{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:53:56Z","timestamp":1787003636345,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100013254","name":"the National College Students\u2019 Innovation and Entrepreneurship Training Program","doi-asserted-by":"crossref","award":["202410366025"],"award-info":[{"award-number":["202410366025"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"crossref","award":["2208085MH225"],"award-info":[{"award-number":["2208085MH225"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Foundational and Clinical Collaborative Research Project from Anhui Medical University","award":["2022xkjT026"],"award-info":[{"award-number":["2022xkjT026"]}]},{"name":"the Doctoral Research Fund Project of the First Affiliated Hospital of Anhui Medical University","award":["1545"],"award-info":[{"award-number":["1545"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-00979-3","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:35:45Z","timestamp":1746758145000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hippocampal NLRP1 inflammasome mediates anxiety-like behavior in mice with hypothyroidism"],"prefix":"10.1038","volume":"15","author":[{"given":"Yu-Wei","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Lu","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Rui","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Fa","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Xia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"979_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41572-022-00357-7","volume":"8","author":"L Chaker","year":"2022","unstructured":"Chaker, L. et al. Nat. Rev. Dis. Primers. 8. 30. https:\/\/doi.org\/10.1038\/s41572-022-00357-7 (2022).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"979_CR2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","volume":"87","author":"JG Hollowell","year":"2002","unstructured":"Hollowell, J. G. et al. T(4), and thyroid antibodies in the united States population (1988 to 1994): National health and nutrition examination survey (NHANES III). J. Clin. Endocrinol. Metab. 87, 489\u2013499. https:\/\/doi.org\/10.1210\/jcem.87.2.8182 (2002).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"979_CR3","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nrendo.2018.18","volume":"14","author":"PN Taylor","year":"2018","unstructured":"Taylor, P. N. et al. Okosieme OE global epidemiology of hyperthyroidism and hypothyroidism. Nat. Rev. Endocrinol. 14, 301\u2013316. https:\/\/doi.org\/10.1038\/nrendo.2018.18 (2018).","journal-title":"Nat. Rev. Endocrinol."},{"key":"979_CR4","doi-asserted-by":"publisher","first-page":"e064613","DOI":"10.1136\/bmjopen-2022-064613","volume":"13","author":"J Li","year":"2023","unstructured":"Li, J. et al. Diabetes epidemiological survey G prevalence and risk factors of hypothyroidism after universal salt iodisation: a large cross-sectional study from 31 provinces of China. BMJ Open. 13, e064613. https:\/\/doi.org\/10.1136\/bmjopen-2022-064613 (2023).","journal-title":"BMJ Open."},{"key":"979_CR5","doi-asserted-by":"publisher","first-page":"113495","DOI":"10.1016\/j.biopha.2022.113495","volume":"153","author":"YX Xu","year":"2022","unstructured":"Xu, Y. X. et al. Activation of cholinergic basal forebrain neurons improved cognitive functions in adult-onset hypothyroid mice. Biomed. Pharmacother. 153, 113495. https:\/\/doi.org\/10.1016\/j.biopha.2022.113495 (2022).","journal-title":"Biomed. Pharmacother."},{"key":"979_CR6","doi-asserted-by":"publisher","first-page":"7540","DOI":"10.1038\/s41598-023-34090-2","volume":"13","author":"S Liu","year":"2023","unstructured":"Liu, S., Claude, H., Yong, S. J. & Chen, D. Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada. Sci. Rep. 13, 7540. https:\/\/doi.org\/10.1038\/s41598-023-34090-2 (2023).","journal-title":"Sci. Rep."},{"key":"979_CR7","doi-asserted-by":"publisher","first-page":"27781","DOI":"10.1038\/s41598-024-77516-1","volume":"14","author":"L Meng","year":"2024","unstructured":"Meng, L. et al. Logistic regression analysis of risk factors for anxiety and depression in patients with coronary heart disease and subclinical hypothyroidism. Sci. Rep. 14, 27781. https:\/\/doi.org\/10.1038\/s41598-024-77516-1 (2024).","journal-title":"Sci. Rep."