{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:12:37Z","timestamp":1787616757543,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-82319-5","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T19:23:58Z","timestamp":1735586638000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of diagnostic genes and molecular mechanisms of Crohn\u2019s disease and colon cancer based on machine learning algorithms"],"prefix":"10.1038","volume":"14","author":[{"given":"Jie","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chusen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"issue":"4","key":"82319_CR1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/joim","volume":"286","author":"A Segal","year":"2019","unstructured":"Segal, A. W.Studies on patients establish Crohn\u2019s disease as a manifestation of impaired innate immunity. J. Intern. Med. 286(4), 373\u2013388. https:\/\/doi.org\/10.1111\/joim (2019).","journal-title":"J. Intern. Med."},{"issue":"1","key":"82319_CR2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13062-020-00280-5","volume":"15","author":"L Petagna","year":"2020","unstructured":"Petagna, L. et al. Pathophysiology of Crohn\u2019s disease inflammation and recurrence. Biol. Direct. 15(1), 23. https:\/\/doi.org\/10.1186\/s13062-020-00280-5 (2020).","journal-title":"Biol. Direct"},{"issue":"2","key":"82319_CR3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/DCR.0000000000002323","volume":"65","author":"JD Vogel","year":"2022","unstructured":"Vogel, J. D. et al. The American Society of Colon and rectal surgeons Clinical Practice guidelines for the management of colon cancer. Dis. Colon Rectum. 65(2), 148\u2013177. https:\/\/doi.org\/10.1097\/DCR.0000000000002323 (2022).","journal-title":"Dis. Colon Rectum"},{"issue":"6","key":"82319_CR4","doi-asserted-by":"publisher","first-page":"729","DOI":"10.21147\/j.issn.1000-9604","volume":"32","author":"Y Yang","year":"2020","unstructured":"Yang, Y. et al. Epidemiology and risk factors of colorectal cancer in China. Chin. J. cancer Res. = Chung-kuo Yen Cheng Yen Chiu. 32(6), 729\u2013741. https:\/\/doi.org\/10.21147\/j.issn.1000-9604 (2020).","journal-title":"Chin. J. cancer Res. = Chung-kuo Yen Cheng Yen Chiu"},{"issue":"8","key":"82319_CR5","doi-asserted-by":"publisher","first-page":"808","DOI":"10.4251\/wjgo.v12.i8.808","volume":"12","author":"S Chakrabarti","year":"2020","unstructured":"Chakrabarti, S., Peterson, C. Y., Sriram, D. & Mahipal, A. Early stage colon cancer: current treatment standards, evolving paradigms, and future directions. World J. Gastrointest. Oncol. 12(8), 808\u2013832. https:\/\/doi.org\/10.4251\/wjgo.v12.i8.808 (2020).","journal-title":"World J. Gastrointest. Oncol."},{"issue":"4","key":"82319_CR6","doi-asserted-by":"publisher","first-page":"100184","DOI":"10.1016\/j.esmoop.2021.100184","volume":"6","author":"J Taieb","year":"2021","unstructured":"Taieb, J., Karoui, M. & Basile, D. How I treat stage II colon cancer patients. ESMO open. 6(4), 100184. https:\/\/doi.org\/10.1016\/j.esmoop.2021.100184 (2021).","journal-title":"ESMO open."},{"issue":"5","key":"82319_CR7","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S2468-1253(20)30005-4","volume":"5","author":"O Ol\u00e9n","year":"2020","unstructured":"Ol\u00e9n, O. et al. Colorectal cancer in Crohn\u2019s disease: a scandinavian population-based cohort study. Lancet Gastroenterol. Hepatol. 5(5), 475\u2013484. https:\/\/doi.org\/10.1016\/S2468-1253(20)30005-4 (2020).","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"1","key":"82319_CR8","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jcmgh.2020.02.001","volume":"10","author":"A Mo","year":"2020","unstructured":"Mo, A. et al. African ancestry proportion influences ileal gene expression in inflammatory bowel disease. Cell. Mol. Gastroenterol. Hepatol. 10(1), 203\u2013205. https:\/\/doi.org\/10.1016\/j.jcmgh.2020.02.001 (2020).","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"6","key":"82319_CR9","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1093\/ecco-jcc\/jjad006","volume":"17","author":"KE Sosnovski","year":"2023","unstructured":"Sosnovski, K. E. et al. GATA6-AS1 regulates intestinal epithelial mitochondrial functions, and its reduced expression is linked to intestinal inflammation and less favourable disease course in ulcerative colitis. J. Crohn\u2019s Colitis. 17(6), 960\u2013971. