022).","DOI":"10.1016\/j.transproceed.2021.09.009"},{"issue":"6","key":"82227_CR36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41590-021-00928-y","volume":"22","author":"P Cheung","year":"2021","unstructured":"Cheung, P. et al. Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation. Nat. Immunol. 22(6), 711\u2013722 (2021).","journal-title":"Nat. Immunol."},{"issue":"20","key":"82227_CR37","doi-asserted-by":"crossref","first-page":"9953","DOI":"10.7150\/thno.63743","volume":"11","author":"HC Chuang","year":"2021","unstructured":"Chuang, H. C. et al. BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus. Theranostics 11(20), 9953\u20139966 (2021).","journal-title":"Theranostics"},{"issue":"6","key":"82227_CR38","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41419-023-05890-1","volume":"14","author":"PY Liu","year":"2023","unstructured":"Liu, P. Y. et al. RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury. Cell. Death Dis. 14(6), 369 (2023).","journal-title":"Cell. Death Dis."},{"key":"82227_CR39","doi-asserted-by":"crossref","first-page":"113816","DOI":"10.1016\/j.addr.2021.05.026","volume":"175","author":"E Kostallari","year":"2021","unstructured":"Kostallari, E., Valainathan, S., Biquard, L., Shah, V. H. & Rautou, P. E. Role of extracellular vesicles in liver diseases and their therapeutic potential. Adv. Drug Deliv. Rev. 175, 113816 (2021).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"82227_CR40","doi-asserted-by":"crossref","unstructured":"Fenollar, F. et al. Evaluation of the panbio COVID-19 rapid antigen detection test device for the screening of patients with COVID-19. J. Clin. Microbiol. 59(2). (2021).","DOI":"10.1128\/JCM.02589-20"},{"issue":"8","key":"82227_CR41","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1056\/NEJMe2001126","volume":"382","author":"S Perlman","year":"2020","unstructured":"Perlman, S. Another decade, another coronavirus. N. Engl. J. Med. 382(8), 760\u2013762 (2020).","journal-title":"N. Engl. J. Med."},{"issue":"13","key":"82227_CR42","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa2118691","volume":"386","author":"V Hall","year":"2022","unstructured":"Hall, V. et al. Protection against SARS-CoV-2 after Covid-19 vaccination and previous infection. N. Engl. J. Med. 386(13), 1207\u20131220 (2022).","journal-title":"N. Engl. J. Med."},{"key":"82227_CR43","doi-asserted-by":"crossref","unstructured":"Yadav, R. et al. Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19. Cells 10(4). (2021).","DOI":"10.3390\/cells10040821"},{"issue":"1","key":"82227_CR44","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/22221751.2020.1729069","volume":"9","author":"X Tian","year":"2020","unstructured":"Tian, X. et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg. Microbes Infect. 9(1), 382\u2013385 (2020).","journal-title":"Emerg. Microbes Infections"},{"issue":"12","key":"82227_CR45","doi-asserted-by":"crossref","first-page":"1654e1651","DOI":"10.1016\/j.cmi.2022.07.015","volume":"28","author":"Y Nguyen","year":"2022","unstructured":"Nguyen, Y. et al. Pre-exposure prophylaxis with tixagevimab and cilgavimab (Evusheld) for COVID-19 among 1112 severely immunocompromised patients. Clin. Microbiol. Infect.: Off. Publ. Eur. Soc. Clin. Microbiol. Infect. Dis. 28(12), 1654e1651\u20131654e1654 (2022).","journal-title":"Clin. Microbiol. Infection: Official Publication Eur. Soc. Clin. Microbiol. Infect. Dis."},{"issue":"1","key":"82227_CR46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.5582\/bst.2020.01030","volume":"14","author":"Z Wang","year":"2020","unstructured":"Wang, Z., Chen, X., Lu, Y., Chen, F. & Zhang, W. Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and western medicine treatment. Biosci. Trends. 14(1), 64\u201368 (2020).","journal-title":"Biosci. Trends"},{"issue":"10","key":"82227_CR47","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.21037\/jtd-22-1220","volume":"14","author":"Y Zhou","year":"2022","unstructured":"Zhou, Y., Li, X., Chen, H., Zhong, X. & Ren, H. Efficacy and safety of sivelestat sodium for the treatment of inflammatory response in acute Stanford type A aortic dissection: a retrospective cohort study. J. Thorac. Dis. 14(10), 3975\u20133982 (2022).","journal-title":"J. Thorac. Disease"},{"issue":"3","key":"82227_CR48","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3390\/tomography7030035","volume":"7","author":"A Guarnera","year":"2021","unstructured":"Guarnera, A., Santini, E. & Podda, P. Idiopathic interstitial pneumonias and COVID-19 pneumonia: review of the main radiological features and differential diagnosis. Tomography (Ann Arbor Mich). 