{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:06:30Z","timestamp":1772136390621,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009602"],"award-info":[{"award-number":["2022YFC2009602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009602"],"award-info":[{"award-number":["2022YFC2009602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009602"],"award-info":[{"award-number":["2022YFC2009602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009602"],"award-info":[{"award-number":["2022YFC2009602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009602"],"award-info":[{"award-number":["2022YFC2009602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009602"],"award-info":[{"award-number":["2022YFC2009602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-83662-3","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T11:57:47Z","timestamp":1736251067000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prediction of ischemic stroke in patients with H-type hypertension based on biomarker"],"prefix":"10.1038","volume":"15","author":[{"given":"Ke","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"83662_CR1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","volume":"20","author":"GBDS Collaborators","year":"2021","unstructured":"Collaborators, G. B. D. S. Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: A systematic analysis for the global burden of Disease Study 2019. Lancet Neurol. 20, 795\u2013820. https:\/\/doi.org\/10.1016\/S1474-4422(21)00252-0 (2021).","journal-title":"Lancet Neurol."},{"key":"83662_CR2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","volume":"5","author":"BCV Campbell","year":"2019","unstructured":"Campbell, B. C. V. et al. Ischaemic stroke. Nat. Rev. Dis. Primers 5, 70. https:\/\/doi.org\/10.1038\/s41572-019-0118-8 (2019).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"83662_CR3","doi-asserted-by":"publisher","first-page":"165260","DOI":"10.1016\/j.bbadis.2018.09.012","volume":"1866","author":"D Barthels","year":"2020","unstructured":"Barthels, D. & Das, H. Current advances in ischemic stroke research and therapies. Biochim. Biophys. Acta Mol. Basis Dis. 1866, 165260. https:\/\/doi.org\/10.1016\/j.bbadis.2018.09.012 (2020).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"83662_CR4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.mcna.2018.10.001","volume":"103","author":"FZ Caprio","year":"2019","unstructured":"Caprio, F. Z. & Sorond, F. A. Cerebrovascular disease: Primary and secondary Stroke Prevention. Med. Clin. North. Am. 103, 295\u2013308. https:\/\/doi.org\/10.1016\/j.mcna.2018.10.001 (2019).","journal-title":"Med. Clin. North. Am."},{"key":"83662_CR5","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S0140-6736(05)17742-3","volume":"365","author":"JP Casas","year":"2005","unstructured":"Casas, J. P., Bautista, L. E., Smeeth, L., Sharma, P. & Hingorani, A. D. Homocysteine and stroke: Evidence on a causal link from mendelian randomisation. Lancet 365, 224\u2013232. https:\/\/doi.org\/10.1016\/S0140-6736(05)17742-3 (2005).","journal-title":"Lancet"},{"key":"83662_CR6","doi-asserted-by":"publisher","first-page":"e21953","DOI":"10.1097\/MD.0000000000021953","volume":"99","author":"F Zhou","year":"2020","unstructured":"Zhou, F., Hou, D., Wang, Y. & Yu, D. Evaluation of H-type hypertension prevalence and its influence on the risk of increased carotid intima-media thickness among a high-risk stroke population in Hainan Province, China. Med. (Baltim). 99, e21953. https:\/\/doi.org\/10.1097\/MD.0000000000021953 (2020).","journal-title":"Med. (Baltim)."},{"key":"83662_CR7","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1161\/CIRCRESAHA.112.270520","volume":"111","author":"Z Liu","year":"2012","unstructured":"Liu, Z. et al. Hyperhomocysteinemia exaggerates adventitial inflammation and angiotensin II-induced abdominal aortic aneurysm in mice. Circ. Res. 111, 1261\u20131273. https:\/\/doi.org\/10.1161\/CIRCRESAHA.112.270520 (2012).","journal-title":"Circ. Res."