{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:16:16Z","timestamp":1793222176873,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Medical Science and Technology Research Fund of Guangdong Province","award":["202311694435185"],"award-info":[{"award-number":["202311694435185"]}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2015JC3131"],"award-info":[{"award-number":["2015JC3131"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-84125-5","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T21:52:28Z","timestamp":1735854748000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The correlation between cumulative cigarette consumption and infarction-related coronary spasm in patients with ST-segment elevation acute myocardial infarction across different age groups"],"prefix":"10.1038","volume":"15","author":[{"given":"Zhihui","family":"Kuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingcheng","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"84125_CR1","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","volume":"72","author":"K Thygesen","year":"2018","unstructured":"Thygesen, K. et al. Fourth Universal Definition of Myocardial Infarction (2018). J. Am. Coll. Cardiol. 72, 2231\u20132264. https:\/\/doi.org\/10.1016\/j.jacc.2018.08.1038 (2018).","journal-title":"J. Am. Coll. Cardiol."},{"key":"84125_CR2","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1056\/nejm197812072992303","volume":"299","author":"A Maseri","year":"1978","unstructured":"Maseri, A. et al. Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from the study of preinfarction angina. N. Engl. J. Med. 299, 1271\u20131277. https:\/\/doi.org\/10.1056\/nejm197812072992303 (1978).","journal-title":"N. Engl. J. Med."},{"key":"84125_CR3","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1067\/mhj.2002.123843","volume":"144","author":"CH Wang","year":"2002","unstructured":"Wang, C. H., Kuo, L. T., Hung, M. J. & Cherng, W. J. Coronary vasospasm as a possible cause of elevated cardiac troponin I in patients with acute coronary syndrome and insignificant coronary artery disease. Am. Heart J. 144, 275\u2013281. https:\/\/doi.org\/10.1067\/mhj.2002.123843 (2002).","journal-title":"Am. Heart J."},{"key":"84125_CR4","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s00380-017-1046-8","volume":"33","author":"S Sueda","year":"2018","unstructured":"Sueda, S. & Kohno, H. Impact of pharmacological spasm provocation test in patients with a history of syncope. Heart Vessels. 33, 126\u2013133. https:\/\/doi.org\/10.1007\/s00380-017-1046-8 (2018).","journal-title":"Heart Vessels"},{"key":"84125_CR5","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s12471-018-1134-0","volume":"26","author":"F Arslan","year":"2018","unstructured":"Arslan, F. et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: comments from the Dutch ACS working group. Neth. Heart Journal: Monthly J. Neth. Soc. Cardiol. Neth. Heart Foundation. 26, 417\u2013421. https:\/\/doi.org\/10.1007\/s12471-018-1134-0 (2018).","journal-title":"Neth. Heart Journal: Monthly J. Neth. Soc. Cardiol. Neth. Heart Foundation"},{"key":"84125_CR6","doi-asserted-by":"publisher","first-page":"102583","DOI":"10.1016\/j.cpcardiol.2024.102583","volume":"49","author":"V Sucato","year":"2024","unstructured":"Sucato, V., Comparato, F., Ortello, A. & Galassi, A. R. Myocardical Infarction with non-obstructive coronary arteries (MINOCA): pathogenesis, diagnosis and treatment. Curr. Probl. Cardiol. 49, 102583. https:\/\/doi.org\/10.1016\/j.cpcardiol.2024.102583 (2024).","journal-title":"Curr. Probl. Cardiol."},{"key":"84125_CR7","doi-asserted-by":"publisher","first-page":"e023207","DOI":"10.1161\/jaha.121.023207","volume":"11","author":"N Mileva","year":"2022","unstructured":"Mileva, N. et al. Prevalence of coronary microvascular disease and coronary vasospasm in patients with nonobstructive coronary artery disease: systematic review and Meta-analysis. J. Am. Heart Association. 