{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:06:19Z","timestamp":1772136379916,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-82298-7","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T22:41:50Z","timestamp":1735339310000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lack of association of the PLD4 SNP rs2841277 with systemic sclerosis in a European American population"],"prefix":"10.1038","volume":"14","author":[{"given":"Yunqing","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen D.","family":"Mayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shervin","family":"Assassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"82298_CR1","first-page":"202","volume":"15","author":"EC LeRoy","year":"1988","unstructured":"LeRoy, E. C. et al. Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis. J. Rheumatol. 15, 202\u2013205 (1988).","journal-title":"J. Rheumatol."},{"key":"82298_CR2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.semarthrit.2005.03.005","volume":"35","author":"VD Steen","year":"2005","unstructured":"Steen, V. D. Autoantibodies in systemic sclerosis. Semin. Arthritis Rheum. 35, 35\u201342 (2005).","journal-title":"Semin. Arthritis Rheum."},{"issue":"1","key":"82298_CR3","doi-asserted-by":"publisher","first-page":"11212","DOI":"10.1038\/s41598-022-15062-4","volume":"12","author":"KEN Clark","year":"2022","unstructured":"Clark, K. E. N. et al. Combinations of scleroderma hallmark autoantibodies associate with distinct clinical phenotypes. Sci. Rep. 12(1), 11212 (2022).","journal-title":"Sci. Rep."},{"key":"82298_CR4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1346-8138.2009.00762.x","volume":"37","author":"Y Hamaguchi","year":"2010","unstructured":"Hamaguchi, Y. Autoantibody profiles in systemic sclerosis: Predictive value for clinical evaluation and prognosis. J. Dermatol. 37, 42\u201353 (2010).","journal-title":"J. Dermatol."},{"key":"82298_CR5","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1073\/pnas.77.3.1627","volume":"77","author":"Y Moroi","year":"1980","unstructured":"Moroi, Y., Peebles, C., Fritzler, M. J., Steigerwald, J. & Tan, E. M. Autoantibody to centromere (kinetochore) in scleroderma sera. Proc. Natl. Acad. Sci. U. S. A. 77, 1627\u20131631 (1980).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"82298_CR6","first-page":"2489","volume":"26","author":"TG Phan","year":"1999","unstructured":"Phan, T. G. et al. Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis sine scleroderma. J. Rheumatol. 26(11), 2489\u20132492 (1999).","journal-title":"J. Rheumatol."},{"key":"82298_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013932","volume":"5","author":"F Yoshikawa","year":"2010","unstructured":"Yoshikawa, F. et al. Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia. PLoS One 5, e13932 (2010).","journal-title":"PLoS One"},{"key":"82298_CR8","doi-asserted-by":"publisher","first-page":"54918","DOI":"10.1074\/jbc.M407798200","volume":"279","author":"RV Stahelin","year":"2004","unstructured":"Stahelin, R. V. et al. Mechanism of membrane binding of the phospholipase D1 PX domain. J. Biol. Chem. 279, 54918\u201354926 (2004).","journal-title":"J. Biol. Chem."},{"key":"82298_CR9","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1093\/emboj\/16.15.4519","volume":"16","author":"TC Sung","year":"1997","unstructured":"Sung, T. C. et al. Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. Embo J. 16, 4519\u20134530 (1997).","journal-title":"Embo J."},{"issue":"12","key":"82298_CR10","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1681\/ASN.2016111222","volume":"28","author":"P Trivedi","year":"2017","unstructured":"Trivedi, P. et al. Targeting phospholipase D4 attenuates kidney fibrosis. J. Am. Soc. Nephrol. 28(12), 3579\u20133589 (2017).","journal-title":"J. Am. Soc. Nephrol."},{"key":"82298_CR11","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/art.37777","volume":"65","author":"C Terao","year":"2013","unstructured":"Terao, C. et al. PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population. Arthritis Rheum. 65, 472\u2013480 (2013).","journal-title":"Arthritis Rheum."},{"issue":"4","key":"82298_CR12","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1136\/annrheumdis-2018-214116","volume":"78","author":"S Akizuki","year":"2019","unstructured":"Akizuki, S. et al. PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes. Ann. Rheum. Dis. 78(4), 509\u2013518 (2019).","journal-title":"Ann. Rheum. Dis."