{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:21:24Z","timestamp":1793463684715,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21gm1610005"],"award-info":[{"award-number":["JP21gm1610005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-85068-7","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T09:08:49Z","timestamp":1736154529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Epidemiology of respiratory viruses according to age group, 2023\u201324 winter season, Kyoto, Japan"],"prefix":"10.1038","volume":"15","author":[{"given":"Yasufumi","family":"Matsumura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Tsuchido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Yukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"85068_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ijid.2023.10.001","volume":"137","author":"ML Schuz","year":"2023","unstructured":"Schuz, M. L. et al. Global prevalence of respiratory virus infections in adults and adolescents during the COVID-19 pandemic: A systematic review and meta-analysis. Int. J. Infect. Dis. 137, 16\u201324 (2023).","journal-title":"Int. J. Infect. Dis."},{"key":"85068_CR2","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1038\/s41467-024-47757-9","volume":"15","author":"E Rios-Guzman","year":"2024","unstructured":"Rios-Guzman, E. et al. Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic. Nat. Commun. 15, 3374 (2024).","journal-title":"Nat. Commun."},{"key":"85068_CR3","unstructured":"National Institute of Infectious Diseases. Infectious Diseases Weekly Report (IDWR) https:\/\/www.niid.go.jp\/niid\/en\/idwr-e.html."},{"key":"85068_CR4","doi-asserted-by":"publisher","first-page":"615099","DOI":"10.3389\/fmed.2021.615099","volume":"8","author":"Y Mardian","year":"2021","unstructured":"Mardian, Y., Kosasih, H., Karyana, M., Neal, A. & Lau, C. Y. Review of current COVID-19 diagnostics and opportunities for further development. Front. Med. (Lausanne). 8, 615099 (2021).","journal-title":"Front. Med. (Lausanne)."},{"key":"85068_CR5","doi-asserted-by":"crossref","unstructured":"Azar, M. M. & Landry, M. L. Detection of influenza A and B viruses and respiratory syncytial virus by use of Clinical Laboratory Improvement Amendments of 1988 (CLIA)-waived point-of-care assays: A paradigm shift to molecular tests. J. Clin. Microbiol. 56 (2018).","DOI":"10.1128\/JCM.00367-18"},{"key":"85068_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcvp.2023.100138","volume":"3","author":"Y Matsumura","year":"2023","unstructured":"Matsumura, Y., Yamazaki, W., Noguchi, T., Yamamoto, M. & Nagao, M. Analytical and clinical performances of seven direct detection assays for SARS-CoV-2. J. Clin. Virol. Plus 3, 100138 (2023).","journal-title":"J. Clin. Virol. Plus"},{"key":"85068_CR7","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1186\/s12889-023-17498-3","volume":"23","author":"H Kyo","year":"2023","unstructured":"Kyo, H. et al. A population-based study of the trend in SARS-CoV-2 diagnostic modalities from the beginning of the pandemic to the Omicron surge in Kyoto City, Kyoto, Japan. BMC Public Health 23, 2551 (2023).","journal-title":"BMC Public Health"},{"key":"85068_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2024.105674","volume":"172","author":"CB Jensen","year":"2024","unstructured":"Jensen, C. B. et al. Evaluation of the analytical and clinical performance of two RT-PCR based point-of-care tests; Cepheid Xpert(R) Xpress CoV-2\/Flu\/RSV plus and SD BioSensor STANDARD M10 Flu\/RSV\/SARS-CoV-2. J. Clin. Virol. 172, 105674 (2024).","journal-title":"J. Clin. Virol."},{"key":"85068_CR9","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cmi.2017.11.018","volume":"24","author":"HS Huang","year":"2018","unstructured":"Huang, H. S. et al. Multiplex PCR system for the rapid diagnosis of respiratory virus infection: Systematic review and meta-analysis. Clin. Microbiol. Infect. 24, 1055\u20131063 (2018).","journal-title":"Clin. Microbiol. Infect."