{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:33:37Z","timestamp":1789144417416,"version":"build-2803163510"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"LumenLabs Foundation"},{"DOI":"10.13039\/100020166","name":"Flu Lab","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["1R41AI125006"],"award-info":[{"award-number":["1R41AI125006"]}]},{"name":"NIH","award":["1R41AI125006"],"award-info":[{"award-number":["1R41AI125006"]}]},{"name":"NIH","award":["1R41AI125006"],"award-info":[{"award-number":["1R41AI125006"]}]},{"name":"NIH","award":["1R41AI125006"],"award-info":[{"award-number":["1R41AI125006"]}]},{"name":"NIH","award":["1R41AI125006"],"award-info":[{"award-number":["1R41AI125006"]}]},{"name":"NIH","award":["1R41AI125006"],"award-info":[{"award-number":["1R41AI125006"]}]},{"name":"NIH","award":["1R41AI125006"],"award-info":[{"award-number":["1R41AI125006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-84196-4","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T22:19:40Z","timestamp":1735856380000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Wavelength-dependent DNA damage induced by single wavelengths of UV-C radiation (215 to 255\u00a0nm) in a human cornea model"],"prefix":"10.1038","volume":"15","author":[{"given":"Manuela","family":"Buonanno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raabia","family":"Hashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camryn E.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Shuryak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"issue":"1","key":"84196_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/003335491012500105","volume":"125","author":"NG Reed","year":"2010","unstructured":"Reed, N. G. The history of ultraviolet germicidal irradiation for air disinfection. Public Health Rep. 125(1), 15\u201327 (2010).","journal-title":"Public Health Rep."},{"issue":"3","key":"84196_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000043","volume":"6","author":"AR Escombe","year":"2009","unstructured":"Escombe, A. R. et al. Upper-room ultraviolet light and negative air ionization to prevent tuberculosis transmission. PLoS Med. 6(3), e43 (2009).","journal-title":"PLoS Med."},{"key":"84196_CR3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1164\/rccm.201501-0060OC","volume":"192","author":"M Mphaphlele","year":"2015","unstructured":"Mphaphlele, M. et al. Institutional tuberculosis transmission. controlled trial of upper room ultraviolet air disinfection: a basis for new dosing guidelines. Am. J. Respir. Crit. Care Med. 192, 477\u2013484 (2015).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"84196_CR4","unstructured":"ACGIH, 2022 TLVs and BEIs based on the documentation of the threshold limit values for chemical substances and physical agents & biological exposure indices, A.C.o.G.I. Hygienists, Editor. 2022: Cincinnati, OH."},{"key":"84196_CR5","doi-asserted-by":"publisher","unstructured":"ICNIRP 2004 Guidelines on limits of exposure to ultraviolet radiation of wavelengths between 180 nm and 400 nm (incoherent optical radiation), in Health Phys, I.C.o.N.-I.R. Protection, Editor 171\u201386 https:\/\/doi.org\/10.1097\/00004032-200408000-00006","DOI":"10.1097\/00004032-200408000-00006"},{"issue":"5","key":"84196_CR6","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1111\/php.13602","volume":"98","author":"D Welch","year":"2022","unstructured":"Welch, D. et al. Wavelength-dependent DNA photodamage in a 3-D human skin model over the far-UVC and germicidal UVC wavelength ranges from 215 to 255 nm. Photochem. Photobiol. 98(5), 1167\u20131171 (2022).","journal-title":"Photochem. Photobiol."},{"issue":"7","key":"84196_CR7","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1167\/iovs.18-23944","volume":"59","author":"Y Kaluzhny","year":"2018","unstructured":"Kaluzhny, Y. et al. New human organotypic corneal tissue model for ophthalmic drug delivery studies. Invest. Ophthalmol. Vis. Sci. 59(7), 2880\u20132898 (2018).