{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:50:48Z","timestamp":1782240648673,"version":"3.54.5"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Shanxi Provincial Basic Research Program","award":["202203021212361"],"award-info":[{"award-number":["202203021212361"]}]},{"name":"the Shanxi Provincial Basic Research Program","award":["202303021221132"],"award-info":[{"award-number":["202303021221132"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82372009"],"award-info":[{"award-number":["No. 82372009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Shanxi Provincial Academic Committee","award":["No. 2024-147"],"award-info":[{"award-number":["No. 2024-147"]}]},{"name":"the Shanxi Provincial Scientific and Technological Innovation Teams","award":["202304051001017"],"award-info":[{"award-number":["202304051001017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-01596-w","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T12:19:31Z","timestamp":1751372371000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic evidence suggests a causal relationship linking thyroid function to prospective memory and dementia and Parkinson\u2019s disease"],"prefix":"10.1038","volume":"15","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"1596_CR1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1037\/0278-7393.16.4.717","volume":"16","author":"O Gilles","year":"1990","unstructured":"Gilles, O. & Einstein, M. A. M. Normal aging and prospective memory. J. Experimental Psychology: Learn. Memory Cognition. 16, 717\u2013726. https:\/\/doi.org\/10.1037\/0278-7393.16.4.717 (1990).","journal-title":"J. Experimental Psychology: Learn. Memory Cognition"},{"key":"1596_CR2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3758\/s13421-020-01100-x","volume":"49","author":"TC Toppino","year":"2021","unstructured":"Toppino, T. C. & Pagano, M. J. Metacognitive control over the distribution of retrieval practice with and without feedback and the efficacy of learners\u2019 spacing choices. Mem. Cognit. 49, 467\u2013479. https:\/\/doi.org\/10.3758\/s13421-020-01100-x (2021).","journal-title":"Mem. Cognit."},{"key":"1596_CR3","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1093\/ije\/dyz121","volume":"48","author":"H Zhou","year":"2019","unstructured":"Zhou, H. et al. Education and lung cancer: a Mendelian randomization study. Int. J. Epidemiol. 48, 743\u2013750. https:\/\/doi.org\/10.1093\/ije\/dyz121 (2019).","journal-title":"Int. J. Epidemiol."},{"key":"1596_CR4","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1093\/geronb\/gbad027","volume":"78","author":"CA Browning","year":"2023","unstructured":"Browning, C. A. et al. Prospective memory function predicts future cognitive decline and incident dementia. J. Gerontol. B-Psychol. 78, 819\u2013829. https:\/\/doi.org\/10.1093\/geronb\/gbad027 (2023).","journal-title":"J. Gerontol. B-Psychol"},{"key":"1596_CR5","doi-asserted-by":"publisher","first-page":"e100054","DOI":"10.1136\/gpsych-2019-100054","volume":"32","author":"JMA Maclin","year":"2019","unstructured":"Maclin, J. M. A., Wang, T. & Xiao, S. Biomarkers for the diagnosis of Alzheimer\u2019s disease, dementia lewy body, frontotemporal dementia and vascular dementia. Gen. Psychiatry. 32, e100054. https:\/\/doi.org\/10.1136\/gpsych-2019-100054 (2019).","journal-title":"Gen. Psychiatry"},{"key":"1596_CR6","doi-asserted-by":"publisher","first-page":"14140","DOI":"10.1038\/s41598-022-17643-9","volume":"12","author":"IE van Zeggeren","year":"2022","unstructured":"van Zeggeren, I. E. et al. Neurofilament light chain in central nervous system infections: a prospective study of diagnostic accuracy. Sci. Rep. 12, 14140. https:\/\/doi.org\/10.1038\/s41598-022-17643-9 (2022).","journal-title":"Sci. Rep."},{"key":"1596_CR7","doi-asserted-by":"publisher","first-page":"22143","DOI":"10.1038\/s41598-021-01391-3","volume":"11","author":"DR Grimes","year":"2021","unstructured":"Grimes, D. R. & Heathers, J. Association between magnetic field exposure and miscarriage risk is not supported by the data. Sci. Rep. 11, 22143. https:\/\/doi.org\/10.1038\/s41598-021-01391-3 (2021).","journal-title":"Sci. Rep."