{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T04:01:29Z","timestamp":1746763289817,"version":"3.40.5"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>To compare postoperative changes in peripapillary retinal nerve fiber layer (pRNFL) thickness between macula-off and macula-on rhegmatogenous retinal detachment (RRD). Patients with RRD who had undergone a single, uncomplicated vitrectomy and been followed for \u2265\u20093 years postoperatively were included. Based on preoperative status, patients were categorized into a macula-on group (Group 1) and a macula-off group (Group 2). The baseline was established after complete gas dissipation from the vitreous cavity, followed by three additional examinations at 1-year intervals. In total, 62 eyes were analyzed: 30 in Group 1 and 32 in Group 2. Global pRNFL thicknesses in Group 1 were 100.0\u2009\u00b1\u200919.5, 99.4\u2009\u00b1\u200919.6, 98.4\u2009\u00b1\u200919.4, and 97.0\u2009\u00b1\u200920.3\u00a0\u03bcm at baseline, 1 year, 2 years, and 3 years, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). In Group 2, the corresponding values were 99.6\u2009\u00b1\u200915.0, 96.2\u2009\u00b1\u200916.4, 95.4\u2009\u00b1\u200916.3, and 94.1\u2009\u00b1\u200917.6\u00a0\u03bcm (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Sectoral analysis showed statistically significant changes in the inferotemporal (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and inferonasal (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) sectors in Group 2. The reduction rates of global pRNFL thickness were \u2212\u20090.89\u00a0\u03bcm\/y in Group 1 and \u2212\u20091.81\u00a0\u03bcm\/y in Group 2; these rates significantly differed between the groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.026). Among RRD patients, pRNFL thickness gradually declined over time, with a more pronounced reduction in the macula-off group. A substantial decrease in inferior pRNFL thickness was observed in macula-off patients.<\/jats:p>","DOI":"10.1038\/s41598-025-00799-5","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T04:46:52Z","timestamp":1746679612000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of long-term changes in peripapillary RNFL thickness between macula-on and macula-off rhegmatogenous retinal detachment"],"prefix":"10.1038","volume":"15","author":[{"given":"Jung-Tae","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee-Sup","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka-Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"issue":"2","key":"799_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1755-3768.1985.tb01527.x","volume":"63","author":"L Laatikainen","year":"1985","unstructured":"Laatikainen, L. & Tolppanen, E. 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