},{"issue":"38","key":"82298_CR13","doi-asserted-by":"publisher","first-page":"64180","DOI":"10.18632\/oncotarget.19419","volume":"8","author":"WC Chen","year":"2017","unstructured":"Chen, W. C. et al. rs2841277 (PLD4) is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis. Oncotarget 8(38), 64180\u201364190 (2017).","journal-title":"Oncotarget"},{"key":"82298_CR14","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1007\/s00018-005-5195-z","volume":"62","author":"GM Jenkins","year":"2005","unstructured":"Jenkins, G. M. & Frohman, M. A. Phospholipase D: A lipid centric review. Cell. Mol. Life Sci. 62, 2305\u20132316 (2005).","journal-title":"Cell. Mol. Life Sci."},{"key":"82298_CR15","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1007\/PL00000805","volume":"58","author":"S Cockcroft","year":"2001","unstructured":"Cockcroft, S. Signalling roles of mammalian phospholipase D1 and D2. Cell. Mol. Life Sci. 58, 1674\u20131687 (2001).","journal-title":"Cell. Mol. Life Sci."},{"key":"82298_CR16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0014-5793(02)03405-1","volume":"531","author":"JH Exton","year":"2002","unstructured":"Exton, J. H. Regulation of phospholipase D. FEBS Lett. 531, 58\u201361 (2002).","journal-title":"FEBS Lett."},{"key":"82298_CR17","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nature12825","volume":"505","author":"C Cruchaga","year":"2014","unstructured":"Cruchaga, C. et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer\u2019s disease. Nature 505, 550\u2013554 (2014).","journal-title":"Nature"},{"key":"82298_CR18","doi-asserted-by":"publisher","first-page":"4072","DOI":"10.1093\/hmg\/ddq307","volume":"19","author":"R Anney","year":"2010","unstructured":"Anney, R. et al. A genome-wide scan for common alleles affecting risk for autism. Hum. Mol. Genet. 19, 4072\u20134082 (2010).","journal-title":"Hum. Mol. Genet."},{"key":"82298_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nature11502","volume":"491","author":"JJ Ipsaro","year":"2012","unstructured":"Ipsaro, J. J., Haase, A. D., Knott, S. R., Joshua-Tor, L. & Hannon, G. J. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature 491, 279\u2013283 (2012).","journal-title":"Nature"},{"key":"82298_CR20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cellsig.2014.09.008","volume":"27","author":"M Mahankali","year":"2015","unstructured":"Mahankali, M., Alter, G. & Gomez-Cambronero, J. Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model. Cell. Signal. 27, 69\u201381 (2015).","journal-title":"Cell. Signal."},{"key":"82298_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1749-6632.2000.tb06538.x","volume":"905","author":"JH Exton","year":"2000","unstructured":"Exton, J. H. Phospholipase D. Ann. N. Y. Acad. Sci. 905, 61\u201368 (2000).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"82298_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S1388-1981(99)00093-1","volume":"1439","author":"MA Frohman","year":"1999","unstructured":"Frohman, M. A., Sung, T. C. & Morris, A. J. Mammalian phospholipase D structure and regulation. Biochim. Biophys. Acta 1439, 175\u2013186 (1999).","journal-title":"Biochim. Biophys. Acta"},{"key":"82298_CR23","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jbior.2013.08.006","volume":"54","author":"J Gomez-Cambronero","year":"2014","unstructured":"Gomez-Cambronero, J. Phosphatidic acid, phospholipase D and tumorigenesis. Adv. Biol. Regul. 54, 197\u2013206 (2014).","journal-title":"Adv. Biol. Regul."},{"key":"82298_CR24","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1100\/tsw.2010.116","volume":"10","author":"J Gomez-Cambronero","year":"2010","unstructured":"Gomez-Cambronero, J. New concepts in phospholipase D signaling in inflammation and cancer. Sci. World J. 10, 1356\u20131369 (2010).","journal-title":"Sci. World J."},{"key":"82298_CR25","doi-asserted-by":"publisher","first-page":"6064","DOI":"10.1021\/cr200296t","volume":"111","author":"PE Selvy","year":"2011","unstructured":"Selvy, P. E., Lavieri, R. R., Lindsley, C. W. & Brown, H. A. Phospholipase D: enzymology, functionality, and chemical modulation. Chem. Rev. 111, 6064\u20136119 (2011).","journal-title":"Chem. Rev."