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"84196_CR8","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0003-2697(02)00460-8","volume":"313","author":"S Kreusch","year":"2003","unstructured":"Kreusch, S. et al. UV measurements in microplates suitable for high-throughput protein determination. Anal. Biochem. 313(2), 208\u2013215 (2003).","journal-title":"Anal. Biochem."},{"issue":"1","key":"84196_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0006-3002(57)90142-7","volume":"24","author":"R Setlow","year":"1957","unstructured":"Setlow, R. & Doyle, B. The action of monochromatic ultraviolet light on proteins. Biochim. Biophys. Acta. 24(1), 27\u201341 (1957).","journal-title":"Biochim. Biophys. Acta."},{"issue":"2954","key":"84196_CR10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1126\/science.114.2954.156","volume":"114","author":"AR Goldfarb","year":"1951","unstructured":"Goldfarb, A. R. & Saidel, L. J. Ultraviolet absorption spectra of proteins. Science 114(2954), 156\u2013157 (1951).","journal-title":"Science"},{"issue":"1","key":"84196_CR11","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1063\/1.1742806","volume":"25","author":"JW Preiss","year":"1956","unstructured":"Preiss, J. W. & Setlow, R. Spectra of some amino acids, peptides, nucleic acids, and protein in the vacuum ultraviolet. J. Chem. Phys. 25(1), 138\u2013141 (1956).","journal-title":"J. Chem. Phys."},{"issue":"3","key":"84196_CR12","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/php.13866","volume":"100","author":"M G\u00f6rlitz","year":"2024","unstructured":"G\u00f6rlitz, M. et al. Assessing the safety of new germicidal far-UVC technologies. Photochem. Photobiol. 100(3), 501\u2013520 (2024).","journal-title":"Photochem. Photobiol."},{"issue":"4","key":"84196_CR13","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1111\/php.13550","volume":"98","author":"L Finlayson","year":"2022","unstructured":"Finlayson, L. et al. Depth penetration of light into skin as a function of wavelength from 200 to 1000 nm. Photochem. Photobiol. 98(4), 974\u2013981 (2022).","journal-title":"Photochem. Photobiol."},{"issue":"4","key":"84196_CR14","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/php.13269","volume":"96","author":"N Yamano","year":"2020","unstructured":"Yamano, N. et al. Long-term effects of 222-nm ultraviolet radiation c sterilizing lamps on mice susceptible to ultraviolet radiation. Photochem. Photobiol. 96(4), 853\u2013862 (2020).","journal-title":"Photochem. Photobiol."},{"issue":"13","key":"84196_CR15","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1016\/j.jprot.2012.04.053","volume":"75","author":"L Zhou","year":"2012","unstructured":"Zhou, L. et al. In-depth analysis of the human tear proteome. J. Proteom. 75(13), 3877\u20133885 (2012).","journal-title":"J. Proteom."},{"key":"84196_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108115","volume":"197","author":"SC Pflugfelder","year":"2020","unstructured":"Pflugfelder, S. C. & Stern, M. E. Biological functions of tear film. Exp. Eye Res. 197, 108115 (2020).","journal-title":"Exp. Eye Res."},{"issue":"3","key":"84196_CR17","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/php.13419","volume":"97","author":"S Kaidzu","year":"2021","unstructured":"Kaidzu, S. et al. Re-Evaluation of rat corneal damage by short-wavelength uv revealed extremely less hazardous property of far-UV-C(dagger). Photochem. Photobiol. 97(3), 505\u2013516 (2021).","journal-title":"Photochem. Photobiol."},{"issue":"12","key":"84196_CR18","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1039\/c7pp00395a","volume":"17","author":"J Cadet","year":"2018","unstructured":"Cadet, J. & Douki, T. Formation of UV-induced DNA damage contributing to skin cancer development. Photochem. Photobiol. Sci. 17(12), 1816\u20131841 (2018).","journal-title":"Photochem. Photobiol. Sci."},{"issue":"1","key":"84196_CR19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0022-2836(66)80105-5","volume":"17","author":"RB Setlow","year":"1966","unstructured":"Setlow, R. B. & Carrier, W. L. Pyrimidine dimers in ultraviolet-irradiated DNA\u2019s. J. Mol. Biol. 17(1), 237\u2013254 (1966).","journal-title":"J. Mol. Biol."