{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:34:30Z","timestamp":1791221670668,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"2022 Shanxi Province Basic Research Program Free Exploration Class","award":["No. 202203021222278"],"award-info":[{"award-number":["No. 202203021222278"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-84771-9","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T13:59:39Z","timestamp":1736863179000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression"],"prefix":"10.1038","volume":"15","author":[{"given":"Lili","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"84771_CR1","doi-asserted-by":"publisher","first-page":"108624","DOI":"10.1016\/j.pharmthera.2024.108624","volume":"3","author":"Y Bai","year":"2024","unstructured":"Bai, Y. et al. Immunotherapy for depression: recent insights and future targets. Pharmacol. Ther. J. Pharmther. 257, 108624 (2024).","journal-title":"Pharmacol. Ther. J. Pharmther."},{"key":"84771_CR2","unstructured":"World Health Organization. Depression and other common mental disorders: global health estimates. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/254610\/WHO-MSD-MER-2017.2-eng.pdf;jsessionid=  (2017)."},{"issue":"2","key":"84771_CR3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","volume":"9","author":"GBD 2019 Mental Disorders Collaborators","year":"2022","unstructured":"GBD 2019 Mental Disorders Collaborators. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the global burden of Disease Study 2019. Lancet Psychiatry 9 (2), 137\u2013150 (2022).","journal-title":"Lancet Psychiatry"},{"issue":"1","key":"84771_CR4","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/s41380-022-01806-1","volume":"28","author":"GR Fries","year":"2023","unstructured":"Fries, G. R. et al. Molecular pathways of major depressive disorder converge on the synapse. Mol. Psychiatry. 28 (1), 284\u2013297 (2023).","journal-title":"Mol. Psychiatry"},{"key":"84771_CR5","doi-asserted-by":"publisher","first-page":"13070","DOI":"10.3390\/ijms222313070","volume":"22","author":"A Caldiroli","year":"2021","unstructured":"Caldiroli, A., Capuzzi, E., Tagliabue, I. & Cet Augmentative pharmacological strategies in treatment-resistant major depression: a comprehensive review. Int. J. Mol. Sci. 22, 13070 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"84771_CR6","doi-asserted-by":"publisher","first-page":"1061877","DOI":"10.3389\/fnbeh.2022.1061877","volume":"16","author":"M Bo","year":"2022","unstructured":"Bo, M. et al. Systematic review of Kaixinsan in treating depression: efficacy and pharmacological mechanisms. Front. Behav. Neurosci. 16, 1061877 (2022). Dec 6;.","journal-title":"Front. Behav. Neurosci."},{"key":"84771_CR7","doi-asserted-by":"publisher","first-page":"1274121","DOI":"10.3389\/fphar.2023.1274121","volume":"14","author":"L Ye","year":"2023","unstructured":"Ye, L. et al. Si-Ni-San alleviates early life stress-induced depression-like behaviors in adolescence via modulating Rac1 activity and associated spine plasticity in the nucleus accumbens. Front. Pharmacol. 14, 1274121 (2023).","journal-title":"Front. Pharmacol."},{"key":"84771_CR8","doi-asserted-by":"crossref","unstructured":"Jiao, H. et al. Xiaoyaosan ameliorates CUMS-induced depressive-like and anorexia behaviors in mice via necroptosis related cellular senescence in hypothalamus. J. Ethnopharmacol. 318(Pt A), 116938 (2024).","DOI":"10.1016\/j.jep.2023.116938"},{"issue":"2","key":"84771_CR9","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jep.2011.08.079","volume":"141","author":"Y Wang","year":"2012","unstructured":"Wang, Y., Fan, R. & Huang, X. Meta-analysis of the clinical effectiveness of traditional Chinese medicine formula Chaihu-Shugan-San in depression. J. Ethnopharmacol. 141 (2), 571\u2013577 (2012).","journal-title":"J. Ethnopharmacol."},{"key":"84771_CR10","doi-asserted-by":"publisher","unstructured":"Ge, C. et al. Quercetin attenuates brain apoptosis in mice with chronic unpredictable mild stress-induced depression. Behav. Brain Res. 2465, 114934. https:\/\/doi.org\/10.1016\/j.bbr.2024.114934 (2024).","DOI":"10.1016\/j.bbr.2024.114934"},{"issue":"7","key":"84771_CR11","doi-asserted-by":"publisher","first-page":"196","DOI":"10.14715\/cmb\/2023.69.7.32","volume":"69","author":"X Wu","year":"2023","unstructured":"Wu, X. et al. Icariin prevents depression-like behaviors in chronic unpredictable mild stress-induced rats through Bax\/cytoplasm C\/caspase-3 axis to alleviate neuronal apoptosis. Cell Mol. Biol. (Noisy-le-grand) 69 (7), 196\u2013204 (2023).","journal-title":"Cell Mol. Biol. (Noisy-le-grand)"},{"key":"84771_CR12","doi-asserted-by":"publisher","first-page":"114299","DOI":"10.1016\/j.bbr.2023.114299","volume":"Mar 12;441","author":"Z Ma","year":"2023","unstructured":"Ma, Z. et al. Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1\/PARP1 signaling pathway. Behav. Brain Res. 441, 114299 (2023).","journal-title":"Behav. Brain Res."},{"key":"84771_CR13","doi-asserted-by":"publisher","first-page":"102157","DOI":"10.1016\/j.jchemneu.2022.102157","volume":"125","author":"M Yuan","year":"2022","unstructured":"Yuan, M. & Yuan, B. Antidepressant-like effects of Rehmannioside A on rats induced by chronic unpredictable mild stress through inhibition of endoplasmic reticulum stress and apoptosis of hippocampus. J. Chem. Neuroanat. 125, 102157 (2022).","journal-title":"J. Chem. Neuroanat."},{"key":"84771_CR14","doi-asserted-by":"crossref","unstructured":"Gao, J. et al. Probiotics for the treatment of depression and its comorbidities: a systemic review. Front. Cell. Infect. Microbiol. 13, 1167116 (2023).","DOI":"10.3389\/fcimb.2023.1167116"},{"key":"84771_CR15","doi-asserted-by":"publisher","first-page":"e13852","DOI":"10.7717\/peerj.13852","volume":"10","author":"L Hu","year":"2022","unstructured":"Hu, L. et al. Utilizing network pharmacology and experimental validation to investigate the underlying mechanism of phellodendrine on inflammation. PeerJ 10, e13852 (2022).","journal-title":"PeerJ"},{"key":"84771_CR16","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/mp.2016.120","volume":"22","author":"J Keller","year":"2017","unstructured":"Keller, J. et al. HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition. Mol. Psychiatry 22, 527\u2013536 (2017).","journal-title":"Mol. Psychiatry"},{"key":"84771_CR17","doi-asserted-by":"crossref","unstructured":"Murray, F., Smith, D. W. & Hutson, P. H. Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. Eur. J. Pharmacol. 583(1), 115\u2013127 (2008).","DOI":"10.1016\/j.ejphar.2008.01.014"},{"issue":"23","key":"84771_CR18","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.3390\/cells11233730","volume":"11","author":"J Huang","year":"2022","unstructured":"Huang, J. et al. Dihydromyricetin attenuates depressive-like behaviors in mice by inhibiting the AGE-RAGE signaling pathway. Cells 11 (23), 3730 (2022).","journal-title":"Cells"},{"key":"84771_CR19","doi-asserted-by":"crossref","unstructured":"Sun, J-Y. et al. Essential oil from the roots of Paeonia lactiflora pall.has protective effect against corticosterone-induced depression in mice via modulation of PI3K\/Akt signaling pathway. Front. Pharmacol. 13, 999712 (2022).","DOI":"10.3389\/fphar.2022.999712"},{"key":"84771_CR20","doi-asserted-by":"crossref","unstructured":"Tian, J. S. et al. Metabolomics studies on corticosterone-induced PC12 cells: a strategy for evaluating an in vitro depression model and revealing the metabolic regulation mechanism. Neurotoxicol. Teratol. 69, 27\u201338 (2013).","DOI":"10.1016\/j.ntt.2018.07.002"},{"issue":"1","key":"84771_CR21","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1080\/13880209.2020.1765812","volume":"Dec;58","author":"L Zhang","year":"2020","unstructured":"Zhang, L. et al. Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice. Pharm. Biol. 58 (1), 498\u2013509 (2020).","journal-title":"Pharm. Biol."},{"key":"84771_CR22","doi-asserted-by":"crossref","unstructured":"Terada, K. et al. Inhibition of nerve growth factor-induced neurite outgrowth from PC12 cells by dexamethasone: signaling pathways through the glucocorticoid receptor and phosphorylated Akt and ERK1\/2. PLoS One 9(3), e93223 (2014).","DOI":"10.1371\/journal.pone.0093223"},{"key":"84771_CR23","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk, D. et al. The STRING database in 2021: customizable pro-tein-protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res. 49, D605\u2013D612 (2021).","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"84771_CR24","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","volume":"50","author":"BT Sherman","year":"2022","unstructured":"Sherman, B. T. et al. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 50 (W1), W216\u2013W221 (2022).","journal-title":"Nucleic Acids Res."},{"key":"84771_CR25","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M. et al. