{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:32:06Z","timestamp":1793917926788,"version":"4.8.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Young Doctor Foundation of Hunan Provincial People\u2019s Hospital","award":["BSJJ202215"],"award-info":[{"award-number":["BSJJ202215"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400050"],"award-info":[{"award-number":["82400050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070057"],"award-info":[{"award-number":["82070057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ6270"],"award-info":[{"award-number":["2024JJ6270"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ30400"],"award-info":[{"award-number":["2021JJ30400"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Changsha","award":["kq2014191"],"award-info":[{"award-number":["kq2014191"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-82552-y","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T04:47:19Z","timestamp":1735361239000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypoxia-induced TPC2 transcription and glycosylation aggravates pulmonary arterial hypertension by blocking autophagy flux"],"prefix":"10.1038","volume":"14","author":[{"given":"Chao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuFei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MoFei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChengYi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaXin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongLiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"issue":"16","key":"82552_CR1","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1056\/NEJMra035488","volume":"351","author":"HW Farber","year":"2004","unstructured":"Farber, H. W. & Loscalzo, J. Pulmonary arterial hypertension. N. Engl. J. Med. 351(16), 1655\u20131665 (2004).","journal-title":"N. Engl. J. Med."},{"key":"82552_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5492","volume":"360","author":"T Thenappan","year":"2018","unstructured":"Thenappan, T., Ormiston, M. L., Ryan, J. J. & Archer, S. L. Pulmonary arterial hypertension: Pathogenesis and clinical management. BMJ 360, j5492 (2018).","journal-title":"BMJ"},{"issue":"138","key":"82552_CR3","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1183\/16000617.0063-2015","volume":"24","author":"M Delcroix","year":"2015","unstructured":"Delcroix, M. & Howard, L. Pulmonary arterial hypertension: The burden of disease and impact on quality of life. Eur. Respir. Rev. 24(138), 621\u2013629 (2015).","journal-title":"Eur. Respir. Rev."},{"issue":"14","key":"82552_CR4","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1001\/jama.2022.4402","volume":"327","author":"NF Ruopp","year":"2022","unstructured":"Ruopp, N. F. & Cockrill, B. A. Diagnosis and treatment of pulmonary arterial hypertension: A review. JAMA 327(14), 1379\u20131391 (2022).","journal-title":"JAMA"},{"issue":"8","key":"82552_CR5","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.tips.2020.06.002","volume":"41","author":"X Jin","year":"2020","unstructured":"Jin, X. et al. Targeting two-pore channels: Current progress and future challenges. Trends Pharmacol. Sci. 41(8), 582\u2013594 (2020).","journal-title":"Trends Pharmacol. Sci."},{"issue":"15","key":"82552_CR6","doi-asserted-by":"publisher","first-page":"4171","DOI":"10.1113\/JP270936","volume":"594","author":"SJ Pitt","year":"2016","unstructured":"Pitt, S. J., Reilly-O\u2019Donnell, B. & Sitsapesan, R. Exploring the biophysical evidence that mammalian two-pore channels are NAADP-activated calcium-permeable channels. J. Physiol. 594(15), 4171\u20134179 (2016).","journal-title":"J. Physiol."},{"issue":"15","key":"82552_CR7","doi-asserted-by":"publisher","first-page":"7485","DOI":"10.1111\/jcmm.16783","volume":"25","author":"W Hu","year":"2021","unstructured":"Hu, W., Zhao, F., Chen, L., Ni, J. & Jiang, Y. NAADP-induced intracellular calcium ion is mediated by the TPCs (two-pore channels) in hypoxia-induced pulmonary arterial hypertension. J. Cell. Mol. Med. 25(15), 7485\u20137499 (2021).","journal-title":"J. Cell. Mol. Med."},{"issue":"15","key":"82552_CR8","doi-asserted-by":"publisher","first-page":"10381","DOI":"10.1074\/jbc.M112.423053","volume":"288","author":"YL Jiang","year":"2013","unstructured":"Jiang, Y. L. et al. Nicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytes. J. Boil. Chem. 288(15), 10381\u201310394 (2013).","journal-title":"J. Boil. Chem."},{"key":"82552_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.biocel.2018.01.012","volume":"97","author":"Y Jiang","year":"2018","unstructured":"Jiang, Y. et al. Two-pore channels mediated receptor-operated Ca(2+) entry in pulmonary artery smooth muscle cells in response to hypoxia. Int. J. Biochem. Cell Biol. 97, 28\u201335 (2018).","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"82552_CR10","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.yexcr.2018.07.013","volume":"370","author":"W Sun","year":"2018","unstructured":"Sun, W. & Yue, J. TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells. Exp. Cell Res. 370(2), 478\u2013489 (2018).","journal-title":"Exp. Cell Res."