{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:59:54Z","timestamp":1779400794875,"version":"3.53.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum RWTH Aachen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Quality of life (QoL) is a crucial factor which has to be taken into account in the treatment of vestibular schwannomas. This study compared microsurgical and radiosurgical treatments, focusing on three. (1) evaluating post-treatment clinical outcomes, (2) assessing the effect on QoL and (3) analyzing complication rates, particularly in geriatric patients. In this retrospective study, 586 patients underwent either microsurgery or gamma knife radiosurgery between 1990 and 2013. Demographic and treatment data were collected, including quality of life (QoL) assessments using the Short Form 36 (SF-36) and evaluations of the Karnofsky Performance Status (KPS). Complication rates were also analyzed. The study included 194 microsurgery patients and 392 radiosurgery patients. Radiosurgery patients showed significantly better postoperative hearing and facial nerve function (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). QoL scores were higher in the radiosurgery group for physical and emotional role functioning, while microsurgery patients (including aged 65 years and older) reported better scores for bodily pain and general health perceptions. Neurological complications were 41.9% in the microsurgery group, most of them being permanent (92.9%). Radiosurgery generally showed better preservation of hearing, facial nerve function, and quality of life compared to microsurgery, although both treatments appeared equally effective in older patients.<\/jats:p>","DOI":"10.1038\/s41598-025-00372-0","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T12:42:55Z","timestamp":1746621775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of quality of life and outcomes of vestibular schwannoma patients after resection and radiosurgery in an interdisciplinary treatment concept"],"prefix":"10.1038","volume":"15","author":[{"given":"Alexander","family":"Romagna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Huffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hitzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf A.","family":"Kristof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Clusmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Blume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"372_CR1","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.3390\/jcm13061611","volume":"13","author":"F Guillemin","year":"2024","unstructured":"Guillemin, F., Puechmaille, M., Khalil, T. & Biau, J. The recent management of vestibular schwannoma radiotherapy: A narrative review of the literature. J. Clin. Med. 13, 1611. https:\/\/doi.org\/10.3390\/jcm13061611 (2024).","journal-title":"J. Clin. Med."},{"key":"372_CR2","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1056\/NEJMra2020394","volume":"384","author":"ML Carlson","year":"2021","unstructured":"Carlson, M. L., Link, M. J. & Vestibular Schwannomas N Engl. J. Med. 384, 1335\u20131348 https:\/\/doi.org\/10.1056\/NEJMra2020394 (2021).","journal-title":"N. Engl. J. Med."},{"key":"372_CR3","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/MAO.0000000000003801","volume":"44","author":"Z F\u00edk","year":"2023","unstructured":"F\u00edk, Z. et al. Hearing after vestibular schwannoma surgery: Is it preserved forever?? Otol Neurotol. 44, 260\u2013265. https:\/\/doi.org\/10.1097\/MAO.0000000000003801 (2023).","journal-title":"Otol Neurotol"},{"key":"372_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/00016480310000822","volume":"123","author":"Y Shin","year":"2003","unstructured":"Shin, Y. et al. Neurotological complications after radiosurgery versus conservative management in acoustic neuromas: A systematic review-based study. Acta Otolaryngol. 123, 59. https:\/\/doi.org\/10.1080\/00016480310000822 (2003).","journal-title":"Acta Otolaryngol."},{"key":"372_CR5","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1097\/MAO.0000000000001664","volume":"39","author":"E Papatsoutsos","year":"2018","unstructured":"Papatsoutsos, E. & Spielmann, P. M. Self-evaluated quality of life and functional outcomes after microsurgery, stereotactic radiation or observation-only for vestibular schwannoma of the adult patient: A systematic review. Otol Neurotol. 39, 232\u2013241. https:\/\/doi.org\/10.1097\/MAO.0000000000001664 (2018).","journal-title":"Otol. Neurotol."},{"key":"372_CR6","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.3171\/2014.10.JNS141028","volume":"123","author":"ML Carlson","year":"2015","unstructured":"Carlson, M. L. et al. Long-term quality of life in patients with vestibular schwannoma: An international multicenter cross-sectional study comparing microsurgery, stereotactic radiosurgery, observation, and nontumor controls. J. Neurosurg. 123, 1059\u20131071. https:\/\/doi.org\/10.3171\/2014.10.JNS141028 (2015).","journal-title":"J. Neurosurg."},{"issue":"3","key":"372_CR7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/ons\/opab170","volume":"21","author":"A Helal","year":"2021","unstructured":"Helal, A. et al. Differential impact of advanced age on clinical outcomes after vestibular schwannoma resection in the very elderly: Cohort study. Oper. Neurosurg. (Hagerstown). 21 (3), 104\u2013110. https:\/\/doi.org\/10.1093\/ons\/opab170 (2021).","journal-title":"Oper. Neurosurg. (Hagerstown)"},{"issue":"1","key":"372_CR8","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/s10143-024-02419-8","volume":"47","author":"L D\u00f6rner","year":"2024","unstructured":"D\u00f6rner, L. et al. Age, preoperative tumor volume and widening of the internal acoustic meatus are independent factors associated with poor preoperative hearing in vestibular schwannoma patients - results of a single-center retrospective analysis. Neurosurg. Rev. 47 (1), 262. https:\/\/doi.org\/10.1007\/s10143-024-02419-8 (2024).","journal-title":"Neurosurg. Rev."},{"key":"372_CR9","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/00005537-200001000-00027","volume":"110","author":"MJ da Cruz","year":"2000","unstructured":"da Cruz, M. J., Moffat, D. A. & Hardy, D. G. Postoperative quality of life in vestibular schwannoma patients measured by the SF36 health questionnaire. Laryngoscope 110, 151\u2013155. https:\/\/doi.org\/10.1097\/00005537-200001000-00027 (2000).","journal-title":"Laryngoscope"},{"issue":"2","key":"372_CR10","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1177\/019459988509300202","volume":"93","author":"JW House","year":"1985","unstructured":"House, J. W. & Brackmann, D. E. Facial nerve grading system. Otolaryngol. Head Neck Surg. 93 (2), 146\u2013147. https:\/\/doi.org\/10.1177\/019459988509300202 (1985).","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"1","key":"372_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1177\/000348948809700110","volume":"97","author":"G Gardner","year":"1988","unstructured":"Gardner, G. & Robertson, J. Hearing preservation in unilateral acoustic neuroma surgery. Ann. 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The study protocol was reviewed and approved by the institutional review board (EK 125\/16) and the need for a formal informed consent to participate was waived by the IRB given the retrospective nature of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"15941"}}