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013D592 (2023).","journal-title":"Nucleic Acids Res."},{"key":"84771_CR26","doi-asserted-by":"publisher","unstructured":"Hu, L. et al. Network pharmacology combined with bioinformatics analysis to TEXPLORE the potential mechanism of phellodendri chinensis cortex against bladder cancer. Cell Biochem. Biophys. https:\/\/doi.org\/10.1007\/s12013-024-01414-6 (2024).","DOI":"10.1007\/s12013-024-01414-6"},{"key":"84771_CR27","doi-asserted-by":"publisher","first-page":"765638","DOI":"10.3389\/fphar.2021.765638","volume":"12","author":"Y Li","year":"2021","unstructured":"Li, Y. et al. Integrated network pharmacology and GC-MS-based metabolomics to investigate the effect of Xiang-Su volatile oil against menopausal depression. Front. Pharmacol. 12, 765638 (2021).","journal-title":"Front. Pharmacol."},{"key":"84771_CR28","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.pnpbp.2010.04.020","volume":"34","author":"C Bonvicini C","year":"2010","unstructured":"Bonvicini C, et al. Serotonin transporter gene polymorphisms and treatment-resistant depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 34 (6), 934-939 (2010)","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"84771_CR29","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/mp.2009.92","volume":"14","author":"C Dong","year":"2009","unstructured":"Dong C, Wong ML, & Licinio J. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. Mol. Psychiatry. 14 (12), 1105-1118 (2009)","journal-title":"Mol Psychiatry."},{"key":"84771_CR30","doi-asserted-by":"publisher","first-page":"110036","DOI":"10.1016\/j.pnpbp.2020.110036","volume":"104","author":"Y Bi","year":"2021","unstructured":"Bi, Y. et al. Influence and interaction of genetic, cognitive, neuroendocrine and personalistic markers to antidepressant response in Chinese patients with major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 104, 110036 (2021).","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"84771_CR31","doi-asserted-by":"crossref","unstructured":"Bakusic, J. et al. Increased methylation of NR3C1 and SLC6A4 is associated with blunted cortisol reactivity to stress in major depression. Neurobiol. Stress 13, 100272 (2020).","DOI":"10.1016\/j.ynstr.2020.100272"},{"key":"84771_CR32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jpsychires.2014.02.002","volume":"53","author":"S Okada","year":"2014","unstructured":"Okada, S. et al. The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression. J. Psychiatr Res. 53, 47\u201353 (2014).","journal-title":"J. Psychiatr Res."},{"issue":"3","key":"84771_CR33","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1055\/s-0034-1398508","volume":"48","author":"L Yin","year":"2015","unstructured":"Yin, L. et al. SLC6A2, SLC6A3, DRD2 and DRD4 polymorphisms and neuroendocrine factors predict SSRIs treatment outcome in the Chinese population with major depression. Pharmacopsychiatry 48 (3), 95\u2013103 (2015).","journal-title":"Pharmacopsychiatry"},{"key":"84771_CR34","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/978-1-0716-3662-6_24","volume":"2761","author":"B Mathew","year":"2024","unstructured":"Mathew, B. et al. Enzyme inhibition assays for monoamine oxidase. Methods Mol. Biol. 2761, 329\u2013336 (2024).","journal-title":"Methods Mol. Biol."},{"key":"84771_CR35","doi-asserted-by":"publisher","unstructured":"Shi, Q. et al. Cardiac MAO-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control. Cardiovasc. Res. 10, cvae012. https:\/\/doi.org\/10.1093\/cvr\/cvae012 (2024).","DOI":"10.1093\/cvr\/cvae012"},{"key":"84771_CR36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0893-133X(94)00058-8","volume":"12","author":"ME Thase","year":"1995","unstructured":"Thase, M. E., Trivedi, M. H. & Rush, A. J. MAOIs in the contemporary treatment of depression. Neuropsychopharmacology 12, 185\u2013219 (1995).","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"84771_CR37","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1158\/1055-9965.EPI-16-0534","volume":"25","author":"T Huang","year":"2016","unstructured":"Huang, T. et al. Association of ovarian tumor \u03b22-adrenergic receptor status with ovarian cancer risk factors and survival. Cancer Epidemiol. Biomark. Prev. 25 (12), 1587\u20131594 (2016).","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"1","key":"84771_CR38","doi-asserted-by":"publisher","first-page":"6937","DOI":"10.1038\/s41467-021-27044-7","volume":"26","author":"S Liu","year":"2021","unstructured":"Liu, S. et al. Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice. Nat. Commun. 26 (1), 6937 (2021).","journal-title":"Nat. Commun."},{"issue":"1","key":"84771_CR39","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12868-020-00574-4","volume":"21","author":"D Rajalingam","year":"2020","unstructured":"Rajalingam, D. et al. Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of \u03b2-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6). BMC Neurosci. 21 (1), 25 (2020).","journal-title":"BMC Neurosci."},{"key":"84771_CR40","doi-asserted-by":"publisher","first-page":"115750","DOI":"10.1016\/j.bcp.2023.115750","volume":"215","author":"C Li","year":"2023","unstructured":"Li, C. et al. RNA methylations in depression, from pathological mechanism to therapeutic potential. Biochem. Pharmacol. 215, 115750. https:\/\/doi.org\/10.1016\/j.bcp.2023.115750 (2023).","journal-title":"Biochem. Pharmacol."},{"key":"84771_CR41","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.3389\/fphar.2019.01000","volume":"Sep 12;10","author":"V Bortolotto","year":"2019","unstructured":"Bortolotto, V. et al. Salmeterol, a \u03b22 adrenergic agonist, promotes adult hippocampal neurogenesis in a region-specific manner. Front. Pharmacol. 10, 1000. https:\/\/doi.org\/10.3389\/fphar.2019.01000 (2019).","journal-title":"Front. Pharmacol."},{"issue":"2","key":"84771_CR42","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1021\/cn500235m","volume":"6","author":"DL Graham","year":"2015","unstructured":"Graham, D. L. et al. Loss of dopamine D2 receptors increases parvalbumin-positive interneurons in the anterior cingulate cortex. ACS Chem. Neurosci. 6 (2), 297\u2013305 (2015).","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"84771_CR43","doi-asserted-by":"publisher","first-page":"6444","DOI":"10.1038\/s41467-021-26769-9","volume":"12","author":"YQ Zhang","year":"2021","unstructured":"Zhang, Y. Q. et al. Dopamine D2 receptor regulates cortical synaptic pruning in rodents. Nat. Commun. 12 (1), 6444 (2021).","journal-title":"Nat. Commun."},{"key":"84771_CR44","doi-asserted-by":"publisher","first-page":"1257617","DOI":"10.3389\/fphar.2023.1257617","volume":"21","author":"Y Zhao","year":"2023","unstructured":"Zhao, Y. et al. The pharmacological mechanism of chaihu-jia-longgu-muli-Tang for treating depression: integrated meta-analysis and network pharmacology analysis. Front. Pharmacol. 14, 1257617 (2023).","journal-title":"Front. Pharmacol."},{"issue":"8","key":"84771_CR45","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1007\/s11011-023-01312-5","volume":"38","author":"JS Tian","year":"2023","unstructured":"Tian, J. S. et al. Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K\/Akt\/mTOR signaling pathways. Metab. Brain Dis. 38 (8), 2849\u20132864 (2023).","journal-title":"Metab. Brain Dis."},{"key":"84771_CR46","doi-asserted-by":"publisher","first-page":"153664","DOI":"10.1016\/j.phymed.2021.153664","volume":"91","author":"S Fakhri","year":"2021","unstructured":"Fakhri, S. et al. Natural products attenuate PI3K\/Akt\/mTOR signaling pathway: a promising strategy in regulating neurodegeneration. Phytomedicine 91, 153664 (2021).","journal-title":"Phytomedicine"},{"key":"84771_CR47","doi-asserted-by":"publisher","first-page":"160","DOI":"10.4062\/biomolther.2018.074","volume":"27","author":"M Xu","year":"2019","unstructured":"Xu, M. et al. Schisantherin B improves the pathological manifestations of mice caused by behavior desperation in different ages-depression with cognitive impairment. Biomol. Ther. 27, 160\u2013167 (2019).","journal-title":"Biomol. Ther."}],"updated-by":[{"DOI":"10.1038\/s41598-025-03862-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84771-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84771-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84771-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:59:46Z","timestamp":1750150786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84771-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["84771"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-84771-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]},"assertion":[{"value":"2 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-025-03862-3","URL":"https:\/\/doi.org\/10.1038\/s41598-025-03862-3","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1958"}}