{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:58:27Z","timestamp":1787500707975,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Scientific and Technological Research Council of Turker","award":["216S387"],"award-info":[{"award-number":["216S387"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-84674-9","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T01:40:50Z","timestamp":1737337250000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Anti-angiogenic effects of cationic zinc (II) phthalocyanine derivatives through photodynamic therapy"],"prefix":"10.1038","volume":"15","author":[{"given":"Seyma","family":"Isik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukaddes","family":"Ozcesmeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayfer Kalkan","family":"Burat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin","family":"Hamuryudan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge","family":"Serhatli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"84674_CR1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","volume":"8","author":"ZL Liu","year":"2023","unstructured":"Liu, Z. L., Chen, H. H., Zheng, L. L., Sun, L. P. & Shi, L. Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal. Transduct. Target. Ther. 8, 198. https:\/\/doi.org\/10.1038\/s41392-023-01460-1 (2023).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"84674_CR2","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/s43018-024-00780-7","volume":"5","author":"M De Palma","year":"2024","unstructured":"De Palma, M. & Hanahan, D. Milestones in tumor vascularization and its therapeutic targeting. Nat. Cancer 5, 827\u2013843. https:\/\/doi.org\/10.1038\/s43018-024-00780-7 (2024).","journal-title":"Nat. Cancer"},{"key":"84674_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3390\/cancers15030585","volume":"15","author":"W Jiang","year":"2023","unstructured":"Jiang, W., Liang, M., Lei, Q., Li, G. & Wu, S. The current status of photodynamic therapy in cancer treatment. Cancers 15, 585. https:\/\/doi.org\/10.3390\/cancers15030585 (2023).","journal-title":"Cancers"},{"key":"84674_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3390\/ph15020235","volume":"15","author":"MJ Szafraniec","year":"2022","unstructured":"Szafraniec, M. J., Toporkiewicz, M. & Gamian, A. Zinc-substituted pheophorbide a is a safe and efficient antivascular photodynamic agent. Pharmaceuticals 15, 235. https:\/\/doi.org\/10.3390\/ph15020235 (2022).","journal-title":"Pharmaceuticals"},{"key":"84674_CR5","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.3390\/cancers12092369","volume":"12","author":"T Suzuki","year":"2020","unstructured":"Suzuki, T. et al. Vascular shutdown by photodynamic therapy using talaporfin sodium. Cancers 12, 2369. https:\/\/doi.org\/10.3390\/cancers12092369 (2020).","journal-title":"Cancers"},{"key":"84674_CR6","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/ptr.2681","volume":"23","author":"V Stup\u00e1kov\u00e1","year":"2009","unstructured":"Stup\u00e1kov\u00e1, V. et al. Photodynamic effect of hypericin in primary cultures of human umbilical endothelial cells and glioma cell lines. Phytother. Res. 23, 827\u2013832. https:\/\/doi.org\/10.1002\/ptr.2681 (2009).","journal-title":"Phytother. Res."