},{"issue":"3","key":"82552_CR11","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/path.5322","volume":"249","author":"MC Gomez-Puerto","year":"2019","unstructured":"Gomez-Puerto, M. C. et al. Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension. J. Pathol. 249(3), 356\u2013367 (2019).","journal-title":"J. Pathol."},{"issue":"1","key":"82552_CR12","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1515\/med-2022-0497","volume":"17","author":"Z Yang","year":"2022","unstructured":"Yang, Z., Zhou, L., Ge, H., Shen, W. & Shan, L. Identification of autophagy-related biomarkers in patients with pulmonary arterial hypertension based on bioinformatics analysis. Open Med. 17(1), 1148\u20131157 (2022).","journal-title":"Open Med."},{"issue":"5","key":"82552_CR13","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.sbi.2011.08.005","volume":"21","author":"F Schwarz","year":"2011","unstructured":"Schwarz, F. & Aebi, M. Mechanisms and principles of N-linked protein glycosylation. Curr. Opin. Struct. Boil. 21(5), 576\u2013582 (2011).","journal-title":"Curr. Opin. Struct. Boil."},{"issue":"1","key":"82552_CR14","doi-asserted-by":"publisher","first-page":"H77","DOI":"10.1152\/ajpheart.00008.2002","volume":"283","author":"Q Gong","year":"2002","unstructured":"Gong, Q., Anderson, C. L., January, C. T. & Zhou, Z. Role of glycosylation in cell surface expression and stability of HERG potassium channels. Am. J. Physiol. Heart Circ. Physiol. 283(1), H77-84 (2002).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"82552_CR15","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.bbrc.2009.12.056","volume":"391","author":"B Egenberger","year":"2010","unstructured":"Egenberger, B., Polleichtner, G., Wischmeyer, E. & Doring, F. N-linked glycosylation determines cell surface expression of two-pore-domain K+ channel TRESK. Biochem. Biophys. Res. Commun. 391(2), 1262\u20131267 (2010).","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"82552_CR16","doi-asserted-by":"publisher","first-page":"9141","DOI":"10.1074\/jbc.M110.189985","volume":"286","author":"R Hooper","year":"2011","unstructured":"Hooper, R., Churamani, D., Brailoiu, E., Taylor, C. W. & Patel, S. Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation. J. Boil. Chem. 286(11), 9141\u20139149 (2011).","journal-title":"J. Boil. Chem."},{"issue":"9","key":"82552_CR17","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1038\/s41418-022-00969-2","volume":"29","author":"K Liu","year":"2022","unstructured":"Liu, K. et al. Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation. Cell Death Differ. 29(9), 1834\u20131849 (2022).","journal-title":"Cell Death Differ."},{"issue":"12","key":"82552_CR18","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/s41580-020-00294-x","volume":"21","author":"KT Schjoldager","year":"2020","unstructured":"Schjoldager, K. T., Narimatsu, Y., Joshi, H. J. & Clausen, H. Global view of human protein glycosylation pathways and functions. Nat. Rev. Mol. Cell. Biol. 21(12), 729\u2013749 (2020).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"82552_CR19","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-1-4939-8597-5_18","volume":"1816","author":"C Bueno-Beti","year":"2018","unstructured":"Bueno-Beti, C., Sassi, Y., Hajjar, R. J. & Hadri, L. Pulmonary artery hypertension model in rats by monocrotaline administration. Methods Mol. Boil. 1816, 233\u2013241 (2018).","journal-title":"Methods Mol. Boil."},{"key":"82552_CR20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0076-6879(08)03610-0","volume":"452","author":"P Yla-Anttila","year":"2009","unstructured":"Yla-Anttila, P., Vihinen, H., Jokitalo, E. & Eskelinen, E. L. Monitoring autophagy by electron microscopy in Mammalian cells. Methods Enzymol. 452, 143\u2013164 (2009).","journal-title":"Methods Enzymol."},{"issue":"1","key":"82552_CR21","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/19336950.2016.1213929","volume":"11","author":"S Feijoo-Bandin","year":"2017","unstructured":"Feijoo-Bandin, S. et al. Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions. Channels 11(1), 20\u201333 (2017).","journal-title":"Channels"},{"issue":"11","key":"82552_CR22","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1113\/JP271332","volume":"594","author":"V Garcia-Rua","year":"2016","unstructured":"Garcia-Rua, V. et al. Endolysosomal two-pore channels regulate autophagy in cardiomyocytes. J. Physiol. 594(11), 3061\u20133077 (2016).","journal-title":"J. Physiol."},{"key":"82552_CR23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fmed.2019.00093","volume":"6","author":"JM Young","year":"2019","unstructured":"Young, J. M., Williams, D. R. & Thompson, A. A. R. Thin air, thick vessels: Historical and current perspectives on hypoxic pulmonary hypertension. Front. Med. 6, 93 (2019).","journal-title":"Front. Med."},{"issue":"3","key":"82552_CR24","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/ncb3114","volume":"17","author":"DL Medina","year":"2015","unstructured":"Medina, D. L. et al. