{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:39:10Z","timestamp":1791844750894,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1136401E"],"award-info":[{"award-number":["TCVGH-1136401E"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1136401E"],"award-info":[{"award-number":["TCVGH-1136401E"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-83694-9","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T21:54:19Z","timestamp":1735595659000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of adverse pregnancy outcomes associated with Helicobacter pylori infection"],"prefix":"10.1038","volume":"14","author":[{"given":"Shao-Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jung","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Han","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chih","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenn-Jhy","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"issue":"7","key":"83694_CR1","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/00006254-198707000-00003","volume":"42","author":"A Jarnfelt-Samsioe","year":"1987","unstructured":"Jarnfelt-Samsioe, A. Nausea and vomiting in pregnancy: A review. Obstet. Gynecol. Surv. 42(7), 422\u2013427 (1987).","journal-title":"Obstet. Gynecol. Surv."},{"issue":"9","key":"83694_CR2","first-page":"CD007575","volume":"2015","author":"A Matthews","year":"2015","unstructured":"Matthews, A., Haas, D. M., O\u2019Math\u00fana, D. P. & Dowswell, T. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst. Rev. 2015(9), CD007575 (2015). Published 2015 Sep 8.","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3 Pt 1","key":"83694_CR3","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.ajog.2005.02.132","volume":"193","author":"JL Bailit","year":"2005","unstructured":"Bailit, J. L. Hyperemesis gravidarium: epidemiologic findings from a large cohort. Am. J. Obstet. Gynecol. 193(3 Pt 1), 811\u2013814 (2005).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"83694_CR4","doi-asserted-by":"crossref","unstructured":"Niebyl JR. Clinical practice. Nausea and vomiting in pregnancy [published correction appears in N Engl J Med. 2010;363(21):2078. N Engl. J. Med. 363(16), 1544\u20131550 (2010).","DOI":"10.1056\/NEJMcp1003896"},{"issue":"2 Pt 1","key":"83694_CR5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/01.AOG.0000195059.82029.74","volume":"107","author":"DB Fell","year":"2006","unstructured":"Fell, D. B., Dodds, L., Joseph, K. S., Allen, V. M. & Butler, B. Risk factors for hyperemesis gravidarum requiring hospital admission during pregnancy. Obstet. Gynecol. 107(2 Pt 1), 277\u2013284 (2006).","journal-title":"Obstet. Gynecol."},{"issue":"8","key":"83694_CR6","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1093\/humrep\/dew128","volume":"31","author":"L Fiaschi","year":"2016","unstructured":"Fiaschi, L., Nelson-Piercy, C. & Tata, L. J. Hospital admission for hyperemesis gravidarum: a nationwide study of occurrence, reoccurrence and risk factors among 8.2 million pregnancies. Hum. Reprod. 31(8), 1675\u20131684 (2016).","journal-title":"Hum. Reprod."},{"issue":"8","key":"83694_CR7","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/aogs.13820","volume":"99","author":"M Nurmi","year":"2020","unstructured":"Nurmi, M., Rautava, P., Gissler, M., Vahlberg, T. & Polo-Kantola, P. Incidence and risk factors of hyperemesis gravidarum: A national register-based study in Finland, 2005\u20132017. Acta Obstet. Gynecol. Scand. 