{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:15:24Z","timestamp":1781763324058,"version":"3.54.5"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-82490-9","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T04:44:27Z","timestamp":1735361067000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of RN7SK LncRNA as a novel biomarker in Alzheimer\u2019s disease using bioinformatics and expression analysis"],"prefix":"10.1038","volume":"14","author":[{"given":"Masoumeh","family":"Kazemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Naghdi Sadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Shekari Khaniani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Rezazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima Mansoori","family":"Derakhshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soudeh","family":"Ghafouri-Fard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"issue":"10043","key":"82490_CR1","first-page":"505","volume":"388","author":"P Scheltens","year":"2016","unstructured":"Scheltens, P. et al. Alzheimer\u2019s Dis. Lancet, 388(10043): 505\u2013517 (2016).","journal-title":"Alzheimer\u2019s Dis. Lancet"},{"key":"82490_CR2","unstructured":"International, A. D. World Alzheimer Report 2019: Attitudes to dementia. (2019)."},{"key":"82490_CR3","unstructured":"Ma\u00eblenn Guerchet, M. P. & Prina, M. Numbers of People with Dementia (Alzheimer\u2019s Disease International, 2020)."},{"issue":"29","key":"82490_CR4","doi-asserted-by":"publisher","first-page":"9321","DOI":"10.1523\/JNEUROSCI.4736-08.2009","volume":"29","author":"S Peng","year":"2009","unstructured":"Peng, S. et al. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer\u2019s disease. J. Neurosci. 29(29), 9321\u20139329 (2009).","journal-title":"J. Neurosci."},{"issue":"8","key":"82490_CR5","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/S1474-4422(07)70178-3","volume":"6","author":"B Dubois","year":"2007","unstructured":"Dubois, B. et al. Research criteria for the diagnosis of Alzheimer\u2019s disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol. 6(8), 734\u2013746 (2007).","journal-title":"Lancet Neurol."},{"issue":"2","key":"82490_CR6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jalz.2015.08.003","volume":"12","author":"FH Duits","year":"2016","unstructured":"Duits, F. H. et al. Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study. Alzheimers Dement. 12(2), 154\u2013163 (2016).","journal-title":"Alzheimers Dement."},{"issue":"10","key":"82490_CR7","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2217\/bmm-2017-0041","volume":"11","author":"J Wojsiat","year":"2017","unstructured":"Wojsiat, J. et al. Search for Alzheimer\u2019s disease biomarkers in blood cells: Hypotheses-driven approach. Biomark. Med. 11(10), 917\u2013931 (2017).","journal-title":"Biomark. Med."},{"issue":"3","key":"82490_CR8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/ajmg.b.30272","volume":"5","author":"PF Sullivan","year":"2006","unstructured":"Sullivan, P. F., Fan, C. & Perou, C. M. Evaluating the comparability of gene expression in blood and brain. Am. J. Med. Genet. B Neuropsychiatr Genet. 5(3), 261\u2013268 (2006).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr Genet."},{"issue":"1","key":"82490_CR9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3233\/JAD-2010-101518","volume":"23","author":"BB Booij","year":"2011","unstructured":"Booij, B. B. et al. A gene expression pattern in blood for the early detection of Alzheimer\u2019s disease. J. Alzheimers Dis. 23(1), 109\u2013119 (2011).","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"82490_CR10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11011-022-01114-1","volume":"38","author":"SP Padala","year":"2023","unstructured":"Padala, S. P. & Newhouse, P. A. Blood-based biomarkers in Alzheimer\u2019s disease: A mini-review. Metab. Brain Dis. 38(1), 185\u2013193 (2023).","journal-title":"Metab. Brain Dis."