11, e023207. https:\/\/doi.org\/10.1161\/jaha.121.023207 (2022).","journal-title":"J. Am. Heart Association"},{"key":"84125_CR8","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.amjmed.2013.02.029","volume":"126","author":"L Saaby","year":"2013","unstructured":"Saaby, L. et al. Classification of myocardial infarction: frequency and features of type 2 myocardial infarction. Am. J. Med. 126, 789\u2013797. https:\/\/doi.org\/10.1016\/j.amjmed.2013.02.029 (2013).","journal-title":"Am. J. Med."},{"key":"84125_CR9","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1007\/s00392-022-02110-2","volume":"112","author":"RA Montone","year":"2023","unstructured":"Montone, R. A. et al. Correction: clinical, angiographic and echocardiographic correlates of epicardial and microvascular spasm in patients with myocardial ischaemia and non-obstructive coronary arteries. Clin. Res. Cardiology: Official J. German Cardiac Soc. 112, 570. https:\/\/doi.org\/10.1007\/s00392-022-02110-2 (2023).","journal-title":"Clin. Res. Cardiology: Official J. German Cardiac Soc."},{"key":"84125_CR10","first-page":"510","volume":"116","author":"D Xiang","year":"2003","unstructured":"Xiang, D. & Kleber, F. X. Smoking and hyperlipidemia are important risk factors for coronary artery spasm. Chin. Med. J. 116, 510\u2013513 (2003).","journal-title":"Chin. Med. J."},{"key":"84125_CR11","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.2169\/internalmedicine.53.2705","volume":"53","author":"S Morita","year":"2014","unstructured":"Morita, S. et al. Differences and interactions between risk factors for coronary spasm and atherosclerosis\u2013smoking, aging, inflammation, and blood pressure. Intern. Med. (Tokyo, Japan). 53, 2663\u20132670. https:\/\/doi.org\/10.2169\/internalmedicine.53.2705 (2014).","journal-title":"Intern. Med. (Tokyo, Japan)"},{"key":"84125_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2183\/pjab.95.005","volume":"95","author":"H Yasue","year":"2019","unstructured":"Yasue, H., Mizuno, Y. & Harada, E. Coronary artery spasm - clinical features, pathogenesis and treatment. Proc. Jpn. Acad. B. 95, 53\u201366. https:\/\/doi.org\/10.2183\/pjab.95.005 (2019).","journal-title":"Proc. Jpn. Acad. B"},{"key":"84125_CR13","doi-asserted-by":"publisher","first-page":"59017","DOI":"10.18632\/oncotarget.10007","volume":"7","author":"X Gao","year":"2016","unstructured":"Gao, X., Zhang, Y., Breitling, L. P. & Brenner, H. Tobacco smoking and methylation of genes related to lung cancer development. Oncotarget 7, 59017\u201359028. https:\/\/doi.org\/10.18632\/oncotarget.10007 (2016).","journal-title":"Oncotarget"},{"key":"84125_CR14","doi-asserted-by":"publisher","unstructured":"Teragawa, H., Uchimura, Y., Oshita, C., Hashimoto, Y. & Nomura, S. Factors contributing to coronary microvascular dysfunction in patients with Angina and Non-obstructive Coronary Artery Disease. J. Cardiovasc. Dev. Disease. 11 https:\/\/doi.org\/10.3390\/jcdd11070217 (2024).","DOI":"10.3390\/jcdd11070217"},{"key":"84125_CR15","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/s0735-1097(97)00236-2","volume":"30","author":"K Kugiyama","year":"1997","unstructured":"Kugiyama, K. et al. Nitric oxide-mediated flow-dependent dilation is impaired in coronary arteries in patients with coronary spastic angina. J. Am. Coll. Cardiol. 30, 920\u2013926. https:\/\/doi.org\/10.1016\/s0735-1097(97)00236-2 (1997).","journal-title":"J. Am. Coll. Cardiol."},{"key":"84125_CR16","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1080\/14017431.2022.2085884","volume":"56","author":"M Oda","year":"2022","unstructured":"Oda, M. et al. Increased plasma glutamate in non-smokers with vasospastic angina pectoris is associated with plasma cystine and antioxidant capacity. Scandinavian Cardiovasc. Journal: SCJ. 56, 180\u2013186. https:\/\/doi.org\/10.1080\/14017431.2022.2085884 (2022).","journal-title":"Scandinavian Cardiovasc. Journal: SCJ"},{"key":"84125_CR17","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1038\/s41440-023-01455-z","volume":"46","author":"Y Higashi","year":"2023","unstructured":"Higashi, Y. Smoking cessation and vascular endothelial function. Hypertens. Research: Official J. Japanese Soc. Hypertens. 