{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:54:19Z","timestamp":1740164059974,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50\u201365, 52% women). TropI and NT-proBNP were measured in plasma. Segment involvement score (SIS) was the primary exposure and TropI the primary outcome. Both SIS and coronary artery calcium score, were associated with TropI levels following adjustment for age, sex and multiple confounders (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with similar relationships in men and women. Proximal segments from all three coronary arteries were related to TropI levels independently of one another. Adding TropI to traditional risk factors marginally increased discrimination of atherosclerosis as compared to risk factors alone (C-statistics\u2009+\u20090.0005, <jats:italic>p<\/jats:italic>\u2009=\u20090.014). SIS was related also to NT-proBNP levels, mainly in men, but with lower estimates than TropI. The burden of CAD was related to TropI levels in both men and women. All three major coronary arteries contributed to this relationship. Adding TropI to traditional risk factors resulted in only marginally improved discrimination of coronary atherosclerosis.<\/jats:p>","DOI":"10.1038\/s41598-024-82777-x","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T15:05:41Z","timestamp":1734361541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac biomarkers for detection of coronary artery disease in the community"],"prefix":"10.1038","volume":"14","author":[{"given":"Lars","family":"Lind","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joakim","family":"Alfredsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas S. O.","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6rjan","family":"Ekblom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Fagman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tove","family":"Fall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Hagstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes Holm","family":"Isholth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Janzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Jernberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Katsoularis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Leander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margr\u00e9t","family":"Le\u00f3sd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Malinovschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Rosengren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"GustavSmith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Spaak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"S\u00f6derberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl Johan","family":"\u00d6stgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"issue":"18","key":"82777_CR1","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1016\/j.jacc.2012.12.048","volume":"61","author":"KM Eggers","year":"2013","unstructured":"Eggers, K. M., Venge, P., Lindahl, B. & Lind, L. Cardiac troponin I levels measured with a high-sensitive assay increase over time and are strong predictors of mortality in an elderly population. J. Am. Coll. Cardiol. 61(18), 1906\u20131913 (2013).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"22","key":"82777_CR2","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1001\/jama.2010.1768","volume":"304","author":"JA de Lemos","year":"2010","unstructured":"de Lemos, J. A. et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 304(22), 2503\u20132512 (2010).","journal-title":"JAMA"},{"issue":"22","key":"82777_CR3","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1161\/CIRCULATIONAHA.109.901413","volume":"121","author":"S Blankenberg","year":"2010","unstructured":"Blankenberg, S. et al. Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project. Circulation 121(22), 2388\u20132397 (2010).","journal-title":"Circulation"},{"issue":"30","key":"82777_CR4","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1093\/eurheartj\/ehw172","volume":"37","author":"S Blankenberg","year":"2016","unstructured":"Blankenberg, S. et al. Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium. Eur. Heart J. 37(30), 2428\u20132437 (2016).","journal-title":"Eur. Heart J."},{"key":"82777_CR5","doi-asserted-by":"publisher","first-page":"1054959","DOI":"10.3389\/fcvm.2022.1054959","volume":"9","author":"L Leite","year":"2022","unstructured":"Leite, L. et al. High sensitivity troponins: a potential biomarkers of cardiovascular risk for primary prevention. Front. Cardiovasc. Med. 9, 1054959. https:\/\/doi.org\/10.3389\/fcvm.2022.1054959 (2022).","journal-title":"Front. Cardiovasc. Med."