{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:27:05Z","timestamp":1791332825004,"version":"4.3.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-84969-x","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T12:45:49Z","timestamp":1737463549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The role of IFN-\u03b3\/CXCL10 axis in Mycoplasma pneumonia infection"],"prefix":"10.1038","volume":"15","author":[{"given":"Yanxia","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengrong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"84969_CR1","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1056\/NEJMoa1405870","volume":"372","author":"S Jain","year":"2015","unstructured":"Jain, S. et al. Community-Acquired Pneumonia requiring hospitalization among U.S. children. N. Engl. J. Med. 372, 835\u2013845 (2015).","journal-title":"N. Engl. J. Med."},{"key":"84969_CR2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S2213-2600(16)00096-5","volume":"4","author":"HJ Zar","year":"2016","unstructured":"Zar, H. J. et al. Aetiology of childhood pneumonia in a well vaccinated South African birth cohort: a nested case-control study of the Drakenstein Child Health Study. Lancet Respir. Med. 4, 463\u2013472 (2016).","journal-title":"Lancet Respir. Med."},{"key":"84969_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/INF.0000000000000171","volume":"33","author":"TP Atkinson","year":"2014","unstructured":"Atkinson, T. P. & Waites, K. B. Mycoplasma pneumoniae infections in childhood. Pediatr. Infect. Dis. J. 33, 92\u201394 (2014).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"84969_CR4","doi-asserted-by":"crossref","unstructured":"Ramasamy, K. et al. Mycoplasma pneumoniae cards toxin exploits host cell endosomal acidic Ph and vacuolar atpase proton pump to execute its biological activities. Sci. Rep. 11 (2021).","DOI":"10.1038\/s41598-021-90948-3"},{"key":"84969_CR5","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1128\/CMR.17.4.697-728.2004","volume":"17","author":"KB Waites","year":"2004","unstructured":"Waites, K. B. & Talkington, D. F. Mycoplasma pneumoniaeand its role as a human pathogen. Clin. Microbiol. Rev. 17, 697\u2013728 (2004).","journal-title":"Clin. Microbiol. Rev."},{"key":"84969_CR6","doi-asserted-by":"crossref","unstructured":"Biagi, C. et al. Pulmonary and extrapulmonary manifestations in hospitalized children with mycoplasma pneumoniae infection. Microorganisms 9 (2021).","DOI":"10.3390\/microorganisms9122553"},{"key":"84969_CR7","doi-asserted-by":"crossref","unstructured":"Schildgen, O., S\u00f8ndergaard, M. J., Friis, M. B., Hansen, D. S. & J\u00f8rgensen, I. M. Clinical manifestations in infants and children with Mycoplasma pneumoniae infection. Plos One 13 (2018).","DOI":"10.1371\/journal.pone.0195288"},{"key":"84969_CR8","doi-asserted-by":"crossref","unstructured":"Yuan, X. et al. Tigecycline in the treatment of fulminant Mycoplasma pneumoniae pneumonia non-responsive to azithromycin and fluoroquinolone. Medicine 99 (2020).","DOI":"10.1097\/MD.0000000000021128"},{"key":"84969_CR9","doi-asserted-by":"crossref","unstructured":"Ahn, J. G. et al. Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and Meta-analysis. BMC Infect. Dis. 21 (2021).","DOI":"10.1186\/s12879-021-06508-7"},{"key":"84969_CR10","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/crj.13620","volume":"17","author":"F Fan","year":"2023","unstructured":"Fan, F., Lv, J., Yang, Q. & Jiang, F. Clinical characteristics and serum inflammatory markers of community-acquired Mycoplasma pneumonia in children. Clin. Respir. J. 17, 607\u2013617 (2023).","journal-title":"Clin. Respir. J."},{"key":"84969_CR11","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.jmii.2020.03.030","volume":"54","author":"YC Lee","year":"2021","unstructured":"Lee, Y. C. et al. Altered chemokine profile in refractory Mycoplasma pneumoniae pneumonia infected children. J. Microbiol. Immunol. Infect. 