},{"key":"83662_CR8","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1161\/01.str.22.3.312","volume":"22","author":"PA Wolf","year":"1991","unstructured":"Wolf, P. A., D\u2019Agostino, R. B., Belanger, A. J. & Kannel, W. B. Probability of stroke: A risk profile from the Framingham Study. Stroke 22, 312\u2013318. https:\/\/doi.org\/10.1161\/01.str.22.3.312 (1991).","journal-title":"Stroke"},{"key":"83662_CR9","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1161\/01.CIR.0000145172.55640.93","volume":"110","author":"BF Gage","year":"2004","unstructured":"Gage, B. F. et al. Selecting patients with atrial fibrillation for anticoagulation: Stroke risk stratification in patients taking aspirin. Circulation 110, 2287\u20132292. https:\/\/doi.org\/10.1161\/01.CIR.0000145172.55640.93 (2004).","journal-title":"Circulation"},{"key":"83662_CR10","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1161\/STROKEAHA.111.644963","volume":"43","author":"D Tong","year":"2012","unstructured":"Tong, D. et al. Times from symptom onset to hospital arrival in the get with the guidelines\u2013Stroke Program 2002 to 2009: Temporal trends and implications. Stroke 43, 1912\u20131917. https:\/\/doi.org\/10.1161\/STROKEAHA.111.644963 (2012).","journal-title":"Stroke"},{"key":"83662_CR11","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1136\/practneurol-2020-002557","volume":"20","author":"R Hurford","year":"2020","unstructured":"Hurford, R., Sekhar, A., Hughes, T. A. T. & Muir, K. W. Diagnosis and management of acute ischaemic stroke. Pract. Neurol. 20, 304\u2013316. https:\/\/doi.org\/10.1136\/practneurol-2020-002557 (2020).","journal-title":"Pract. Neurol."},{"key":"83662_CR12","doi-asserted-by":"publisher","first-page":"100406","DOI":"10.1016\/j.lanwpc.2022.100406","volume":"21","author":"Q Ye","year":"2022","unstructured":"Ye, Q. et al. Rates of intravenous thrombolysis and endovascular therapy for acute ischaemic stroke in China between 2019 and 2020. Lancet Reg. Health West. Pac. 21, 100406. https:\/\/doi.org\/10.1016\/j.lanwpc.2022.100406 (2022).","journal-title":"Lancet Reg. Health West. Pac."},{"key":"83662_CR13","doi-asserted-by":"publisher","first-page":"105935","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105935","volume":"30","author":"M Kolmos","year":"2021","unstructured":"Kolmos, M., Christoffersen, L. & Kruuse, C. Recurrent ischemic stroke - A systematic review and Meta-analysis. J. Stroke Cerebrovasc. Dis. 30, 105935. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2021.105935 (2021).","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"83662_CR14","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1161\/STR.0b013e3181fcb238","volume":"42","author":"LB Goldstein","year":"2011","unstructured":"Goldstein, L. B. et al. Guidelines for the primary prevention of stroke: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 42, 517\u2013584. https:\/\/doi.org\/10.1161\/STR.0b013e3181fcb238 (2011).","journal-title":"Stroke"},{"key":"83662_CR15","first-page":"228","volume":"10","author":"JY Huang","year":"2013","unstructured":"Huang, J. Y., Cao, Y. F. & JP, G. Modified Framingham Stroke Profile in the prediction of the risk of stroke among Chinese. Chin. J. Cerebrovasc. Dis. 10, 228\u2013232 (2013).","journal-title":"Chin. J. Cerebrovasc. Dis."},{"key":"83662_CR16","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1515\/jtim-2015-0027","volume":"3","author":"J Li","year":"2015","unstructured":"Li, J. et al. H-type hypertension and risk of stroke in Chinese adults: A prospective, nested case-control study. J. Transl. Int. Med. 3, 171\u2013178. https:\/\/doi.org\/10.1515\/jtim-2015-0027 (2015).","journal-title":"J. Transl Int. Med."},{"key":"83662_CR17","doi-asserted-by":"publisher","unstructured":"Goff, D. C. et al. Jr. ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. J. Am. Coll. Cardiol. 