{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:28:52Z","timestamp":1773890932628,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03017"],"award-info":[{"award-number":["22H03017"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03017"],"award-info":[{"award-number":["22H03017"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02763"],"award-info":[{"award-number":["18H02763"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Fukui Fund for the Promotion of Collaborative Research","award":["2022-2023"],"award-info":[{"award-number":["2022-2023"]}]},{"name":"University of Fukui Fund for the Promotion of Collaborative Research","award":["2022-2023"],"award-info":[{"award-number":["2022-2023"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-85027-2","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T12:30:30Z","timestamp":1740745830000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationship between renal oxidative stress levels and disease severity in patients with chronic kidney disease assessed by [Cu-64]ATSM PET\/MRI"],"prefix":"10.1038","volume":"15","author":[{"given":"Ya\u2019nan","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudai","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munenobu","family":"Nogami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Kiyono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7046-3383","authenticated-orcid":false,"given":"Hidehiko","family":"Okazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"issue":"3","key":"85027_CR1","doi-asserted-by":"publisher","first-page":"e382","DOI":"10.1016\/S2214-109X(23)00570-3","volume":"12","author":"AK Bello","year":"2024","unstructured":"Bello, A. K. et al. An update on the global disparities in kidney disease burden and care across world countries and regions. Lancet Glob Health 12(3), e382\u2013e395 (2024).","journal-title":"Lancet Glob Health"},{"issue":"3","key":"85027_CR2","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1148\/radiol.11110668","volume":"261","author":"WC Wu","year":"2011","unstructured":"Wu, W. C., Su, M. Y., Chang, C. C., Tseng, W. Y. & Liu, K. L. Renal perfusion 3-T MR imaging: a comparative study of arterial spin labeling and dynamic contrast-enhanced techniques. Radiology 261(3), 845\u2013853 (2011).","journal-title":"Radiology"},{"issue":"10","key":"85027_CR3","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.3390\/diagnostics13101685","volume":"13","author":"Y Nishikawa","year":"2023","unstructured":"Nishikawa, Y. et al. Feasibility of renal blood Flow Measurement using 64Cu-ATSM PET\/MRI: a quantitative PET and MRI study. Diagnostics 13(10), 1685 (2023).","journal-title":"Diagnostics"},{"issue":"4","key":"85027_CR4","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1002\/jmri.27888","volume":"55","author":"BA Alhummiany","year":"2022","unstructured":"Alhummiany, B. A. et al. Bias and Precision in magnetic resonance imaging-based estimates of Renal Blood Flow: Assessment by Triangulation. J. Magn. Reson. Imaging 55(4), 1241\u20131250 (2022).","journal-title":"J. Magn. Reson. Imaging"},{"issue":"1","key":"85027_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s40658-021-00389-0","volume":"8","author":"SS Langaa","year":"2021","unstructured":"Langaa, S. S. et al. Estimation of renal perfusion based on measurement of rubidium-82 clearance by PET\/CT scanning in healthy subjects. EJNMMI Phys. 8(1), 43 (2021).","journal-title":"EJNMMI Phys."},{"issue":"8","key":"85027_CR6","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1097\/MNM.0000000000001865","volume":"45","author":"M Spiliotopoulou","year":"2024","unstructured":"Spiliotopoulou, M. et al. 99mTc-DTPA dynamic SPECT\/CT renogram in adults: feasibility and diagnostic benefit. Nucl. Med. Commun. 45(8), 673\u2013682 (2024).","journal-title":"Nucl. Med. Commun."},{"issue":"6","key":"85027_CR7","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s00467-018-4005-4","volume":"34","author":"K Daenen","year":"2019","unstructured":"Daenen, K. et al. Oxidative stress in chronic kidney disease. Pediatr. Nephrol. 34(6), 975\u2013991 (2019).","journal-title":"Pediatr. Nephrol."},{"issue":"2","key":"85027_CR8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41581-023-00775-0","volume":"20","author":"S Kishi","year":"2024","unstructured":"Kishi, S., Nagasu, H., Kidokoro, K. & Kashihara, N. Oxidative stress and the role of redox signalling in chronic kidney disease. Nat. Rev. Nephrol. 