},{"key":"82298_CR26","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0074-7696(06)50005-1","volume":"250","author":"G Kraal","year":"2006","unstructured":"Kraal, G. & Mebius, R. New insights into the cell biology of the marginal zone of the spleen. Int. Rev. Cytol. 250, 175\u2013215 (2006).","journal-title":"Int. Rev. Cytol."},{"key":"82298_CR27","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1002\/1529-0131(200106)44:6<1359::AID-ART228>3.0.CO;2-S","volume":"44","author":"FC Arnett","year":"2001","unstructured":"Arnett, F. C. et al. Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts. Arthritis Rheum. 44, 1359\u20131362 (2001).","journal-title":"Arthritis Rheum."},{"key":"82298_CR28","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1136\/annrheumdis-2012-202357","volume":"72","author":"LM Diaz-Gallo","year":"2013","unstructured":"Diaz-Gallo, L. M. et al. Implication of IL-2\/IL-21 region in systemic sclerosis genetic susceptibility. Ann. Rheum. Dis. 72, 1233\u20131238 (2013).","journal-title":"Ann. Rheum. Dis."},{"key":"82298_CR29","doi-asserted-by":"publisher","first-page":"3794","DOI":"10.1002\/art.24958","volume":"60","author":"P Gourh","year":"2009","unstructured":"Gourh, P. et al. Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: Evidence of possible gene-gene interaction and alterations in Th1\/Th2 cytokines. Arthritis Rheum. 60, 3794\u20133806 (2009).","journal-title":"Arthritis Rheum."},{"key":"82298_CR30","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1002\/art.38870","volume":"66","author":"E Lopez-Isac","year":"2014","unstructured":"Lopez-Isac, E. et al. Identification of IL12RB1 as a novel systemic sclerosis susceptibility locus. Arthritis Rheumatol. 66, 3521\u20133523 (2014).","journal-title":"Arthritis Rheumatol."},{"key":"82298_CR31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ajhg.2013.12.002","volume":"94","author":"MD Mayes","year":"2014","unstructured":"Mayes, M. D. et al. Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. Am. J. Hum. Genet. 94, 47\u201361 (2014).","journal-title":"Am. J. Hum. Genet."},{"key":"82298_CR32","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1002\/art.24982","volume":"60","author":"X Zhou","year":"2009","unstructured":"Zhou, X. et al. HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: A genome-wide association study in Koreans with replication in North Americans. Arthritis Rheum. 60, 3807\u20133814 (2009).","journal-title":"Arthritis Rheum."},{"key":"82298_CR33","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1002\/art.10601","volume":"46","author":"X Zhou","year":"2002","unstructured":"Zhou, X. et al. Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma. Arthritis Rheum. 46, 2990\u20132999 (2002).","journal-title":"Arthritis Rheum."},{"key":"82298_CR34","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/ng.565","volume":"42","author":"TR Radstake","year":"2010","unstructured":"Radstake, T. R. et al. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat. Genet. 42, 426\u2013429 (2010).","journal-title":"Nat. Genet."},{"key":"82298_CR35","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1093\/oxfordjournals.aje.a009786","volume":"149","author":"S Hennessy","year":"1999","unstructured":"Hennessy, S., Bilker, W. B., Berlin, J. A. & Strom, B. L. Factors influencing the optimal control-to-case ratio in matched case-control studies. Am. J. Epidemiol. 149, 195\u2013197 (1999).","journal-title":"Am. J. Epidemiol."},{"key":"82298_CR36","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1097\/BOR.0000000000000334","volume":"28","author":"Y Ma","year":"2016","unstructured":"Ma, Y. & Zhou, X. Multiple genes, especially immune-regulating genes, contribute to disease susceptibility in systemic sclerosis. Curr. Opin. Rheumatol. 28, 595\u2013605 (2016).","journal-title":"Curr. Opin. Rheumatol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82298-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82298-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82298-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T12:06:47Z","timestamp":1735387607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82298-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["82298"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-82298-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4238970\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"9 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31068"}}