{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:11:03Z","timestamp":1785179463318,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-83547-5","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T21:54:13Z","timestamp":1735595653000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Macrocytic anemia, kidney dysfunction, and mortality in general population: Japan specific health checkup study"],"prefix":"10.1038","volume":"14","author":[{"given":"Yoichiro","family":"Otaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneo","family":"Konta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Asahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouichi","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Tsuruya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiei","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kasahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugo","family":"Shibagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunitoshi","family":"Iseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"83547_CR1","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","volume":"123","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum, N. J. et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood 123, 615\u2013624 (2014).","journal-title":"Blood"},{"key":"83547_CR2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1182\/blood-2017-07-746446","volume":"131","author":"R Stauder","year":"2018","unstructured":"Stauder, R., Valent, P. & Theurl, I. Anemia at older age: etiologies, clinical implications, and management. Blood 131, 505\u2013514 (2018).","journal-title":"Blood"},{"key":"83547_CR3","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1053\/j.seminhematol.2008.06.006","volume":"45","author":"KV Patel","year":"2008","unstructured":"Patel, K. V. Epidemiology of anemia in older adults. Semin Hematol. 45, 210\u2013217 (2008).","journal-title":"Semin Hematol."},{"key":"83547_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ajh.23336","volume":"88","author":"NA Zakai","year":"2013","unstructured":"Zakai, N. A. et al. Hemoglobin decline, function, and mortality in the elderly: the cardiovascular health study. Am. J. Hematol. 88, 5\u20139 (2013).","journal-title":"Am. J. Hematol."},{"key":"83547_CR5","first-page":"437","volume":"98","author":"JB Lanier","year":"2018","unstructured":"Lanier, J. B., Park, J. J. & Callahan, R. C. Anemia in older adults. Am. Fam Physician. 98, 437\u2013442 (2018).","journal-title":"Am. Fam Physician"},{"key":"83547_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.archger.2016.11.005","volume":"69","author":"E Riva","year":"2017","unstructured":"Riva, E. et al. Prognostic value of degree and types of anaemia on clinical outcomes for hospitalised older patients. Arch. Gerontol. Geriatr. 69, 21\u201330 (2017).","journal-title":"Arch. Gerontol. Geriatr."},{"key":"83547_CR7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s12325-020-01524-6","volume":"38","author":"RM Hanna","year":"2021","unstructured":"Hanna, R. M., Streja, E. & Kalantar-Zadeh, K. Burden of Anemia in chronic kidney disease: beyond erythropoietin. Adv. Ther. 38, 52\u201375 (2021).","journal-title":"Adv. Ther."},{"key":"83547_CR8","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/ndt\/gfg021","volume":"18","author":"K Iseki","year":"2003","unstructured":"Iseki, K., Ikemiya, Y., Iseki, C. & Takishita, S. Haematocrit and the risk of developing end-stage renal disease. Nephrol. Dial Transpl. 18, 899\u2013905 (2003).","journal-title":"Nephrol. Dial Transpl."},{"key":"83547_CR9","doi-asserted-by":"crossref","unstructured":"Kidney Disease. Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 98, S1-S115 (2020).Improving Global Outcomes Diabetes Work, G. KDIGO (2020).","DOI":"10.1016\/j.kint.2020.06.019"},{"key":"83547_CR10","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1681\/ASN.2011111078","volume":"23","author":"JL Babitt","year":"2012","unstructured":"Babitt, J. L. & Lin, H. Y. Mechanisms of anemia in CKD. J. Am. Soc. Nephrol. 23, 1631\u20131634 (2012).","journal-title":"J. Am. Soc. Nephrol."},{"key":"83547_CR11","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1001\/archinte.162.12.1401","volume":"162","author":"BC Astor","year":"2002","unstructured":"Astor, B. C., Muntner, P., Levin, A., Eustace, J. A. & Coresh, J. Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988\u20131994). Arch. Intern. Med. 162, 1401\u20131408 (2002).","journal-title":"Arch. Intern. Med."