{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:57:40Z","timestamp":1785769060780,"version":"3.56.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-84214-5","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T03:42:52Z","timestamp":1735875772000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasma concentration of MMP-17 is elevated in boys with cryptorchidism and correlates with HSP-70"],"prefix":"10.1038","volume":"15","author":[{"given":"Ma\u0142gorzata","family":"Kowalska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Tylicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Martyna","family":"Koper-Lenkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kami\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Dorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Matuszczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"84214_CR1","doi-asserted-by":"crossref","unstructured":"Wagner-Mahler, K. et al. Prospective study on the prevalence and associated risk factors of cryptorchidism in 6246 newborn boys from Nice area, France. Int. J. Androl. 34 (2011).","DOI":"10.1111\/j.1365-2605.2011.01211.x"},{"key":"84214_CR2","doi-asserted-by":"crossref","unstructured":"Berkowitz, G. S. et al. Prevalence and natural history of cryptorchidism. Pediatrics 92 (1993).","DOI":"10.1542\/peds.92.1.44"},{"key":"84214_CR3","doi-asserted-by":"crossref","unstructured":"Abdullah, N. A. et al. Q. Birth prevalence of cryptorchidism and hypospadias in northern England, 1993\u20132000. Arch. Dis. Child. 92 (2007).","DOI":"10.1136\/adc.2006.102913"},{"key":"84214_CR4","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/nrurol.2017.90","volume":"14","author":"JK Gurney","year":"2017","unstructured":"Gurney, J. K. et al. Risk factors for cryptorchidism. Nat. Rev. Urol. 14, 534 (2017).","journal-title":"Nat. Rev. Urol."},{"key":"84214_CR5","doi-asserted-by":"publisher","unstructured":"Batra, N. V., DeMarco, R. T. & Bayne, C. E. A narrative review of the history and evidence-base for the timing of orchidopexy for cryptorchidism. J. Pediatr. Urol. 17. https:\/\/doi.org\/10.1016\/j.jpurol.2021.01.013 (2021).","DOI":"10.1016\/j.jpurol.2021.01.013"},{"key":"84214_CR6","doi-asserted-by":"crossref","unstructured":"Koch, T. et al. & J\u00f8rgensen, N. A history of cryptorchidism is associated with impaired testicular function in early adulthood: a cross-sectional study of 6376 men from the general population. Hum. Reprod. 35 (2020).","DOI":"10.1093\/humrep\/deaa127"},{"key":"84214_CR7","doi-asserted-by":"crossref","unstructured":"Virtanen, H. E. & Toppari, J. Epidemiology and pathogenesis of cryptorchidism. Hum. Reprod. Update 14 (2008).","DOI":"10.1093\/humupd\/dmm027"},{"key":"84214_CR8","doi-asserted-by":"crossref","unstructured":"Huff, D. S. et al. Abnormal germ cell development in cryptorchidism. Horm. Res. 55 (2001).","DOI":"10.1159\/000049957"},{"key":"84214_CR9","doi-asserted-by":"publisher","unstructured":"Malemud, C. J. Matrix metalloproteinases (MMPs) in health and disease: An overview. Front. Biosci. 11. https:\/\/doi.org\/10.2741\/1915 (2006).","DOI":"10.2741\/1915"},{"key":"84214_CR10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3390\/ijms20020354","volume":"20","author":"C Yip","year":"2019","unstructured":"Yip, C., Foidart, P., No\u00ebl, A. & Sounni, N. E. MT4-MMP: The GPI-anchored membrane-type matrix metalloprotease with multiple functions in diseases. Int. J. Mol. Sci. 20, 354 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"84214_CR11","doi-asserted-by":"crossref","unstructured":"Zhao, J. et al. BMAL1 Deficiency contributes to mandibular dysplasia by upregulating MMP3. Stem Cell Rep. 10 (2018).","DOI":"10.1016\/j.stemcr.2017.11.017"},{"key":"84214_CR12","doi-asserted-by":"publisher","first-page":"663978","DOI":"10.3389\/fphys.2021.663978","volume":"12","author":"J Wan","year":"2021","unstructured":"Wan, J. et al. Matrix metalloproteinase 3: A promoting and destabilizing factor in the pathogenesis of disease and cell differentiation. Front. Physiol. 