7(3), 397\u2013411 (2021).","journal-title":"Tomography (Ann Arbor Mich)"},{"issue":"12","key":"82227_CR49","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nrd4390","volume":"13","author":"RE Vandenbroucke","year":"2014","unstructured":"Vandenbroucke, R. E. & Libert, C. Is there new hope for therapeutic matrix metalloproteinase inhibition? Nat. Rev. Drug Discovery. 13(12), 904\u2013927 (2014).","journal-title":"Nat. Rev. Drug Discovery"},{"key":"82227_CR50","doi-asserted-by":"crossref","unstructured":"Gutman, H. et al. Matrix metalloproteinases expression is associated with SARS-CoV-2-induced lung pathology and extracellular-matrix remodeling in K18-hACE2 mice. Viruses 14(8). (2022).","DOI":"10.3390\/v14081627"},{"issue":"11","key":"82227_CR51","doi-asserted-by":"crossref","first-page":"e3939","DOI":"10.1093\/cid\/ciaa1843","volume":"73","author":"MA Gillette","year":"2021","unstructured":"Gillette, M. A. et al. Biomarkers to distinguish bacterial from viral pediatric clinical pneumonia in a malaria-endemic setting. Clin. Infect. Dis.: Off. Publ. Infect. Dis. Soc. Am. 73(11), e3939\u2013e3948 (2021).","journal-title":"Clin. Infect. Diseases: Official Publication Infect. Dis. Soc. Am."},{"issue":"4","key":"82227_CR52","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1164\/rccm.200203-258OC","volume":"167","author":"CM Hartog","year":"2003","unstructured":"Hartog, C. M. et al. Pulmonary matrix metalloproteinase excess in hospital-acquired pneumonia. Am. J. Respir Crit. Care Med. 167(4), 593\u2013598 (2003).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"82227_CR53","doi-asserted-by":"crossref","unstructured":"da Silva-Neto, P. V. et al. Matrix metalloproteinases on severe COVID-19 lung disease pathogenesis: cooperative actions of MMP-8\/MMP-2 axis on immune response through HLA-G shedding and oxidative stress. Biomolecules 12(5). (2022).","DOI":"10.3390\/biom12050604"},{"issue":"3","key":"82227_CR54","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1007\/s12035-017-0509-3","volume":"55","author":"H Kumar","year":"2018","unstructured":"Kumar, H. et al. Matrix metalloproteinase-8 inhibition prevents disruption of blood-spinal cord barrier and attenuates inflammation in rat model of spinal cord injury. Mol. Neurobiol. 55(3), 2577\u20132590 (2018).","journal-title":"Mol. Neurobiol."},{"issue":"11","key":"82227_CR55","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.autrev.2017.09.012","volume":"16","author":"KH Lee","year":"2017","unstructured":"Lee, K. H. et al. Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review. Autoimmun. rev. 16(11), 1160\u20131173 (2017).","journal-title":"Autoimmun. rev."},{"issue":"2","key":"82227_CR56","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","volume":"22","author":"C Lood","year":"2016","unstructured":"Lood, C. et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat. Med. 22(2), 146\u2013153 (2016).","journal-title":"Nat. Med."},{"issue":"11","key":"82227_CR57","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ni.2987","volume":"15","author":"N Branzk","year":"2014","unstructured":"Branzk, N. et al. Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nat. Immunol. 15(11), 1017\u20131025 (2014).","journal-title":"Nat. Immunol."},{"issue":"2","key":"82227_CR58","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","volume":"18","author":"V Papayannopoulos","year":"2018","unstructured":"Papayannopoulos, V. Neutrophil extracellular traps in immunity and disease. Nat. Rev. Immunol. 18(2), 134\u2013147 (2018).","journal-title":"Nat. Rev. Immunol."},{"key":"82227_CR59","doi-asserted-by":"crossref","first-page":"953195","DOI":"10.3389\/fimmu.2022.953195","volume":"13","author":"D Scozzi","year":"2022","unstructured":"Scozzi, D., Liao, F., Krupnick, A. S., Kreisel, D. & Gelman, A. E. The role of neutrophil extracellular traps in acute lung injury. Front. Immunol. 13, 953195 (2022).","journal-title":"Front. Immunol."},{"key":"82227_CR60","doi-asserted-by":"crossref","unstructured":"Zuo, Y. et al. Neutrophil extracellular traps in COVID-19. JCI Insight 5(11). (2020).","DOI":"10.1172\/jci.insight.138999"},{"issue":"10","key":"82227_CR61","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1182\/blood.2020007008","volume":"136","author":"EA Middleton","year":"2020","unstructured":"Middleton, E. A. et al. Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood 136(10), 1169\u20131179 (2020).","journal-title":"Blood"},{"issue":"1","key":"82227_CR62","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1038\/s41598-022-09017-y","volume":"12","author":"K Nakamura","year":"2022","unstructured":"Nakamura, K., Nakayama, H., Sasaki, S., Takahashi, K. & Iwabuchi, K. Mycobacterium avium-intracellulare complex promote release of pro-inflammatory enzymes matrix metalloproteinases by inducing neutrophil extracellular trap formation. Sci. Rep. 12(1), 5181 (2022).","journal-title":"Sci. Rep."