},{"issue":"25","key":"82777_CR6","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1016\/j.jacc.2016.10.020","volume":"68","author":"I Ford","year":"2016","unstructured":"Ford, I. et al. High-sensitivity Cardiac Troponin, Statin Therapy, and risk of Coronary Heart Disease. J. Am. Coll. Cardiol. 68(25), 2719\u20132728 (2016).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"82777_CR7","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.amjcard.2011.04.012","volume":"108","author":"G Ndrepepa","year":"2011","unstructured":"Ndrepepa, G. et al. High-sensitivity troponin T level and angiographic severity of coronary artery disease. Am. J. Cardiol. 108(5), 639\u2013643 (2011).","journal-title":"Am. J. Cardiol."},{"key":"82777_CR8","doi-asserted-by":"publisher","unstructured":"Samman Tahhan, A. et al. High-sensitivity troponin I levels and coronary artery Disease Severity, Progression, and long-term outcomes. J. Am. Heart Assoc. 7(5). https:\/\/doi.org\/10.1161\/JAHA.117.007914 (2018).","DOI":"10.1161\/JAHA.117.007914"},{"issue":"4","key":"82777_CR9","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1161\/ATVBAHA.115.306818","volume":"36","author":"C Caselli","year":"2016","unstructured":"Caselli, C. et al. Effect of coronary atherosclerosis and myocardial ischemia on plasma levels of high-sensitivity troponin T and NT-proBNP in patients with stable angina. Arterioscler. Thromb. Vasc Biol. 36(4), 757\u2013764 (2016).","journal-title":"Arterioscler. Thromb. Vasc Biol."},{"issue":"6","key":"82777_CR10","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.jcmg.2018.01.021","volume":"12","author":"JL Januzzi Jr","year":"2019","unstructured":"Januzzi, J. L. Jr. et al. High-sensitivity troponin I and Coronary computed tomography in symptomatic outpatients with suspected CAD: insights from the PROMISE trial. JACC Cardiovasc. Imaging 12(6), 1047\u20131055 (2019).","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"1","key":"82777_CR11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40001-017-0290-9","volume":"22","author":"J Rusnak","year":"2017","unstructured":"Rusnak, J. et al. Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score. Eur. J. Med. Res. 22(1), 47 (2017).","journal-title":"Eur. J. Med. Res."},{"key":"82777_CR12","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.atherosclerosis.2015.12.017","volume":"245","author":"F Olson","year":"2016","unstructured":"Olson, F. et al. Association between high-sensitive troponin I and coronary artery calcification in a Danish general population. Atherosclerosis 245, 88\u201393 (2016).","journal-title":"Atherosclerosis"},{"issue":"17","key":"82777_CR13","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/j.jacc.2010.06.029","volume":"56","author":"SE Elias-Smale","year":"2010","unstructured":"Elias-Smale, S. E. et al. Coronary calcium score improves classification of coronary heart disease risk in the elderly: the Rotterdam study. J. Am. Coll. Cardiol. 56(17), 1407\u20131414 (2010).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"17","key":"82777_CR14","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.jacc.2010.06.030","volume":"56","author":"R Erbel","year":"2010","unstructured":"Erbel, R. et al. Coronary risk stratification, discrimination, and reclassification improvement based on quantification of subclinical coronary atherosclerosis: the Heinz Nixdorf Recall study. J. Am. Coll. Cardiol. 56(17), 1397\u20131406 (2010).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"82777_CR15","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/joim.12384","volume":"278","author":"G Bergstrom","year":"2015","unstructured":"Bergstrom, G. et al. The Swedish CArdioPulmonary BioImage Study: objectives and design. J. Intern. Med. 278(6), 645\u2013659 (2015).","journal-title":"J. Intern. Med."},{"issue":"12","key":"82777_CR16","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1161\/CIRCULATIONAHA.121.055340","volume":"144","author":"G Bergstrom","year":"2021","unstructured":"Bergstrom, G. et al. Prevalence of subclinical coronary artery atherosclerosis in the General Population. Circulation 144(12), 916\u2013929 (2021).","journal-title":"Circulation"},{"issue":"4","key":"82777_CR17","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.jacc.2006.05.041","volume":"48","author":"CE Barbier","year":"2006","unstructured":"Barbier, C. E., Bjerner, T., Johansson, L., Lind, L. & Ahlstrom, H. Myocardial scars more frequent than expected: magnetic resonance imaging detects potential risk group. J. Am. Coll. Cardiol. 48(4), 765\u2013771 (2006).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"82777_CR18","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1373\/clinchem.2014.222430","volume":"60","author":"CE Barbier","year":"2014","unstructured":"Barbier, C. E. et al. Cardiac troponin I associated with the development of unrecognized myocardial infarctions detected with MRI. Clin. Chem. 60(10), 1327\u20131335 (2014).","journal-title":"Clin. Chem."