},{"key":"82490_CR11","doi-asserted-by":"crossref","unstructured":"Rahman, M. H. et al. A network-based bioinformatics approach to identify molecular biomarkers for type 2 diabetes that are linked to the progression of neurological diseases. Int. J. Environ. Res. Public. Health 17(3) (2020).","DOI":"10.3390\/ijerph17031035"},{"key":"82490_CR12","doi-asserted-by":"crossref","unstructured":"Rahman, M. H. et al. Bioinformatics and machine learning methodologies to identify the effects of central nervous system disorders on glioblastoma progression. Brief. Bioinform 22(5) (2021).","DOI":"10.1093\/bib\/bbaa365"},{"issue":"559","key":"82490_CR13","first-page":"1471","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: An R package for weighted correlation network analysis. BMC Bioinform. 9(559), 1471\u20132105 (2008).","journal-title":"BMC Bioinform."},{"issue":"4","key":"82490_CR14","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.3233\/JAD-180400","volume":"65","author":"JW Liang","year":"2018","unstructured":"Liang, J. W. et al. Application of weighted gene co-expression network analysis to explore the key genes in Alzheimer\u2019s disease. J. Alzheimers Dis. 65(4), 1353\u20131364 (2018).","journal-title":"J. Alzheimers Dis."},{"key":"82490_CR15","doi-asserted-by":"crossref","unstructured":"Wu, Z. et al. A computational approach based on weighted gene co-expression network analysis for biomarkers analysis of Parkinson\u2019s disease and construction of diagnostic model. Front. Comput. Neurosci., 16(1095676) (2023).","DOI":"10.3389\/fncom.2022.1095676"},{"issue":"2","key":"82490_CR16","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.molcel.2019.01.033","volume":"74","author":"A Bugai","year":"2019","unstructured":"Bugai, A. et al. P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress. Mol. Cell. 74(2), 254\u2013267 (2019).","journal-title":"Mol. Cell."},{"issue":"7","key":"82490_CR17","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/s0092-8674(02)00758-4","volume":"109","author":"N Adachi","year":"2002","unstructured":"Adachi, N. & Lieber, M. R. Bidirectional gene organization: A common architectural feature of the human genome. Cell 109(7), 807\u2013809. https:\/\/doi.org\/10.1016\/s0092-8674(02)00758-4 (2002).","journal-title":"Cell"},{"issue":"4","key":"82490_CR18","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1002\/jcb.26472","volume":"119","author":"Z Bazi","year":"2018","unstructured":"Bazi, Z. et al. Rn7SK small nuclear RNA is involved in neuronal differentiation. J. Cell. Biochem. 119(4), 3174\u20133182 (2018).","journal-title":"J. Cell. Biochem."},{"issue":"8","key":"82490_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/bies.202100092","volume":"43","author":"M Briese","year":"2021","unstructured":"Briese, M. & Sendtner, M. Keeping the balance: The noncoding RNA 7SK as a master regulator for neuron development and function. Bioessays 43(8), 29 (2021).","journal-title":"Bioessays"},{"key":"82490_CR20","doi-asserted-by":"crossref","unstructured":"Ahmad, I. et al. Long non-coding RNAs RN7SK and GAS5 regulate macrophage polarization and innate immune responses. Front. Immunol. 11(604981) (2020).","DOI":"10.3389\/fimmu.2020.604981"},{"issue":"3","key":"82490_CR21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","volume":"21","author":"H Akiyama","year":"2000","unstructured":"Akiyama, H. et al. Inflammation and Alzheimer\u2019s disease. Neurobiol. Aging 21(3), 383\u2013421 (2000).","journal-title":"Neurobiol. Aging"},{"key":"82490_CR22","doi-asserted-by":"crossref","unstructured":"Chang, R., Yee, K. L. & Sumbria, R. K. Tumor necrosis factor \u03b1 Inhibition for Alzheimer\u2019s disease. J. Cent. Nerv. Syst. Dis., 9(1179573517709278) (2017).","DOI":"10.1177\/1179573517709278"},{"issue":"4","key":"82490_CR23","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1523\/JNEUROSCI.21-04-01179.2001","volume":"21","author":"CK Combs","year":"2001","unstructured":"Combs, C. K. et al. beta-amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J. Neurosci. 21(4), 1179\u20131188 (2001).","journal-title":"J. Neurosci."},{"issue":"47","key":"82490_CR24","doi-asserted-by":"publisher","first-page":"49523","DOI":"10.1074\/jbc.M402034200","volume":"279","author":"YF Liao","year":"2004","unstructured":"Liao, Y. F. et al. Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J. Biol. Chem. 279(47), 49523\u201349532 (2004).","journal-title":"J. Biol. Chem."},{"issue":"2","key":"82490_CR25","doi-asserted-by":"publisher","first-page":"680","DOI":"10.2353\/ajpath.2007.060378","volume":"170","author":"M Yamamoto","year":"2007","unstructured":"Yamamoto, M. et al. