{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T15:10:04Z","timestamp":1748185804578,"version":"3.41.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Currently, due to the absence of economic evaluation information, automated peritoneal dialysis (APD) is not included in Thailand\u2019s Universal Health Coverage (UHC) benefit package. Therefore, we aimed to assess the cost-utility and budget impact of APD and continuous ambulatory peritoneal dialysis (CAPD) in pediatric end-stage kidney disease (ESKD) patients. A Markov model was applied to compare lifetime costs and health outcomes based on a social perspective using cost, utility, and transitional probability data from literature reviews. The results were presented as the incremental cost-effectiveness ratio (ICER). Moreover, one-way and probabilistic sensitivity analyses were performed to evaluate the uncertainty of all parameters. From a social perspective, patients receiving APD had higher total lifetime cost (14,791,473 baht) than those receiving CAPD (13,380,356 baht), but fewer life years (APD\u2009=\u200918.39, CAPD\u2009=\u200918.44) and higher quality adjusted life years (QALY) (APD\u2009=\u200916.31 and CAPD 15.65). At the societal willingness to pay in Thailand equal to 160,000 baht per QALY gained, APD would not be cost-effective (ICER\u2009=\u20093,063,598 baht per QALY gained). The inclusion of APD can result in an increase in annual budget of 54\u00a0million baht. Therefore, this study would help inform policy decisions regarding the inclusion of APD for pediatric with ESKD in the UHC benefit package.<\/jats:p>","DOI":"10.1038\/s41598-025-00352-4","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T14:33:11Z","timestamp":1748183591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Economic evaluation of automated peritoneal dialysis among pediatric patients with end state kidney diseases in Thailand"],"prefix":"10.1038","volume":"15","author":[{"given":"Montira","family":"Assanatham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitaporn","family":"Youngkong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montarat","family":"Thavorncharoensap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirut","family":"Pattaragarn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usa","family":"Chaikledkaew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"issue":"7","key":"352_CR1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41581-024-00820-6","volume":"20","author":"A Francis","year":"2024","unstructured":"Francis, A. et al. Chronic kidney disease and the global public health agenda: An international consensus. Nat. Rev. Nephrol. 20 (7), 473\u2013485 (2024).","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"352_CR2","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000514550","volume":"52","author":"JS Thurlow","year":"2021","unstructured":"Thurlow, J. S. et al. Global epidemiology of end-stage kidney disease and disparities in kidney replacement therapy. Am. J. Nephrol. 52 (2), 98\u2013107 (2021).","journal-title":"Am. J. Nephrol."},{"key":"352_CR3","unstructured":"The Nephrology Society of Thailand. Thailand Renal Replacement Therapy: Year 2020 (2020)."},{"issue":"10","key":"352_CR4","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/j.ajt.2023.07.006","volume":"23","author":"B Shi","year":"2023","unstructured":"Shi, B., Ying, T. & Chadban, S. J. Survival after kidney transplantation compared with ongoing dialysis for people over 70 years of age: A matched-pair analysis. Am. J. Transpl. 23 (10), 1551\u20131560 (2023).","journal-title":"Am. J. Transpl."},{"issue":"4","key":"352_CR5","first-page":"244","volume":"29","author":"A Boonmachai","year":"2023","unstructured":"Boonmachai, A. & Arayangkoon, C. Pretransplant dialytic modality and outcomes of kidney transplantation: Analysis of the nationwide data from Thailand transplant registry. J. Nephrol. Soc. Thail. 29 (4), 244\u2013255 (2023).","journal-title":"J. Nephrol. Soc. Thail."},{"issue":"10","key":"352_CR6","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1093\/ndt\/gfz011","volume":"34","author":"R Shroff","year":"2019","unstructured":"Shroff, R. et al. European society for paediatric nephrology Dialysis working group. Vascular access in children requiring maintenance haemodialysis: A consensus document by the European society for paediatric nephrology Dialysis working group. Nephrol. Dial Transpl. 34 (10), 1746\u20131765 (2019).","journal-title":"Nephrol. Dial Transpl."