},{"key":"1596_CR8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","volume":"89","author":"IG McKeith","year":"2017","unstructured":"McKeith, I. G. et al. Diagnosis and management of dementia with lewy bodies. Neurology 89, 88\u2013100. https:\/\/doi.org\/10.1212\/WNL.0000000000004058 (2017).","journal-title":"Neurology"},{"key":"1596_CR9","doi-asserted-by":"publisher","first-page":"1137584","DOI":"10.3389\/fnagi.2023.1137584","volume":"15","author":"LY Ma","year":"2023","unstructured":"Ma, L. Y. et al. Association of thyroid disease with risks of dementia and cognitive impairment: A meta-analysis and systematic review. Front. Aging Neurosci. 15, 1137584. https:\/\/doi.org\/10.3389\/fnagi.2023.1137584 (2023).","journal-title":"Front. Aging Neurosci."},{"key":"1596_CR10","doi-asserted-by":"publisher","first-page":"276","DOI":"10.14283\/jpad.2023.20","volume":"10","author":"A Salehipour","year":"2023","unstructured":"Salehipour, A., Dolatshahi, M., Haghshomar, M. & Amin, J. The role of thyroid dysfunction in Alzheimer\u2019s disease: A systematic review and Meta-Analysis. J. Prev. Alzheimer\u2019s Disease. 10, 276\u2013286. https:\/\/doi.org\/10.14283\/jpad.2023.20 (2023).","journal-title":"J. Prev. Alzheimer\u2019s Disease"},{"key":"1596_CR11","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1089\/thy.2021.0321","volume":"31","author":"E Marouli","year":"2021","unstructured":"Marouli, E. et al. Thyroid function and the risk of Alzheimer\u2019s disease: A Mendelian randomization study. Thyroid 31, 1794\u20131799. https:\/\/doi.org\/10.1089\/thy.2021.0321 (2021).","journal-title":"Thyroid"},{"key":"1596_CR12","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1001\/jamainternmed.2021.5078","volume":"181","author":"NA van Vliet","year":"2021","unstructured":"van Vliet, N. A. et al. Association of thyroid dysfunction with cognitive function. JAMA Intern. Med. 181, 1440\u20131450. https:\/\/doi.org\/10.1001\/jamainternmed.2021.5078 (2021).","journal-title":"JAMA Intern. Med."},{"key":"1596_CR13","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1016\/j.psyneuen.2009.05.016","volume":"34","author":"\u00c5 Livner","year":"2009","unstructured":"Livner, \u00c5., Wahlin, \u00c5. & B\u00e4ckman, L. Thyroid stimulating hormone and prospective memory functioning in old age. Psychoneuroendocrinology 34, 1554\u20131559. https:\/\/doi.org\/10.1016\/j.psyneuen.2009.05.016 (2009).","journal-title":"Psychoneuroendocrinology"},{"key":"1596_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ije\/dyg070","volume":"32","author":"G Davey Smith","year":"2003","unstructured":"Davey Smith, G. & Ebrahim, S. Mendelian randomization\u2019: can genetic epidemiology contribute to Understanding environmental determinants of disease?*. Int. J. Epidemiol. 32, 1\u201322. https:\/\/doi.org\/10.1093\/ije\/dyg070 (2003).","journal-title":"Int. J. Epidemiol."},{"key":"1596_CR15","doi-asserted-by":"publisher","unstructured":"Richmond, R. C. & Smith, G. D. Mendelian randomization: concepts and scope. Cold Spring Harbor Perspect. Med. 12 https:\/\/doi.org\/10.1101\/cshperspect.a040501 (2022).","DOI":"10.1101\/cshperspect.a040501"},{"key":"1596_CR16","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1161\/Circulationaha.122.060700","volume":"146","author":"L Gaziano","year":"2022","unstructured":"Gaziano, L. et al. Mild-to-Moderate kidney dysfunction and cardiovascular disease: observational and Mendelian randomization analyses. Circulation 146, 1507\u20131517. https:\/\/doi.org\/10.1161\/Circulationaha.122.060700 (2022).","journal-title":"Circulation"},{"key":"1596_CR17","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s40471-017-0128-6","volume":"4","author":"J Zheng","year":"2017","unstructured":"Zheng, J. et al. Recent developments in Mendelian randomization studies. Curr. Epidemiol. Rep. 4, 330\u2013345. https:\/\/doi.org\/10.1007\/s40471-017-0128-6 (2017).","journal-title":"Curr. Epidemiol. Rep."