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad006 (2023).","journal-title":"J. Crohn\u2019s Colitis"},{"key":"82319_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku864","author":"JT Leek","year":"2014","unstructured":"Leek, J. T. svaseq: removing batch effects and other unwanted noise from sequencing data. Nucleic Acids Res., 42(21), e161. https:\/\/doi.org\/10.1093\/nar\/gku864 (2014)."},{"key":"82319_CR11","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 9, 559. https:\/\/doi.org\/10.1186\/1471-2105-9-559 (2008).","journal-title":"BMC Bioinform."},{"key":"82319_CR12","unstructured":"Liaw, A. & Wiener, M. C. Classification and Regression by randomForest. (2007)."},{"issue":"8","key":"82319_CR13","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1200\/JCO.2007.12.9791","volume":"26","author":"A Iasonos","year":"2008","unstructured":"Iasonos, A., Schrag, D., Raj, G. V. & Panageas, K. S. How to build and interpret a nomogram for cancer prognosis. J. Clin. Oncology: Official J. Am. Soc. Clin. Oncol. 26(8), 1364\u20131370. https:\/\/doi.org\/10.1200\/JCO.2007.12.9791 (2008).","journal-title":"J. Clin. Oncology: Official J. Am. Soc. Clin. Oncol."},{"key":"82319_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin, X. et al. pROC: an open-source package for R and S\u2009+\u2009to analyze and compare ROC curves. BMC Bioinform. 12, 77. https:\/\/doi.org\/10.1186\/1471-2105-12-77 (2011).","journal-title":"BMC Bioinform."},{"issue":"43","key":"82319_CR15","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U.S.A. 102(43), 15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102 (2005).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"25","key":"82319_CR16","doi-asserted-by":"publisher","first-page":"5620","DOI":"10.1016\/j.cell.2023.11.006","volume":"186","author":"CN Heiser","year":"2023","unstructured":"Heiser, C. N. et al. Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors. Cell 186(25), 5620\u20135637e16. https:\/\/doi.org\/10.1016\/j.cell.2023.11.006 (2023).","journal-title":"Cell"},{"key":"82319_CR17","doi-asserted-by":"publisher","first-page":"113897","DOI":"10.1016\/j.ecoenv.2022.113897","volume":"242","author":"C Huang","year":"2022","unstructured":"Huang, C. et al. R.Uncovering the functions of plasma proteins in ulcerative colitis and identifying biomarkers for BPA-induced severe ulcerative colitis: a plasma proteome analysis. Ecotoxicol. Environ. Saf. 242, 113897. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113897 (2022).","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"82319_CR18","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/s41575-023-00769-0","volume":"20","author":"LM Hegarty","year":"2023","unstructured":"Hegarty, L. M., Jones, G. R. & Bain, C. C. Macrophages in intestinal homeostasis and inflammatory bowel disease. Nat. Reviews Gastroenterol. Hepatol. 20(8), 538\u2013553. https:\/\/doi.org\/10.1038\/s41575-023-00769-0 (2023).","journal-title":"Nat. Reviews Gastroenterol. Hepatol."},{"key":"82319_CR19","doi-asserted-by":"publisher","first-page":"1093990","DOI":"10.3389\/fimmu.2022.1093990","volume":"13","author":"L He","year":"2023","unstructured":"He, L. et al. The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer. Front. Immunol. 13, 1093990. https:\/\/doi.org\/10.3389\/fimmu.2022.1093990 (2023).","journal-title":"Front. Immunol."},{"key":"82319_CR20","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202308.0624.v1","author":"G Pasternak","year":"2023","unstructured":"Pasternak, G. et al. Tissue metalloproteinases as crohn disease recurrence markers. Preprints https:\/\/doi.org\/10.20944\/preprints202308.0624.v1 (2023).","journal-title":"Preprints"},{"key":"82319_CR21","doi-asserted-by":"publisher","first-page":"771099","DOI":"10.3389\/fonc.2021.771099","volume":"11","author":"J Yu","year":"2021","unstructured":"Yu, J. et al. Comprehensive analysis of the expression and prognosis for MMPs in human colorectal cancer. Front. Oncol. 11, 771099. https:\/\/doi.org\/10.3389\/fonc.2021.771099 (2021).","journal-title":"Front. Oncol."