},{"key":"84674_CR7","doi-asserted-by":"publisher","first-page":"102137","DOI":"10.1016\/j.pdpdt.2020.102137","volume":"33","author":"J Xue","year":"2021","unstructured":"Xue, J., Gruber, F., Tschachler, E. & Zhao, Y. Crosstalk between oxidative stress, autophagy and apoptosis in hemoporfin photodynamic therapy treated human umbilical vein endothelial cells. Photodiagn. Photodyn. Ther. 33, 102137. https:\/\/doi.org\/10.1016\/j.pdpdt.2020.102137 (2021).","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"84674_CR8","doi-asserted-by":"publisher","first-page":"2001059","DOI":"10.1002\/smll.202001059","volume":"16","author":"D Chen","year":"2020","unstructured":"Chen, D. et al. A highly-efficient type I photosensitizer with robust vascular\u2010disruption activity for hypoxic\u2010and\u2010metastatic tumor specific photodynamic therapy. Small 16, 2001059. https:\/\/doi.org\/10.1002\/smll.202001059 (2020).","journal-title":"Small"},{"key":"84674_CR9","doi-asserted-by":"publisher","first-page":"13972","DOI":"10.1021\/acs.inorgchem.4c01414","volume":"63","author":"S Hattori","year":"2024","unstructured":"Hattori, S. et al. Photodynamic effect of amphiphilic N\u2227 C\u2227 N-Coordinated platinum (II) complexes in human umbilical vein endothelial cells. Inorg. Chem. 63, 13972\u201313979. https:\/\/doi.org\/10.1021\/acs.inorgchem.4c01414 (2024).","journal-title":"Inorg. Chem."},{"key":"84674_CR10","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1021\/bc700233w","volume":"18","author":"IV Nesterova","year":"2007","unstructured":"Nesterova, I. V. et al. Metallo-phthalocyanine near-IR fluorophores: Oligonucleotide conjugates and their applications in PCR assays. Bioconjug. Chem. 18, 2159\u20132168. https:\/\/doi.org\/10.1021\/bc700233w (2007).","journal-title":"Bioconjug. Chem."},{"key":"84674_CR11","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.2174\/092986707780830970","volume":"14","author":"JP Taquet","year":"2007","unstructured":"Taquet, J. P., Frochot, C., Manneville, V. & Barberi-Heyob, M. Phthalocyanines covalently bound to biomolecules for a targeted photodynamic therapy. Curr. Med. Chem. 14, 1673\u20131687. https:\/\/doi.org\/10.2174\/092986707780830970 (2007).","journal-title":"Curr. Med. Chem."},{"key":"84674_CR12","doi-asserted-by":"publisher","first-page":"2300263","DOI":"10.1002\/adhm.202300263","volume":"12","author":"D Li","year":"2023","unstructured":"Li, D. et al. Innovative design strategies advance biomedical applications of phthalocyanines. Adv. Healthc. Mater. 12, 2300263. https:\/\/doi.org\/10.1002\/adhm.202300263 (2023).","journal-title":"Adv. Healthc. Mater."},{"key":"84674_CR13","doi-asserted-by":"publisher","first-page":"5934","DOI":"10.3390\/molecules28165934","volume":"28","author":"C Ma","year":"2023","unstructured":"Ma, C. et al. Caspase-1 regulates the apoptosis and pyroptosis induced by phthalocyanine zinc-mediated photodynamic therapy in breast cancer MCF-7 cells. Molecules 28, 5934. https:\/\/doi.org\/10.3390\/molecules28165934 (2023).","journal-title":"Molecules"},{"key":"84674_CR14","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.freeradbiomed.2020.01.018","volume":"152","author":"F Valli","year":"2020","unstructured":"Valli, F., Vior, M. C. G., Roguin, L. P. & Marino, J. Crosstalk between oxidative stress-induced apoptotic and autophagic signaling pathways in Zn (II) phthalocyanine photodynamic therapy of melanoma. Free Radic Biol. Med. 152, 743\u2013754. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.01.018 (2020).","journal-title":"Free Radic Biol. Med."},{"key":"84674_CR15","doi-asserted-by":"publisher","first-page":"10136","DOI":"10.1039\/D2DT00704E","volume":"51","author":"B Akko\u00e7","year":"2022","unstructured":"Akko\u00e7, B. et al. Pegylated metal-free and zinc (II) phthalocyanines: synthesis, photophysicochemical properties and in vitro photodynamic activities against head, neck and colon cancer cell lines. Dalton Trans. 51, 10136\u201310147. https:\/\/doi.org\/10.1039\/D2DT00704E (2022).","journal-title":"Dalton Trans."},{"key":"84674_CR16","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3892\/ijmm.2018.3620","volume":"42","author":"J Schmidt","year":"2018","unstructured":"Schmidt, J. et al. Novel zinc\u2013and silicon\u2013phthalocyanines as photosensitizers for photodynamic therapy of cholangiocarcinoma. Int. J. Mol. Med. 42, 534\u2013546. https:\/\/doi.org\/10.3892\/ijmm.2018.3620 (2018).","journal-title":"Int. J. Mol. Med."