},{"issue":"3","key":"84196_CR20","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1751-1097.1991.tb02034.x","volume":"54","author":"T Matsunaga","year":"1991","unstructured":"Matsunaga, T., Hieda, K. & Nikaido, O. Wavelength dependent formation of thymine dimers and (6\u20134)photoproducts in dna by monochromatic ultraviolet light ranging from 150 to 365 nm. Photochem. Photobiol. 54(3), 403\u2013410 (1991).","journal-title":"Photochem. Photobiol."},{"issue":"21","key":"84196_CR21","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","volume":"19","author":"Y Kabeya","year":"2000","unstructured":"Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo j 19(21), 5720\u20135728 (2000).","journal-title":"Embo j"},{"issue":"5","key":"84196_CR22","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMra1310050","volume":"370","author":"A Linkermann","year":"2014","unstructured":"Linkermann, A. & Green, D. R. Necroptosis. N. Engl. J. Med. 370(5), 455\u2013465 (2014).","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"84196_CR23","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1167\/iovs.04-1364","volume":"46","author":"DL Shurman","year":"2005","unstructured":"Shurman, D. L. et al. In vivo and in vitro expression of connexins in the human corneal epithelium. Invest. Ophthalmol. Vis. Sci. 46(6), 1957\u20131965 (2005).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"12","key":"84196_CR24","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0962-8924(98)01372-5","volume":"8","author":"AM Simon","year":"1998","unstructured":"Simon, A. M. & Goodenough, D. A. Diverse functions of vertebrate gap junctions. Trends Cell Biol. 8(12), 477\u2013483 (1998).","journal-title":"Trends Cell Biol."},{"issue":"6","key":"84196_CR25","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1080\/10643389.2022.2084315","volume":"53","author":"ER Blatchley","year":"2022","unstructured":"Blatchley, E. R. et al. Far UV-C radiation: An emerging tool for pandemic control. Crit. Rev. Environ. Sci. Technol. 53(6), 733\u2013753 (2022).","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"84196_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/v14040684","author":"D Welch","year":"2022","unstructured":"Welch, D. et al. inactivation rates for airborne human coronavirus by low doses of 222 nm far-UVC radiation. Viruses https:\/\/doi.org\/10.3390\/v14040684 (2022).","journal-title":"Viruses"},{"issue":"1","key":"84196_CR27","doi-asserted-by":"publisher","first-page":"10285","DOI":"10.1038\/s41598-020-67211-2","volume":"10","author":"M Buonanno","year":"2020","unstructured":"Buonanno, M. et al. Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses. Sci. Rep. 10(1), 10285 (2020).","journal-title":"Sci. Rep."},{"issue":"4","key":"84196_CR28","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1667\/RR0010CC.1","volume":"187","author":"M Buonanno","year":"2017","unstructured":"Buonanno, M. et al. Germicidal efficacy and mammalian skin safety of 222-nm UV light. Radiat. Res. 187(4), 483\u2013491 (2017).","journal-title":"Radiat. Res."},{"issue":"2","key":"84196_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192053","volume":"13","author":"B Ponnaiya","year":"2018","unstructured":"Ponnaiya, B. et al. Far-UVC light prevents MRSA infection of superficial wounds in vivo. PLoS One 13(2), e0192053 (2018).","journal-title":"PLoS One"},{"issue":"1","key":"84196_CR30","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1039\/c1pp05144j","volume":"11","author":"GP Pfeifer","year":"2012","unstructured":"Pfeifer, G. P. & Besaratinia, A. UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer. Photochem. Photobiol. Sci. 11(1), 90\u201397 (2012).","journal-title":"Photochem. Photobiol. Sci."},{"issue":"2","key":"84196_CR31","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1016\/j.jfo.2018.12.001","volume":"42","author":"A Herbaut","year":"2019","unstructured":"Herbaut, A. et al. Tear film analysis and evaluation of optical quality: A review of the literature. J. Fr. Ophtalmol. 