},{"key":"1596_CR18","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova, V. W. et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement. Jama-Journal Am. Med. Association. 326, 1614\u20131621. https:\/\/doi.org\/10.1001\/jama.2021.18236 (2021).","journal-title":"Jama-Journal Am. Med. Association"},{"key":"1596_CR19","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/s41467-024-44701-9","volume":"15","author":"RBTM Sterenborg","year":"2024","unstructured":"Sterenborg, R. B. T. M. et al. Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications. Nat. Commun. 15, 888. https:\/\/doi.org\/10.1038\/s41467-024-44701-9 (2024).","journal-title":"Nat. Commun."},{"key":"1596_CR20","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"S Burgess","year":"2011","unstructured":"Burgess, S., Thompson, S. G. & Collaboration, C. C. G. Avoiding bias from weak instruments in Mendelian randomization studies. Int. J. Epidemiol. 40, 755\u2013764. https:\/\/doi.org\/10.1093\/ije\/dyr036 (2011).","journal-title":"Int. J. Epidemiol."},{"key":"1596_CR21","doi-asserted-by":"publisher","first-page":"n2233","DOI":"10.1136\/bmj.n2233","volume":"375","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova, V. W. et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomisation (STROBE-MR): explanation and elaboration. BMJ 375, n2233. https:\/\/doi.org\/10.1136\/bmj.n2233 (2021).","journal-title":"BMJ"},{"key":"1596_CR22","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/gepi.21758","volume":"37","author":"S Burgess","year":"2013","unstructured":"Burgess, S., Butterworth, A. & Thompson, S. G. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet. Epidemiol. 37, 658\u2013665. https:\/\/doi.org\/10.1002\/gepi.21758 (2013).","journal-title":"Genet. Epidemiol."},{"key":"1596_CR23","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/Ede.0000000000000559","volume":"28","author":"S Burgess","year":"2017","unstructured":"Burgess, S., Bowden, J., Fall, T., Ingelsson, E. & Thompson, S. G. Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants. Epidemiology 28, 30\u201342. https:\/\/doi.org\/10.1097\/Ede.0000000000000559 (2017).","journal-title":"Epidemiology"},{"key":"1596_CR24","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1093\/ije\/dyx191","volume":"46","author":"EAW Slob","year":"2017","unstructured":"Slob, E. A. W., Groenen, P. J. F., Thurik, A. R. & Rietveld, C. A. A note on the use of Egger regression in Mendelian randomization studies. Int. J. Epidemiol. 46, 2094\u20132097. https:\/\/doi.org\/10.1093\/ije\/dyx191 (2017).","journal-title":"Int. J. Epidemiol."},{"key":"1596_CR25","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1093\/ije\/dyx034","volume":"46","author":"OO Yavorska","year":"2017","unstructured":"Yavorska, O. O. & Burgess, S. MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data. Int. J. Epidemiol. 46, 1734\u20131739. https:\/\/doi.org\/10.1093\/ije\/dyx034 (2017).","journal-title":"Int. J. Epidemiol."},{"key":"1596_CR26","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1080\/14767058.2019.1586875","volume":"33","author":"A Eerdekens","year":"2019","unstructured":"Eerdekens, A. et al. The placenta in fetal thyroid hormone delivery: from normal physiology to adaptive mechanisms in complicated pregnancies. J. Maternal-Fetal Neonatal Med. 33, 3857\u20133866. https:\/\/doi.org\/10.1080\/14767058.2019.1586875 (2019).","journal-title":"J. Maternal-Fetal Neonatal Med."},{"key":"1596_CR27","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.ajem.2018.08.076","volume":"37","author":"M Apostol","year":"2019","unstructured":"Apostol, M. et al. Thyroid stimulating hormone testing in ED evaluation of patients with atrial fibrillation and various psychiatric diagnoses. Am. J. Emerg. Med. 37, 1114\u20131117. https:\/\/doi.org\/10.1016\/j.ajem.2018.08.076 (2019).","journal-title":"Am. J. Emerg. Med."},{"key":"1596_CR28","doi-asserted-by":"publisher","unstructured":"Remaud, S., Gothi\u00e9, J. D., Morvan-Dubois, G. & Demeneix, B. A. Thyroid hormone signaling and adult neurogenesis in mammals. Front. Endocrinol. 