54, 673\u2013679 (2021).","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"84969_CR12","doi-asserted-by":"crossref","unstructured":"Li, M. et al. Serum Cxcl10\/Ip-10 May be a potential biomarker for severe Mycoplasma Pneumoniae Pneumonia in Children. BMC Infect. Dis. 21 (2021).","DOI":"10.1186\/s12879-021-06632-4"},{"key":"84969_CR13","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Ke, J., Wang, X. & Xia, S. Clinical characteristics and changes in serum Cxcl10 and Cxcl16 levels in patients with severe Mycoplasma pneumonia. Medicine 103 (2024).","DOI":"10.1097\/MD.0000000000037814"},{"key":"84969_CR14","first-page":"248","volume":"39","author":"J Shi","year":"2023","unstructured":"Shi, J., Ma, C., Hao, X., Luo, H. & Li, M. Dickkopf-1 inhibits the secretion of Muc5ac induced by Mycoplasma pneumoniae P1-C in mouse lung epithelial cells. Sheng Wu Gong. Cheng Xue Bao 39, 248\u2013261 (2023).","journal-title":"Sheng Wu Gong. Cheng Xue Bao"},{"key":"84969_CR15","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.molimm.2022.11.003","volume":"153","author":"J Shi","year":"2023","unstructured":"Shi, J., Ma, C., Hao, X., Luo, H. & Li, M. Reserve of Wnt\/\u0392-catenin signaling alleviates Mycoplasma pneumoniae P1-C-induced inflammation in airway epithelial cells and lungs of mice. Mol. Immunol. 153, 60\u201374 (2023).","journal-title":"Mol. Immunol."},{"key":"84969_CR16","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.1093\/ndt\/gfn361","volume":"23","author":"U Panzer","year":"2008","unstructured":"Panzer, U. et al. 15-Deoxy-Delta12,14-Prostaglandin J2 inhibits Inf-Gamma-Induced Jak\/Stat1 signalling pathway activation and Ip-10\/Cxcl10 expression in mesangial cells. Nephrol. Dial. Transpl. 23, 3776\u20133785 (2008).","journal-title":"Nephrol. Dial. Transpl."},{"key":"84969_CR17","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s10067-022-06400-y","volume":"42","author":"D Shi","year":"2023","unstructured":"Shi, D. et al. Transcriptional expression of Cxcl10 and Stat1 in Lupus nephritis and the intervention effect of Triptolide. Clin. Rheumatol. 42, 539\u2013548 (2023).","journal-title":"Clin. Rheumatol."},{"key":"84969_CR18","doi-asserted-by":"publisher","first-page":"146040","DOI":"10.1016\/j.gene.2021.146040","volume":"809","author":"T Liang","year":"2022","unstructured":"Liang, T. et al. Stat1 and Cxcl10 involve in M1 macrophage polarization that may affect osteolysis and bone remodeling in extrapulmonary tuberculosis. Gene 809, 146040 (2022).","journal-title":"Gene"},{"key":"84969_CR19","unstructured":"Guidelines for Management of Community Acquired Pneumonia in Children (the revised Edition of 2013) (Ii). Zhonghua Er Ke Za Zhi 51, 856\u2013862 (2013)."},{"key":"84969_CR20","unstructured":"Guidelines for the Management of Community-Acquired Pneumonia in Children. Zhonghua Er Ke Za Zhi 62, 920\u2013930 (2024)."},{"key":"84969_CR21","first-page":"260","volume":"49","author":"G Pasternak","year":"2020","unstructured":"Pasternak, G., Lewandowicz-Uszy\u0144ska, A. & Kr\u00f3lak-Olejnik, B. Recurrent respiratory tract infections in Children. Pol. Merkur Lekarski 49, 260\u2013266 (2020).","journal-title":"Pol. Merkur Lekarski"},{"key":"84969_CR22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M., Goto, S. & Kegg Kyoto Encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"84969_CR23","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of Cellular organisms. Protein Sci. 28, 1947\u20131951 (2019).","journal-title":"Protein Sci."},{"key":"84969_CR24","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. Kegg for Taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013d592 (2023).","journal-title":"Nucleic Acids Res."