},{"key":"979_CR8","doi-asserted-by":"publisher","first-page":"bvab194","DOI":"10.1210\/jendso\/bvab194","volume":"6","author":"M Jurado-Flores","year":"2022","unstructured":"Jurado-Flores, M., Warda, F. &  Mooradian, A. Pathophysiology and clinical features of neuropsychiatric manifestations of thyroid disease. J. Endocr. Soc. 6, bvab194. https:\/\/doi.org\/10.1210\/jendso\/bvab194 (2022).","journal-title":"J. Endocr. Soc."},{"key":"979_CR9","doi-asserted-by":"publisher","first-page":"102473","DOI":"10.1016\/j.nicl.2020.102473","volume":"28","author":"B Liu","year":"2020","unstructured":"Liu, B. et al. Brain GABA\u2009+\u2009changes in primary hypothyroidism patients before and after Levothyroxine treatment: A longitudinal magnetic resonance spectroscopy study. Neuroimage Clin. 28, 102473. https:\/\/doi.org\/10.1016\/j.nicl.2020.102473 (2020).","journal-title":"Neuroimage Clin."},{"key":"979_CR10","doi-asserted-by":"publisher","unstructured":"Kubiak, K., Szmidt, M. K., Kaluza, J., Zylka, A. & Sicinska, E. Do dietary supplements affect inflammation, oxidative stress, and antioxidant status in adults with hypothyroidism or Hashimoto\u2019s disease?-A systematic review of controlled trials. Antioxid. (Basel). 12 https:\/\/doi.org\/10.3390\/antiox12101798 (2023).","DOI":"10.3390\/antiox12101798"},{"key":"979_CR11","doi-asserted-by":"publisher","first-page":"6757154","DOI":"10.1155\/2016\/6757154","volume":"2016","author":"A Mancini","year":"2016","unstructured":"Mancini, A. et al. Oxidative stress, and inflammation. Mediat. Inflamm. 2016, 6757154. https:\/\/doi.org\/10.1155\/2016\/6757154 (2016).","journal-title":"Mediat. Inflamm."},{"key":"979_CR12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3109\/08916934.2013.768617","volume":"46","author":"A Alkhateeb","year":"2013","unstructured":"Alkhateeb, A., Jarun, Y. & Tashtoush, R. Polymorphisms in NLRP1 gene and susceptibility to autoimmune thyroid disease. Autoimmunity 46, 215\u2013221. https:\/\/doi.org\/10.3109\/08916934.2013.768617 (2013).","journal-title":"Autoimmunity"},{"key":"979_CR13","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.3389\/fimmu.2018.01197","volume":"9","author":"Q Guo","year":"2018","unstructured":"Guo, Q. et al. Cytokine secretion and pyroptosis of thyroid follicular cells mediated by enhanced NLRP3, NLRP1, NLRC4, and AIM2 inflammasomes are associated with autoimmune thyroiditis. Front. Immunol. 9, 1197. https:\/\/doi.org\/10.3389\/fimmu.2018.01197 (2018).","journal-title":"Front. Immunol."},{"key":"979_CR14","doi-asserted-by":"publisher","first-page":"7393","DOI":"10.1038\/s41380-021-01188-w","volume":"26","author":"Y Milaneschi","year":"2021","unstructured":"Milaneschi, Y. et al. Khandaker GM association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK biobank and NESDA cohorts. Mol. Psychiatry. 26, 7393\u20137402. https:\/\/doi.org\/10.1038\/s41380-021-01188-w (2021).","journal-title":"Mol. Psychiatry"},{"key":"979_CR15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41398-022-02297-y","volume":"13","author":"B Guo","year":"2023","unstructured":"Guo, B. et al. Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression. Transl. Psychiatry. 13, 5. https:\/\/doi.org\/10.1038\/s41398-022-02297-y (2023).","journal-title":"Transl. Psychiatry"},{"key":"979_CR16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41392-023-01687-y","volume":"9","author":"J Yao","year":"2024","unstructured":"Yao, J., Sterling, K., Wang, Z., Zhang, Y. & Song, W. The role of inflammasomes in human diseases and their potential as therapeutic targets. Signal. Transduct. Target. Ther. 9, 10. https:\/\/doi.org\/10.1038\/s41392-023-01687-y (2024).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"979_CR17","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41421-020-0167-x","volume":"6","author":"D Zheng","year":"2020","unstructured":"Zheng, D., Liwinski, T. & Elinav, E. Inflammasome activation and regulation: toward a better Understanding of complex mechanisms. Cell. Discov. 6, 36. https:\/\/doi.org\/10.1038\/s41421-020-0167-x (2020).","journal-title":"Cell. Discov."