{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:41:27Z","timestamp":1792597287245,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-83553-7","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T21:27:04Z","timestamp":1735594024000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["NF2 can mediate the expression of CAMK2A in a tissue specific manner"],"prefix":"10.1038","volume":"14","author":[{"given":"Zhaoying","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"issue":"Suppl 5","key":"83553_CR1","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1093\/neuonc\/noz150","volume":"21","author":"T Ostrom Q","year":"2019","unstructured":"Ostrom Q, T. et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012\u20132016 [J]. Neuro Oncol. 21 (Suppl 5), v1\u2013v100 (2019).","journal-title":"Neuro Oncol."},{"issue":"1","key":"83553_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.neuchi.2014.11.013","volume":"64","author":"S Zouaoui","year":"2018","unstructured":"Zouaoui, S. et al. Descriptive epidemiology of 13,038 newly diagnosed and histologically confirmed meningiomas in France: 2006\u20132010 [J]. Neuro-Chirurgie 64 (1), 15\u201321 (2018).","journal-title":"Neuro-Chirurgie"},{"issue":"12","key":"83553_CR3","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S1474-4422(06)70625-1","volume":"5","author":"MJ RIEMENSCHNEIDER","year":"2006","unstructured":"Riemenschneider, M. J. & Perry, A. Histological classification and molecular genetics of meningiomas [J]. Lancet Neurol. 5(12), 1045\u20131054 (2006).","journal-title":"Lancet Neurol."},{"issue":"11","key":"83553_CR4","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1634\/theoncologist.2011-0193","volume":"16","author":"S SARAF","year":"2011","unstructured":"Saraf, S. & Mccarthy B. J, Villano, J. L. Update on meningiomas [J]. oncologist 16(11), 1604\u20131613 (2011).","journal-title":"oncologist"},{"key":"83553_CR5","doi-asserted-by":"publisher","first-page":"101562","DOI":"10.1016\/j.canep.2019.07.001","volume":"62","author":"B HOLLECZEK","year":"2019","unstructured":"Holleczek, B. & Zampella, D. Incidence, mortality and outcome of meningiomas: A population-based study from Germany [J]. Cancer Epidemiol. 62, 101562 (2019).","journal-title":"Cancer Epidemiol."},{"issue":"8","key":"83553_CR6","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1093\/neuonc\/nos129","volume":"14","author":"S GOUTAGNY","year":"2012","unstructured":"Goutagny, S. et al. Long-term follow-up of 287 meningiomas in neurofibromatosis type 2 patients: clinical, radiological, and molecular features [J]. Neuro-oncology 14 (8), 1090\u20131096 (2012).","journal-title":"Neuro-oncology"},{"issue":"3","key":"83553_CR7","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1080\/14737175.2018.1429920","volume":"18","author":"C APRA","year":"2018","unstructured":"Apra, C. & Peyre, M. Current treatment options for meningioma [J]. Expert Rev. Neurother. 18 (3), 241\u2013249 (2018).","journal-title":"Expert Rev. Neurother."},{"issue":"11","key":"83553_CR8","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.3390\/cancers11111633","volume":"11","author":"S LEE","year":"2019","unstructured":"Lee, S. et al. The role of merlin\/NF2 loss in meningioma biology [J]. Cancers (Basel), 11(11) 1633. (2019).","journal-title":"Cancers (Basel)"},{"issue":"6429","key":"83553_CR9","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/363515a0","volume":"363","author":"GA ROULEAU","year":"1993","unstructured":"Rouleau, G. A. et al. Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2 [J]. Nature 363 (6429), 515\u2013521 (1993).","journal-title":"Nature"},{"issue":"8","key":"83553_CR10","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/nm0898-915","volume":"4","author":"Y KIMURA","year":"1998","unstructured":"Kimura, Y. et al. The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas [J]. Nat. Med. 4 (8), 915\u2013922 (1998).","journal-title":"Nat. Med."},{"issue":"4","key":"83553_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nrc.2017.5","volume":"17","author":"G SCHNEIDER","year":"2017","unstructured":"Schneider, G. et al. Tissue-specific tumorigenesis: context matters [J]. Nat. Rev. Cancer. 17 (4), 239\u2013253 (2017).","journal-title":"Nat. Rev. Cancer"},{"issue":"11","key":"83553_CR12","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"KANEHISA M","year":"2019","unstructured":"Kanehisa M. Toward understanding the origin and evolution of cellular organisms [J]. Protein Sci. 28 (11), 1947\u20131951 (2019).","journal-title":"Protein Sci."},{"issue":"W1","key":"83553_CR13","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","volume":"50","author":"M SHERMAN B T, HAO","year":"2022","unstructured":"Sherman B T, Hao, M. et al. David: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update) [J]. Nucleic Acids Res. 50 (W1), W216\u2013w21 (2022).","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"83553_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"RA HUANG DA W, SHERMAN B T, LEMPICKI","year":"2009","unstructured":"Huang Da W., Sherman B. T, Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources [J]. Nat. Protoc. 