{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:43:13Z","timestamp":1793396593144,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Infectious Disease Medical Center startup fund","award":["(YZ)(B2022011-1)"],"award-info":[{"award-number":["(YZ)(B2022011-1)"]}]},{"name":"Jinan Microecological Biomedicine Shandong Laboratory project","award":["JNL-2022050B"],"award-info":[{"award-number":["JNL-2022050B"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-82380-0","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T04:41:26Z","timestamp":1735360886000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Antifungal activity of essential oils and their potential synergistic effect with amphotericin B"],"prefix":"10.1038","volume":"14","author":[{"given":"Xin","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghui","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"82380_CR1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/civ933","volume":"62","author":"PG Pappas","year":"2016","unstructured":"Pappas, P. G. et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious diseases society of America. Clin. Infect. Dis. 62, e1\u201350. https:\/\/doi.org\/10.1093\/cid\/civ933 (2016).","journal-title":"Clin. Infect. Dis."},{"key":"82380_CR2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1080\/21505594.2020.1748930","volume":"11","author":"H Chen","year":"2020","unstructured":"Chen, H., Zhou, X., Ren, B. & Cheng, L. The regulation of hyphae growth in Candida albicans. Virulence 11, 337\u2013348. https:\/\/doi.org\/10.1080\/21505594.2020.1748930 (2020).","journal-title":"Virulence"},{"key":"82380_CR3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jpba.2019.01.026","volume":"167","author":"M Espino","year":"2019","unstructured":"Espino, M. et al. NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans. J. Pharm. Biomed. Anal. 167, 15\u201320. https:\/\/doi.org\/10.1016\/j.jpba.2019.01.026 (2019).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"82380_CR4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nrmicro.2017.107","volume":"16","author":"MB Lohse","year":"2018","unstructured":"Lohse, M. B., Gulati, M., Johnson, A. D. & Nobile, C. J. Development and regulation of single- and multi-species Candida albicans biofilms. Nat. Rev. Microbiol. 16, 19\u201331. https:\/\/doi.org\/10.1038\/nrmicro.2017.107 (2018).","journal-title":"Nat. Rev. Microbiol."},{"key":"82380_CR5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mib.2018.02.005","volume":"45","author":"NM Revie","year":"2018","unstructured":"Revie, N. M., Iyer, K. R., Robbins, N. & Cowen, L. E. Antifungal drug resistance: evolution, mechanisms and impact. Curr. Opin. Microbiol. 45, 70\u201376. https:\/\/doi.org\/10.1016\/j.mib.2018.02.005 (2018).","journal-title":"Curr. Opin. Microbiol."},{"key":"82380_CR6","doi-asserted-by":"publisher","unstructured":"Fuentefria, A. M., Pippi, B., Dalla Lana, D. F., Donato, K. K. & de Andrade, S. F. Antifungals discovery: an insight into new strategies to combat antifungal resistance. Lett. Appl. Microbiol. 66 https:\/\/doi.org\/10.1111\/lam.12820 (2018).","DOI":"10.1111\/lam.12820"},{"key":"82380_CR7","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.cmi.2019.03.028","volume":"25","author":"KE Pristov","year":"2019","unstructured":"Pristov, K. E. & Ghannoum, M. A. Resistance of Candida to azoles and echinocandins worldwide. Clin. Microbiol. Infect. 25, 792\u2013798. https:\/\/doi.org\/10.1016\/j.cmi.2019.03.028 (2019).","journal-title":"Clin. Microbiol. Infect."