46, 2670\u20132678. https:\/\/doi.org\/10.1038\/s41440-023-01455-z (2023).","journal-title":"Hypertens. Research: Official J. Japanese Soc. Hypertens."},{"key":"84125_CR18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.mayocp.2019.05.001","volume":"95","author":"R Gulati","year":"2020","unstructured":"Gulati, R. et al. Acute myocardial infarction in Young individuals. Mayo Clin. Proc. 95, 136\u2013156. https:\/\/doi.org\/10.1016\/j.mayocp.2019.05.001 (2020).","journal-title":"Mayo Clin. Proc."},{"key":"84125_CR19","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1253\/circj.69.521","volume":"69","author":"K Tsuchida","year":"2005","unstructured":"Tsuchida, K. et al. Relationship between serum lipoprotein(a) concentrations and coronary vasomotion in coronary spastic angina. Circulation Journal: Official J. Japanese Circulation Soc. 69, 521\u2013525. https:\/\/doi.org\/10.1253\/circj.69.521 (2005).","journal-title":"Circulation Journal: Official J. Japanese Circulation Soc."},{"key":"84125_CR20","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1161\/01.cir.101.10.1102","volume":"101","author":"C Pristipino","year":"2000","unstructured":"Pristipino, C. et al. Major racial differences in coronary constrictor response between Japanese and caucasians with recent myocardial infarction. Circulation 101, 1102\u20131108. https:\/\/doi.org\/10.1161\/01.cir.101.10.1102 (2000).","journal-title":"Circulation"},{"key":"84125_CR21","doi-asserted-by":"publisher","first-page":"456","DOI":"10.4330\/wjc.v13.i9.456","volume":"13","author":"J Jewulski","year":"2021","unstructured":"Jewulski, J., Khanal, S. & Dahal, K. Coronary vasospasm: a narrative review. World J. Cardiol. 13, 456\u2013463. https:\/\/doi.org\/10.4330\/wjc.v13.i9.456 (2021).","journal-title":"World J. Cardiol."},{"key":"84125_CR22","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1556\/650.2019.31555","volume":"160","author":"A J\u00e1nosi","year":"2019","unstructured":"J\u00e1nosi, A. et al. [Myocardial infarction without obstructive coronary artery disease (MINOCA) - prevalence and prognosis]. Orv. Hetil. 160, 1791\u20131797. https:\/\/doi.org\/10.1556\/650.2019.31555 (2019).","journal-title":"Orv. Hetil."},{"key":"84125_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00017.2013","volume":"94","author":"CH Chen","year":"2014","unstructured":"Chen, C. H., Ferreira, J. C., Gross, E. R. & Mochly-Rosen, D. Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. Physiol. Rev. 94, 1\u201334. https:\/\/doi.org\/10.1152\/physrev.00017.2013 (2014).","journal-title":"Physiol. Rev."},{"key":"84125_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ijcard.2021.11.047","volume":"349","author":"Y Saito","year":"2022","unstructured":"Saito, Y., Saito, Y., Kato, K. & Kobayashi, Y. Gender differences in factors associated with vasospastic angina. Int. J. Cardiol. 349, 7\u201311. https:\/\/doi.org\/10.1016\/j.ijcard.2021.11.047 (2022).","journal-title":"Int. J. Cardiol."},{"key":"84125_CR25","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1093\/eurheartj\/ehv351","volume":"38","author":"JF Beltrame","year":"2017","unstructured":"Beltrame, J. F. et al. International standardization of diagnostic criteria for vasospastic angina. Eur. Heart J. 38, 2565\u20132568. https:\/\/doi.org\/10.1093\/eurheartj\/ehv351 (2017).","journal-title":"Eur. Heart J."},{"key":"84125_CR26","doi-asserted-by":"publisher","first-page":"46878","DOI":"10.18632\/oncotarget.9795","volume":"7","author":"X Gao","year":"2016","unstructured":"Gao, X., Zhang, Y., Breitling, L. P. & Brenner, H. Relationship of tobacco smoking and smoking-related DNA methylation with epigenetic age acceleration. Oncotarget 7, 46878\u201346889. https:\/\/doi.org\/10.18632\/oncotarget.9795 (2016).","journal-title":"Oncotarget"},{"key":"84125_CR27","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.jjcc.2012.12.008","volume":"61","author":"S Satoh","year":"2013","unstructured":"Satoh, S. et al. Clinical impact of coronary artery spasm in patients with no significant coronary stenosis who are experiencing acute coronary syndrome. J. Cardiol. 