{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:38:51Z","timestamp":1772163531457,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Beijing Key Clinical Specialty Project"},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-00928-0","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T13:53:43Z","timestamp":1747317223000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A bioinformatics-driven approach to identify biomarkers and elucidate the pathogenesis of type 2 diabetes concurrent with pulmonary tuberculosis"],"prefix":"10.1038","volume":"15","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonglan","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenjie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"issue":"1","key":"928_CR1","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1016\/S2666-5247(22)00359-7","volume":"4","author":"S Bagcchi","year":"2023","unstructured":"Bagcchi, S. WHO\u2019s global tuberculosis report 2022. Lancet Microbe. 4 (1), e20 (2023).","journal-title":"Lancet Microbe"},{"key":"928_CR2","doi-asserted-by":"crossref","unstructured":"Saeedi, P. et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. ; 157: 107843. (2019).","DOI":"10.1016\/j.diabres.2019.107843"},{"issue":"2","key":"928_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Y Zheng","year":"2018","unstructured":"Zheng, Y., Ley, S. H. & Hu, F. B. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat. Rev. Endocrinol. 14 (2), 88\u201398 (2018).","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"928_CR4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.pcad.2019.07.003","volume":"62","author":"E Braunwald","year":"2019","unstructured":"Braunwald, E. Diabetes, heart failure, and renal dysfunction: the vicious circles. Prog Cardiovasc. Dis. 62 (4), 298\u2013302 (2019).","journal-title":"Prog Cardiovasc. Dis."},{"issue":"11","key":"928_CR5","doi-asserted-by":"publisher","first-page":"e0187967","DOI":"10.1371\/journal.pone.0187967","volume":"12","author":"RH Al-Rifai","year":"2017","unstructured":"Al-Rifai, R. H. et al. Association between diabetes mellitus and active tuberculosis: a systematic review and Meta-analysis. PloS One. 12 (11), e0187967 (2017).","journal-title":"PloS One"},{"issue":"12","key":"928_CR6","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/S1473-3099(09)70282-8","volume":"9","author":"KE Dooley","year":"2009","unstructured":"Dooley, K. E. & Chaisson, R. E. Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect. Dis. 9 (12), 737\u2013746 (2009).","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"928_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/nar\/27.1.29","volume":"27","author":"H Ogata","year":"1999","unstructured":"Ogata, H. et al. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 27 (1), 29\u201334 (1999).","journal-title":"Nucleic Acids Res."},{"key":"928_CR8","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.3389\/fimmu.2018.02427","volume":"9","author":"R Lubbers","year":"2018","unstructured":"Lubbers, R. et al. Complement component C1q as serum biomarker to detect active tuberculosis. Front. Immunol. 9, 2427 (2018).","journal-title":"Front. Immunol."},{"issue":"7","key":"928_CR9","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.trecan.2022.02.006","volume":"8","author":"M Revel","year":"2022","unstructured":"Revel, M., Saut\u00e8s-Fridman, C., Fridman, W. H. & Roumenina, L. T. C1q\u2009+\u2009macrophages: passengers or drivers of cancer progression. Trends Cancer. 8 (7), 517\u2013526 (2022).","journal-title":"Trends Cancer"},{"issue":"1","key":"928_CR10","doi-asserted-by":"publisher","first-page":"6290","DOI":"10.1038\/s41598-020-63041-4","volume":"10","author":"K Dijkman","year":"2020","unstructured":"Dijkman, K. et al. Systemic and pulmonary C1q as biomarker of progressive disease in experimental non-human primate tuberculosis. Sci. Rep. 10 (1), 6290 (2020).","journal-title":"Sci. Rep."},{"issue":"1","key":"928_CR11","doi-asserted-by":"publisher","first-page":"7769","DOI":"10.1038\/s41598-023-34847-9","volume":"13","author":"ATL Queiroz","year":"2023","unstructured":"Queiroz, A. T. L. et al. A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction. Sci. Rep. 13 (1), 7769 (2023).","journal-title":"Sci. Rep."