20(2), 101\u2013119 (2024).","journal-title":"Nat. Rev. Nephrol."},{"issue":"10075","key":"85027_CR9","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","volume":"389","author":"AC Webster","year":"2017","unstructured":"Webster, A. C., Nagler, E. V., Morton, R. L. & Masson, P. Chronic kidney disease. Lancet 389(10075), 1238\u20131252 (2017).","journal-title":"Lancet"},{"issue":"6","key":"85027_CR10","doi-asserted-by":"publisher","first-page":"687","DOI":"10.3390\/antiox13060687","volume":"13","author":"W Fr\u0105k","year":"2024","unstructured":"Fr\u0105k, W. et al. Role of Uremic Toxins, oxidative stress, and renal fibrosis in chronic kidney disease. Antioxidants 13(6), 687 (2024).","journal-title":"Antioxidants"},{"key":"85027_CR11","doi-asserted-by":"publisher","first-page":"121432","DOI":"10.1016\/j.lfs.2023.121432","volume":"319","author":"A Srivastava","year":"2023","unstructured":"Srivastava, A., Tomar, B., Sharma, D. & Rath, S. K. Mitochondrial dysfunction and oxidative stress: role in chronic kidney disease. Life Sci. 319, 121432 (2023).","journal-title":"Life Sci."},{"issue":"2","key":"85027_CR12","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s00223-024-01233-0","volume":"115","author":"R Qaisar","year":"2024","unstructured":"Qaisar, R., Burki, A., Karim, A., Ustrana, S. & Ahmad, F. The Association of Intestinal Leak with Sarcopenia and physical disability in patients with various stages of chronic kidney disease. Calcif Tissue Int. 115(2), 132\u2013141 (2024).","journal-title":"Calcif Tissue Int."},{"issue":"1","key":"85027_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/metabo14010037","volume":"14","author":"DC Villalpando-S\u00e1nchez","year":"2024","unstructured":"Villalpando-S\u00e1nchez, D. C. et al. Advanced oxidative protein products had a diagnostic accuracy for identifying chronic kidney Disease in Adult Population. Metabolites 14(1), 37 (2024).","journal-title":"Metabolites"},{"issue":"7","key":"85027_CR14","first-page":"1155","volume":"38","author":"Y Fujibayashi","year":"1997","unstructured":"Fujibayashi, Y. et al. Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J. Nucl. Med. 38(7), 1155\u20131160 (1997).","journal-title":"J. Nucl. Med."},{"issue":"11","key":"85027_CR15","first-page":"1557","volume":"43","author":"JS Lewis","year":"2002","unstructured":"Lewis, J. S. et al. Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N4-methylthiosemicarbazone). J. Nucl. Med. 43(11), 1557\u20131569 (2002).","journal-title":"J. Nucl. Med."},{"issue":"6","key":"85027_CR16","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s00259-011-1734-z","volume":"38","author":"M Isozaki","year":"2011","unstructured":"Isozaki, M. et al. Feasibility of 62Cu-ATSM PET for evaluation of brain ischaemia and misery perfusion in patients with cerebrovascular disease. Eur. J. Nucl. Med. Mol. Imaging 38(6), 1075\u20131082 (2011).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"20","key":"85027_CR17","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1212\/WNL.0000000000001588","volume":"84","author":"M Ikawa","year":"2015","unstructured":"Ikawa, M. et al. Increased oxidative stress is related to disease severity in the ALS motor cortex: a PET study. Neurology 84(20), 2033\u20132039 (2015).","journal-title":"Neurology"},{"issue":"3","key":"85027_CR18","doi-asserted-by":"publisher","first-page":"437","DOI":"10.2967\/jnumed.115.155663","volume":"57","author":"F Li","year":"2016","unstructured":"Li, F., J\u00f8rgensen, J. T., Forman, J., Hansen, A. E. & Kjaer, A. 64Cureflectsflects pO2 Levels in Human Head and Neck Cxenograftsgraftnotut Not in Colorectal Cxenograftsgrcomparisonarison with 64CuCl2. J. Nucl. Med. 57(3), 437\u2013443 (2016).","journal-title":"J. Nucl. Med."},{"issue":"3\u20134","key":"85027_CR19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000479627","volume":"78","author":"H Neishi","year":"2017","unstructured":"Neishi, H. et al. Precise Evaluation of Striatal Oxidative Stress Corrected for Severity of Dopaminergic Neuronal Degeneration in patients with Parkinson\u2019s Disease: a study with 62Cu-ATSM PET and 123I-FP-CIT SPECT. Eur. Neurol. 78(3\u20134), 161\u2013168 (2017).","journal-title":"Eur. Neurol."},{"issue":"12","key":"85027_CR20","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1007\/s00259-022-05887-6","volume":"49","author":"F Xie","year":"2022","unstructured":"Xie, F. & Wei, W. [64Cu]Cu-ATSM: an emerging theranostic agent for cancer and neuroinflammation. Eur. J. Nucl. Med. Mol. Imaging 49(12), 3964\u20133972 (2022).