},{"key":"84674_CR17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.pdpdt.2015.07.001","volume":"13","author":"W Kuzyniak","year":"2016","unstructured":"Kuzyniak, W. et al. Tetra-triethyleneoxysulfonyl substituted zinc phthalocyanine for photodynamic cancer therapy. Photodiagn. Photodyn. Ther. 13, 148\u2013157. https:\/\/doi.org\/10.1016\/j.pdpdt.2015.07.001 (2016).","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"84674_CR18","doi-asserted-by":"publisher","first-page":"6348","DOI":"10.3390\/molecules17066348","volume":"17","author":"F Lv","year":"2012","unstructured":"Lv, F., Cao, B., Cui, Y. & Liu, T. Zinc phthalocyanine labelled polyethylene glycol: Preparation, characterization, interaction with bovine serum albumin and near infrared fluorescence imaging in vivo. Molecules 17, 6348\u20136361. https:\/\/doi.org\/10.3390\/molecules17066348 (2012).","journal-title":"Molecules"},{"key":"84674_CR19","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1016\/j.ejmech.2010.06.002","volume":"45","author":"J Marino","year":"2010","unstructured":"Marino, J., Vior, M. C. G., Dicelio, L. E., Roguin, L. P. & Awruch, J. Photodynamic effects of isosteric water-soluble phthalocyanines on human nasopharynx KB carcinoma cells. Eur. J. Med. Chem. 45, 4129\u20134139. https:\/\/doi.org\/10.1016\/j.ejmech.2010.06.002 (2010).","journal-title":"Eur. J. Med. Chem."},{"key":"84674_CR20","doi-asserted-by":"publisher","unstructured":"Bird, C. & Kirstein, S. Real-time, label-free monitoring of cellular invasion and migration with the xCELLigence system. Nat. Methods 6. https:\/\/doi.org\/10.1038\/nmeth.f.263 (2009).","DOI":"10.1038\/nmeth.f.263"},{"key":"84674_CR21","doi-asserted-by":"publisher","unstructured":"Justus, C. R., Marie, M. A., Sanderlin, E. J. & Yang, L. V. Transwell in vitro cell migration and invasion assays. Cell. Viability Assays 349\u2013359. https:\/\/doi.org\/10.1007\/978-1-0716-3052-5_22 (2023).","DOI":"10.1007\/978-1-0716-3052-5_22"},{"key":"84674_CR22","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nprot.2010.6","volume":"5","author":"I Arnaoutova","year":"2010","unstructured":"Arnaoutova, I. & Kleinman, H. K. In vitro angiogenesis: Endothelial cell tube formation on gelled basement membrane extract. Nat. Protoc. 5, 628\u2013635. https:\/\/doi.org\/10.1038\/nprot.2010.6 (2010).","journal-title":"Nat. Protoc."},{"key":"84674_CR23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/j.1751-1097.1990.tb01721.x","volume":"51","author":"D W\u00f6hrle","year":"1990","unstructured":"W\u00f6hrle, D. et al. Synthesis of positively charged phthalocyanines and their activity in the photodynamic therapy of cancer cells. Photochem. Photobiol 51, 351\u2013356. https:\/\/doi.org\/10.1111\/j.1751-1097.1990.tb01721.x (1990).","journal-title":"Photochem. Photobiol."},{"key":"84674_CR24","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/bs.adioch.2017.03.002","volume":"70","author":"JM D\u0105browski","year":"2017","unstructured":"D\u0105browski, J. M. Reactive oxygen species in photodynamic therapy: Mechanisms of their generation and potentiation. Adv. Inorg. Chem. 70, 343\u2013394. https:\/\/doi.org\/10.1016\/bs.adioch.2017.03.002 (2017).","journal-title":"Inorg. Chem."},{"issue":"10","key":"84674_CR25","doi-asserted-by":"publisher","first-page":"2002927","DOI":"10.1002\/advs.202002927","volume":"8","author":"S Wang","year":"2021","unstructured":"Wang, S. et al. Photodynamic-chemodynamic cascade reactions for efficient drug delivery and enhanced combination therapy. Adv. Sci. 8(10), 2002927. https:\/\/doi.org\/10.1002\/advs.202002927 (2021).","journal-title":"Adv. Sci."