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am. J. Pathol. 170(2), 680\u2013692 (2007).","journal-title":"Am. J. Pathol."},{"issue":"13","key":"82490_CR26","doi-asserted-by":"publisher","first-page":"8217","DOI":"10.1074\/jbc.R800032200","volume":"284","author":"B Coornaert","year":"2009","unstructured":"Coornaert, B., Carpentier, I. & Beyaert, R. A20: Central gatekeeper in inflammation and immunity. J. Biol. Chem. 284(13), 8217\u20138221 (2009).","journal-title":"J. Biol. Chem."},{"issue":"137223","key":"82490_CR27","first-page":"3","volume":"805","author":"C Ma","year":"2023","unstructured":"Ma, C. et al. Tumor necrosis factor \u03b1-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson\u2019s disease via the NF\u03baB and mTOR pathways. Neurosci. Lett. 805(137223), 3 (2023).","journal-title":"Neurosci. Lett."},{"issue":"1","key":"82490_CR28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/glia.1128","volume":"37","author":"P Rezaie","year":"2002","unstructured":"Rezaie, P. et al. Expression of beta-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: Potential role of chemokines in the developing CNS. Glia 37(1), 64\u201375 (2002).","journal-title":"Glia"},{"issue":"12","key":"82490_CR29","first-page":"8342","volume":"7","author":"C Liu","year":"2014","unstructured":"Liu, C. et al. Neuroinflammation in Alzheimer\u2019s disease: Chemokines produced by astrocytes and chemokine receptors. Int. J. Clin. Exp. Pathol. 7(12), 8342\u20138355 (2014).","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"6","key":"82490_CR30","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.biocel.2004.12.005","volume":"37","author":"A Markovic","year":"2005","unstructured":"Markovic, A., MacKenzie, K. L. & Lock, R. B. FLT-3: A new focus in the understanding of acute leukemia. Int. J. Biochem. Cell. Biol. 37(6), 1168\u20131172 (2005).","journal-title":"Int. J. Biochem. Cell. Biol."},{"issue":"2","key":"82490_CR31","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.yexmp.2010.05.009","volume":"89","author":"CA DeBoy","year":"2010","unstructured":"DeBoy, C. A. et al. FLT-3 expression and function on microglia in multiple sclerosis. Exp. Mol. Pathol. 89(2), 109\u2013116 (2010).","journal-title":"Exp. Mol. Pathol."},{"key":"82490_CR32","unstructured":"Leandro, G. Whole Genome Transcriptional Analysis of Alzheimer\u2019s Disease Patients Compared with Age-Matched Non-demented Controls (BioStudies, E-MTAB-6094, 2017)."},{"issue":"10","key":"82490_CR33","first-page":"1544","volume":"4","author":"B Zhang","year":"2005","unstructured":"Zhang, B. & Horvath, S. A general framework for weighted gene co-expression network analysis. Stat. Appl. Genet. Mol. Biol. 4(10), 1544\u20136115 (2005).","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"issue":"1","key":"82490_CR34","doi-asserted-by":"crossref","first-page":"022","DOI":"10.1038\/s41598-021-04035-8","volume":"12","author":"C Wang","year":"2022","unstructured":"Wang, C. & Liu, H. Factors influencing degradation kinetics of mRNAs and half-lives of microRNAs, circRNAs, lncRNAs in blood in vitro using quantitative PCR. Sci. Rep. 12(1), 022\u201311339 (2022).","journal-title":"Sci. Rep."},{"issue":"2","key":"82490_CR35","first-page":"149","volume":"14","author":"M Kazemi","year":"2015","unstructured":"Kazemi, M. et al. Evaluation of the effect of ascorbic acid administration on gene expression level of IL-6 and TNF-\u03b1 cytokines in deceased donors. Iran. J. Allergy Asthma Immunol. 14(2), 149\u2013157 (2015).","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"82490_CR36","doi-asserted-by":"crossref","unstructured":"Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29(9) (2001).","DOI":"10.1093\/nar\/29.9.e45"},{"issue":"10","key":"82490_CR37","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman, R. C. et al. Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol. 5(10), R80 (2004).","journal-title":"Genome Biol."},{"issue":"1","key":"82490_CR38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4097\/kja.21209","volume":"75","author":"FS Nahm","year":"2022","unstructured":"Nahm, F. S. Receiver operating characteristic curve: Overview and practical use for clinicians. Korean J. Anesthesiol. 