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The study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Ethical Committee of the CERMEL (CEI-CERMEL N\u00ba13\/2013).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical consideration"}},{"value":"The principal component analysis was performed on all available antibody glycosylation data measured in this study. As variables, we included the main derived traits on the different IgG isotypes, namely galactosylation, bisection, fucosylation and sialylation of IgG1, IgG2 and IgG3\/IgG4. Lastly, these variables were scaled to unit variance. The percentage of glycan structures between samples was compared using an unmatched two-sample Wilcoxon test. The identified low\/medium\/high group of glycosylation for the different traits was based on splitting the values into three equal-sized quantiles for each sample type. To compare these quantiles over time, each sample origin (cord blood, child 9 months, child 12 months) was compared to the mother with Fischer\u2019s exact test for a 3\u2009\u00d7\u20093 table. Using the \u2018stats\u2019 package, the statistical test was performed in R (4.3.1), and p-values\u2009<\u20090.05 were considered statistically significant.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistical consideration"}}],"article-number":"31879"}}