61, 404\u2013409. https:\/\/doi.org\/10.1016\/j.jjcc.2012.12.008 (2013).","journal-title":"J. Cardiol."},{"key":"84125_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.31083\/j.rcm2305175","volume":"23","author":"Z Lin","year":"2022","unstructured":"Lin, Z. et al. Coronary artery spasm: risk factors, pathophysiological mechanisms and Novel Diagnostic approaches. Rev. Cardiovasc. Med. 23, 175. https:\/\/doi.org\/10.31083\/j.rcm2305175 (2022).","journal-title":"Rev. Cardiovasc. Med."},{"key":"84125_CR29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1161\/01.cir.87.1.76","volume":"87","author":"M Sugiishi","year":"1993","unstructured":"Sugiishi, M. & Takatsu, F. Cigarette smoking is a major risk factor for coronary spasm. Circulation 87, 76\u201379. https:\/\/doi.org\/10.1161\/01.cir.87.1.76 (1993).","journal-title":"Circulation"},{"key":"84125_CR30","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.phrs.2009.06.005","volume":"60","author":"P Balakumar","year":"2009","unstructured":"Balakumar, P. & Kaur, J. Is nicotine a key player or spectator in the induction and progression of cardiovascular disorders? Pharmacol. Res. 60, 361\u2013368. https:\/\/doi.org\/10.1016\/j.phrs.2009.06.005 (2009).","journal-title":"Pharmacol. Res."},{"key":"84125_CR31","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/0003-9861(91)90224-7","volume":"288","author":"R Radi","year":"1991","unstructured":"Radi, R., Beckman, J. S., Bush, K. M. & Freeman, B. A. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch. Biochem. Biophys. 288, 481\u2013487. https:\/\/doi.org\/10.1016\/0003-9861(91)90224-7 (1991).","journal-title":"Arch. Biochem. Biophys."},{"key":"84125_CR32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1084\/jem.190.1.135","volume":"190","author":"MH Zou","year":"1999","unstructured":"Zou, M. H. & Bachschmid, M. Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase. J. Exp. Med. 190, 135\u2013139. https:\/\/doi.org\/10.1084\/jem.190.1.135 (1999).","journal-title":"J. Exp. Med."},{"key":"84125_CR33","doi-asserted-by":"publisher","first-page":"96","DOI":"10.2105\/ajph.2012.301091","volume":"104","author":"JS Tolstrup","year":"2014","unstructured":"Tolstrup, J. S. et al. Smoking and risk of coronary heart disease in younger, middle-aged, and older adults. Am. J. Public Health. 104, 96\u2013102. https:\/\/doi.org\/10.2105\/ajph.2012.301091 (2014).","journal-title":"Am. J. Public Health"},{"key":"84125_CR34","first-page":"505","volume":"28","author":"M Imazio","year":"1998","unstructured":"Imazio, M., Bobbio, M., Bergerone, S., Barlera, S. & Maggioni, A. P. Clinical and epidemiological characteristics of juvenile myocardial infarction in Italy: the GISSI experience. G. Ital. Cardiol. 28, 505\u2013512 (1998).","journal-title":"G. Ital. Cardiol."},{"key":"84125_CR35","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/MAJ.0b013e3181b9147f","volume":"338","author":"MY Hung","year":"2009","unstructured":"Hung, M. Y. et al. Interaction between cigarette smoking and high-sensitivity C-reactive protein in the development of coronary vasospasm in patients without hemodynamically significant coronary artery disease. Am. J. Med. Sci. 338, 440\u2013446. https:\/\/doi.org\/10.1097\/MAJ.0b013e3181b9147f (2009).","journal-title":"Am. J. Med. Sci."},{"key":"84125_CR36","doi-asserted-by":"publisher","first-page":"e1014","DOI":"10.1016\/s2468-2667(22)00227-4","volume":"7","author":"KH Chan","year":"2022","unstructured":"Chan, K. H. et al. Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study. Lancet Public. Health. 