42(2), e21\u2013e35 (2019).","journal-title":"J. Fr. Ophtalmol."},{"issue":"5","key":"84196_CR32","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1001\/archopht.1961.01840020697016","volume":"65","author":"C Hanna","year":"1961","unstructured":"Hanna, C., Bicknell, D. S. & O\u2019Brien, J. E. Cell turnover in the adult human eye. Archives Ophthalmol. 65(5), 695\u2013698 (1961).","journal-title":"Archives Ophthalmol."},{"key":"84196_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2022.101981","volume":"77","author":"V Lee","year":"2022","unstructured":"Lee, V. & Rompolas, P. Corneal regeneration: Insights in epithelial stem cell heterogeneity and dynamics. Curr. Opin. Genetics Dev. 77, 101981 (2022).","journal-title":"Curr. Opin. Genetics Dev."},{"issue":"10","key":"84196_CR34","doi-asserted-by":"publisher","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","volume":"273","author":"EP Rogakou","year":"1998","unstructured":"Rogakou, E. P. et al. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273(10), 5858\u20135868 (1998).","journal-title":"J. Biol. Chem."},{"issue":"4","key":"84196_CR35","first-page":"645","volume":"37","author":"NC Joyce","year":"1996","unstructured":"Joyce, N. C. et al. Cell cycle protein expression and proliferative status in human corneal cells. Invest. Ophthalmol. Visual Sci. 37(4), 645\u2013655 (1996).","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"3","key":"84196_CR36","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","volume":"182","author":"T Scholzen","year":"2000","unstructured":"Scholzen, T. & Gerdes, J. The Ki-67 protein: from the known and the unknown. J. Cell Physiol. 182(3), 311\u2013322 (2000).","journal-title":"J. Cell Physiol."},{"issue":"3","key":"84196_CR37","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0092-8674(00)81282-9","volume":"84","author":"NM Kumar","year":"1996","unstructured":"Kumar, N. M. & Gilula, N. B. The gap junction communication channel. Cell 84(3), 381\u2013388 (1996).","journal-title":"Cell"},{"key":"84196_CR38","doi-asserted-by":"publisher","DOI":"10.1111\/php.13960","author":"D Welch","year":"2024","unstructured":"Welch, D. et al. Film dosimetry for occupant exposure monitoring within Far-UVC installations. Photochem. Photobiol. https:\/\/doi.org\/10.1111\/php.13960 (2024).","journal-title":"Photochem. Photobiol."},{"issue":"3","key":"84196_CR39","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/php.13364","volume":"97","author":"D Welch","year":"2021","unstructured":"Welch, D. & Brenner, D. J. Improved ultraviolet radiation film dosimetry using orthochromic OC-1 Film(dagger). Photochem. Photobiol. 97(3), 498\u2013504 (2021).","journal-title":"Photochem. Photobiol."},{"key":"84196_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109101","volume":"220","author":"S Masoudi","year":"2022","unstructured":"Masoudi, S. Biochemistry of human tear film: a review. Exp. Eye Res. 220, 109101 (2022).","journal-title":"Exp. Eye Res."},{"issue":"29","key":"84196_CR41","doi-asserted-by":"publisher","first-page":"7987","DOI":"10.1364\/AO.58.007987","volume":"58","author":"Y Cohen","year":"2019","unstructured":"Cohen, Y. et al. Tear film imager for dynamic mapping of the human tear film. Appl. Opt. 58(29), 7987\u20137995 (2019).","journal-title":"Appl. Opt."},{"issue":"4\u20135","key":"84196_CR42","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1080\/02713680490516099","volume":"29","author":"PE King-Smith","year":"2004","unstructured":"King-Smith, P. E. et al. The thickness of the tear film. Curr. Eye Res. 29(4\u20135), 357\u2013368 (2004).","journal-title":"Curr. Eye Res."},{"issue":"4","key":"84196_CR43","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.survophthal.2022.01.010","volume":"67","author":"RK Khanna","year":"2022","unstructured":"Khanna, R. K. et al. Metabolomics and lipidomics approaches in human tears: A systematic review. Surv. Ophthalmol. 