4 (1), 44\u201357 (2009).","journal-title":"Nat. Protoc."},{"key":"83553_CR15","doi-asserted-by":"publisher","first-page":"957317","DOI":"10.3389\/fgene.2022.957317","volume":"13","author":"T ZHAO","year":"2022","unstructured":"Zhao, T., Wang, Z. & GraphBio A shiny web app to easily perform popular visualization analysis for omics data [J]. Front. Genet. 13, 957317 (2022).","journal-title":"Front. Genet."},{"issue":"1","key":"83553_CR16","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1212\/WNL.49.1.267","volume":"49","author":"GUTMANN D H","year":"1997","unstructured":"Gutmann D. H. et al. Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas [J]. Neurology 49 (1), 267\u2013270 (1997).","journal-title":"Neurology"},{"issue":"13","key":"83553_CR17","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1038\/sj.onc.1202531","volume":"18","author":"LEONE P E","year":"1999","unstructured":"Leone P. E. et al. NF2 gene mutations and allelic status of 1p, 14q and 22q in sporadic meningiomas [J]. Oncogene 18 (13), 2231\u20132239 (1999).","journal-title":"Oncogene"},{"issue":"2","key":"83553_CR18","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/ng0294-180","volume":"6","author":"J RUTTLEDGE M H, SARRAZIN","year":"1994","unstructured":"Ruttledge M. H, Sarrazin, J. Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas [J]. Nat. Genet. 6 (2), 180\u2013184 (1994).","journal-title":"Nat. Genet."},{"issue":"1","key":"83553_CR19","first-page":"vdz055","volume":"2","author":"J DENG","year":"2020","unstructured":"Deng, J. et al. The CREB-binding protein inhibitor ICG-001: a promising therapeutic strategy in sporadic meningioma with NF2 mutations [J]. Neurooncol Adv. 2 (1), vdz055 (2020).","journal-title":"Neurooncol Adv."},{"issue":"3","key":"83553_CR20","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/gcc.20141","volume":"42","author":"J LOMAS","year":"2005","unstructured":"Lomas, J. et al. Genetic and epigenetic alteration of the NF2 gene in sporadic meningiomas [J]. Genes Chromosomes Cancer. 42 (3), 314\u2013319 (2005).","journal-title":"Genes Chromosomes Cancer"},{"issue":"24","key":"83553_CR21","doi-asserted-by":"publisher","first-page":"9275","DOI":"10.1073\/pnas.84.24.9275","volume":"84","author":"JP DUMANSKI","year":"1987","unstructured":"Dumanski, J. P. et al. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma [J]. Proc. Natl. Acad. Sci. U S A. 84 (24), 9275\u20139279 (1987).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"5","key":"83553_CR22","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3171\/jns.1996.84.5.0847","volume":"84","author":"T HARADA","year":"1996","unstructured":"Harada, T. et al. Molecular genetic investigation of the neurofibromatosis type 2 tumor suppressor gene in sporadic meningioma [J]. J. Neurosurg. 84 (5), 847\u2013851 (1996).","journal-title":"J. Neurosurg."},{"issue":"6123","key":"83553_CR23","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1126\/science.1233009","volume":"339","author":"CLARKVE ERSON-OMAY E Z","year":"2013","unstructured":"Erson-Omay E. Z., Clark V. E., Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO [J]. Science 339 (6123), 1077\u20131080 (2013).","journal-title":"Science"},{"issue":"3","key":"83553_CR24","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1200\/JCO.21.02371","volume":"41","author":"BRASTIANOS P K","year":"2023","unstructured":"Brastianos P. K. et al. Alliance A071401: Phase II Trial of focal adhesion kinase inhibition in meningiomas with somatic NF2 mutations [J]. J. Clin. Oncol. 41 (3), 618\u2013628 (2023).","journal-title":"J. Clin. Oncol."},{"issue":"5","key":"83553_CR25","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1093\/neuonc\/noaa226","volume":"23","author":"L YOUNGBLOOD M W, MIYAGISHIMA D F, JI","year":"2021","unstructured":"Youngblood M. W, Miyagishima D. F, Jin, L. et al. Associations of meningioma molecular subgroup and tumor recurrence [J]. Neuro-oncology 23 (5), 783\u2013794 (2021).","journal-title":"Neuro-oncology"},{"issue":"11","key":"83553_CR26","doi-asserted-by":"publisher","first-page":"105275","DOI":"10.1016\/j.isci.2022.105275","volume":"25","author":"Z JIA","year":"2022","unstructured":"Jia, Z. et al. A novel NF2 splicing mutant causes neurofibromatosis type 2 via liquid-liquid phase separation with large tumor suppressor and Hippo pathway [J]. iScience 25 (11), 105275 (2022).","journal-title":"iScience"},{"issue":"5","key":"83553_CR27","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/onc.2015.125","volume":"35","author":"C PETRILLI A M, FERN\u00e1NDEZ-VALLE","year":"2016","unstructured":"Petrilli