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat. Cell Biol. 17(3), 288\u2013299 (2015).","journal-title":"Nat. Cell Biol."},{"issue":"13","key":"82552_CR25","doi-asserted-by":"publisher","first-page":"8398","DOI":"10.1021\/acs.analchem.9b01250","volume":"91","author":"SS Li","year":"2019","unstructured":"Li, S. S. et al. Monitoring the changes of pH in lysosomes during autophagy and apoptosis by plasmon enhanced Raman imaging. Anal. Chem. 91(13), 8398\u20138405 (2019).","journal-title":"Anal. Chem."},{"issue":"5","key":"82552_CR26","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/S0959-437X(98)80016-6","volume":"8","author":"GL Semenza","year":"1998","unstructured":"Semenza, G. L. Hypoxia-inducible factor 1: Master regulator of O2 homeostasis. Curr. Opin. Genet. Dev. 8(5), 588\u2013594 (1998).","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"8","key":"82552_CR27","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1083\/jcb.201904004","volume":"218","author":"NA Cherepanova","year":"2019","unstructured":"Cherepanova, N. A., Venev, S. V., Leszyk, J. D., Shaffer, S. A. & Gilmore, R. Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites. J. Cell Biol. 218(8), 2782\u20132796 (2019).","journal-title":"J. Cell Biol."},{"issue":"2","key":"82552_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3858\/emm.2012.44.2.030","volume":"44","author":"W Quan","year":"2012","unstructured":"Quan, W., Lim, Y. M. & Lee, M. S. Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic beta-cells. Exp. Mol. Med. 44(2), 81\u201388 (2012).","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"82552_CR29","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nrn3961","volume":"16","author":"FM Menzies","year":"2015","unstructured":"Menzies, F. M., Fleming, A. & Rubinsztein, D. C. Compromised autophagy and neurodegenerative diseases. Nat. Rev. Neurosci. 16(6), 345\u2013357 (2015).","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"82552_CR30","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/s41418-019-0474-7","volume":"27","author":"JM Mulcahy Levy","year":"2020","unstructured":"Mulcahy Levy, J. M. & Thorburn, A. Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients. Cell Death Differ. 27(3), 843\u2013857 (2020).","journal-title":"Cell Death Differ."},{"issue":"5","key":"82552_CR31","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1164\/rccm.201005-0746OC","volume":"183","author":"SJ Lee","year":"2011","unstructured":"Lee, S. J. et al. Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am. J. Respir Crit. Care Med. 183(5), 649\u2013658 (2011).","journal-title":"Am. J. Respir Crit. Care Med."},{"issue":"8","key":"82552_CR32","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/CIRCRESAHA.111.300483","volume":"112","author":"L Long","year":"2013","unstructured":"Long, L. et al. Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. Circ. Res. 112(8), 1159\u20131170 (2013).","journal-title":"Circ. Res."},{"issue":"5","key":"82552_CR33","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s00210-019-01615-4","volume":"392","author":"W Feng","year":"2019","unstructured":"Feng, W. et al. Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy. Naunyn-Schmiedeberg\u2019s Arch. Pharmacol. 392(5), 605\u2013613 (2019).","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"2","key":"82552_CR34","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ncb2152","volume":"13","author":"J Kim","year":"2011","unstructured":"Kim, J., Kundu, M., Viollet, B. & Guan, K. L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13(2), 132\u2013141 (2011).","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"82552_CR35","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1164\/rccm.202001-0087ED","volume":"201","author":"EA Goncharova","year":"2020","unstructured":"Goncharova, E. A., Simon, M. A. & Yuan, J. X. mTORC1 in pulmonary arterial hypertension. At the crossroads between vasoconstriction and vascular remodeling?. Am. J. Respir. Crit. Care Med. 201(10), 1177\u20131179 (2020).","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"82552_CR36","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/jcmm.12208","volume":"18","author":"H Zhang","year":"2014","unstructured":"Zhang, H. et al. Apelin inhibits the proliferation and migration of rat PASMCs via the activation of PI3K\/Akt\/mTOR signal and the inhibition of autophagy under hypoxia. J. Cell. Mol. Med. 18(3), 542\u2013553 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"82552_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113500","volume":"236","author":"X Han","year":"2022","unstructured":"Han, X. et al. Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity. Ecotoxicol. Environ. Saf. 236, 113500 (2022).","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"82552_CR38","doi-asserted-by":"publisher","first-page":"154","DOI":"10.4161\/auto.3634","volume":"3","author":"A Kawai","year":"2007","unstructured":"Kawai, A., Uchiyama, H., Takano, S., Nakamura, N. & Ohkuma, S. Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells. Autophagy 3(2), 154\u2013157 (2007).","journal-title":"Autophagy"},{"issue":"1","key":"82552_CR39","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.1038\/s41467-022-31959-0","volume":"13","author":"Y Yuan","year":"2022","unstructured":"Yuan, Y. et al. Segregated cation flux by TPC2 biases Ca(2+) signaling through lysosomes. Nat. Commun. 13(1), 4481 (2022).","journal-title":"Nat. Commun."},{"issue":"2","key":"82552_CR40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jphs.2019.09.010","volume":"141","author":"X Zhang","year":"2019","unstructured":"Zhang, X. et al. Puerarin prevents progression of experimental hypoxia-induced pulmonary hypertension via inhibition of autophagy. J. Pharmacol. Sci. 141(2), 97\u2013105 (2019).","journal-title":"J. Pharmacol. Sci."},{"issue":"5","key":"82552_CR41","doi-asserted-by":"publisher","first-page":"H1087","DOI":"10.1152\/ajpheart.00314.2020","volume":"319","author":"R Yamanaka","year":"2020","unstructured":"Yamanaka, R. et al. TIGAR reduces smooth muscle cell autophagy to prevent pulmonary hypertension. Am. J. Physiol. Heart Circ. Physiol. 319(5), H1087\u2013H1096 (2020).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"82552_CR42","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","volume":"5","author":"GN Masoud","year":"2015","unstructured":"Masoud, G. N. & Li, W. HIF-1alpha pathway: Role, regulation and intervention for cancer therapy. Acta Pharmaceut. Sin. B 5(5), 378\u2013389 (2015).","journal-title":"Acta Pharmaceut. Sin. B"},{"issue":"4","key":"82552_CR43","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/cdd.2008.12","volume":"15","author":"A Weidemann","year":"2008","unstructured":"Weidemann, A. & Johnson, R. S. Biology of HIF-1alpha. Cell Death Differ. 15(4), 621\u2013627 (2008).","journal-title":"Cell Death Differ."},{"issue":"22","key":"82552_CR44","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1161\/CIRCULATIONAHA.105.609008","volume":"113","author":"S Bonnet","year":"2006","unstructured":"Bonnet, S. et al. An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension. Circulation 113(22), 2630\u20132641 (2006).","journal-title":"Circulation"},{"issue":"5","key":"82552_CR45","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.3892\/mmr.2016.5752","volume":"14","author":"W Lei","year":"2016","unstructured":"Lei, W. et al. Expression and analyses of the HIF-1 pathway in the lungs of humans with pulmonary arterial hypertension. Mol. Med. Rep. 14(5), 4383\u20134390 (2016).","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"82552_CR46","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1038\/s41467-019-11500-6","volume":"10","author":"Y Luo","year":"2019","unstructured":"Luo, Y. et al. CD146-HIF-1alpha hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension. Nat. Commun. 10(1), 3551 (2019).","journal-title":"Nat. Commun."},{"issue":"3","key":"82552_CR47","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.2353\/ajpath.2010.090832","volume":"176","author":"I Fijalkowska","year":"2010","unstructured":"Fijalkowska, I. et al. Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells. Am. J. Pathol. 176(3), 1130\u20131138 (2010).","journal-title":"Am. J. Pathol."},{"issue":"5","key":"82552_CR48","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1159\/000471912","volume":"41","author":"AF Silva-Filho","year":"2017","unstructured":"Silva-Filho, A. F. et al. Glycobiology modifications in intratumoral hypoxia: The breathless side of glycans interaction. Cell. Physiol. Biochem. 41(5), 1801\u20131829 (2017).","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"82552_CR49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/19336918.2018.1491234","volume":"13","author":"C Arriagada","year":"2019","unstructured":"Arriagada, C., Silva, P. & Torres, V. A. Role of glycosylation in hypoxia-driven cell migration and invasion. Cell Adhes. Migrat. 13(1), 13\u201322 (2019).","journal-title":"Cell Adhes. Migrat."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82552-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82552-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82552-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T19:05:28Z","timestamp":1735412728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82552-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["82552"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-82552-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"5 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted in accordance with the Guide for the Care and Use of Laboratory Animals which was approved by the Institutional Animal Care Committee (IACUC) and the Experimental Animal Committee of Hunan Normal University (No.2022103218). This study follows the ARRIVE guidelines. We followed all relevant ethical standards during the study and ensured the welfare of all laboratory animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31223"}}