63, 2935\u20132959, (2013). https:\/\/doi.org\/10.1016\/j.jacc.2013.11.005 (2014).","DOI":"10.1016\/j.jacc.2013.11.005"},{"key":"83662_CR18","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1001\/jama.2015.2274","volume":"313","author":"Y Huo","year":"2015","unstructured":"Huo, Y. et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: The CSPPT randomized clinical trial. JAMA 313, 1325\u20131335. https:\/\/doi.org\/10.1001\/jama.2015.2274 (2015).","journal-title":"JAMA"},{"key":"83662_CR19","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1751-7176.2011.00538.x","volume":"13","author":"M Houston","year":"2011","unstructured":"Houston, M. The role of magnesium in hypertension and cardiovascular disease. J. Clin. Hypertens. (Greenwich). 13, 843\u2013847. https:\/\/doi.org\/10.1111\/j.1751-7176.2011.00538.x (2011).","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"83662_CR20","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1159\/000339380","volume":"61","author":"EA Kupetsky-Rincon","year":"2012","unstructured":"Kupetsky-Rincon, E. A. & Uitto, J. Magnesium: Novel applications in cardiovascular disease\u2013a review of the literature. Ann. Nutr. Metab. 61, 102\u2013110. https:\/\/doi.org\/10.1159\/000339380 (2012).","journal-title":"Ann. Nutr. Metab."},{"key":"83662_CR21","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1212\/wnl.59.3.314","volume":"59","author":"DM Green","year":"2002","unstructured":"Green, D. M. et al. Serum potassium level and dietary potassium intake as risk factors for stroke. Neurology 59, 314\u2013320. https:\/\/doi.org\/10.1212\/wnl.59.3.314 (2002).","journal-title":"Neurology"},{"key":"83662_CR22","doi-asserted-by":"publisher","first-page":"e051121189015","DOI":"10.2174\/1573403X16999201210200342","volume":"17","author":"A Alloubani","year":"2021","unstructured":"Alloubani, A., Nimer, R. & Samara, R. Relationship between hyperlipidemia, cardiovascular disease and stroke: A systematic review. Curr. Cardiol. Rev. 17, e051121189015. https:\/\/doi.org\/10.2174\/1573403X16999201210200342 (2021).","journal-title":"Curr. Cardiol. Rev."},{"key":"83662_CR23","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1161\/CIRCULATIONAHA.119.043826","volume":"140","author":"JW Jukema","year":"2019","unstructured":"Jukema, J. W. et al. Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES. Circulation 140, 2054\u20132062. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.043826 (2019).","journal-title":"Circulation"},{"key":"83662_CR24","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1161\/STROKEAHA.119.027759","volume":"51","author":"RP Giugliano","year":"2020","unstructured":"Giugliano, R. P. et al. Stroke Prevention with the PCSK9 (Proprotein Convertase Subtilisin-Kexin type 9) inhibitor Evolocumab added to statin in high-risk patients with stable atherosclerosis. Stroke 51, 1546\u20131554. https:\/\/doi.org\/10.1161\/STROKEAHA.119.027759 (2020).","journal-title":"Stroke"},{"key":"83662_CR25","doi-asserted-by":"publisher","first-page":"e445","DOI":"10.1212\/WNL.0000000000007853","volume":"93","author":"C Ma","year":"2019","unstructured":"Ma, C. et al. Low-density lipoprotein cholesterol and risk of intracerebral hemorrhage: A prospective study. Neurology 93, e445\u2013e457. https:\/\/doi.org\/10.1212\/WNL.0000000000007853 (2019).","journal-title":"Neurology"},{"key":"83662_CR26","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ijcard.2003.02.007","volume":"95","author":"R Pujadas Capmany","year":"2004","unstructured":"Pujadas Capmany, R., Arboix, A. & Casanas-Munoz, R. Anguera-Ferrando, N. Specific cardiac disorders in 402 consecutive patients with ischaemic cardioembolic stroke. Int. J. Cardiol. 95, 129\u2013134. https:\/\/doi.org\/10.1016\/j.ijcard.2003.02.007 (2004).","journal-title":"Int. J. Cardiol."