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A recent genome-wide association study in individuals of African ancestries identified a region on chromosome 1 significantly associated with decreased HIV set-point viral load. Knockout of the closest gene, <jats:italic>CHD1L<\/jats:italic>, enhanced HIV replication in vitro in myeloid cells. However, it remains unclear if HIV spVL associated variants are associated with <jats:italic>CHD1L<\/jats:italic> gene expression changes. Here we apply a heuristic fine-mapping approach to prioritize combinations of variants that explain the majority of set-point viral load variance and identify variants likely driving the association. We assess the combined impact of these variants on <jats:italic>CHD1L<\/jats:italic> regulation using publicly available sequencing studies, and test the relationship between <jats:italic>CHD1L<\/jats:italic> expression and set-point viral load using imputed <jats:italic>CHD1L<\/jats:italic> expression from monocytes. Taken together, this work characterizes genetically regulated <jats:italic>CHD1L<\/jats:italic> expression and further expands our knowledge of <jats:italic>CHD1L<\/jats:italic>-mediated HIV restriction in monocytes.<\/jats:p>","DOI":"10.1038\/s41598-024-84817-y","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T14:05:31Z","timestamp":1737122731000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Functionally-informed fine-mapping identifies genetic variants linking increased CHD1L expression and HIV restriction in monocytes"],"prefix":"10.1038","volume":"15","author":[{"given":"Riley H.","family":"Tough","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"McLaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The International Collaboration for the Genomics of HIV","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"84817_CR1","unstructured":"The path that ends AIDS: UNAIDS Global AIDS Update 2023. 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