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"6","key":"85027_CR21","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","volume":"53","author":"S Matsuo","year":"2009","unstructured":"Matsuo, S. et al. Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan. Am. J. Kidney Dis. 53(6), 982\u2013992 (2009).","journal-title":"Am. J. Kidney Dis."},{"issue":"5","key":"85027_CR22","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S0969-8051(03)00024-6","volume":"30","author":"A Obata","year":"2003","unstructured":"Obata, A. et al. Production of therapeutic quantities of (64)Cu using a 12\u00a0MeV cyclotron. Nucl. Med. Biol. 30(5), 535\u2013539 (2003).","journal-title":"Nucl. Med. Biol."},{"issue":"6","key":"85027_CR23","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.nucmedbio.2006.05.005","volume":"33","author":"T Tanaka","year":"2006","unstructured":"Tanaka, T. et al. Double-tracer autoradiography with Cu-ATSM\/FDG and immunohistochemical interpretation in four different mouse implanted tumor models. Nucl. Med. Biol. 33(6), 743\u2013750 (2006).","journal-title":"Nucl. Med. Biol."},{"key":"85027_CR24","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ejrad.2018.05.033","volume":"105","author":"H Okazawa","year":"2018","unstructured":"Okazawa, H. et al. Noninvasive method for measurement of cerebral blood flow using O-15 water PET\/MRI with ASL correlation. Eur. J. Radiol. 105, 102\u2013109 (2018).","journal-title":"Eur. J. Radiol."},{"issue":"5","key":"85027_CR25","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.3390\/antiox11051022","volume":"11","author":"H Okazawa","year":"2022","unstructured":"Okazawa, H. et al. Cerebral oxidative stress in early Alzheimer\u2019s Disease evaluated by 64Cu-ATSM PET\/MRI: a preliminary study. Antioxidants 11(5), 1022 (2022).","journal-title":"Antioxidants"},{"issue":"5","key":"85027_CR26","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1053\/j.ajkd.2006.08.015","volume":"48","author":"E Dounousi","year":"2006","unstructured":"Dounousi, E. et al. Oxidative stress is progressively enhanced with advancing stages of CKD. Am. J. Kidney Dis. 48(5), 752\u2013760 (2006).","journal-title":"Am. J. Kidney Dis."},{"key":"85027_CR27","doi-asserted-by":"publisher","first-page":"100596","DOI":"10.1016\/j.pacs.2024.100596","volume":"36","author":"AV Nikolaev","year":"2024","unstructured":"Nikolaev, A. V. et al. Pre-transplant kidney quality evaluation using photoacoustic imaging during normothermic machine perfusion. Photoacoustics 36, 100596 (2024).","journal-title":"Photoacoustics"},{"key":"85027_CR28","doi-asserted-by":"publisher","first-page":"121460","DOI":"10.1016\/j.lfs.2023.121460","volume":"317","author":"HH Atteia","year":"2023","unstructured":"Atteia, H. H. et al. Soluble guanylate cyclase agonist, isoliquiritigenin attenuates renal damage and aortic calcification in a rat model of chronic kidney failure. Life Sci. 317, 121460 (2023).","journal-title":"Life Sci."},{"issue":"11","key":"85027_CR29","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1111\/bph.15586","volume":"179","author":"D Stehle","year":"2022","unstructured":"Stehle, D. et al. Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney. Br. J. Pharmacol. 179(11), 2476\u20132489 (2022).","journal-title":"Br. J. Pharmacol."},{"key":"85027_CR30","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.freeradbiomed.2024.05.034","volume":"221","author":"M Ribeiro","year":"2024","unstructured":"Ribeiro, M. et al. Sulforaphane upregulates the mRNA expression of NRF2 and NQO1 in non-dialysis patients with chronic kidney disease. Free Radic Biol. Med. 221, 181\u2013187 (2024).","journal-title":"Free Radic Biol. Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-85027-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-85027-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-85027-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T12:30:34Z","timestamp":1740745834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-85027-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["85027"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-85027-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5202422\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"4 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7227"}}