67(4), 1229\u20131243 (2022).","journal-title":"Surv. Ophthalmol."},{"issue":"3","key":"84196_CR44","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","volume":"182","author":"JST Gerdes","year":"2000","unstructured":"Gerdes, J. S. T. & Scholzen, T. The Ki-67 protein: from the known and the unknown. J. Cell Physiol. 182(3), 311\u2013322 (2000).","journal-title":"J. Cell Physiol."},{"key":"84196_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076968","author":"M Buonanno","year":"2013","unstructured":"Buonanno, M. et al. 207-nm UV light - a promising tool for safe low-cost reduction of surgical site infections. I: In vitro studies. PLoS ONE https:\/\/doi.org\/10.1371\/journal.pone.0076968 (2013).","journal-title":"PLoS ONE"},{"issue":"6","key":"84196_CR46","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S1350-9462(00)00006-9","volume":"19","author":"RA Sack","year":"2000","unstructured":"Sack, R. A. et al. Towards a closed eye model of the pre-ocular tear layer. Progr. Retinal Eye Res. 19(6), 649\u2013668 (2000).","journal-title":"Progr. Retinal Eye Res."},{"issue":"1","key":"84196_CR47","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1091\/mbc.01-05-0225","volume":"13","author":"TR Dunkern","year":"2002","unstructured":"Dunkern, T. R. & Kaina, B. Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells. Mol. Biol. Cell 13(1), 348\u2013361 (2002).","journal-title":"Mol. Biol. Cell"},{"issue":"2\u20133","key":"84196_CR48","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.mrrev.2008.09.001","volume":"681","author":"LFZ Batista","year":"2009","unstructured":"Batista, L. F. Z. et al. How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis. Mutat. Res. 681(2\u20133), 197\u2013208 (2009).","journal-title":"Mutat. Res."},{"issue":"1","key":"84196_CR49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1073\/pnas.231611798","volume":"99","author":"CL Limoli","year":"2002","unstructured":"Limoli, C. L. et al. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc. Natl. Acad. Sci. U S A 99(1), 233\u2013238 (2002).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"51","key":"84196_CR50","doi-asserted-by":"publisher","first-page":"47759","DOI":"10.1074\/jbc.C100569200","volume":"276","author":"IM Ward","year":"2001","unstructured":"Ward, I. M. & Chen, J. Histone H2AX Is phosphorylated in an ATR-dependent manner in response to replicational stress*. J. Bio. Chem. 276(51), 47759\u201347762 (2001).","journal-title":"J. Bio. Chem."},{"issue":"Pt 4","key":"84196_CR51","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/eye.1989.65","volume":"3","author":"MA Lemp","year":"1989","unstructured":"Lemp, M. A. & Mathers, W. D. Corneal epithelial cell movement in humans. Eye (Lond) 3(Pt 4), 438\u2013445 (1989).","journal-title":"Eye (Lond)"},{"issue":"3","key":"84196_CR52","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L Galluzzi","year":"2018","unstructured":"Galluzzi, L. et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 25(3), 486\u2013541 (2018).","journal-title":"Cell Death Differ."},{"issue":"4","key":"84196_CR53","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","volume":"73","author":"SL Fink","year":"2005","unstructured":"Fink, S. L. & Cookson, B. T. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect. Immun. 73(4), 1907\u20131916 (2005).","journal-title":"Infect. Immun."},{"key":"84196_CR54","doi-asserted-by":"publisher","first-page":"2695212","DOI":"10.1155\/2022\/2695212","volume":"2022","author":"W Lin","year":"2022","unstructured":"Lin, W. et al. Roles and mechanisms of regulated necrosis in corneal diseases: progress and perspectives. J. Ophthalmol. 2022, 2695212 (2022).","journal-title":"J. Ophthalmol."},{"issue":"1","key":"84196_CR55","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/php.13656","volume":"99","author":"D Welch","year":"2023","unstructured":"Welch, D. et al. No evidence of induced skin cancer or other skin abnormalities after long-term (66 week) chronic exposure to 222-nm far-UVC radiation. Photochem. Photobiol. 