{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:54:30Z","timestamp":1771476870205,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H03029"],"award-info":[{"award-number":["21H03029"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-83934-y","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T23:36:33Z","timestamp":1735601793000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hydrogen gas inhalation therapy may not work sufficiently to mitigate oxidative stress induced with REBOA"],"prefix":"10.1038","volume":"14","author":[{"given":"Yosuke","family":"Matsumura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimitsu","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"83934_CR1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/01.ta.0000251558.38388.47","volume":"62","author":"HC Tien","year":"2007","unstructured":"Tien, H. C., Spencer, F., Tremblay, L. N., Rizoli, S. B. & Brenneman, F. D. Preventable deaths from hemorrhage at a level I Canadian trauma center. J. Trauma 62, 142\u2013146. https:\/\/doi.org\/10.1097\/01.ta.0000251558.38388.47 (2007).","journal-title":"J. Trauma"},{"key":"83934_CR2","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1097\/TA.0b013e31823fe90c","volume":"71","author":"A Stannard","year":"2011","unstructured":"Stannard, A., Eliason, J. L. & Rasmussen, T. E. Resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct for hemorrhagic shock. J. Trauma 71, 1869\u20131872. https:\/\/doi.org\/10.1097\/TA.0b013e31823fe90c (2011).","journal-title":"J. Trauma"},{"key":"83934_CR3","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/TA.0000000000001711","volume":"84","author":"AJ Davidson","year":"2018","unstructured":"Davidson, A. J. et al. The pitfalls of resuscitative endovascular balloon occlusion of the aorta: Risk factors and mitigation strategies. J. Trauma Acute Care Surg. 84, 192\u2013202. https:\/\/doi.org\/10.1097\/TA.0000000000001711 (2018).","journal-title":"J. Trauma Acute Care Surg."},{"key":"83934_CR4","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/TA.0000000000000310","volume":"77","author":"M Brenner","year":"2014","unstructured":"Brenner, M. et al. Basic endovascular skills for trauma course: Bridging the gap between endovascular techniques and the acute care surgeon. J. Trauma Acute Care Surg. 77, 286\u2013291. https:\/\/doi.org\/10.1097\/TA.0000000000000310 (2014).","journal-title":"J. Trauma Acute Care Surg."},{"key":"83934_CR5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5005\/jp-journals-10030-1298","volume":"9","author":"W Teeter","year":"2020","unstructured":"Teeter, W. et al. Monitoring organs susceptible to Ischemia\/Reperfusion Injury after prolonged resuscitative endovascular balloon occlusion of the Aorta in a hemorrhagic shock swine model. Panamerican J. Trauma Crit. Care Emerg. Surg. 9, 169\u2013180 (2020).","journal-title":"Panamerican J. Trauma Crit. Care Emerg. Surg."},{"key":"83934_CR6","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1097\/TA.0000000000000940","volume":"80","author":"RM Russo","year":"2016","unstructured":"Russo, R. M. et al. Extending the golden hour: Partial resuscitative endovascular balloon occlusion of the aorta in a highly lethal swine liver injury model. J. Trauma Acute Care Surg. 80, 372\u2013378. https:\/\/doi.org\/10.1097\/TA.0000000000000940 (2016). discussion 378\u2013380.","journal-title":"J. Trauma Acute Care Surg."},{"key":"83934_CR7","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jamcollsurg.2016.04.037","volume":"223","author":"RM Russo","year":"2016","unstructured":"Russo, R. M. et al. Partial resuscitative endovascular balloon occlusion of the Aorta in Swine Model of hemorrhagic shock. J. Am. Coll. Surg. 223, 359\u2013368. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2016.04.037 (2016).","journal-title":"J. Am. Coll. Surg."},{"key":"83934_CR8","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/TA.0000000000002008","volume":"85","author":"TK Williams","year":"2018","unstructured":"Williams, T. K. et al. Endovascular variable aortic control (EVAC) versus resuscitative endovascular balloon occlusion of the aorta (REBOA) in a swine model of hemorrhage and ischemia reperfusion injury. J. Trauma Acute Care Surg. 85, 519\u2013526. https:\/\/doi.org\/10.1097\/TA.0000000000002008 (2018).","journal-title":"J. Trauma Acute Care Surg."},{"key":"83934_CR9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1097\/TA.0000000000002718","volume":"89","author":"DM Forte","year":"2020","unstructured":"Forte, D. M. et al. Validation of a novel partial resuscitative endovascular balloon occlusion of the aorta device in a swine hemorrhagic shock model: fine tuning flow to optimize bleeding control and reperfusion injury. J. Trauma Acute Care Surg. 89, 58\u201367. https:\/\/doi.org\/10.1097\/TA.0000000000002718 (2020).","journal-title":"J. Trauma Acute Care Surg."