A. M., Fern\u00e1ndez-Valle, C. Role of Merlin\/NF2 inactivation in tumor biology [J]. Oncogene 35 (5), 537\u2013548 (2016).","journal-title":"Oncogene"},{"issue":"6432","key":"83553_CR28","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1126\/science.aaw3472","volume":"363","author":"K HAIGIS K M, CICHOWSKI","year":"2019","unstructured":"Haigis K. M, Cichowski, K. & Elledge, S. J., Tissue-specificity in cancer: The rule, not the exception [J]. Science 363 (6432), 1150\u20131151 (2019).","journal-title":"Science"},{"issue":"3\u20134","key":"83553_CR29","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s10555-012-9375-7","volume":"31","author":"Y Drabsch","year":"2012","unstructured":"Drabsch, Y. & Ten Dijke, P. TGF-\u03b2 signalling and its role in cancer progression and metastasis [J]. Cancer Metastasis Rev 31(3\u20134), 553\u201368 (2012).","journal-title":"Cancer Metastasis Rev"},{"issue":"2","key":"83553_CR30","first-page":"205","volume":"223","author":"MEULMEESTER E, TEN DIJKE P","year":"2011","unstructured":"Meulmeester E., Ten Dijke P. The dynamic roles of TGF-\u03b2 in cancer [J]. J. Pathol. 223 (2), 205\u2013218 (2011).","journal-title":"J. Pathol."},{"issue":"5","key":"83553_CR31","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1002\/hep.24282","volume":"53","author":"FJ DRVAROV O, CUBERO","year":"2011","unstructured":"Drvarov O., Cubero, F. J. Neurofibromatosis type 2\/Merlin: sharpening the myth of prometheus [J]. Hepatology 53 (5), 1767\u20131770 (2011).","journal-title":"Hepatology"},{"issue":"3","key":"83553_CR32","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s12253-013-9644-y","volume":"19","author":"PE\u0106INA-\u0160LAUS N","year":"2013","unstructured":"Pe\u0107ina-\u0160laus N. Merlin, the NF2 gene product [J]. Pathol. Oncol. Res. 19 (3), 365\u2013373 (2013).","journal-title":"Pathol. Oncol. Res."},{"issue":"11","key":"83553_CR33","doi-asserted-by":"publisher","first-page":"105303","DOI":"10.1016\/j.isci.2022.105303","volume":"25","author":"M RIGTER P M F, WALLAARD I, AGHADAVOU","year":"2022","unstructured":"Rigter P. M. F., Wallaard I., Aghadavoud Jolfaei, M. et al. Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice [J]. iScience 25 (11), 105303 (2022).","journal-title":"iScience"},{"issue":"3","key":"83553_CR34","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/acn3.528","volume":"5","author":"T AKITA","year":"2018","unstructured":"Akita, T. et al. De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders [J]. Ann. Clin. Transl Neurol. 5 (3), 280\u2013296 (2018).","journal-title":"Ann. Clin. Transl Neurol."},{"key":"83553_CR35","first-page":"410","volume-title":"CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation [J]","author":"SQ WANG","year":"2020","unstructured":"Wang, S. Q. et al. CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation [J]11410 (Cell death & disease, 2020). 6."},{"issue":"21","key":"83553_CR36","doi-asserted-by":"publisher","first-page":"5491","DOI":"10.1158\/0008-5472.CAN-21-0747","volume":"81","author":"YU T J","year":"2021","unstructured":"Yu T. J. et al. PDSS1-mediated activation of CAMK2A-STAT3 signaling promotes metastasis in triple-negative breast cancer [J]. Cancer Res. 81 (21), 5491\u20135505 (2021).","journal-title":"Cancer Res."},{"issue":"3","key":"83553_CR37","doi-asserted-by":"publisher","first-page":"7785","DOI":"10.1080\/21655979.2022.2048995","volume":"13","author":"H WANG","year":"2022","unstructured":"Wang, H. et al. MicroRNA-3200-3p targeting CAMK2A modulates the proliferation and metastasis of glioma in vitro [J]. Bioengineered 13 (3), 7785\u20137797 (2022).","journal-title":"Bioengineered"},{"issue":"1","key":"83553_CR38","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF00690417","volume":"13","author":"K COLE","year":"1994","unstructured":"Cole, K. Calcium-mediated signal transduction: biology, biochemistry, and therapy [J]. Cancer Metastasis Rev. 13 (1), 31\u201344 (1994).","journal-title":"Cancer Metastasis Rev."},{"issue":"4","key":"83553_CR39","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.tcb.2022.07.004","volume":"33","author":"S ZHENG","year":"2023","unstructured":"Zheng, S., & Wang, X. Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications [J]. Trends Cell. Biol. 33 (4), 312\u2013323 (2023).","journal-title":"Trends Cell. Biol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83553-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83553-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83553-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T11:05:37Z","timestamp":1735643137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83553-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["83553"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-83553-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"24 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31992"}}