99(8), 1003\u20131013 (2020).","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"11","key":"83694_CR8","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1111\/j.1471-0528.2011.03023.x","volume":"118","author":"MV Veenendaal","year":"2011","unstructured":"Veenendaal, M. V., van Abeelen, A. F., Painter, R. C., van der Post, J. A. & Roseboom, T. J. Consequences of hyperemesis gravidarum for offspring: a systematic review and meta-analysis. BJOG 118(11), 1302\u20131313 (2011).","journal-title":"BJOG"},{"key":"83694_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/1471-2393-13-169","volume":"13","author":"\u00c5V Vikanes","year":"2013","unstructured":"Vikanes, \u00c5. V., St\u00f8er, N. C., Magnus, P. & Grjibovski, A. M. Hyperemesis gravidarum and pregnancy outcomes in the Norwegian mother and child cohort: a cohort study. BMC Pregnancy Childbirth. 13, 169 (2013). Published 2013 Sep 3.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"2","key":"83694_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0301-2115(95)02238-4","volume":"63","author":"A Bashiri","year":"1995","unstructured":"Bashiri, A., Neumann, L., Maymon, E. & Katz, M. Hyperemesis gravidarum: Epidemiologic features, complications and outcome. Eur. J. Obstet. Gynecol. Reprod. Biol. 63(2), 135\u2013138 (1995).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"3\u20134","key":"83694_CR11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000477853","volume":"100","author":"V London","year":"2017","unstructured":"London, V., Grube, S., Sherer, D. M. & Abulafia, O. Hyperemesis Gravidarum: a review of recent literature. Pharmacology 100(3\u20134), 161\u2013171 (2017).","journal-title":"Pharmacology"},{"issue":"5","key":"83694_CR12","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.gastha.2022.06.001","volume":"1","author":"H Brown","year":"2022","unstructured":"Brown, H., Cantrell, S., Tang, H., Epplein, M. & Garman, K. S. Racial differences in Helicobacter pylori Prevalence in the US: A systematic review. Gastro Hep Adv. 1(5), 857\u2013868 (2022).","journal-title":"Gastro Hep Adv."},{"issue":"2","key":"83694_CR13","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","volume":"153","author":"JKY Hooi","year":"2017","unstructured":"Hooi, J. K. Y. et al. Global prevalence of Helicobacter pylori infection: Systematic review and Meta-analysis. Gastroenterology 153(2), 420\u2013429 (2017).","journal-title":"Gastroenterology"},{"key":"83694_CR14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.15296\/ijwhr.2017.06","volume":"5","author":"A Milad","year":"2017","unstructured":"Milad, A. et al. Global prevalence of Helicobacter pylori infection in pregnant women: A systematic review and Meta-analysis study. Int. J. Women\u2019s Health Reprod. 5, 30\u201336 (2017).","journal-title":"Int. J. Women\u2019s Health Reprod."},{"key":"83694_CR15","doi-asserted-by":"crossref","unstructured":"Zhan, Y., Si, M., Li, M. & Jiang, Y. The risk of Helicobacter pylori infection for adverse pregnancy outcomes: a systematic review and meta-analysis. Helicobacter 24(2): (2019). e12562.512.e1-512.e9","DOI":"10.1111\/hel.12562"},{"key":"83694_CR16","unstructured":"The TriNetX publication guidelines. June 5. (2023). https:\/\/trinetx.com\/real-world-resources\/publications\/trinetx-publication-guidelines\/"},{"key":"83694_CR17","doi-asserted-by":"publisher","first-page":"103847","DOI":"10.1016\/j.jbi.2021.103847","volume":"119","author":"L Evans","year":"2021","unstructured":"Evans, L., London, J. W. & Palchuk, M. B. Assessing real-world medication data completeness. J. Biomed. Inf. 119, 103847 (2021).","journal-title":"J. Biomed. Inf."},{"issue":"6","key":"83694_CR18","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1111\/hel.12316","volume":"21","author":"RK Breckan","year":"2016","unstructured":"Breckan, R. K. et al. The All-Age Prevalence of Helicobacter pylori infection and potential transmission routes. A Population-based study. Helicobacter 21(6), 586\u2013595 (2016).","journal-title":"Helicobacter"},{"issue":"1","key":"83694_CR19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/0973-3930.60008","volume":"30","author":"BR Devrajani","year":"2010","unstructured":"Devrajani, B. R., Shah, S. Z., Soomro, A. A. & Devrajani, T. Type 2 diabetes mellitus: A risk factor for Helicobacter pylori infection: a hospital based case-control study. Int. J. Diabetes Dev. Ctries. 