12, 663978 (2021).","journal-title":"Front. Physiol."},{"key":"84214_CR13","doi-asserted-by":"crossref","unstructured":"Harada, A. et al. Essential involvement of interleukin-8 (IL-8) in acute inflammation. in J. Leukoc. Biol. 56 (1994).","DOI":"10.1002\/jlb.56.5.559"},{"key":"84214_CR14","doi-asserted-by":"crossref","unstructured":"Brown, A. S. et al. Elevated maternal Interleukin-8 levels and risk of Schizophrenia in adult offspring. Am. J. Psychiatry 161 (2004).","DOI":"10.1176\/appi.ajp.161.5.889"},{"key":"84214_CR15","doi-asserted-by":"publisher","unstructured":"Goldstein, M. G. & Li, Z. Heat-shock proteins In infection-mediated inflammation-induced tumorigenesis. J. Hematol. Oncol. 2. https:\/\/doi.org\/10.1186\/1756-8722-2-5 (2009).","DOI":"10.1186\/1756-8722-2-5"},{"key":"84214_CR16","doi-asserted-by":"crossref","unstructured":"Shrestha, L. & Young, C. J. Function and chemotypes of human Hsp70 chaperones. Curr. Top. Med. Chem. 16 (2016).","DOI":"10.2174\/1568026616666160413142028"},{"key":"84214_CR17","doi-asserted-by":"publisher","first-page":"e161","DOI":"10.1002\/mco2.161","volume":"3","author":"C Hu","year":"2022","unstructured":"Hu, C. et al. Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities. MedComm 3, e161 (2022).","journal-title":"MedComm"},{"key":"84214_CR18","unstructured":"Rappa, F. et al. L. HSP-Molecular chaperones in cancer biogenesis and tumor therapy: An overview. Anticancer Res. 32 (2012)."},{"key":"84214_CR19","doi-asserted-by":"crossref","unstructured":"Shiraishi, K., Takihara, H. & Matsuyama, H. Testicular temperature and the effects of orchiopexy in infants with cryptorchidism. J. Urol. 206 (2021).","DOI":"10.1097\/JU.0000000000001896"},{"key":"84214_CR20","doi-asserted-by":"publisher","unstructured":"Aitken, R. J., Drevet, J. R., Moazamian, A. & Gharagozloo, P. Male infertility and oxidative stress: A focus on the underlying mechanisms. Antioxidants 11.  https:\/\/doi.org\/10.3390\/antiox11020306 (2022).","DOI":"10.3390\/antiox11020306"},{"key":"84214_CR21","doi-asserted-by":"publisher","first-page":"799294","DOI":"10.3389\/fmolb.2021.799294","volume":"8","author":"A Mannucci","year":"2022","unstructured":"Mannucci, A. et al. The impact of oxidative stress in male infertility. Front. Mol. Biosci. 8, 799294 (2022).","journal-title":"Front. Mol. Biosci."},{"key":"84214_CR22","doi-asserted-by":"crossref","unstructured":"Harwell, B. Biochemistry of oxidative stress. Biochem. Soc. Trans. 35 (2007).","DOI":"10.1042\/BST0351147"},{"key":"84214_CR23","doi-asserted-by":"crossref","unstructured":"Koper-Lenkiewicz, O. M. et al. Serum and cerebrospinal fluid neudesin concentration and Neudesin Quotient as potential circulating biomarkers of a primary brain tumor. BMC Cancer 19 (2019).","DOI":"10.1186\/s12885-019-5525-4"},{"key":"84214_CR24","doi-asserted-by":"crossref","unstructured":"Koper, O. M. et al. Cerebrospinal fluid and serum IL-8, CCL2, and ICAM-1 concentrations in astrocytic brain tumor patients. Ir. J. Med. Sci. 187 (2018).","DOI":"10.1007\/s11845-017-1695-8"},{"key":"84214_CR25","unstructured":"Puente, X. S., Pend\u00e1s, A. M., Llano, E. & Velasco, G. & L\u00f3pez-Ot\u00edn, C. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res. 56 (1996)."