},{"key":"82380_CR8","doi-asserted-by":"publisher","unstructured":"Viazis, N. et al. A four-probiotics regimen combined with a standard Helicobacter pylori-eradication treatment reduces Side effects and increases eradication rates. Nutrients 14 https:\/\/doi.org\/10.3390\/nu14030632 (2022).","DOI":"10.3390\/nu14030632"},{"key":"82380_CR9","doi-asserted-by":"publisher","first-page":"e2100706","DOI":"10.1002\/adhm.202100706","volume":"10","author":"PY Ho","year":"2021","unstructured":"Ho, P. Y. et al. Fluorescence imaging and photodynamic inactivation of bacteria based on Cationic Cyclometalated Iridium(III) complexes with aggregation-induced emission properties. Adv. Healthc. Mater. 10, e2100706. https:\/\/doi.org\/10.1002\/adhm.202100706 (2021).","journal-title":"Adv. Healthc. Mater."},{"key":"82380_CR10","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1111\/jam.12881","volume":"119","author":"A Nakonieczna","year":"2015","unstructured":"Nakonieczna, A., Cooper, C. J. & Gryko, R. Bacteriophages and bacteriophage-derived endolysins as potential therapeutics to combat gram-positive spore forming bacteria. J. Appl. Microbiol. 119, 620\u2013631. https:\/\/doi.org\/10.1111\/jam.12881 (2015).","journal-title":"J. Appl. Microbiol."},{"key":"82380_CR11","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.phymed.2017.10.013","volume":"36","author":"JH Lee","year":"2017","unstructured":"Lee, J. H., Kim, Y. G., Shim, S. H. & Lee, J. Antibiofilm activities of norharmane and its derivatives against Escherichia coli O157:H7 and other bacteria. Phytomedicine 36, 254\u2013261. https:\/\/doi.org\/10.1016\/j.phymed.2017.10.013 (2017).","journal-title":"Phytomedicine"},{"key":"82380_CR12","doi-asserted-by":"publisher","first-page":"127373","DOI":"10.1016\/j.micres.2023.127373","volume":"272","author":"Z Shahina","year":"2023","unstructured":"Shahina, Z., Yennamalli, R. M. & Dahms, T. E. Key essential oil components delocalize Candida albicans Kar3p and impact microtubule structure. Microbiol. Res. 272, 127373. https:\/\/doi.org\/10.1016\/j.micres.2023.127373 (2023).","journal-title":"Microbiol. Res."},{"key":"82380_CR13","doi-asserted-by":"publisher","first-page":"131221","DOI":"10.1016\/j.foodchem.2021.131221","volume":"372","author":"A Kumar Chaudhari","year":"2022","unstructured":"Kumar Chaudhari, A., Kumar Singh, V. & Das, S. Deepika & Kishore Dubey, N. Fabrication, characterization, and bioactivity assessment of Chitosan nanoemulsion containing allspice essential oil to mitigate aspergillus flavus contamination and aflatoxin B1 production in maize. Food Chem. 372, 131221. https:\/\/doi.org\/10.1016\/j.foodchem.2021.131221 (2022).","journal-title":"Food Chem."},{"key":"82380_CR14","doi-asserted-by":"publisher","unstructured":"Vella, F. M. et al. Chemometric screening of fourteen essential oils for their composition and biological properties. Molecules 25 https:\/\/doi.org\/10.3390\/molecules25215126 (2020).","DOI":"10.3390\/molecules25215126"},{"key":"82380_CR15","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/lam.13053","volume":"67","author":"F Di\u00e1nez","year":"2018","unstructured":"Di\u00e1nez, F. et al. Screening of antifungal activity of 12 essential oils against eight pathogenic fungi of vegetables and mushroom. Lett. Appl. Microbiol. 67, 400\u2013410. https:\/\/doi.org\/10.1111\/lam.13053 (2018).","journal-title":"Lett. Appl. Microbiol."},{"key":"82380_CR16","doi-asserted-by":"publisher","first-page":"28","DOI":"10.31083\/j.fbl2802028","volume":"28","author":"TM Karpi\u0144ski","year":"2023","unstructured":"Karpi\u0144ski, T. M., O\u017carowski, M., Seremak-Mrozikiewicz, A. & Wolski, H. Anti-candida and Antibiofilm activity of selected Lamiaceae essential oils. Front. Biosci. (Landmark Ed). 