30(1), 22\u201326 (2010).","journal-title":"Int. J. Diabetes Dev. Ctries."},{"issue":"2","key":"83694_CR20","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.diabres.2012.11.012","volume":"99","author":"X Zhou","year":"2013","unstructured":"Zhou, X., Zhang, C., Wu, J. & Zhang, G. Association between Helicobacter pylori infection and diabetes mellitus: a meta-analysis of observational studies. Diabetes Res. Clin. Pract. 99(2), 200\u2013208 (2013).","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"4","key":"83694_CR21","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s10096-011-1337-4","volume":"31","author":"GC Koh","year":"2012","unstructured":"Koh, G. C., Peacock, S. J., van der Poll, T. & Wiersinga, W. J. The impact of diabetes on the pathogenesis of sepsis. Eur. J. Clin. Microbiol. Infect. Dis. 31(4), 379\u2013388 (2012).","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"3","key":"83694_CR22","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/BF02853157","volume":"17","author":"CY Wu","year":"2000","unstructured":"Wu, C. Y. et al. Correlation between Helicobacter pylori infection and gastrointestinal symptoms in pregnancy. Adv. Ther. 17(3), 152\u2013158 (2000).","journal-title":"Adv. Ther."},{"key":"83694_CR23","doi-asserted-by":"publisher","first-page":"278905","DOI":"10.1155\/2015\/278905","volume":"2015","author":"L Li","year":"2015","unstructured":"Li, L. et al. Helicobacter pylori infection is associated with an increased risk of Hyperemesis Gravidarum: A meta-analysis. Gastroenterol. Res. Pract. 2015, 278905 (2015).","journal-title":"Gastroenterol. Res. Pract."},{"issue":"4","key":"83694_CR24","first-page":"615","volume":"91","author":"P Frigo","year":"1998","unstructured":"Frigo, P., Lang, C., Reisenberger, K., K\u00f6lbl, H. & Hirschl, A. M. Hyperemesis gravidarum associated with Helicobacter pylori seropositivity. Obstet. Gynecol. 91(4), 615\u2013617 (1998).","journal-title":"Obstet. Gynecol."},{"key":"83694_CR25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jri.2015.02.004","volume":"109","author":"S Cardaropoli","year":"2015","unstructured":"Cardaropoli, S., Giuffrida, D., Piazzese, A. & Todros, T. Helicobacter pylori seropositivity and pregnancy-related diseases: A prospective cohort study. J. Reprod. Immunol. 109, 41\u201347 (2015).","journal-title":"J. Reprod. Immunol."},{"issue":"8","key":"83694_CR26","doi-asserted-by":"publisher","first-page":"686","DOI":"10.21037\/atm-21-1209","volume":"9","author":"J Li","year":"2021","unstructured":"Li, J., Fan, M., Ma, F., Zhang, S. & Li, Q. The effects of Helicobacter pylori infection on pregnancy-related diseases and fetal development in diabetes in pregnancy. Ann. Transl Med. 9(8), 686 (2021).","journal-title":"Ann. Transl Med."},{"key":"83694_CR27","doi-asserted-by":"crossref","unstructured":"Grooten, I. J. et al. Helicobacter pylori infection: a predictor of vomiting severity in pregnancy and adverse birth outcome. Am. J. Obstet. Gynecol. ;216(5): (2017).","DOI":"10.1016\/j.ajog.2017.01.042"},{"issue":"10","key":"83694_CR28","doi-asserted-by":"publisher","first-page":"e14588","DOI":"10.1111\/ijcp.14588","volume":"75","author":"Y Tang","year":"2021","unstructured":"Tang, Y., Yang, Y. & Lv, Z. Adverse pregnancy outcomes and Helicobacter pylori infection: a meta-analysis. Int. J. Clin. Pract. 75(10), e14588 (2021).","journal-title":"Int. J. Clin. Pract."},{"issue":"11","key":"83694_CR29","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrgastro.2010.154","volume":"7","author":"Y Yamaoka","year":"2010","unstructured":"Yamaoka, Y. Mechanisms of disease: Helicobacter pylori virulence factors. Nat. Rev. Gastroenterol. Hepatol. 7(11), 629\u2013641 (2010).