},{"key":"83934_CR10","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1161\/CIRCULATIONAHA.114.011848","volume":"130","author":"K Hayashida","year":"2014","unstructured":"Hayashida, K. et al. Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management. Circulation 130, 2173\u20132180. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.011848 (2014).","journal-title":"Circulation"},{"key":"83934_CR11","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1097\/shk.0000000000001092","volume":"50","author":"G Chen","year":"2018","unstructured":"Chen, G. et al. Hydrogen inhalation is Superior to mild hypothermia for improving neurological outcome and survival in a Cardiac arrest model of spontaneously hypertensive rat. Shock 50, 689\u2013695. https:\/\/doi.org\/10.1097\/shk.0000000000001092 (2018).","journal-title":"Shock"},{"key":"83934_CR12","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1253\/circj.CJ-17-0105","volume":"81","author":"Y Katsumata","year":"2017","unstructured":"Katsumata, Y. et al. The effects of Hydrogen Gas Inhalation on adverse left ventricular remodeling after percutaneous coronary intervention for ST-Elevated myocardial infarction- first pilot study in humans. Circ. J. 81, 940\u2013947. https:\/\/doi.org\/10.1253\/circj.CJ-17-0105 (2017).","journal-title":"Circ. J."},{"key":"83934_CR13","doi-asserted-by":"publisher","first-page":"8997","DOI":"10.1111\/jcmm.16863","volume":"25","author":"C Nie","year":"2021","unstructured":"Nie, C. et al. Hydrogen gas inhalation ameliorates cardiac remodelling and fibrosis by regulating NLRP3 inflammasome in myocardial infarction rats. J. Cell. Mol. Med. 25, 8997\u20139010. https:\/\/doi.org\/10.1111\/jcmm.16863 (2021).","journal-title":"J. Cell. Mol. Med."},{"key":"83934_CR14","doi-asserted-by":"publisher","DOI":"10.1159\/000369068","author":"K Homma","year":"2015","unstructured":"Homma, K. et al. Inhalation of Hydrogen Gas is Beneficial for preventing contrast-Induced Acute kidney Injury in rats. Nephron Exp. Nephrol. https:\/\/doi.org\/10.1159\/000369068 (2015).","journal-title":"Nephron Exp. Nephrol."},{"key":"83934_CR15","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/SHK.0000000000001459","volume":"54","author":"T Tamura","year":"2020","unstructured":"Tamura, T. et al. Hydrogen Gas Inhalation attenuates endothelial glycocalyx damage and stabilizes Hemodynamics in a rat hemorrhagic shock model. Shock 54, 377\u2013385. https:\/\/doi.org\/10.1097\/SHK.0000000000001459 (2020).","journal-title":"Shock"},{"key":"83934_CR16","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.06.012","volume":"26","author":"H Ono","year":"2017","unstructured":"Ono, H. et al. Hydrogen gas inhalation treatment in acute cerebral infarction: a randomized controlled clinical study on safety and neuroprotection. J. Stroke Cerebrovasc. Dis. 26, 2587\u20132594. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2017.06.012 (2017).","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"83934_CR17","doi-asserted-by":"publisher","first-page":"101907","DOI":"10.1016\/j.eclinm.2023.101907","volume":"58","author":"T Tamura","year":"2023","unstructured":"Tamura, T., Suzuki, M., Homma, K. & Sano, M. Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial. EClinicalMedicine 58, 101907. https:\/\/doi.org\/10.1016\/j.eclinm.2023.101907 (2023).","journal-title":"EClinicalMedicine"},{"key":"83934_CR18","doi-asserted-by":"publisher","first-page":"18745","DOI":"10.1038\/s41598-022-23524-y","volume":"12","author":"Y Matsumura","year":"2022","unstructured":"Matsumura, Y., Higashi, A., Izawa, Y. & Hishikawa, S. Organ perfusion during partial REBOA in haemorrhagic shock: dynamic 4D-CT analyses in swine. Sci. Rep. 12, 18745. https:\/\/doi.org\/10.1038\/s41598-022-23524-y (2022).","journal-title":"Sci. Rep."},{"key":"83934_CR19","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00068-019-01257-4","volume":"47","author":"Y Matsumura","year":"2021","unstructured":"Matsumura, Y. et al. Distal pressure monitoring and titration with percent balloon volume: feasible management of partial resuscitative endovascular balloon occlusion of the aorta (P-REBOA). Eur. J. Trauma Emerg. Surgery: Off. Publ. Eur. Trauma Soc. 47, 1023\u20131029. https:\/\/doi.org\/10.1007\/s00068-019-01257-4 (2021).","journal-title":"Eur. J. Trauma Emerg. Surgery: Off. Publ. Eur. Trauma Soc."},{"key":"83934_CR20","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jss.2007.01.031","volume":"143","author":"DA Frankel","year":"2007","unstructured":"Frankel, D. A. et al. Physiologic response to hemorrhagic shock depends on rate and means of hemorrhage. J. Surg. Res. 143, 276\u2013280. https:\/\/doi.org\/10.1016\/j.jss.2007.01.031 (2007).","journal-title":"J. Surg. Res."