},{"key":"979_CR18","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nm.3893","volume":"21","author":"H Guo","year":"2015","unstructured":"Guo, H., Callaway, J. B. & Ting, J. P. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21, 677\u2013687. https:\/\/doi.org\/10.1038\/nm.3893 (2015).","journal-title":"Nat. Med."},{"key":"979_CR19","doi-asserted-by":"publisher","first-page":"111023","DOI":"10.1016\/j.intimp.2023.111023","volume":"124","author":"M Liu","year":"2023","unstructured":"Liu, M. et al. The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice. Int. Immunopharmacol. 124, 111023. https:\/\/doi.org\/10.1016\/j.intimp.2023.111023 (2023).","journal-title":"Int. Immunopharmacol."},{"key":"979_CR20","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12974-020-01848-8","volume":"17","author":"AQ Song","year":"2020","unstructured":"Song, A. Q. et al. WN NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice. J. Neuroinflamm. 17, 178. https:\/\/doi.org\/10.1186\/s12974-020-01848-8 (2020).","journal-title":"J. Neuroinflamm."},{"key":"979_CR21","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3389\/fnhum.2019.00242","volume":"13","author":"Y Zhu","year":"2019","unstructured":"Zhu, Y. et al. Emotion regulation of Hippocampus using Real-Time fMRI neurofeedback in healthy human. Front. Hum. Neurosci. 13, 242. https:\/\/doi.org\/10.3389\/fnhum.2019.00242 (2019).","journal-title":"Front. Hum. Neurosci."},{"key":"979_CR22","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1089\/thy.2013.0058","volume":"24","author":"GE Cooke","year":"2014","unstructured":"Cooke, G. E., Mullally, S., Correia, N., O\u2019Mara, S. M. & Gibney, J. Hippocampal volume is decreased in adults with hypothyroidism. Thyroid. 24, 433\u2013440. https:\/\/doi.org\/10.1089\/thy.2013.0058 (2014).","journal-title":"Thyroid"},{"key":"979_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.vh.2021.10.001","volume":"118","author":"D Kapri","year":"2022","unstructured":"Kapri, D., Fanibunda, S. E. & Vaidya, V. A. Thyroid hormone regulation of adult hippocampal neurogenesis: putative molecular and cellular mechanisms. Vitam. Horm. 118, 1\u201333. https:\/\/doi.org\/10.1016\/bs.vh.2021.10.001 (2022).","journal-title":"Vitam. Horm."},{"key":"979_CR24","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1210\/clinem\/dgae070","volume":"109","author":"T Zhang","year":"2024","unstructured":"Zhang, T. et al. Structural and functional alterations of hippocampal subfields in patients with adult-onset primary hypothyroidism. J. Clin. Endocrinol. Metab. 109, 1707\u20131717. https:\/\/doi.org\/10.1210\/clinem\/dgae070 (2024).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"979_CR25","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s11011-010-9208-8","volume":"25","author":"C Koromilas","year":"2010","unstructured":"Koromilas, C. et al. Structural and functional alterations in the hippocampus due to hypothyroidism. Metab. Brain Dis. 25, 339\u2013354. https:\/\/doi.org\/10.1007\/s11011-010-9208-8 (2010).","journal-title":"Metab. Brain Dis."},{"key":"979_CR26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neuroscience.2019.05.025","volume":"412","author":"Q Li","year":"2019","unstructured":"Li, Q. et al. Hippocampal PKR\/NLRP1 inflammasome pathway is required for the Depression-Like behaviors in rats with neuropathic pain. Neuroscience 412, 16\u201328. https:\/\/doi.org\/10.1016\/j.neuroscience.2019.05.025 (2019).","journal-title":"Neuroscience"},{"key":"979_CR27","doi-asserted-by":"publisher","unstructured":"Shen, Y. et al. The significance of NLRP inflammasome in neuropsychiatric disorders. Brain Sci. 12 https:\/\/doi.org\/10.3390\/brainsci12081057 (2022).","DOI":"10.3390\/brainsci12081057"},{"key":"979_CR28","doi-asserted-by":"publisher","first-page":"769","DOI":"10.4149\/BLL_2019_129","volume":"120","author":"GR Mahmoudiasl","year":"2019","unstructured":"Mahmoudiasl, G. R. et al. Nod-like receptor protein 3 and nod-like receptor protein 1 inflammasome activation in the hippocampal region of postmortem methamphetamine chronic user. Bratisl Lek Listy. 