},{"key":"84969_CR25","doi-asserted-by":"crossref","unstructured":"Kumar, S. & Mycoplasma pneumoniae: A significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections. Indian J. Med. Res. 147 (2018).","DOI":"10.4103\/ijmr.IJMR_1582_16"},{"key":"84969_CR26","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.3892\/mmr.2016.5765","volume":"14","author":"J He","year":"2016","unstructured":"He, J. et al. Insights into the pathogenesis of Mycoplasma pneumoniae. Mol. Med. Rep. 14, 4030\u20134036 (2016).","journal-title":"Mol. Med. Rep."},{"key":"84969_CR27","doi-asserted-by":"crossref","unstructured":"Hu, J. et al. Insight into the pathogenic mechanism of Mycoplasma pneumoniae. Curr. Microbiol. 80 (2022).","DOI":"10.1007\/s00284-022-03103-0"},{"key":"84969_CR28","doi-asserted-by":"crossref","unstructured":"Xu, C. et al. Diagnostic values of soluble triggering receptor expressed on myeloid cells (Strem-1) and interferon-inducible protein-10 (Ip-10) for severe Mycoplasma pneumoniae pneumonia in children. Clinics 79 (2024).","DOI":"10.1016\/j.clinsp.2024.100361"},{"key":"84969_CR29","doi-asserted-by":"crossref","unstructured":"Gudowska-Sawczuk, M. & Mroczko, B. What is currently known about the role of Cxcl10 in Sars-Cov-2 infection? Int. J. Mol. Sci. 23 (2022).","DOI":"10.3390\/ijms23073673"},{"key":"84969_CR30","first-page":"7497","volume":"24","author":"N Zhang","year":"2020","unstructured":"Zhang, N., Zhao, Y. D. & Wang, X. M. Cxcl10 an important chemokine associated with cytokine storm in Covid-19 infected patients. Eur. Rev. Med. Pharmacol. Sci. 24, 7497\u20137505 (2020).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"84969_CR31","doi-asserted-by":"crossref","unstructured":"Li, W. et al. Th1\/Th2 Cytokine Profile and its diagnostic value in Mycoplasma pneumoniae pneumonia. Iran. J. Pediatr. 26 (2016).","DOI":"10.5812\/ijp.3807"},{"key":"84969_CR32","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.2147\/TCRM.S121928","volume":"12","author":"J Zhao","year":"2016","unstructured":"Zhao, J., Wang, X. & Wang, Y. Relationships between Th1\/Th2 cytokine profiles and chest radiographic manifestations in childhood\u2009<\u2009em\u2009>\u2009Mycoplasma pneumoniae pneumonia. Ther. Clin. Risk Manag. 12, 1683\u20131692 (2016).","journal-title":"Ther. Clin. Risk Manag."},{"key":"84969_CR33","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/1471-2180-14-156","volume":"14","author":"S Kurata","year":"2014","unstructured":"Kurata, S. et al. Role of Il-17a and Il-10 in the antigen induced inflammation model by Mycoplasma pneumoniae. BMC Microbiol. 14, 156 (2014).","journal-title":"BMC Microbiol."},{"key":"84969_CR34","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1159\/000357780","volume":"21","author":"R Vazirinejad","year":"2014","unstructured":"Vazirinejad, R., Ahmadi, Z., Kazemi Arababadi, M., Hassanshahi, G. & Kennedy, D. The Biological functions, structure and sources of Cxcl10 and its outstanding part in the pathophysiology of multiple sclerosis. Neuroimmunomodulation 21, 322\u2013330 (2014).","journal-title":"Neuroimmunomodulation"},{"key":"84969_CR35","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.4049\/jimmunol.1202222","volume":"191","author":"V Peperzak","year":"2013","unstructured":"Peperzak, V. et al. Cd8+ T cells produce the chemokine Cxcl10 in response to Cd27\/Cd70 costimulation to promote generation of the Cd8+ effector T cell pool. J. Immunol. 191, 3025\u20133036 (2013).","journal-title":"J. Immunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84969-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84969-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84969-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T12:45:58Z","timestamp":1737463558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-84969-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["84969"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-84969-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]},"assertion":[{"value":"18 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2671"}}