},{"key":"83547_CR12","doi-asserted-by":"crossref","unstructured":"Gluba-Brzozka, A., Franczyk, B., Olszewski, R. & Rysz, J. The influence of inflammation on Anemia in CKD patients. Int. J. Mol. Sci. 21 (2020).","DOI":"10.3390\/ijms21030725"},{"key":"83547_CR13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/BF01757345","volume":"69","author":"P Zachee","year":"1994","unstructured":"Zachee, P., Vermylen, J. & Boogaerts, M. A. Hematologic aspects of end-stage renal failure. Ann. Hematol. 69, 33\u201340 (1994).","journal-title":"Ann. Hematol."},{"key":"83547_CR14","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1111\/nep.12130","volume":"18","author":"Y Solak","year":"2013","unstructured":"Solak, Y. et al. Mean corpuscular volume is associated with endothelial dysfunction and predicts composite cardiovascular events in patients with chronic kidney disease. Nephrol. (Carlton). 18, 728\u2013735 (2013).","journal-title":"Nephrol. (Carlton)"},{"key":"83547_CR15","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1159\/000495726","volume":"141","author":"A Dratch","year":"2019","unstructured":"Dratch, A. et al. Mean Corpuscular volume and mortality in Incident Hemodialysis patients. Nephron 141, 188\u2013200 (2019).","journal-title":"Nephron"},{"key":"83547_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1471-2369-12-19","volume":"12","author":"KK Tennankore","year":"2011","unstructured":"Tennankore, K. K., Soroka, S. D., West, K. A. & Kiberd, B. A. Macrocytosis may be associated with mortality in chronic hemodialysis patients: a prospective study. BMC Nephrol. 12, 19 (2011).","journal-title":"BMC Nephrol."},{"key":"83547_CR17","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s10157-017-1468-8","volume":"22","author":"Y Sato","year":"2018","unstructured":"Sato, Y. et al. Anemia as a risk factor for all-cause mortality: obscure synergic effect of chronic kidney disease. Clin. Exp. Nephrol. 22, 388\u2013394 (2018).","journal-title":"Clin. Exp. Nephrol."},{"key":"83547_CR18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12875-016-0514-z","volume":"17","author":"K Stouten","year":"2016","unstructured":"Stouten, K. et al. Prevalence of potential underlying aetiology of macrocytic anaemia in Dutch general practice. BMC Fam Pract. 17, 113 (2016).","journal-title":"BMC Fam Pract."},{"key":"83547_CR19","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/aas.14198","volume":"67","author":"SB Benediktsson","year":"2023","unstructured":"Benediktsson, S. B., Karason, S. & Sigurdsson, M. I. Haemoglobin levels and outcomes of subgroups of patients with pre-operative anaemia based on red cell size: a retrospective cohort study. Acta Anaesthesiol. Scand. 67, 422\u2013431 (2023).","journal-title":"Acta Anaesthesiol. Scand."},{"key":"83547_CR20","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.atherosclerosis.2011.11.044","volume":"221","author":"M Myojo","year":"2012","unstructured":"Myojo, M. et al. Prognostic implication of macrocytosis on adverse outcomes after coronary intervention. Atherosclerosis 221, 148\u2013153 (2012).","journal-title":"Atherosclerosis"},{"key":"83547_CR21","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10654-014-9929-9","volume":"29","author":"A Martinsson","year":"2014","unstructured":"Martinsson, A. et al. Anemia in the general population: prevalence, clinical correlates and prognostic impact. Eur. J. Epidemiol. 29, 489\u2013498 (2014).","journal-title":"Eur. J. Epidemiol."},{"key":"83547_CR22","doi-asserted-by":"publisher","first-page":"3810","DOI":"10.1182\/blood-2009-02-201087","volume":"115","author":"L Ferrucci","year":"2010","unstructured":"Ferrucci, L. et al. Proinflammatory state, hepcidin, and anemia in older persons. Blood 115, 3810\u20133816 (2010).","journal-title":"Blood"},{"key":"83547_CR23","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.3324\/haematol.2010.023101","volume":"95","author":"M Tettamanti","year":"2010","unstructured":"Tettamanti, M. et al. Prevalence, incidence and types of mild anemia in the elderly: the Health and Anemia population-based study. Haematologica 95, 1849\u20131856 (2010).","journal-title":"Haematologica"},{"key":"83547_CR24","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1111\/1744-9987.12712","volume":"22","author":"T Akizawa","year":"2018","unstructured":"Akizawa, T. et al. Burden of Anemia in chronic kidney disease patients in Japan: A literature review. Ther. Apher Dial. 22, 444\u2013456 (2018).","journal-title":"Ther. Apher Dial"},{"key":"83547_CR25","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/00000441-200006000-00001","volume":"319","author":"DG Savage","year":"2000","unstructured":"Savage, D. G., Ogundipe, A., Allen, R. H., Stabler, S. P. & Lindenbaum, J. Etiology and diagnostic evaluation of macrocytosis. Am. J. Med. Sci. 319, 343\u2013352 (2000).","journal-title":"Am. J. Med. Sci."