120, 769\u2013776. https:\/\/doi.org\/10.4149\/BLL_2019_129 (2019).","journal-title":"Bratisl Lek Listy"},{"key":"979_CR29","doi-asserted-by":"publisher","first-page":"468","DOI":"10.4103\/2230-8210.183476","volume":"20","author":"M Bathla","year":"2016","unstructured":"Bathla, M., Singh, M. & Relan, P. Prevalence of anxiety and depressive symptoms among patients with hypothyroidism. Indian J. Endocrinol. Metab. 20, 468\u2013474. https:\/\/doi.org\/10.4103\/2230-8210.183476 (2016).","journal-title":"Indian J. Endocrinol. Metab."},{"key":"979_CR30","doi-asserted-by":"publisher","first-page":"110027","DOI":"10.1016\/j.pnpbp.2020.110027","volume":"105","author":"S Lai","year":"2021","unstructured":"Lai, S. et al. Association of altered thyroid hormones and neurometabolism to cognitive dysfunction in unmedicated bipolar II depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 105, 110027. https:\/\/doi.org\/10.1016\/j.pnpbp.2020.110027 (2021).","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"979_CR31","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1001\/jamainternmed.2021.5078","volume":"181","author":"NA van Vliet","year":"2021","unstructured":"van Vliet, N. A. et al. Association of thyroid dysfunction with cognitive function: an individual participant data analysis. JAMA Intern. Med. 181, 1440\u20131450. https:\/\/doi.org\/10.1001\/jamainternmed.2021.5078 (2021).","journal-title":"JAMA Intern. Med."},{"key":"979_CR32","doi-asserted-by":"publisher","first-page":"4533","DOI":"10.1210\/jc.2018-01361","volume":"103","author":"EA McAninch","year":"2018","unstructured":"McAninch, E. A., Rajan, K. B., Miller, C. H. & Bianco, A. C. Systemic thyroid hormone status during Levothyroxine therapy in hypothyroidism: A systematic review and Meta-Analysis. J. Clin. Endocrinol. Metab. 103, 4533\u20134542. https:\/\/doi.org\/10.1210\/jc.2018-01361 (2018).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"979_CR33","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.eprac.2021.12.003","volume":"28","author":"MD Ettleson","year":"2022","unstructured":"Ettleson, M. D. et al. Bianco AC brain fog in hypothyroidism: Understanding the patient\u2019s perspective. Endocr. Pract. 28, 257\u2013264. https:\/\/doi.org\/10.1016\/j.eprac.2021.12.003 (2022).","journal-title":"Endocr. Pract."},{"key":"979_CR34","doi-asserted-by":"publisher","first-page":"181","DOI":"10.31887\/DCNS.2017.19.2\/wcarlezon","volume":"19","author":"KR Lezak","year":"2017","unstructured":"Lezak, K. R., Missig, G. & Carlezon, W. A. Jr. Behavioral methods to study anxiety in rodents. Dialog. Clin. Neurosci. 19, 181\u2013191. https:\/\/doi.org\/10.31887\/DCNS.2017.19.2\/wcarlezon (2017).","journal-title":"Dialogues Clin. Neurosci."},{"key":"979_CR35","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.bbr.2017.10.016","volume":"352","author":"J Harro","year":"2018","unstructured":"Harro, J. Animals, anxiety, and anxiety disorders: how to measure anxiety in rodents and why. Behav. Brain Res. 352, 81\u201393. https:\/\/doi.org\/10.1016\/j.bbr.2017.10.016 (2018).","journal-title":"Behav. Brain Res."},{"key":"979_CR36","doi-asserted-by":"publisher","first-page":"261","DOI":"10.9758\/cpn.2019.17.2.261","volume":"17","author":"F Aricioglu","year":"2019","unstructured":"Aricioglu, F. et al. Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats. Clin. Psychopharmacol. Neurosci. 17, 261\u2013272. https:\/\/doi.org\/10.9758\/cpn.2019.17.2.261 (2019).","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"979_CR37","doi-asserted-by":"publisher","unstructured":"Song, A. et al. The role and mechanism of Hyperoside against Depression-like behavior in mice via the NLRP1 inflammasome. Med. (Kaunas). 58. https:\/\/doi.org\/10.3390\/medicina58121749 (2022).","DOI":"10.3390\/medicina58121749"},{"key":"979_CR38","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12974-023-02995-4","volume":"21","author":"YJ Zhu","year":"2024","unstructured":"Zhu, Y. J. et al. Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice. J. Neuroinflamm. 21, 6. https:\/\/doi.org\/10.1186\/s12974-023-02995-4 (2024).","journal-title":"J. Neuroinflamm."},{"key":"979_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2022.07.010","author":"N Kuga","year":"2022","unstructured":"Kuga, N. & Sasaki, T. Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility. Neurosci. Res. https:\/\/doi.org\/10.1016\/j.neures.2022.07.010 (2022).","journal-title":"Neurosci. Res."