5 https:\/\/doi.org\/10.3389\/fendo.2014.00062 (2014).","DOI":"10.3389\/fendo.2014.00062"},{"key":"1596_CR29","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.ecl.2014.02.006","volume":"43","author":"MH Samuels","year":"2014","unstructured":"Samuels, M. H. Thyroid disease and cognition. Endocrinol. Metab. Clin. North Am. 43, 529\u2013543. https:\/\/doi.org\/10.1016\/j.ecl.2014.02.006 (2014).","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"1596_CR30","doi-asserted-by":"publisher","first-page":"4527","DOI":"10.1007\/s00213-014-3595-1","volume":"231","author":"JPR Jacobsen","year":"2014","unstructured":"Jacobsen, J. P. R. et al. The interaction of Escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse. Psychopharmacology 231, 4527\u20134540. https:\/\/doi.org\/10.1007\/s00213-014-3595-1 (2014).","journal-title":"Psychopharmacology"},{"key":"1596_CR31","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s11011-010-9208-8","volume":"25","author":"C Koromilas","year":"2010","unstructured":"Koromilas, C. et al. Structural and functional alterations in the hippocampus due to hypothyroidism. Metab. Brain Dis. 25, 339\u2013354. https:\/\/doi.org\/10.1007\/s11011-010-9208-8 (2010).","journal-title":"Metab. Brain Dis."},{"key":"1596_CR32","doi-asserted-by":"publisher","unstructured":"Lauffer, P., Zwaveling-Soonawala, N., Naafs, J. C., Boelen, A. & van Trotsenburg, A. S. P. Diagnosis and management of central congenital hypothyroidism. Front. Endocrinol. 12 https:\/\/doi.org\/10.3389\/fendo.2021.686317 (2021).","DOI":"10.3389\/fendo.2021.686317"},{"key":"1596_CR33","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ijrobp.2023.03.044","volume":"117","author":"CL Rogers","year":"2023","unstructured":"Rogers, C. L. et al. Low-Dose whole brain radiation therapy for Alzheimer\u2019s dementia: results from a pilot trial in humans. Int. J. Radiat. Oncol. Biol. Phys. 117, 87\u201395. https:\/\/doi.org\/10.1016\/j.ijrobp.2023.03.044 (2023).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"1596_CR34","doi-asserted-by":"publisher","first-page":"82","DOI":"10.14740\/jem588","volume":"9","author":"KM George","year":"2019","unstructured":"George, K. M. et al. Association between thyroid dysfunction and incident dementia in the atherosclerosis risk in communities neurocognitive study. J. Endocrinol. Metabolism. 9, 82\u201389. https:\/\/doi.org\/10.14740\/jem588 (2019).","journal-title":"J. Endocrinol. Metabolism"},{"key":"1596_CR35","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1212\/Wnl.0000000000003227","volume":"87","author":"L Chaker","year":"2016","unstructured":"Chaker, L. et al. Thyroid function and the risk of dementia the Rotterdam study. Neurology 87, 1688\u20131695. https:\/\/doi.org\/10.1212\/Wnl.0000000000003227 (2016).","journal-title":"Neurology"},{"key":"1596_CR36","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev-med-060622-101007","volume":"75","author":"AC Bianco","year":"2024","unstructured":"Bianco, A. C. Emerging therapies in hypothyroidism. Annu. Rev. Med. 75, 307\u2013319. https:\/\/doi.org\/10.1146\/annurev-med-060622-101007 (2024).","journal-title":"Annu. Rev. Med."},{"key":"1596_CR37","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00401-016-1641-2","volume":"132","author":"PT Nelson","year":"2016","unstructured":"Nelson, P. T. et al. Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging. Acta Neuropathol. 132, 841\u2013858. https:\/\/doi.org\/10.1007\/s00401-016-1641-2 (2016).","journal-title":"Acta Neuropathol."},{"key":"1596_CR38","doi-asserted-by":"publisher","unstructured":"Akintola, A. A. et al. Subclinical hypothyroidism and cognitive function in people over 60 years: a systematic review and meta-analysis. Front. Aging Neurosci. 