},{"key":"83934_CR21","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1590\/s0102-86502011000400007","volume":"26","author":"OM Gomes","year":"2011","unstructured":"Gomes, O. M. et al. Ischemia-reperfusion histopathology alterations of the rabbit intestinal wall with and without ischemic preconditioning. Acta Cir. Bras. 26, 285\u2013288. https:\/\/doi.org\/10.1590\/s0102-86502011000400007 (2011).","journal-title":"Acta Cir. Bras."},{"key":"83934_CR22","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/TA.0000000000002307","volume":"87","author":"J Kuckelman","year":"2019","unstructured":"Kuckelman, J. et al. Efficacy of intermittent versus standard resuscitative endovascular balloon occlusion of the aorta in a lethal solid organ injury model. J. Trauma Acute Care Surg. 87, 9\u201317. https:\/\/doi.org\/10.1097\/TA.0000000000002307 (2019).","journal-title":"J. Trauma Acute Care Surg."},{"key":"83934_CR23","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1097\/TA.0000000000002439","volume":"87","author":"DS Kauvar","year":"2019","unstructured":"Kauvar, D. S. et al. Effect of partial and complete aortic balloon occlusion on survival and shock in a swine model of uncontrolled splenic hemorrhage with delayed resuscitation. J. Trauma Acute Care Surg. 87, 1026\u20131034. https:\/\/doi.org\/10.1097\/TA.0000000000002439 (2019).","journal-title":"J. Trauma Acute Care Surg."},{"key":"83934_CR24","doi-asserted-by":"publisher","unstructured":"Sadeghi, M. et al. Total resuscitative endovascular balloon occlusion of the aorta causes inflammatory activation and organ damage within 30 minutes of occlusion in normovolemic pigs. BMC Surg. 20 https:\/\/doi.org\/10.1186\/s12893-020-00700-3 (2020).","DOI":"10.1186\/s12893-020-00700-3"},{"key":"83934_CR25","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1097\/TA.0000000000003482","volume":"92","author":"JJ Franko","year":"2022","unstructured":"Franko, J. J. et al. Adenosine, lidocaine, and magnesium for attenuating ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta in a porcine model. J. Trauma Acute Care Surg. 92, 631\u2013639. https:\/\/doi.org\/10.1097\/TA.0000000000003482 (2022).","journal-title":"J. Trauma Acute Care Surg."},{"key":"83934_CR26","doi-asserted-by":"publisher","DOI":"10.3233\/ch-231768","author":"D Astapenko","year":"2023","unstructured":"Astapenko, D. et al. Protection of the endothelium and endothelial glycocalyx by hydrogen against ischaemia-reperfusion injury in a porcine model of cardiac arrest. Clin. Hemorheol Microcirc. https:\/\/doi.org\/10.3233\/ch-231768 (2023).","journal-title":"Clin. Hemorheol Microcirc"},{"key":"83934_CR27","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.19-101","author":"T Tamura","year":"2020","unstructured":"Tamura, T. et al. Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome. J. Clin. Biochem. Nutr. Advpub. https:\/\/doi.org\/10.3164\/jcbn.19-101 (2020).","journal-title":"J. Clin. Biochem. Nutr. Advpub"},{"key":"83934_CR28","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.4240\/wjgs.v14.i12.1329","volume":"14","author":"R Yamamoto","year":"2022","unstructured":"Yamamoto, R. et al. Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion. World J. Gastrointest. Surg. 14, 1329\u20131339. https:\/\/doi.org\/10.4240\/wjgs.v14.i12.1329 (2022).","journal-title":"World J. Gastrointest. Surg."},{"key":"83934_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.04.012","author":"JJ Morrison","year":"2014","unstructured":"Morrison, J. J. et al. The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock. J. Surg. Res. https:\/\/doi.org\/10.1016\/j.jss.2014.04.012 (2014).","journal-title":"J. Surg. Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83934-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83934-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83934-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:06:15Z","timestamp":1735603575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-83934-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["83934"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-83934-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"1 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science (JSPS), Grant Number 21H03029.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was conducted in an accredited animal research laboratory (Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, Japan). Approval was obtained before conducting the research from the Animal Experiment Committee of the Center for Experimental Medicine, Jichi Medical University (authorization no. 17045-05; October 29, 2020). This study is reported following ARRIVE guidelines ().","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"32128"}}