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This study aimed to investigate the feasibility and efficacy of narrative video game-based cognitive intervention for MCI. A four-week (\u00b1\u20091-week) mobile game intervention was given to 17 MCI participants (mean age (SD)\u2009=\u200972.8(4.75)). At baseline and post-intervention, the participants received neuropsychological tests and a depression scale. Frontal function was assessed using the Corsi block-tapping test, Color Word Stroop Test, Controlled Oral Word Association Test, Digit Symbol Coding, and Trail Making Test-Elderly\u2019s Version; depression was assessed using the Geriatric Depression Scale. User\u2019s compliance and gaming experience were also evaluated. MCI patients showed significant improvements in frontal function, particularly in Digit Symbol Coding (mean\u2009\u00b1\u2009SD, 0.47\u2009\u00b1\u20090.49,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) and phonemic fluency (mean\u2009\u00b1\u2009SD, 0.39\u2009\u00b1\u20090.55,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024). Each frontal subtest\u2019s mean z-score was increased (mean\u2009\u00b1\u2009SD, 0.44\u2009\u00b1\u20090.38,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008). Block span and depression scale remained unchanged. High adherence rates (122.35%) and favorable feedback on the gaming experience indicated that the game intervention\u2019s usability boosted patients\u2019 motivation and engagement. Our findings demonstrate that narrative game-based cognitive intervention was not only beneficial but also enjoyable for elderly MCI.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-84086-9","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T21:51:39Z","timestamp":1735854699000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Narrative mobile video game-based cognitive training to enhance frontal function in patients with mild cognitive impairment"],"prefix":"10.1038","volume":"15","author":[{"given":"Yeseul","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Sung","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hoe","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunkyung","family":"Seong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inseok","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Won","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Wha","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"84086_CR1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1001\/archneur.56.3.303","volume":"56","author":"RC Petersen","year":"1999","unstructured":"Petersen, R. 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The authors declare the following potential competing interests: JSL and JHL have no competing interests. CYS and DK were former employees of Nunaps Inc. during the study period. HC, YHR, EKS, and ISP are current employees of Nunaps Inc. DWK is the founder and chief executive officer of Nunaps Inc. and owns stock.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"195"}}