},{"key":"83547_CR26","doi-asserted-by":"publisher","first-page":"e607","DOI":"10.1097\/MD.0000000000000607","volume":"94","author":"D Fuster","year":"2015","unstructured":"Fuster, D. et al. Markers of inflammation and mortality in a cohort of patients with alcohol dependence. Med. (Baltim). 94, e607 (2015).","journal-title":"Med. (Baltim)."},{"key":"83547_CR27","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s10016-001-0115-7","volume":"16","author":"M Haltmayer","year":"2002","unstructured":"Haltmayer, M., Mueller, T., Luft, C., Poelz, W. & Haidinger, D. Erythrocyte mean corpuscular volume associated with severity of peripheral arterial disease: an angiographic evaluation. Ann. Vasc Surg. 16, 474\u2013479 (2002).","journal-title":"Ann. Vasc Surg."},{"key":"83547_CR28","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1177\/0003319720943816","volume":"72","author":"M Tscharre","year":"2021","unstructured":"Tscharre, M., Lee, S., Kopp, C. W., Panzer, S. & Gremmel, T. Mean Corpuscular volume predicts adverse outcomes following peripheral angioplasty with stenting and is Associated with On-Treatment platelet reactivity. Angiology 72, 16\u201323 (2021).","journal-title":"Angiology"},{"key":"83547_CR29","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1253\/circj.CJ-13-0718","volume":"77","author":"T Ueda","year":"2013","unstructured":"Ueda, T. et al. High mean corpuscular volume is a new indicator of prognosis in acute decompensated heart failure. Circ. J. 77, 2766\u20132771 (2013).","journal-title":"Circ. J."},{"key":"83547_CR30","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jcin.2008.11.014","volume":"2","author":"MH Shishehbor","year":"2009","unstructured":"Shishehbor, M. H. et al. Impact of drug-eluting versus bare-metal stents on mortality in patients with anemia. JACC Cardiovasc. Interv. 2, 329\u2013336 (2009).","journal-title":"JACC Cardiovasc. Interv"},{"key":"83547_CR31","doi-asserted-by":"crossref","unstructured":"Yokoyama, M. et al. Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up. Dis Markers. 4857917 (2016). (2016).","DOI":"10.1155\/2016\/4857917"},{"key":"83547_CR32","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.ijcard.2017.11.019","volume":"252","author":"Y Honda","year":"2018","unstructured":"Honda, Y. et al. Gender differences in the impact of anemia on subclinical myocardial damage and cardiovascular mortality in the general population: the Yamagata (Takahata) study. Int. J. Cardiol. 252, 207\u2013212 (2018).","journal-title":"Int. J. Cardiol."},{"key":"83547_CR33","unstructured":"Angelini, A. et al. The link between homocysteine, folic acid and vitamin B12 in chronic kidney disease. G Ital. Nefrol 38 (2021)."},{"key":"83547_CR34","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1159\/000471813","volume":"7","author":"G Cianciolo","year":"2017","unstructured":"Cianciolo, G. et al. Folic acid and homocysteine in chronic kidney Disease and Cardiovascular Disease Progression: which comes first? Cardiorenal Med. 7, 255\u2013266 (2017).","journal-title":"Cardiorenal Med."},{"key":"83547_CR35","first-page":"5","volume":"405","author":"<number>35.<\/number>","year":"1968","unstructured":"Nutritional anaemias. Report of a WHO scientific group. World Health Organ. Tech. Rep. Ser. 405, 5\u201337 (1968).","journal-title":"World Health Organ. Tech. Rep. Ser."},{"key":"83547_CR36","unstructured":"Hibino, M. et al. Blood pressure, hypertension and the risk of aortic dissection incidence and mortality: results from the Japan-Specific Health checkups Study, the UK Biobank Study and a Meta-analysis of Cohort studies. Circulation (2021)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83547-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83547-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83547-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T11:08:39Z","timestamp":1735643319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83547-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["83547"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-83547-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"2 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32005"}}