},{"key":"979_CR40","doi-asserted-by":"publisher","unstructured":"Rovet, J. F. Targeting the Manifestations of Subclinical and Overt Hypothyroidism Within the Hippocampus. J. Clin. Endocrinol. Metab. 109, e1950-e (1954). https:\/\/doi.org\/10.1210\/clinem\/dgae453 (2024).","DOI":"10.1210\/clinem\/dgae453"},{"key":"979_CR41","doi-asserted-by":"publisher","first-page":"115245","DOI":"10.1016\/j.biopha.2023.115245","volume":"165","author":"LI Alotayk","year":"2023","unstructured":"Alotayk, L. I., Aldubayan, M. A., Alenezi, S. K., Anwar, M. J. & Alhowail, A. H. Comparative evaluation of doxorubicin, cyclophosphamide, 5-fluorouracil, and cisplatin on cognitive dysfunction in rats: delineating the role of inflammation of hippocampal neurons and hypothyroidism. Biomed. Pharmacother. 165, 115245. https:\/\/doi.org\/10.1016\/j.biopha.2023.115245 (2023).","journal-title":"Biomed. Pharmacother."},{"key":"979_CR42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuro.2016.12.009","volume":"59","author":"ME Gilbert","year":"2017","unstructured":"Gilbert, M. E., Goodman, J. H., Gomez, J., Johnstone, A. F. M. & Ramos, R. L. Adult hippocampal neurogenesis is impaired by transient and moderate developmental thyroid hormone disruption. Neurotoxicology. 59, 9\u201321. https:\/\/doi.org\/10.1016\/j.neuro.2016.12.009 (2017).","journal-title":"Neurotoxicology"},{"key":"979_CR43","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.1038\/s41598-019-40249-7","volume":"9","author":"KL O\u2019Shaughnessy","year":"2019","unstructured":"O\u2019Shaughnessy, K. L., Thomas, S. E., Spring, S. R., Ford, J. L. & Ford, R. L. Gilbert ME A transient window of hypothyroidism alters neural progenitor cells and results in abnormal brain development. Sci. Rep. 9, 4662. https:\/\/doi.org\/10.1038\/s41598-019-40249-7 (2019).","journal-title":"Sci. Rep."},{"key":"979_CR44","doi-asserted-by":"publisher","first-page":"e13453","DOI":"10.1111\/jne.13453","volume":"36","author":"D Kapri","year":"2024","unstructured":"Kapri, D., Pradhan, A., Vuruputuri, R. M. & Vaidya, V. A. Sex differences in the influence of adult-onset hypothyroidism on hippocampal progenitor survival and neuronal differentiation in mice. J. Neuroendocrinol. 36, e13453. https:\/\/doi.org\/10.1111\/jne.13453 (2024).","journal-title":"J. Neuroendocrinol."},{"key":"979_CR45","doi-asserted-by":"publisher","unstructured":"Li, M., Long, C. & Yang, L. Hippocampal-prefrontal circuit and disrupted functional connectivity in psychiatric and neurodegenerative disorders. Biomed. Res. Int. 2015, 810548. https:\/\/doi.org\/10.1155\/2015\/810548 (2015).","DOI":"10.1155\/2015\/810548"},{"key":"979_CR46","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cortex.2021.11.014","volume":"147","author":"Q Ma","year":"2022","unstructured":"Ma, Q., Rolls, E. T., Huang, C. C., Cheng, W. & Feng, J. Extensive cortical functional connectivity of the human hippocampal memory system. Cortex. 147, 83\u2013101. https:\/\/doi.org\/10.1016\/j.cortex.2021.11.014 (2022).","journal-title":"Cortex"},{"key":"979_CR47","doi-asserted-by":"publisher","first-page":"e3000411","DOI":"10.1371\/journal.pbio.3000411","volume":"18","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert, N. et al. Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol. 18, e3000411. https:\/\/doi.org\/10.1371\/journal.pbio.3000411 (2020).","journal-title":"PLoS Biol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-00979-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-00979-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-00979-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:35:47Z","timestamp":1746758147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-00979-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["979"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-00979-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"assertion":[{"value":"27 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All procedures involving animals were performed in accordance with the ARRIVE guidelines 2.0 and were approved by Anhui Medical University\u2019s Animal Care and Use Committee (LLSC: 20220741).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"16176"}}