75(1), 25\u201336 (2022).","journal-title":"Korean J. Anesthesiol."},{"issue":"1","key":"82490_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28(1), 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"82490_CR40","doi-asserted-by":"publisher","first-page":"888946","DOI":"10.3389\/fnagi.2022.888946","volume":"14","author":"LT Huang","year":"2022","unstructured":"Huang, L. T. et al. Association of peripheral blood cell profile with Alzheimer\u2019s disease: A meta-analysis. Front. Aging Neurosci. 14, 888946. https:\/\/doi.org\/10.3389\/fnagi.2022.888946 (2022). eCollection 2022.","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"82490_CR41","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.neuron.2016.07.007","volume":"91","author":"M Bacioglu","year":"2016","unstructured":"Bacioglu, M. et al. Neurofilament light chain in blood and CSF as marker of disease progression in mouse models and in neurodegenerative diseases. Neuron 91(2), 494\u2013496 (2016).","journal-title":"Neuron"},{"issue":"7691","key":"82490_CR42","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nature25456","volume":"554","author":"A Nakamura","year":"2018","unstructured":"Nakamura, A. et al. High performance plasma amyloid-\u03b2 biomarkers for Alzheimer\u2019s disease. Nature 554(7691), 249\u2013254 (2018).","journal-title":"Nature"},{"issue":"3","key":"82490_CR43","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41591-020-0755-1","volume":"26","author":"S Janelidze","year":"2020","unstructured":"Janelidze, S. et al. Plasma P-tau181 in Alzheimer\u2019s disease: Relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer\u2019s dementia. Nat. Med. 26(3), 379\u2013386 (2020).","journal-title":"Nat. Med."},{"issue":"8","key":"82490_CR44","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1001\/jama.2020.12134","volume":"324","author":"S Palmqvist","year":"2020","unstructured":"Palmqvist, S. et al. Discriminative accuracy of plasma Phospho-tau217 for Alzheimer disease vs other neurodegenerative disorders. Jama 324(8), 772\u2013781 (2020).","journal-title":"Jama"},{"issue":"5","key":"82490_CR45","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00401-021-02275-6","volume":"141","author":"NJ Ashton","year":"2021","unstructured":"Ashton, N. J. et al. Plasma p-tau231: A new biomarker for incipient Alzheimer\u2019s disease pathology. Acta Neuropathol. 141(5), 709\u2013724 (2021).","journal-title":"Acta Neuropathol."},{"issue":"1","key":"82490_CR46","doi-asserted-by":"publisher","first-page":"019","DOI":"10.1186\/s12974-019-1531-3","volume":"16","author":"A Villar-Piqu\u00e9","year":"2019","unstructured":"Villar-Piqu\u00e9, A. et al. Plasma YKL-40 in the spectrum of neurodegenerative dementia. J. Neuroinflamm. 16(1), 019\u20131531 (2019).","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"82490_CR47","doi-asserted-by":"publisher","first-page":"021","DOI":"10.1186\/s13195-021-00804-9","volume":"13","author":"C Cicognola","year":"2021","unstructured":"Cicognola, C. et al. Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment. Alzheimers Res. Ther. 13(1), 021\u201300804 (2021).","journal-title":"Alzheimers Res. Ther."},{"issue":"18","key":"82490_CR48","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1016\/j.neuron.2023.05.017","volume":"111","author":"H Hampel","year":"2023","unstructured":"Hampel, H. et al. Blood-based biomarkers for Alzheimer\u2019s disease: Current state and future use in a transformed global healthcare landscape. Neuron 111(18), 2781\u20132799 (2023).","journal-title":"Neuron"},{"issue":"1","key":"82490_CR49","doi-asserted-by":"publisher","first-page":"022","DOI":"10.1186\/s13195-022-01117-1","volume":"14","author":"AL Brand","year":"2022","unstructured":"Brand, A. L. et al. The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer\u2019s disease: A literature review. Alzheimers Res. Ther. 14(1), 022\u201301117 (2022).","journal-title":"Alzheimers Res. Ther."},{"issue":"1","key":"82490_CR50","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/alz.12647","volume":"19","author":"SE O\u2019Bryant","year":"2023","unstructured":"O\u2019Bryant, S. E. et al. Medical comorbidities and ethnicity impact plasma Alzheimer\u2019s disease biomarkers: Important considerations for clinical trials and practice. Alzheimers Dement. 