},{"key":"85068_CR10","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1093\/cid\/ciaa508","volume":"71","author":"KE Hanson","year":"2020","unstructured":"Hanson, K. E. et al. Molecular testing for acute respiratory tract infections: Clinical and diagnostic recommendations from the IDSA\u2019s diagnostics committee. Clin. Infect. Dis. 71, 2744\u20132751 (2020).","journal-title":"Clin. Infect. Dis."},{"key":"85068_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s10096-021-04375-3","volume":"41","author":"J Wils","year":"2022","unstructured":"Wils, J., Saegeman, V. & Schuermans, A. Impact of multiplexed respiratory viral panels on infection control measures and antimicrobial stewardship: A review of the literature. Eur. J. Clin. Microbiol. Infect. Dis. 41, 187\u2013202 (2022).","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"85068_CR12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s40506-016-0085-5","volume":"8","author":"H Zaraket","year":"2016","unstructured":"Zaraket, H. & Saito, R. Japanese surveillance systems and treatment for influenza. Curr. Treat. Options Infect. Dis. 8, 311\u2013328 (2016).","journal-title":"Curr. Treat. Options Infect. Dis."},{"key":"85068_CR13","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.15585\/mmwr.mm7240a2","volume":"72","author":"D Surie","year":"2023","unstructured":"Surie, D. et al. Disease severity of respiratory syncytial virus compared with COVID-19 and influenza among hospitalized adults aged >\/=60 Years - IVY Network, 20 U.S. States, February 2022-May 2023. MMWR Morb. Mortal. Wkly. Rep. 72, 1083\u20131088 (2023).","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"85068_CR14","doi-asserted-by":"publisher","first-page":"e10903","DOI":"10.1097\/MD.0000000000010903","volume":"97","author":"NJ Tsagarakis","year":"2018","unstructured":"Tsagarakis, N. J. et al. Age-related prevalence of common upper respiratory pathogens, based on the application of the FilmArray Respiratory panel in a tertiary hospital in Greece. Medicine (Baltimore) 97, e10903 (2018).","journal-title":"Medicine (Baltimore)"},{"key":"85068_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13278","volume":"18","author":"Y Hirotsu","year":"2024","unstructured":"Hirotsu, Y. et al. Changes in viral dynamics following the legal relaxation of COVID-19 mitigation measures in Japan from children to adults: A single center study, 2020\u20132023. Influenza Other Respir. Viruses 18, e13278 (2024).","journal-title":"Influenza Other Respir. Viruses"},{"key":"85068_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e14424","volume":"9","author":"D Kitagawa","year":"2023","unstructured":"Kitagawa, D. et al. Epidemiology of respiratory tract infections using multiplex PCR in a Japanese acute care hospital during the COVID19 pandemic. Heliyon 9, e14424 (2023).","journal-title":"Heliyon"},{"key":"85068_CR17","doi-asserted-by":"publisher","first-page":"1208235","DOI":"10.3389\/fcimb.2023.1208235","volume":"13","author":"MD Weidmann","year":"2023","unstructured":"Weidmann, M. D., Green, D. A., Berry, G. J. & Wu, F. Assessing respiratory viral exclusion and affinity interactions through co-infection incidence in a pediatric population during the 2022 resurgence of influenza and RSV. Front. Cell. Infect. Microbiol. 13, 1208235 (2023).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"85068_CR18","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/S0140-6736(10)61459-6","volume":"377","author":"O Ruuskanen","year":"2011","unstructured":"Ruuskanen, O., Lahti, E., Jennings, L. C. & Murdoch, D. R. Viral pneumonia. Lancet 377, 1264\u20131275 (2011).","journal-title":"Lancet"},{"key":"85068_CR19","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1056\/NEJMoa1405870","volume":"372","author":"S Jain","year":"2015","unstructured":"Jain, S. et al. Community-acquired pneumonia requiring hospitalization among U.S. children. N. Engl. J. Med. 372, 835\u2013845 (2015).","journal-title":"N. Engl. J. Med."},{"key":"85068_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.107118","volume":"146","author":"B Zeng","year":"2024","unstructured":"Zeng, B. et al. Efficacy and safety of vaccines to prevent respiratory syncytial virus infection in infants and older adults: A systematic review and meta-analysis. Int. J. Infect. Dis. 146, 107118 (2024).","journal-title":"Int. J. Infect. Dis."