},{"key":"82319_CR22","doi-asserted-by":"publisher","unstructured":"Chrzanowski, G. et al. An analysis of the content of metalloproteinases in the intestinal wall of patients with Crohn\u2019s disease. Life 13(10) https:\/\/doi.org\/10.3390\/life13102013 (2023).","DOI":"10.3390\/life13102013"},{"issue":"24","key":"82319_CR23","doi-asserted-by":"publisher","first-page":"6226","DOI":"10.3390\/cancers13246226","volume":"13","author":"Z Pezeshkian","year":"2021","unstructured":"Pezeshkian, Z. et al. Insights into the role of matrix metalloproteinases in precancerous conditions and in colorectal cancer. Cancers 13(24), 6226. https:\/\/doi.org\/10.3390\/cancers13246226 (2021).","journal-title":"Cancers"},{"issue":"13","key":"82319_CR24","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.3390\/cancers14133263","volume":"14","author":"S Li","year":"2022","unstructured":"Li, S., Pritchard, D. M. & Yu, L. G. Regulation and function of matrix metalloproteinase-13 in cancer progression and metastasis. Cancers 14(13), 3263. https:\/\/doi.org\/10.3390\/cancers14133263 (2022).","journal-title":"Cancers"},{"issue":"9","key":"82319_CR25","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.3390\/ijms21093062","volume":"21","author":"T Hirano","year":"2020","unstructured":"Hirano, T. et al. Immunological mechanisms in inflammation-associated colon carcinogenesis. Int. J. Mol. Sci. 21(9), 3062. https:\/\/doi.org\/10.3390\/ijms21093062 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"26","key":"82319_CR26","doi-asserted-by":"publisher","first-page":"E2332","DOI":"10.1073\/pnas.1222669110","volume":"110","author":"CG Knutson","year":"2013","unstructured":"Knutson, C. G. et al. Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Proc. Natl. Acad. Sci. U.S.A. 110(26), E2332\u2013E2341. https:\/\/doi.org\/10.1073\/pnas.1222669110 (2013).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"82319_CR27","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","volume":"140","author":"SI Grivennikov","year":"2010","unstructured":"Grivennikov, S. I., Greten, F. R. & Karin, M. Immunity, inflammation, and cancer. Cell 140(6), 883\u2013899. https:\/\/doi.org\/10.1016\/j.cell.2010.01.025 (2010).","journal-title":"Cell"},{"key":"82319_CR28","doi-asserted-by":"publisher","first-page":"144132","DOI":"10.1016\/j.gene.2019.144132","volume":"726","author":"A Soleimani","year":"2020","unstructured":"Soleimani, A. et al. Role of the NF-\u03baB signaling pathway in the pathogenesis of colorectal cancer. Gene 726, 144132. https:\/\/doi.org\/10.1016\/j.gene.2019.144132 (2020).","journal-title":"Gene"},{"issue":"35","key":"82319_CR29","doi-asserted-by":"publisher","first-page":"eadh5016","DOI":"10.1126\/sciadv.adh5016","volume":"9","author":"W Bao","year":"2023","unstructured":"Bao, W. et al. Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. Sci. Adv. 9(35), eadh5016. https:\/\/doi.org\/10.1126\/sciadv.adh5016 (2023).","journal-title":"Sci. Adv."},{"issue":"6565","key":"82319_CR30","doi-asserted-by":"publisher","first-page":"eabe9977","DOI":"10.1126\/science.abe9977","volume":"374","author":"M Lisci","year":"2021","unstructured":"Lisci, M. et al. Mitochondrial translation is required for sustained killing by cytotoxic T cells. Science 374(6565), eabe9977. https:\/\/doi.org\/10.1126\/science.abe9977 (2021).","journal-title":"Science"},{"issue":"8","key":"82319_CR31","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.7150\/ijms.34386","volume":"16","author":"Z Dong","year":"2019","unstructured":"Dong, Z. et al. Ribosomal protein L15 is involved in colon carcinogenesis. Int. J. Med. Sci. 16(8), 1132\u20131141. https:\/\/doi.org\/10.7150\/ijms.34386 (2019).","journal-title":"Int. J. Med. Sci."},{"key":"82319_CR32","doi-asserted-by":"publisher","unstructured":"Huanhuan, L. et al. Punicalagin ameliorates DSS-induced colitis in mice through strengthening gut barrier, decreasing oxidative stress and downregulating inflammation via AMPK\u2013NF\u2013\u03baB-STAT3 pathway. Food Biosci. 60,104384 https:\/\/doi.org\/10.1016\/j.fbio.2024.104384 (2024).","DOI":"10.1016\/j.fbio.2024.104384"},{"key":"82319_CR33","doi-asserted-by":"publisher","unstructured":"Abd-Rabou, A. A., Shalby, A. B. & Kotob, S. E. An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells. Cell Biochem. Biophys., 81(2), 313\u2013323. https:\/\/doi.org\/10.1007\/s12013-023-01132-5 (2023).","DOI":"10.1007\/s12013-023-01132-5"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82319-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82319-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82319-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T13:04:10Z","timestamp":1735650250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82319-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["82319"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-82319-5","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"2 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for NHANES was secured from the NCHSR esearch Ethics Review Board,and each participant willingly provided written informed consent..","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31736"}}