},{"issue":"1","key":"352_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13052-024-01590-4","volume":"50","author":"DM Salah","year":"2024","unstructured":"Salah, D. M. et al. Vascular access challenges in Hemodialysis children. Ital. J. Pediatr. 50 (1), 11 (2024).","journal-title":"Ital. J. Pediatr."},{"key":"352_CR8","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2147\/IJNRD.S236553","volume":"14","author":"A Domenici","year":"2021","unstructured":"Domenici, A. & Giuliani, A. Automated peritoneal dialysis: Patient perspectives and outcomes. Int. J. Nephrol. Renovasc. Dis. 14, 385\u2013392 (2021).","journal-title":"Int. J. Nephrol. Renovasc. Dis."},{"issue":"6","key":"352_CR9","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2215\/CJN.0000000000000436","volume":"19","author":"HE Giles","year":"2024","unstructured":"Giles, H. E. et al. Trends in automated peritoneal Dialysis prescriptions in a large Dialysis organization in the united States. Clin. J. Am. Soc. Nephrol. 19 (6), 723\u2013731 (2024).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"9","key":"352_CR10","first-page":"CD006515","volume":"9","author":"E Driehuis","year":"2024","unstructured":"Driehuis, E., Eshuis, M., Abrahams, A., Francois, K. & Vernooij, R. W. Automated peritoneal dialysis versus continuous ambulatory peritoneal dialysis for people with kidney failure. Cochrane Database Syst. Rev. 9 (9), CD006515 (2024).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"10","key":"352_CR11","first-page":"e47364","volume":"15","author":"RM AlMojalled","year":"2023","unstructured":"AlMojalled, R. M., Almabadi, R. M., Alghamdi, A. A. & Alnugali, R. Z. Correlation of serum albumin levels with laboratory parameters in automated peritoneal dialysis and continuous ambulatory peritoneal Dialysis patients: A prospective cohort study. Cureus 15 (10), e47364 (2023).","journal-title":"Cureus"},{"issue":"6","key":"352_CR12","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1007\/s11255-020-02678-6","volume":"53","author":"A Roumeliotis","year":"2021","unstructured":"Roumeliotis, A. et al. APD or CAPD: One glove does not fit all. Int. Urol. Nephrol. 53 (6), 1149\u20131160 (2021).","journal-title":"Int. Urol. Nephrol."},{"issue":"6","key":"352_CR13","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1177\/08968608211061126","volume":"42","author":"G Roberts","year":"2022","unstructured":"Roberts, G. et al. Current costs of dialysis modalities: A comprehensive analysis within the united Kingdom. Perit. Dial Int. 42 (6), 578\u2013584 (2022).","journal-title":"Perit. Dial Int."},{"key":"352_CR14","unstructured":"Pattaragarn, A. et al. The Quality of Life and Clinical Outcomes of Children with End Stage Kidney Disease Undergoing Automated Compared with Continuous Ambulatory Peritoneal dialysis Under the National Health Security System Coverage. (2023)."},{"issue":"3","key":"352_CR15","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1053\/j.ajkd.2020.11.031","volume":"78","author":"S van Ploos","year":"2021","unstructured":"van Ploos, S. et al. Mortality in children treated with maintenance peritoneal dialysis: Findings from the international pediatric peritoneal dialysis network registry. Am. J. Kidney Dis. 78 (3), 380\u2013390 (2021).","journal-title":"Am. J. Kidney Dis."},{"issue":"2","key":"352_CR16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/petr.12047","volume":"17","author":"P Rianthavorn","year":"2013","unstructured":"Rianthavorn, P. et al. Outcomes and predictive factors of pediatric kidney transplants: An analysis of the Thai transplant registry. Pediatr. Transpl. 17 (2), 112\u2013118 (2013).","journal-title":"Pediatr. Transpl."},{"issue":"7","key":"352_CR17","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1016\/j.transproceed.2008.07.023","volume":"40","author":"A Sumboonnanonda","year":"2008","unstructured":"Sumboonnanonda, A., Lumpaopong, A., Kingwatanakul, P., Tangnararatchakit, K. & Jiravuttipong, A. Pediatric kidney transplantation in Thailand: Experience in a developing country. Transpl. Proc. 40 (7), 2271\u20132273 (2008).","journal-title":"Transpl. Proc."},{"key":"352_CR18","doi-asserted-by":"crossref","unstructured":"Kanjanabuch, T. & Takkavatakarn, K. Global Dialysis Perspective: Thailand. Kidney360 1(7), 671\u2013675 (2020).","DOI":"10.34067\/KID.0000762020"},{"key":"352_CR19","unstructured":"World Health Organization. Mortality by Age and Sex: Thailand. 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