},{"key":"85068_CR21","doi-asserted-by":"publisher","DOI":"10.1017\/ash.2023.172","volume":"3","author":"K Ohyama","year":"2023","unstructured":"Ohyama, K. et al. Resurgence of human coronavirus OC43 at a long-term care facility during the coronavirus disease 2019 (COVID-19) pandemic: Outbreak investigation. Antimicrob. Steward. Healthc. Epidemiol. 3, e97 (2023).","journal-title":"Antimicrob. Steward. Healthc. Epidemiol."},{"key":"85068_CR22","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1093\/infdis\/jiy261","volume":"218","author":"Y Karimata","year":"2018","unstructured":"Karimata, Y. et al. Clinical features of human metapneumovirus pneumonia in non-immunocompromised patients: An investigation of three long-term care facility outbreaks. J. Infect. Dis. 218, 868\u2013875 (2018).","journal-title":"J. Infect. Dis."},{"key":"85068_CR23","doi-asserted-by":"publisher","DOI":"10.1111\/ped.15525","volume":"65","author":"M Kuribayashi","year":"2023","unstructured":"Kuribayashi, M. et al. Clinical influence of multiplex polymerase chain reaction routine uses in urgent pediatric admissions. Pediatr. Int. 65, e15525 (2023).","journal-title":"Pediatr. Int."},{"key":"85068_CR24","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1128\/JCM.06186-11","volume":"50","author":"NE Babady","year":"2012","unstructured":"Babady, N. E. et al. Comparison of the Luminex xTAG RVP Fast assay and the Idaho Technology FilmArray RP assay for detection of respiratory viruses in pediatric patients at a cancer hospital. J. Clin. Microbiol. 50, 2282\u20132288 (2012).","journal-title":"J. Clin. Microbiol."},{"key":"85068_CR25","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1017\/ice.2015.204","volume":"36","author":"BA Cunha","year":"2015","unstructured":"Cunha, B. A., Connolly, J. J., Musta, A. C. & Abruzzo, E. Infection control implications of protracted lengths of stay with noninfluenza viral influenza-like illnesses in hospitalized adults during the 2015 influenza A (H3N2) epidemic. Infect. Control Hosp. Epidemiol. 36, 1368\u20131370 (2015).","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"85068_CR26","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12931-024-02862-7","volume":"25","author":"M Lustrek","year":"2024","unstructured":"Lustrek, M. et al. Influenza A, Influenza B, human respiratory syncytial virus and SARSCoV-2 molecular diagnostics and epidemiology in the post COVID-19 era. Respir. Res. 25, 234 (2024).","journal-title":"Respir. Res."},{"key":"85068_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2019.113676","volume":"271","author":"L Wang","year":"2019","unstructured":"Wang, L. et al. Duplex real-time RT-PCR assay for detection and subgroup-specific identification of human respiratory syncytial virus. J. Virol. Methods 271, 113676 (2019).","journal-title":"J. Virol. Methods"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-85068-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-85068-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-85068-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T21:28:00Z","timestamp":1736198880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-85068-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["85068"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-85068-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"assertion":[{"value":"24 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"YM received research funds from Beckman Coulter, Precision System Science, and Toyobo. MN received research funds from Beckman Coulter and Precision System Science. MY, Y.Tsuda, KS, Y.Tsuchido, SY, TN, and KT declare no potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was performed in accordance with the principles of the Declaration of Helsinki. The Ethics Committee of Kyoto University Graduate School and the Faculty of Medicine approved this study (R4195), and the need to obtain informed consent from each patient was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"924"}}