},{"issue":"6","key":"84674_CR26","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1111\/php.13136","volume":"95","author":"JD Monroe","year":"2019","unstructured":"Monroe, J. D., Belekov, E., Er, A. O. & Smith, M. E. Anticancer photodynamic therapy properties of sulfur-doped graphene quantum dot and methylene blue preparations in MCF\u20107 breast cancer cell culture. Photochem. Photobiol. 95(6), 1473\u20131481. https:\/\/doi.org\/10.1111\/php.13136 (2019).","journal-title":"Photochem. Photobiol."},{"key":"84674_CR27","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.279.6.L1005","author":"VJ Thannickal","year":"2000","unstructured":"Thannickal, V. J. & Fanburg, B. L. Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell. Mol. Physiol. 279. https:\/\/doi.org\/10.1152\/ajplung.2000.279.6.L1005 (2000).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol. 279"},{"key":"84674_CR28","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0891-5849(00)00302-6","volume":"29","author":"J Chandra","year":"2000","unstructured":"Chandra, J., Samali, A. & Orrenius, S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol. Med. 29, 323\u2013333. https:\/\/doi.org\/10.1016\/S0891-5849(00)00302-6 (2000).","journal-title":"Free Radic Biol. Med."},{"key":"84674_CR29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/ijc.21685","volume":"119","author":"J Alexandre","year":"2006","unstructured":"Alexandre, J. et al. Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int. J. Cancer 119, 41\u201348. https:\/\/doi.org\/10.1002\/ijc.21685 (2006).","journal-title":"Int. J. Cancer"},{"key":"84674_CR30","doi-asserted-by":"publisher","first-page":"731414","DOI":"10.3389\/fonc.2021.731414","volume":"11","author":"Y He","year":"2021","unstructured":"He, Y. et al. Integrated transcriptome analysis reveals the impact of photodynamic therapy on cerebrovascular endothelial cells. Front. Oncol. 11, 731414. https:\/\/doi.org\/10.3389\/fonc.2021.731414 (2021).","journal-title":"Front. Oncol."},{"issue":"2","key":"84674_CR31","doi-asserted-by":"publisher","first-page":"023001","DOI":"10.1088\/1612-2011\/10\/2\/023001","volume":"10","author":"W Wang","year":"2012","unstructured":"Wang, W., Moriyama, L. T. & Bagnato, V. S. Photodynamic therapy induced vascular damage: An overview of experimental PDT. Laser Phys. Lett. 10(2), 023001. https:\/\/doi.org\/10.1088\/1612-2011\/10\/2\/023001 (2012).","journal-title":"Laser Phys. Lett."},{"key":"84674_CR32","doi-asserted-by":"publisher","unstructured":"Pathak, A., Pal, A. K., Roy, S., Nandave, M. & Jain, K. Role of angiogenesis and its biomarkers in development of targeted tumor therapies. Stem Cells Int 9077926. https:\/\/doi.org\/10.1155\/2024\/9077926 (2024).","DOI":"10.1155\/2024\/9077926"},{"key":"84674_CR33","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.3390\/ijms22073765","volume":"22","author":"F Lopes-Coelho","year":"2021","unstructured":"Lopes-Coelho, F., Martins, F., Pereira, S. A. & Serpa, J. Anti-angiogenic therapy: Current challenges and future perspectives.Int. J. Mol. Sci. 22, 3765. https:\/\/doi.org\/10.3390\/ijms22073765 (2021).","journal-title":"J. Mol. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84674-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84674-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84674-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T13:32:31Z","timestamp":1737379951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84674-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["84674"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-84674-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,20]]},"assertion":[{"value":"17 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2498"}}