},{"issue":"5","key":"82227_CR63","doi-asserted-by":"crossref","first-page":"e1004917","DOI":"10.1371\/journal.ppat.1004917","volume":"11","author":"CW Ong","year":"2015","unstructured":"Ong, C. W. et al. Neutrophil-derived MMP-8 drives AMPK-dependent matrix destruction in human pulmonary tuberculosis. PLoS Pathog. 11(5), e1004917 (2015).","journal-title":"PLoS Pathog"},{"issue":"10","key":"82227_CR64","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1515\/hsz-2013-0295","volume":"395","author":"KE Bernstein","year":"2014","unstructured":"Bernstein, K. E. et al. Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response. Biol. Chem. 395(10), 1173\u20131178 (2014).","journal-title":"Biol. Chem."},{"issue":"3","key":"82227_CR65","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.imbio.2016.10.018","volume":"222","author":"K Bukowska-Strakova","year":"2017","unstructured":"Bukowska-Strakova, K. et al. Heme oxygenase 1 affects granulopoiesis in mice through control of myelocyte proliferation. Immunobiology 222(3), 506\u2013517 (2017).","journal-title":"Immunobiology"},{"key":"82227_CR66","doi-asserted-by":"crossref","unstructured":"Diaz-Garrido, N., Cordero, C., Olivo-Martinez, Y., Badia, J. & Baldom\u00e0, L. Cell-to-cell communication by host-released extracellular vesicles in the gut: implications in health and disease. Int. J. Mol. Sci. 22(4). (2021).","DOI":"10.3390\/ijms22042213"},{"issue":"1","key":"82227_CR67","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","volume":"21","author":"M Mathieu","year":"2019","unstructured":"Mathieu, M., Martin-Jaular, L., Lavieu, G. & Th\u00e9ry, C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat. Cell. Biol. 21(1), 9\u201317 (2019).","journal-title":"Nat. Cell. Biol."},{"issue":"1","key":"82227_CR68","doi-asserted-by":"crossref","first-page":"101456","DOI":"10.1016\/j.jbc.2021.101456","volume":"298","author":"Q Yang","year":"2022","unstructured":"Yang, Q. et al. A proteomic atlas of ligand-receptor interactions at the ovine maternal-fetal interface reveals the role of histone lactylation in uterine remodeling. J. Biol. Chem. 298(1), 101456 (2022).","journal-title":"J. Biol. Chem."},{"key":"82227_CR69","doi-asserted-by":"crossref","unstructured":"Goruganthu, M. U. L., Shanker, A., Dikov, M. M. & Carbone, D. P. Specific targeting of notch ligand-receptor interactions to modulate immune responses: a review of clinical and preclinical findings. Front Immunol 11:1958. (2020).","DOI":"10.3389\/fimmu.2020.01958"},{"key":"82227_CR70","doi-asserted-by":"crossref","unstructured":"C\u00f3rdova-Bahena, L. & Velasco-Vel\u00e1zquez, M. A. Anti-PD-1 and Anti-PD-L1 antibodies as immunotherapy against cancer: a structural perspective. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 73(1):008\u2013016. (2020).","DOI":"10.24875\/RIC.20000341"},{"key":"82227_CR71","doi-asserted-by":"crossref","unstructured":"Leslie, J. et al. FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis. JCI Insight 5(4). (2020).","DOI":"10.1172\/jci.insight.125937"},{"issue":"4","key":"82227_CR72","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41419-023-05814-z","volume":"14","author":"S Qin","year":"2023","unstructured":"Qin, S. et al. Novel insight into the underlying dysregulation mechanisms of immune cell-to-cell communication by analyzing multitissue single-cell atlas of two COVID-19 patients. Cell. Death Dis. 14(4), 286 (2023).","journal-title":"Cell. Death Dis."},{"issue":"1","key":"82227_CR73","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s40478-018-0576-3","volume":"6","author":"H Kumar","year":"2018","unstructured":"Kumar, H. et al. Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury. Acta Neuropathol. Commun. 6(1), 73 (2018).","journal-title":"Acta Neuropathol. Commun."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82227-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82227-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82227-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T21:50:00Z","timestamp":1738360200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82227-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["82227"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-82227-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"23 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Our study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee, Shaanxi Provincial People\u2019s Hospital\u00a0(no. SPPH-LLBG-17-3_2).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"31086"}}