19(1), 36\u201343 (2023).","journal-title":"Alzheimers Dement."},{"issue":"1","key":"82490_CR51","doi-asserted-by":"publisher","first-page":"020","DOI":"10.1038\/s41467-020-14612-6","volume":"11","author":"M Khalil","year":"2020","unstructured":"Khalil, M. et al. Serum neurofilament light levels in normal aging and their association with morphologic brain changes. Nat. Commun. 11(1), 020\u201314612 (2020).","journal-title":"Nat. Commun."},{"issue":"10","key":"82490_CR52","doi-asserted-by":"publisher","first-page":"4314","DOI":"10.1038\/s41380-022-01675-8","volume":"27","author":"AA Tsiknia","year":"2022","unstructured":"Tsiknia, A. A. et al. Sex differences in plasma p-tau181 associations with Alzheimer\u2019s disease biomarkers, cognitive decline, and clinical progression. Mol. Psychiatry. 27(10), 4314\u20134322 (2022).","journal-title":"Mol. Psychiatry"},{"issue":"7","key":"82490_CR53","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1080\/15476286.2020.1788848","volume":"18","author":"D Li","year":"2021","unstructured":"Li, D. et al. Insights into lncRNAs in Alzheimer\u2019s disease mechanisms. RNA Biol. 18(7), 1037\u20131047 (2021).","journal-title":"RNA Biol."},{"issue":"3","key":"82490_CR54","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/nsmb.2480","volume":"20","author":"TR Mercer","year":"2013","unstructured":"Mercer, T. R. & Mattick, J. S. Structure and function of long noncoding RNAs in epigenetic regulation. Nat. Struct. Mol. Biol. 20(3), 300\u2013307 (2013).","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"2","key":"82490_CR55","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/cbin.11263","volume":"44","author":"D Yue","year":"2020","unstructured":"Yue, D. et al. Silencing of long noncoding RNA XIST attenuated Alzheimer\u2019s disease-related BACE1 alteration through miR-124. Cell. Biol. Int. 44(2), 630\u2013636 (2020).","journal-title":"Cell. Biol. Int."},{"issue":"3","key":"82490_CR56","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s12031-019-01364-2","volume":"69","author":"SN Fotuhi","year":"2019","unstructured":"Fotuhi, S. N. et al. Long non-coding RNA BACE1-AS may serve as an Alzheimer\u2019s disease blood-based biomarker. J. Mol. Neurosci. 69(3), 351\u2013359 (2019).","journal-title":"J. Mol. Neurosci."},{"issue":"7","key":"82490_CR57","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nm1784","volume":"14","author":"MA Faghihi","year":"2008","unstructured":"Faghihi, M. A. et al. Expression of a noncoding RNA is elevated in Alzheimer\u2019s disease and drives rapid feed-forward regulation of beta-secretase. Nat. Med. 14(7), 723\u2013730 (2008).","journal-title":"Nat. Med."},{"issue":"1","key":"82490_CR58","doi-asserted-by":"publisher","first-page":"021","DOI":"10.1038\/s41467-021-21529-1","volume":"12","author":"C Ji","year":"2021","unstructured":"Ji, C. et al. Interaction of 7SK with the Smn complex modulates snRNP production. Nat. Commun. 12(1), 021\u201321529 (2021).","journal-title":"Nat. Commun."},{"issue":"10","key":"82490_CR59","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1002\/humu.22175","volume":"33","author":"AM Alazami","year":"2012","unstructured":"Alazami, A. M. et al. Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism. Hum. Mutat. 33(10), 1429\u20131434 (2012).","journal-title":"Hum. Mutat."},{"issue":"1","key":"82490_CR60","doi-asserted-by":"publisher","first-page":"019","DOI":"10.1038\/s41598-019-49032-0","volume":"9","author":"PE Schneeberger","year":"2019","unstructured":"Schneeberger, P. E. et al. De novo MEPCE nonsense variant associated with a neurodevelopmental disorder causes disintegration of 7SK snRNP and enhanced RNA polymerase II activation. Sci. Rep. 9(1), 019\u201349032 (2019).","journal-title":"Sci. Rep."},{"issue":"4","key":"82490_CR61","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1007\/s13277-014-2907-8","volume":"36","author":"F Keramati","year":"2015","unstructured":"Keramati, F. et al. 7SK small nuclear RNA inhibits cancer cell proliferation through apoptosis induction. Tumour Biol. 36(4), 2809\u20132814 (2015).","journal-title":"Tumour Biol."