28, 28. https:\/\/doi.org\/10.31083\/j.fbl2802028 (2023).","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"82380_CR17","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3109\/1040841X.2013.813904","volume":"41","author":"D Poulain","year":"2015","unstructured":"Poulain, D. Candida albicans, plasticity and pathogenesis. Crit. Rev. Microbiol. 41, 208\u2013217. https:\/\/doi.org\/10.3109\/1040841X.2013.813904 (2015).","journal-title":"Crit. Rev. Microbiol."},{"key":"82380_CR18","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/j.drudis.2014.06.009","volume":"19","author":"SSW Wong","year":"2014","unstructured":"Wong, S. S. W., Samaranayake, L. P. & Seneviratne, C. J. In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules. Drug Discov Today. 19, 1721\u20131730. https:\/\/doi.org\/10.1016\/j.drudis.2014.06.009 (2014).","journal-title":"Drug Discov Today"},{"key":"82380_CR19","doi-asserted-by":"publisher","unstructured":"Wi\u0144ska, K. et al. Essential oils as Antimicrobial agents-myth or real alternative? Molecules 24 https:\/\/doi.org\/10.3390\/molecules24112130 (2019).","DOI":"10.3390\/molecules24112130"},{"key":"82380_CR20","doi-asserted-by":"publisher","unstructured":"Ma, X., Shi, W. & Zhang, Y. Essential oils with high activity against stationary phase bartonella henselae. Antibiot. (Basel). 8 https:\/\/doi.org\/10.3390\/antibiotics8040246 (2019).","DOI":"10.3390\/antibiotics8040246"},{"key":"82380_CR21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12906-020-02898-4","volume":"20","author":"S Xiao","year":"2020","unstructured":"Xiao, S., Cui, P., Shi, W. & Zhang, Y. Identification of essential oils with activity against stationary phase Staphylococcus aureus. BMC Complement. Med. Ther. 20, 99. https:\/\/doi.org\/10.1186\/s12906-020-02898-4 (2020).","journal-title":"BMC Complement. Med. Ther."},{"key":"82380_CR22","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1515\/znc-2021-0002","volume":"76","author":"M Hacioglu","year":"2021","unstructured":"Hacioglu, M., Oyardi, O. & Kirinti, A. Oregano essential oil inhibits Candida spp. biofilms. Z. Naturforsch C J. Biosci. 76, 443\u2013450. https:\/\/doi.org\/10.1515\/znc-2021-0002 (2021).","journal-title":"Z. Naturforsch C J. Biosci."},{"key":"82380_CR23","doi-asserted-by":"publisher","unstructured":"Behmanesh, F. et al. Antifungal effect of lavender Essential Oil (Lavandula angustifolia) and clotrimazole on Candida albicans: An in vitro study. Scientifica (Cairo). 261397. https:\/\/doi.org\/10.1155\/2015\/261397 (2015).","DOI":"10.1155\/2015\/261397"},{"key":"82380_CR24","doi-asserted-by":"publisher","unstructured":"Noble, S. M., Gianetti, B. A. & Witchley, J. N. Candida albicans cell-type switching and functional plasticity in the mammalian host. Nat. Rev. Microbiol. 15 https:\/\/doi.org\/10.1038\/nrmicro.2016.157 (2017).","DOI":"10.1038\/nrmicro.2016.157"},{"key":"82380_CR25","doi-asserted-by":"publisher","unstructured":"Witchley, J. N. et al. Candida albicans morphogenesis Programs Control the balance between gut commensalism and invasive infection. Cell. Host Microbe. 25 https:\/\/doi.org\/10.1016\/j.chom.2019.02.008 (2019).","DOI":"10.1016\/j.chom.2019.02.008"},{"key":"82380_CR26","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.phymed.2013.10.028","volume":"21","author":"A Khan","year":"2014","unstructured":"Khan, A., Ahmad, A., Xess, I., Khan, L. A. & Manzoor, N. Ocimum sanctum essential oil inhibits virulence attributes in Candida albicans. Phytomedicine 21, 448\u2013452. https:\/\/doi.org\/10.1016\/j.phymed.2013.10.028 (2014).","journal-title":"Phytomedicine"},{"key":"82380_CR27","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.3389\/fmicb.2017.01476","volume":"8","author":"RK Manoharan","year":"2017","unstructured":"Manoharan, R. K., Lee, J. H. & Lee, J. Antibiofilm and Antihyphal activities of cedar Leaf Essential Oil, Camphor, and fenchone derivatives against Candida albicans. Front. Microbiol. 