},{"key":"83662_CR27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cca.2017.10.012","volume":"475","author":"Y Yao","year":"2017","unstructured":"Yao, Y., Shang, M. S., Dong, J. Z. & Ma, C. S. Homocysteine in non-valvular atrial fibrillation: Role and clinical implications. Clin. Chim. Acta 475, 85\u201390. https:\/\/doi.org\/10.1016\/j.cca.2017.10.012 (2017).","journal-title":"Clin. Chim. Acta"},{"key":"83662_CR28","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1093\/europace\/eux189","volume":"20","author":"Y Yao","year":"2018","unstructured":"Yao, Y. et al. Elevated homocysteine increases the risk of left atrial\/left atrial appendage thrombus in non-valvular atrial fibrillation with low CHA2DS2-VASc score. Europace 20, 1093\u20131098. https:\/\/doi.org\/10.1093\/europace\/eux189 (2018).","journal-title":"Europace"},{"key":"83662_CR29","first-page":"688","volume":"63","author":"W Pieniazek","year":"2006","unstructured":"Pieniazek, W. & Dimitrow, P. P. [Autoregulation of cerebral circulation: Adaptation to hypertension and re-adaptation in response to antihypertensive treatment]. Przegl Lek. 63, 688\u2013690 (2006).","journal-title":"Przegl Lek"},{"key":"83662_CR30","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1177\/0271678X18800589","volume":"38","author":"MJ Cipolla","year":"2018","unstructured":"Cipolla, M. J., Liebeskind, D. S. & Chan, S. L. The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation. J. Cereb. Blood Flow. Metab. 38, 2129\u20132149. https:\/\/doi.org\/10.1177\/0271678X18800589 (2018).","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"83662_CR31","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1161\/HYPERTENSIONAHA.115.06565","volume":"67","author":"S Umesalma","year":"2016","unstructured":"Umesalma, S., Houwen, F. K., Baumbach, G. L. & Chan, S. L. Roles of caveolin-1 in angiotensin II-induced hypertrophy and inward remodeling of cerebral pial arterioles. Hypertension 67, 623\u2013629. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.115.06565 (2016).","journal-title":"Hypertension"},{"key":"83662_CR32","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1248\/bpb.29.2222","volume":"29","author":"J Ikeda","year":"2006","unstructured":"Ikeda, J., Yao, K. & Matsubara, M. Effects of benidipine, a long-lasting dihydropyridine-Ca2\u2009+\u2009channel blocker, on cerebral blood flow autoregulation in spontaneously hypertensive rats. Biol. Pharm. Bull. 29, 2222\u20132225. https:\/\/doi.org\/10.1248\/bpb.29.2222 (2006).","journal-title":"Biol. Pharm. Bull."},{"key":"83662_CR33","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1161\/01.res.60.2.229","volume":"60","author":"SL Harper","year":"1987","unstructured":"Harper, S. L. Antihypertensive drug therapy prevents cerebral microvascular abnormalities in hypertensive rats. Circ. Res. 60, 229\u2013237. https:\/\/doi.org\/10.1161\/01.res.60.2.229 (1987).","journal-title":"Circ. Res."},{"key":"83662_CR34","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1097\/hjh.0b013e328339f1f3","volume":"28","author":"F Dupuis","year":"2010","unstructured":"Dupuis, F. et al. Effects of suboptimal doses of the AT1 receptor blocker, telmisartan, with the angiotensin-converting enzyme inhibitor, ramipril, on cerebral arterioles in spontaneously hypertensive rat. J. Hypertens. 28, 1566\u20131573. https:\/\/doi.org\/10.1097\/hjh.0b013e328339f1f3 (2010).","journal-title":"J. Hypertens."},{"key":"83662_CR35","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1053\/j.ajkd.2008.08.032","volume":"53","author":"T Ninomiya","year":"2009","unstructured":"Ninomiya, T. et al. Proteinuria and stroke: A meta-analysis of cohort studies. Am. J. Kidney Dis. 53, 417\u2013425. https:\/\/doi.org\/10.1053\/j.ajkd.2008.08.032 (2009).","journal-title":"Am. J. Kidney Dis."