},{"issue":"8","key":"82490_CR62","doi-asserted-by":"publisher","first-page":"14234","DOI":"10.1002\/jcp.28119","volume":"234","author":"M Musavi","year":"2019","unstructured":"Musavi, M. et al. Rn7SK small nuclear RNA is involved in cellular senescence. J. Cell. Physiol. 234(8), 14234\u201314245 (2019).","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"82490_CR63","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s12031-016-0741-8","volume":"59","author":"M Santoro","year":"2016","unstructured":"Santoro, M. et al. Expression profile of long non-coding RNAs in serum of patients with multiple sclerosis. J. Mol. Neurosci. 59(1), 18\u201323 (2016).","journal-title":"J. Mol. Neurosci."},{"issue":"2","key":"82490_CR64","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/0304-3940(91)90490-K","volume":"129","author":"H Fillit","year":"1991","unstructured":"Fillit, H. et al. Elevated circulating tumor necrosis factor levels in Alzheimer\u2019s disease. Neurosci. Lett. 129(2), 318\u2013320 (1991).","journal-title":"Neurosci. Lett."},{"issue":"1","key":"82490_CR65","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2174\/1872213X12666180703163824","volume":"12","author":"T Baj","year":"2018","unstructured":"Baj, T. & Seth, R. Role of curcumin in regulation of TNF-\u03b1 mediated brain inflammatory responses. Recent. Pat. Inflamm. Allergy Drug Discov. 12(1), 69\u201377 (2018).","journal-title":"Recent. Pat. Inflamm. Allergy Drug Discov"},{"issue":"1","key":"82490_CR66","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1186\/1742-2094-2-9","volume":"2","author":"NS Patel","year":"2005","unstructured":"Patel, N. S. et al. Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer\u2019s disease. J. Neuroinflammation. 2(1), 1742\u20132094 (2005).","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"82490_CR67","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.cmet.2013.11.002","volume":"18","author":"MV Lourenco","year":"2013","unstructured":"Lourenco, M. V. et al. TNF-\u03b1 mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer\u2019s \u03b2-amyloid oligomers in mice and monkeys. Cell. Metab. 18(6), 831\u2013843 (2013).","journal-title":"Cell. Metab."},{"issue":"103914","key":"82490_CR68","first-page":"5","volume":"340","author":"BA Malynn","year":"2019","unstructured":"Malynn, B. A. & Ma, A. A20: A multifunctional tool for regulating immunity and preventing disease. Cell. Immunol. 340(103914), 5 (2019).","journal-title":"Cell. Immunol."},{"issue":"5488","key":"82490_CR69","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1126\/science.289.5488.2350","volume":"289","author":"EG Lee","year":"2000","unstructured":"Lee, E. G. et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 289(5488), 2350\u20132354 (2000).","journal-title":"Science"},{"issue":"134480","key":"82490_CR70","first-page":"4","volume":"712","author":"X Chen","year":"2019","unstructured":"Chen, X. et al. A20 protects neuronal apoptosis stimulated by lipopolysaccharide-induced microglial exosomes. Neurosci. Lett. 712(134480), 4 (2019).","journal-title":"Neurosci. Lett."},{"issue":"5","key":"82490_CR71","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.celrep.2019.12.097","volume":"30","author":"AN Mohebiany","year":"2020","unstructured":"Mohebiany, A. N. et al. Microglial A20 protects the brain from CD8 T-cell-mediated immunopathology. Cell. Rep. 30(5), 1585\u20131597 (2020).","journal-title":"Cell. Rep."},{"issue":"1","key":"82490_CR72","doi-asserted-by":"publisher","first-page":"022","DOI":"10.1038\/s41421-022-00377-3","volume":"8","author":"W Tan","year":"2022","unstructured":"Tan, W. et al. Distinct phases of adult microglia proliferation: A myc-mediated early phase and a Tnfaip3-mediated late phase. Cell. Discov. 8(1), 022\u201300377 (2022).","journal-title":"Cell. Discov"},{"key":"82490_CR73","doi-asserted-by":"crossref","unstructured":"Cucos, C. A. et al. Altered blood and brain expression of inflammation and redox genes in Alzheimer\u2019s disease, common to APP(V717I) \u00d7 TAU(P301L) mice and patients. Int. J. Mol. Sci. 23(10) (2022).","DOI":"10.3390\/ijms23105799"},{"key":"82490_CR74","doi-asserted-by":"crossref","unstructured":"Kang, Y. et al. Cellular protection using Flt3 and PI3K\u03b1 inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity. Nat. Commun. 