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"42","key":"83694_CR30","doi-asserted-by":"publisher","first-page":"6865","DOI":"10.3748\/wjg.v12.i42.6865","volume":"12","author":"M Aslan","year":"2006","unstructured":"Aslan, M. et al. Insulin resistance in H pylori infection and its association with oxidative stress. World J. Gastroenterol. 12(42), 6865\u20136868 (2006).","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"83694_CR31","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/j.1523-5378.2012.00966.x","volume":"17","author":"F Franceschi","year":"2012","unstructured":"Franceschi, F. et al. Antibodies anti-CagA cross-react with trophoblast cells: a risk factor for pre-eclampsia? Helicobacter 17(6), 426\u2013434 (2012).","journal-title":"Helicobacter"},{"issue":"3","key":"83694_CR32","doi-asserted-by":"publisher","first-page":"654","DOI":"10.3748\/wjg.v20.i3.654","volume":"20","author":"S Cardaropoli","year":"2014","unstructured":"Cardaropoli, S., Rolfo, A. & Todros, T. Helicobacter pylori and pregnancy-related disorders. World J. Gastroenterol. 20(3), 654\u2013664 (2014).","journal-title":"World J. Gastroenterol."},{"key":"83694_CR33","doi-asserted-by":"publisher","unstructured":"den Hollander, W. J. et al. Helicobacter pylori colonization and pregnancies complicated by preeclampsia, spontaneous prematurity, and small for gestational age birth. Helicobacter 22(2). https:\/\/doi.org\/10.1111\/hel.12364 (2017).","DOI":"10.1111\/hel.12364"},{"key":"83694_CR34","doi-asserted-by":"publisher","first-page":"108044","DOI":"10.1016\/j.diabres.2020.108044","volume":"162","author":"Y Li","year":"2020","unstructured":"Li, Y. et al. Maternal age and the risk of gestational diabetes mellitus: A systematic review and meta-analysis of over 120 million participants. Diabetes Res. Clin. Pract. 162, 108044 (2020).","journal-title":"Diabetes Res. Clin. Pract."},{"key":"83694_CR35","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1471-2393-12-47","volume":"12","author":"R Lamminp\u00e4\u00e4","year":"2012","unstructured":"Lamminp\u00e4\u00e4, R., Vehvil\u00e4inen-Julkunen, K., Gissler, M. & Heinonen, S. Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997\u20132008. BMC Pregnancy Childbirth. 12, 47 (2012). Published 2012 Jun 11.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"8","key":"83694_CR36","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1111\/j.1471-0528.2008.01763.x","volume":"115","author":"DA Savitz","year":"2008","unstructured":"Savitz, D. A., Janevic, T. M., Engel, S. M., Kaufman, J. S. & Herring, A. H. Ethnicity and gestational diabetes in New York City, 1995\u20132003. BJOG 115(8), 969\u2013978 (2008).","journal-title":"BJOG"},{"key":"83694_CR37","doi-asserted-by":"crossref","unstructured":"Baradaran, A. et al. The association between Helicobacter pylori and obesity: A systematic review and meta-analysis of case-control studies. Clin Diabetes Endocrinol. ;7(1):15. Published 2021 Jul 10. (2021).","DOI":"10.1186\/s40842-021-00131-w"},{"issue":"1","key":"83694_CR38","doi-asserted-by":"publisher","first-page":"e13032","DOI":"10.1111\/hel.13032","volume":"29","author":"Y Feng","year":"2024","unstructured":"Feng, Y. et al. The association between Helicobacter pylori and gastrointestinal disorders during pregnancy: A Multicenter retrospective study. Helicobacter 29(1), e13032 (2024).","journal-title":"Helicobacter"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83694-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83694-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83694-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T11:09:36Z","timestamp":1735643376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83694-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["83694"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-83694-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"11 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32023"}}