7, e1014\u2013e1026. https:\/\/doi.org\/10.1016\/s2468-2667(22)00227-4 (2022).","journal-title":"Lancet Public. Health"},{"key":"84125_CR37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.24875\/acm.20000386","volume":"91","author":"CA Dattoli-Garc\u00eda","year":"2021","unstructured":"Dattoli-Garc\u00eda, C. A. et al. [Infarto Agudo De Miocardio: revisi\u00f3n sobre factores de riesgo, etiolog\u00eda, hallazgos angiogr\u00e1ficos y desenlaces en pacientes j\u00f3venes]. Arch. De cardiologia de Mexico. 91, 485\u2013492. https:\/\/doi.org\/10.24875\/acm.20000386 (2021).","journal-title":"Arch. De cardiologia de Mexico"},{"key":"84125_CR38","doi-asserted-by":"publisher","first-page":"e939020","DOI":"10.12659\/msm.939020","volume":"29","author":"AG Matta","year":"2023","unstructured":"Matta, A. G., Carri\u00e9, D. & Epidemiology Pathophysiology, diagnosis, and principles of management of Takotsubo Cardiomyopathy: a review. Med. Sci. Monitor: Int. Med. J. Experimental Clin. Res. 29, e939020. https:\/\/doi.org\/10.12659\/msm.939020 (2023).","journal-title":"Med. Sci. Monitor: Int. Med. J. Experimental Clin. Res."},{"key":"84125_CR39","unstructured":"Gao, X. & Yang, J. Analysis of cardiovascular risk factors in patients with acute myocardial infarction in China. Chinese circulation journal 30, 206\u2013210, doi:CNKI:SUN:ZGGZ.0.2016-01-037 (2015). (2015)."},{"key":"84125_CR40","first-page":"234","volume":"26","author":"YJ Li","year":"2014","unstructured":"Li, Y. J. et al. Diabetes mellitus is not a risk factor for coronary artery spasm as assessed by an intracoronary acetylcholine provocation test: angiographic and clinical characteristics of 986 patients. J. Invasive Cardiol. 26, 234\u2013239 (2014).","journal-title":"J. Invasive Cardiol."},{"key":"84125_CR41","doi-asserted-by":"publisher","first-page":"e77655","DOI":"10.1371\/journal.pone.0077655","volume":"8","author":"MJ Hung","year":"2013","unstructured":"Hung, M. J., Hsu, K. H., Hu, W. S., Chang, N. C. & Hung, M. Y. C-reactive protein for predicting prognosis and its gender-specific associations with diabetes mellitus and hypertension in the development of coronary artery spasm. PloS One. 8, e77655. https:\/\/doi.org\/10.1371\/journal.pone.0077655 (2013).","journal-title":"PloS One"},{"key":"84125_CR42","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1093\/clinchem\/46.7.934","volume":"46","author":"WL Hutchinson","year":"2000","unstructured":"Hutchinson, W. L. et al. Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population. Clin. Chem. 46, 934\u2013938 (2000).","journal-title":"Clin. Chem."},{"key":"84125_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2024.05.024","author":"D Peeters","year":"2024","unstructured":"Peeters, D. et al. Association between Coronary Artery Spasm and atherosclerotic disease. JACC Cardiovasc. Imaging. https:\/\/doi.org\/10.1016\/j.jcmg.2024.05.024 (2024).","journal-title":"JACC Cardiovasc. Imaging"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84125-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84125-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84125-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T16:16:13Z","timestamp":1735920973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84125-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["84125"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-84125-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4933356\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,2]]},"assertion":[{"value":"18 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The approval for this study was obtained from the Ethics Committee of General Hospital of Southern Theater Command (2018-54). Since data were evaluated retrospectively, anonymously, and solely obtained for the study purposes, a requirement of informed consent was waived by General Hospital of Southern Theater Command ethics committee. All study methods were performed in accordance with Helsinki Declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"253"}}