5(3672) (2014).","DOI":"10.1038\/ncomms4672"},{"issue":"11","key":"82490_CR75","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.2174\/1567205013666160703174254","volume":"13","author":"Y Liao","year":"2016","unstructured":"Liao, Y. et al. Elevations in the levels of NF-\u03baB and inflammatory chemotactic factors in the brains with Alzheimer\u2019s disease - one mechanism may involve \u03b13 nicotinic acetylcholine receptor. Curr. Alzheimer Res. 13(11), 1290\u20131301 (2016).","journal-title":"Curr. Alzheimer Res."},{"issue":"45","key":"82490_CR76","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1126\/sciadv.abe3954","volume":"7","author":"H Karahan","year":"2021","unstructured":"Karahan, H. et al. Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer\u2019s disease in a mouse model of A\u03b2 amyloidosis. Sci. Adv. 7(45), 3 (2021).","journal-title":"Sci. Adv."},{"issue":"6","key":"82490_CR77","doi-asserted-by":"publisher","first-page":"2742","DOI":"10.4049\/jimmunol.160.6.2742","volume":"160","author":"D Guo","year":"1998","unstructured":"Guo, D. et al. Induction of Jak\/STAT signaling by activation of the type 1 TNF receptor. J. Immunol. 160(6), 2742\u20132750 (1998).","journal-title":"J. Immunol."},{"issue":"5","key":"82490_CR78","doi-asserted-by":"publisher","first-page":"6738","DOI":"10.3892\/mmr.2015.4278","volume":"12","author":"Y Xiong","year":"2015","unstructured":"Xiong, Y. et al. STAT3\u2013regulated long non-coding RNAs lnc\u20137SK and lnc\u2013IGF2\u2013AS promote hepatitis C virus replication. Mol. Med. Rep. 12(5), 6738\u20136744 (2015).","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"82490_CR79","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1136\/svn-2021-001028","volume":"7","author":"ZV Zheng","year":"2022","unstructured":"Zheng, Z. V. et al. Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage. Stroke Vasc. Neurol. 7(1), 62\u201370 (2022).","journal-title":"Stroke Vasc. Neurol."},{"issue":"2","key":"82490_CR80","doi-asserted-by":"publisher","first-page":"9902","DOI":"10.1080\/21655979.2021.1969195","volume":"12","author":"L Li","year":"2021","unstructured":"Li, L. et al. MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-\u03b1-induced protein 3). Bioengineered 12(2), 9902\u20139913 (2021).","journal-title":"Bioengineered"},{"key":"82490_CR81","doi-asserted-by":"crossref","unstructured":"Nie, C. et al. Differential expression of plasma Exo-miRNA in neurodegenerative diseases by Next-Generation sequencing. Front. Neurosci., 14(438) (2020).","DOI":"10.3389\/fnins.2020.00438"},{"key":"82490_CR82","doi-asserted-by":"publisher","first-page":"807764","DOI":"10.3389\/fnagi.2021.807764","volume":"13","author":"N Ogonowski","year":"2022","unstructured":"Ogonowski, N. et al. Systematic review: MicroRNAs as potential biomarkers in mild cognitive impairment diagnosis. Front. Aging Neurosci. 13, 807764. https:\/\/doi.org\/10.3389\/fnagi.2021.807764 (2022). eCollection 2021.","journal-title":"Front. Aging Neurosci."},{"key":"82490_CR83","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jneuroim.2018.01.005","volume":"317","author":"N Baulina","year":"2018","unstructured":"Baulina, N. et al. Immune-related miRNA expression patterns in peripheral blood mononuclear cells differ in multiple sclerosis relapse and remission. J. Neuroimmunol. 317, 67\u201376 (2018).","journal-title":"J. Neuroimmunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82490-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82490-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82490-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T19:04:09Z","timestamp":1735412649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82490-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":83,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["82490"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-82490-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"6 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent has been obtained from all patients. Ethical approval for this study was obtained from the Ethical Committee of Shahid Beheshti University of Medical Sciences. All methods were performed in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Informed consent has been obtained from all patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"31192"}}