8, 1476. https:\/\/doi.org\/10.3389\/fmicb.2017.01476 (2017).","journal-title":"Front. Microbiol."},{"key":"82380_CR28","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1016\/j.apsb.2021.04.010","volume":"11","author":"X Wang","year":"2021","unstructured":"Wang, X. et al. Delivery strategies of amphotericin B for invasive fungal infections. Acta Pharm. Sin B. 11, 2585\u20132604. https:\/\/doi.org\/10.1016\/j.apsb.2021.04.010 (2021).","journal-title":"Acta Pharm. Sin B"},{"key":"82380_CR29","doi-asserted-by":"publisher","unstructured":"Ulanowska, M. & Olas, B. Biological properties and prospects for the application of Eugenol-A review. Int. J. Mol. Sci. 22 https:\/\/doi.org\/10.3390\/ijms22073671 (2021).","DOI":"10.3390\/ijms22073671"},{"key":"82380_CR30","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1080\/10408398.2011.653458","volume":"55","author":"ZE Suntres","year":"2015","unstructured":"Suntres, Z. E., Coccimiglio, J. & Alipour, M. The bioactivity and toxicological actions of carvacrol. Crit. Rev. Food Sci. Nutr. 55, 304\u2013318. https:\/\/doi.org\/10.1080\/10408398.2011.653458 (2015).","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"82380_CR31","doi-asserted-by":"publisher","unstructured":"M\u0105czka, W., Wi\u0144ska, K. & Grabarczyk, M. One hundred faces of Geraniol. Molecules 25 https:\/\/doi.org\/10.3390\/molecules25143303 (2020).","DOI":"10.3390\/molecules25143303"},{"key":"82380_CR32","doi-asserted-by":"publisher","first-page":"22029","DOI":"10.1038\/s41598-021-01536-4","volume":"11","author":"HBM Oliveira","year":"2021","unstructured":"Oliveira, H. B. M. et al. Citral modulates human monocyte responses to Staphylococcus aureus infection. Sci. Rep. 11, 22029. https:\/\/doi.org\/10.1038\/s41598-021-01536-4 (2021).","journal-title":"Sci. Rep."},{"key":"82380_CR33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3389\/fmed.2017.00169","volume":"4","author":"J Feng","year":"2017","unstructured":"Feng, J. et al. Selective essential oils from spice or culinary herbs have high activity against stationary phase and Biofilm Borrelia burgdorferi. Front. Med. (Lausanne). 4, 169. https:\/\/doi.org\/10.3389\/fmed.2017.00169 (2017).","journal-title":"Front. Med. (Lausanne)"},{"key":"82380_CR34","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1111\/jam.15425","volume":"132","author":"R Kumpakha","year":"2022","unstructured":"Kumpakha, R. & Gordon, D. M. Inhibition of morphological transition and hyphae extension in Candida spp. by occidiofungin. J. Appl. Microbiol. 132, 3038\u20133048. https:\/\/doi.org\/10.1111\/jam.15425 (2022).","journal-title":"J. Appl. Microbiol."},{"key":"82380_CR35","doi-asserted-by":"publisher","first-page":"119877","DOI":"10.1016\/j.ijpharm.2020.119877","volume":"590","author":"J Wang","year":"2020","unstructured":"Wang, J., Kutter, J. P., Mu, H., Moodley, A. & Yang, M. Synergistic antibacterial effect of inhaled aztreonam and tobramycin fixed dose combination to combat multidrug-resistant Gram-negative bacteria. Int. J. Pharm. 590, 119877. https:\/\/doi.org\/10.1016\/j.ijpharm.2020.119877 (2020).","journal-title":"Int. J. Pharm."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82380-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82380-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82380-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T19:02:44Z","timestamp":1735412564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82380-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["82380"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-82380-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"30 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31125"}}