},{"issue":"3","key":"928_CR12","doi-asserted-by":"publisher","first-page":"109135","DOI":"10.1016\/j.isci.2024.109135","volume":"27","author":"CL Vinhaes","year":"2024","unstructured":"Vinhaes, C. L. et al. An integrative multi-omics approach to characterize interactions between tuberculosis and diabetes mellitus. iScience 27 (3), 109135 (2024).","journal-title":"iScience"},{"issue":"5","key":"928_CR13","doi-asserted-by":"publisher","first-page":"e1004917","DOI":"10.1371\/journal.ppat.1004917","volume":"11","author":"CW Ong","year":"2015","unstructured":"Ong, C. W. et al. Neutrophil-Derived MMP-8 drives AMPK-Dependent matrix destruction in human pulmonary tuberculosis. PLoS Pathog. 11 (5), e1004917 (2015).","journal-title":"PLoS Pathog"},{"issue":"1","key":"928_CR14","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s12035-013-8538-z","volume":"49","author":"M Chaturvedi","year":"2014","unstructured":"Chaturvedi, M. & Kaczmarek, L. Mmp-9 Inhibition: a therapeutic strategy in ischemic stroke. Mol. Neurobiol. 49 (1), 563\u2013573 (2014).","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"928_CR15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1183\/09031936.00127807","volume":"33","author":"P Sheen","year":"2009","unstructured":"Sheen, P. et al. High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation. Eur. Respir J. 33 (1), 134\u2013141 (2009).","journal-title":"Eur. Respir J."},{"issue":"4","key":"928_CR16","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1165\/rcmb.2007-0011OC","volume":"37","author":"PT Elkington","year":"2007","unstructured":"Elkington, P. T. et al. Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis. Am. J. Respir Cell. Mol. Biol. 37 (4), 431\u2013437 (2007).","journal-title":"Am. J. Respir Cell. Mol. Biol."},{"issue":"6","key":"928_CR17","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1002\/bab.1434","volume":"63","author":"PR Meena","year":"2016","unstructured":"Meena, P. R. & Monu, Meena, L. S. Fibronectin binding protein and Ca2\u2009+\u2009play an access key role to mediate pathogenesis in Mycobacterium tuberculosis: an overview. Biotechnol. Appl. Biochem. 63 (6), 820\u2013826 (2016).","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"3","key":"928_CR18","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1128\/IAI.70.3.1287-1292.2002","volume":"70","author":"R Pasula","year":"2002","unstructured":"Pasula, R., Wisniowski, P. & Martin, W. J. 2 nd. Fibronectin facilitates Mycobacterium tuberculosis attachment to murine alveolar macrophages. Infect. Immun. 70 (3), 1287\u20131292 (2002).","journal-title":"Infect. Immun."},{"key":"928_CR19","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1471-2334-14-52","volume":"14","author":"C Wang","year":"2014","unstructured":"Wang, C. et al. Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis. BMC Infect. Dis. 14, 52 (2014).","journal-title":"BMC Infect. Dis."},{"issue":"9","key":"928_CR20","doi-asserted-by":"publisher","first-page":"993","DOI":"10.18632\/oncotarget.26590","volume":"10","author":"BA Teicher","year":"2019","unstructured":"Teicher, B. A. CD248: A therapeutic target in cancer and fibrotic diseases. Oncotarget 10 (9), 993\u20131009 (2019).","journal-title":"Oncotarget"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-00928-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-00928-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-00928-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T13:53:48Z","timestamp":1747317228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-00928-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["928"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-00928-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"assertion":[{"value":"30 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The studies involving human participants were reviewed and approved by the Biomedical Research Ethics Committee of Taicang First People\u2019s Hospital (Ethics Approval No. 2022-ky-050). Written informed consent to participate in this study was provided by the patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"16931"}}