},{"key":"83662_CR36","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1177\/1747493019895206","volume":"15","author":"DM Kelly","year":"2020","unstructured":"Kelly, D. M. & Rothwell, P. M. Proteinuria as an independent predictor of stroke: Systematic review and meta-analysis. Int. J. Stroke 15, 29\u201338. https:\/\/doi.org\/10.1177\/1747493019895206 (2020).","journal-title":"Int. J. Stroke"},{"key":"83662_CR37","doi-asserted-by":"publisher","unstructured":"Hsieh, C. Y. & Sung, S. F. From kidney protection to stroke prevention: The potential role of Sodium glucose Cotransporter-2 inhibitors. Int. J. Mol. Sci. 24 https:\/\/doi.org\/10.3390\/ijms24010351 (2022).","DOI":"10.3390\/ijms24010351"},{"key":"83662_CR38","doi-asserted-by":"publisher","first-page":"566","DOI":"10.5551\/jat.ED091","volume":"25","author":"M Koga","year":"2018","unstructured":"Koga, M. Cerebrorenal interaction and stroke outcome. J. Atheroscler. Thromb. 25, 566\u2013567. https:\/\/doi.org\/10.5551\/jat.ED091 (2018).","journal-title":"J. Atheroscler Thromb."},{"key":"83662_CR39","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","volume":"135","author":"EJ Benjamin","year":"2017","unstructured":"Benjamin, E. J. et al. Heart Disease and Stroke Statistics-2017 update: A Report from the American Heart Association. Circulation 135, e146\u2013e603. https:\/\/doi.org\/10.1161\/CIR.0000000000000485 (2017).","journal-title":"Circulation"},{"key":"83662_CR40","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/s1474-4422(03)00266-7","volume":"2","author":"VL Feigin","year":"2003","unstructured":"Feigin, V. L., Lawes, C. M., Bennett, D. A. & Anderson, C. S. Stroke epidemiology: A review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol. 2, 43\u201353. https:\/\/doi.org\/10.1016\/s1474-4422(03)00266-7 (2003).","journal-title":"Lancet Neurol."},{"key":"83662_CR41","doi-asserted-by":"publisher","first-page":"587","DOI":"10.2174\/1570161119666210208202621","volume":"19","author":"X Wang","year":"2021","unstructured":"Wang, X. et al. Exosomes and Exosomal microRNAs in Age-associated stroke. Curr. Vasc. Pharmacol. 19, 587\u2013600. https:\/\/doi.org\/10.2174\/1570161119666210208202621 (2021).","journal-title":"Curr. Vasc Pharmacol."},{"key":"83662_CR42","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/j.1468-1331.2004.00910.x","volume":"11","author":"A Arboix","year":"2004","unstructured":"Arboix, A., Roig, H., Rossich, R., Martinez, E. M. & Garcia-Eroles, L. Differences between hypertensive and non-hypertensive ischemic stroke. Eur. J. Neurol. 11, 687\u2013692. https:\/\/doi.org\/10.1111\/j.1468-1331.2004.00910.x (2004).","journal-title":"Eur. J. Neurol."},{"key":"83662_CR43","doi-asserted-by":"publisher","unstructured":"Arboix, A. et al. Clinical predictors of lacunar syndrome not due to lacunar infarction. BMC Neurol. 10 https:\/\/doi.org\/10.1186\/1471-2377-10-31 (2010).","DOI":"10.1186\/1471-2377-10-31"},{"key":"83662_CR44","doi-asserted-by":"publisher","unstructured":"Unger, T. et al. International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension 75, 1334\u20131357,  (2020). https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.120.15026 (2020).","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"83662_CR45","doi-asserted-by":"publisher","first-page":"492","DOI":"10.5551\/jat.61275","volume":"29","author":"Y Tan","year":"2022","unstructured":"Tan, Y. et al. Impact of H-Type hypertension on Intraplaque Neovascularization assessed by contrast-enhanced Ultrasound. J. Atheroscler Thromb. 29, 492\u2013501. https:\/\/doi.org\/10.5551\/jat.61275 (2022).","journal-title":"J. Atheroscler Thromb."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83662-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83662-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83662-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T12:13:34Z","timestamp":1736252014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83662-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["83662"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-83662-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5223664\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"assertion":[{"value":"8 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1221"}}