},{"key":"84214_CR26","doi-asserted-by":"crossref","unstructured":"Rikimaru, A. et al. Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP\/MMP-17 expression in vivo using \u03b2-galactosidase. Genes Cells 12 (2007).","DOI":"10.1111\/j.1365-2443.2007.01110.x"},{"key":"84214_CR27","doi-asserted-by":"crossref","unstructured":"Davidoff, M. S., Middendorff, R., M\u00fcller, D. & Holstein, A. F. The neuroendocrine leydig cells and their stem cell progenitors, the pericytes. Adv. Anat. Embryol. Cell. Biol. 205 (2009).","DOI":"10.1007\/978-3-642-00513-8"},{"key":"84214_CR28","doi-asserted-by":"crossref","unstructured":"Lobo, M. V. T. et al. Nestin, a neuroectodermal stem cell marker molecule, is expressed in Leydig cells of the human testis and in some specific cell types from human testicular tumours. Cell. Tissue Res. 316 (2004).","DOI":"10.1007\/s00441-003-0848-4"},{"key":"84214_CR29","doi-asserted-by":"crossref","unstructured":"Trabert, B., Zugna, D., Richiardi, L., McGlynn, K. A. & Akre, O. Congenital malformations and testicular germ cell tumors. Int. J. Cancer 133 (2013).","DOI":"10.1002\/ijc.28207"},{"key":"84214_CR30","doi-asserted-by":"crossref","unstructured":"Li, Y. C. et al. X. An oligonucleotide microarray study on gene expression profile in mouse testis of experimental cryptorchidism. Front. Biosci. 11 (2006).","DOI":"10.2741\/1983"},{"key":"84214_CR31","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.theriogenology.2024.01.019","volume":"217","author":"M Cinone","year":"2024","unstructured":"Cinone, M., Albrizio, M., Guaricci, A. C., Lacitignola, L. & Desantis, S. Testicular expression of heat SHOCK proteins 60, 70, and 90 in cryptorchid horses. Theriogenology 217, 83\u201391 (2024).","journal-title":"Theriogenology"},{"key":"84214_CR32","doi-asserted-by":"crossref","unstructured":"Yazama, F., Sato, H. & Sonoda, T. Malfunction of spermatogenesis in experimental ischemic mice. J. Reprod. Dev. 61 (2015).","DOI":"10.1262\/jrd.2015-028"},{"key":"84214_CR33","doi-asserted-by":"crossref","unstructured":"L\u00e9gar\u00e9, C., Thabet, M. & Sullivan, R. Expression of heat shock protein 70 in normal and cryptorchid human excurrent duct. Mol. Hum. Reprod. 10 (2004).","DOI":"10.1093\/molehr\/gah027"},{"key":"84214_CR34","doi-asserted-by":"crossref","unstructured":"Erata, G. \u00d6. et al. The role of heat shock protein 70 (hsp 70) in male infertility: Is it a line of defense against sperm DNA fragmentation? Fertil. Steril. 90 (2008).","DOI":"10.1016\/j.fertnstert.2007.06.021"},{"key":"84214_CR35","doi-asserted-by":"crossref","unstructured":"Koumantakis, E., Matalliotakis, I., Kyriakou, D., Fragouli, Y. & Relakis, K. Increased levels of interleukin-8 in human seminal plasma. Andrologia 30 (1998).","DOI":"10.1111\/j.1439-0272.1998.tb01180.x"},{"key":"84214_CR36","doi-asserted-by":"crossref","unstructured":"Kanaroglou, N. et al. Inappropriate use of ultrasound in management of pediatric cryptorchidism. Pediatrics 136 (2015).","DOI":"10.1542\/peds.2015-0222"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84214-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84214-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84214-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T05:02:14Z","timestamp":1735966934000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84214-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["84214"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-84214-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,2]]},"assertion":[{"value":"31 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"474"}}