99(1), 168\u2013175 (2023).","journal-title":"Photochem. Photobiol."},{"issue":"4","key":"84196_CR56","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/php.13294","volume":"96","author":"J Cadet","year":"2020","unstructured":"Cadet, J. Harmless effects of sterilizing 222-nm far-UV radiation on mouse skin and eye tissues. Photochem. Photobiol. 96(4), 949\u2013950 (2020).","journal-title":"Photochem. Photobiol."},{"issue":"6","key":"84196_CR57","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1080\/10715762.2019.1603378","volume":"53","author":"S Kaidzu","year":"2019","unstructured":"Kaidzu, S. et al. Evaluation of acute corneal damage induced by 222-nm and 254-nm ultraviolet light in sprague-dawley rats. Free Radic. Res. 53(6), 611\u2013617 (2019).","journal-title":"Free Radic. Res."},{"issue":"7","key":"84196_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201259","volume":"13","author":"K Narita","year":"2018","unstructured":"Narita, K. et al. Chronic irradiation with 222-nm UVC light induces neither DNA damage nor epidermal lesions in mouse skin, even at high doses. PLoS One 13(7), e0201259 (2018).","journal-title":"PLoS One"},{"issue":"8","key":"84196_CR59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235948","volume":"15","author":"T Fukui","year":"2020","unstructured":"Fukui, T. et al. Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans. PLoS One 15(8), e0235948 (2020).","journal-title":"PLoS One"},{"issue":"1","key":"84196_CR60","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/01.icu.0000512373.81749.b7","volume":"27","author":"MS Milner","year":"2017","unstructured":"Milner, M. S. et al. Dysfunctional tear syndrome: dry eye disease and associated tear film disorders - new strategies for diagnosis and treatment. Curr. Opin. Ophthalmol. 27(1), 3\u201347 (2017).","journal-title":"Curr. Opin. Ophthalmol."},{"key":"84196_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2022.101105","volume":"91","author":"M Wu","year":"2022","unstructured":"Wu, M. et al. Neuroimmune crosstalk in the cornea: the role of immune cells in corneal nerve maintenance during homeostasis and inflammation. Progr. Retinal Eye Res. 91, 101105 (2022).","journal-title":"Progr. Retinal Eye Res."},{"key":"84196_CR62","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.2147\/OPTH.S262060","volume":"14","author":"N Ebrahimiadib","year":"2020","unstructured":"Ebrahimiadib, N. et al. Ocular neuropathic pain: An overview focusing on ocular surface pains. Clin. Ophthalmol.. 14, 2843\u20132854. https:\/\/doi.org\/10.2147\/OPTH.S262060 (2020).","journal-title":"Clin. Ophthalmol.."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84196-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84196-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84196-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T21:04:18Z","timestamp":1735938258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84196-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["84196"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-84196-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5129114\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,2]]},"assertion":[{"value":"21 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare the following pending patent: Patent Title: \u201cApparatus, method and system for selectively affecting and\/or killing a virus\u201d. Applicant: The Trustees of Columbia University in the City of New York. Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow. Application #: US20180169279A1. Aspect of manuscript covered in patent application: Spectrum filtering elements such as multilayer dielectric filters or chemical filters are used to remove unwanted wavelengths, or those wavelengths that can be outside of the preferable range of wavelengths. URL:\n                      \n                      \u2009=\u200920200085984. The other authors have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"252"}}