},{"issue":"1","key":"82777_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1136\/heartjnl-2016-309530","volume":"103","author":"AR Chapman","year":"2017","unstructured":"Chapman, A. R., Adamson, P. D. & Mills, N. L. Assessment and classification of patients with myocardial injury and infarction in clinical practice. Heart 103(1), 10\u201318 (2017).","journal-title":"Heart"},{"issue":"7","key":"82777_CR20","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.jacc.2013.03.065","volume":"62","author":"S Takashio","year":"2013","unstructured":"Takashio, S. et al. Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure. J. Am. Coll. Cardiol. 62(7), 632\u2013640 (2013).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"82777_CR21","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1093\/clinchem\/hvab278","volume":"68","author":"WG Miller","year":"2022","unstructured":"Miller, W. G. et al. National Kidney Foundation Laboratory Engagement Working Group Recommendations for implementing the CKD-EPI 2021 race-free equations for estimated glomerular filtration rate: practical Guidance for Clinical Laboratories. Clin. Chem. 68(4), 511\u2013520 (2022).","journal-title":"Clin. Chem."},{"issue":"12","key":"82777_CR22","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.jacc.2007.03.067","volume":"50","author":"JK Min","year":"2007","unstructured":"Min, J. K. et al. Prognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortality. J. Am. Coll. Cardiol. 50(12), 1161\u20131170 (2007).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"82777_CR23","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1007\/s00330-002-1394-2","volume":"12","author":"B Ohnesorge","year":"2002","unstructured":"Ohnesorge, B. et al. Reproducibility of coronary calcium quantification in repeat examinations with retrospectively ECG-gated multisection spiral CT. Eur. Radiol. 12(6), 1532\u20131540 (2002).","journal-title":"Eur. Radiol."},{"issue":"2","key":"82777_CR24","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jcct.2009.01.001","volume":"3","author":"GL Raff","year":"2009","unstructured":"Raff, G. L. et al. SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography. J. Cardiovasc. Comput. Tomogr 3(2), 122\u2013136 (2009).","journal-title":"J. Cardiovasc. Comput. Tomogr"},{"issue":"4","key":"82777_CR25","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jcct.2017.05.001","volume":"11","author":"C Ayoub","year":"2017","unstructured":"Ayoub, C. et al. Prognostic value of segment involvement score compared to other measures of coronary atherosclerosis by computed tomography: a systematic review and meta-analysis. J. Cardiovasc. Comput. Tomogr 11(4), 258\u2013267 (2017).","journal-title":"J. Cardiovasc. Comput. Tomogr"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82777-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82777-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82777-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T16:05:03Z","timestamp":1734365103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-82777-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["82777"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-82777-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"8 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"J.A. reports lectures fees from Boehringer Ingelheim, AstraZeneca, MSD, Bayer, and Novartis, support for abstract presentation from Novartis, and advisory board reimbursement from AstraZeneca and Novartis. T.A. reports speakers\u2019 honoraria from AstraZeneca, Vifor Pharma, Boehringer Ingelheim and Pharmacosmos, and participation on advisory boards for Vifor Pharma and Pharmacosmos. E.H. reports support from Uppsala University, , small personal fees from AMGEN, NovoNordisk, Bayer, AstraZeneca, fees for charing the Swedish secondary prevention registry and work as national coordinator for DalCore. M.L. reports payments from Bonnier Health Care, payments for pectures and educational events from AstraZeneca, NovoNordisk, Amarin, and Amgen as well as being principal investigator for the AstraZeneca DAPA-MI study in Malm\u00f6. J.S. reports, speaker honoraria from Bayer, AstraZeneca, Medtronics, Boehringer Ingelheim, Novo Nordisk, being president of the Swedish Society for Hypertension, Stroke and Vascular Medicine, the Swedish representative and advisory board member for VAS (Vascular Independent Research and Education European Organisation), and being a minor shareholder in Beat Vascular Health. S.S reports speakers\u2019 honoraria from Actelion Ltd and support for meetings from Actelion Ltd. The rest of the authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30514"}}