7 https:\/\/doi.org\/10.3389\/fnagi.2015.00150 (2015).","DOI":"10.3389\/fnagi.2015.00150"},{"key":"1596_CR39","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1089\/thy.2019.0672","volume":"30","author":"L Folkestad","year":"2020","unstructured":"Folkestad, L., Brandt, F., Lillevang-Johansen, M., Brix, T. H. & Heged\u00fcs, L. Graves\u2019 disease and toxic nodular goiter, aggravated by duration of hyperthyroidism, are associated with Alzheimer\u2019s and vascular dementia: A Registry-Based Long-Term Follow-Up of two large cohorts. Thyroid 30, 672\u2013680. https:\/\/doi.org\/10.1089\/thy.2019.0672 (2020).","journal-title":"Thyroid"},{"key":"1596_CR40","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/j.ejrad.2014.07.003","volume":"83","author":"W Zhang","year":"2014","unstructured":"Zhang, W. et al. Disrupted functional connectivity of the hippocampus in patients with hyperthyroidism: evidence from resting-state fMRI. Eur. J. Radiol. 83, 1907\u20131913. https:\/\/doi.org\/10.1016\/j.ejrad.2014.07.003 (2014).","journal-title":"Eur. J. Radiol."},{"key":"1596_CR41","doi-asserted-by":"publisher","first-page":"13548","DOI":"10.1038\/s41598-019-49795-6","volume":"9","author":"S Seddighi","year":"2019","unstructured":"Seddighi, S., Houck, A. L., Rowe, J. B. & Pharoah, P. D. P. Evidence of a causal association between Cancer and Alzheimer\u2019s disease: a Mendelian randomization analysis. Sci. Rep. 9, 13548. https:\/\/doi.org\/10.1038\/s41598-019-49795-6 (2019).","journal-title":"Sci. Rep."},{"key":"1596_CR42","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1186\/s12967-023-04357-3","volume":"21","author":"Z Dong","year":"2023","unstructured":"Dong, Z., Xu, M., Sun, X. & Wang, X. Mendelian randomization and transcriptomic analysis reveal an inverse causal relationship between Alzheimer\u2019s disease and cancer. J. Translational Med. 21, 527. https:\/\/doi.org\/10.1186\/s12967-023-04357-3 (2023).","journal-title":"J. Translational Med."},{"key":"1596_CR43","doi-asserted-by":"publisher","unstructured":"Li, R., Peng, L., Deng, D., Li, G. & Wu, S. Causal relationship between Alzheimer\u2019s disease and prostate cancer: a bidirectional Mendelian randomization analysis. Front. Endocrinol. 15 https:\/\/doi.org\/10.3389\/fendo.2024.1354528 (2024).","DOI":"10.3389\/fendo.2024.1354528"},{"key":"1596_CR44","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1007\/s12149-024-01963-z","volume":"38","author":"X Dai","year":"2024","unstructured":"Dai, X. et al. Advances in the selection and timing of postoperative radioiodine treatment in patients with differentiated thyroid carcinoma. Ann. Nucl. Med. 38, 688\u2013699. https:\/\/doi.org\/10.1007\/s12149-024-01963-z (2024).","journal-title":"Ann. Nucl. Med."},{"key":"1596_CR45","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3233\/jad-190984","volume":"74","author":"K Ceyz\u00e9riat","year":"2020","unstructured":"Ceyz\u00e9riat, K. et al. Low-Dose radiation therapy: A new treatment strategy for Alzheimer\u2019s disease?? J. Alzheimers Dis. 74, 411\u2013419. https:\/\/doi.org\/10.3233\/jad-190984 (2020).","journal-title":"J. Alzheimers Dis."},{"key":"1596_CR46","doi-asserted-by":"crossref","unstructured":"Bevelacqua, J. J. & Mortazavi, S. M. J. Alzheimer \u2018s Disease: Possible Mechanisms Behind Neurohormesis Induced by Exposure to Low Doses of Ionizing Radiation, < (2018). http:\/\/europepmc.org\/abstract\/MED\/29951441","DOI":"10.31661\/jbpe.v8i2.919"},{"key":"1596_CR47","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1200\/jco.2006.09.2536","volume":"25","author":"J Li","year":"2007","unstructured":"Li, J., Bentzen, S. M., Renschler, M. & Mehta, M. P. Regression after Whole-Brain radiation therapy for brain metastases correlates with survival and improved neurocognitive function. J. Clin. Oncol. 25, 1260\u20131266. https:\/\/doi.org\/10.1200\/jco.2006.09.2536 (2007).","journal-title":"J. Clin. Oncol."},{"key":"1596_CR48","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/s0140-6736(17)30703-1","volume":"390","author":"L Chaker","year":"2017","unstructured":"Chaker, L., Bianco, A. C., Jonklaas, J., Peeters, R. P. & Hypothyroidism Lancet 390, 1550\u20131562, doi:https:\/\/doi.org\/10.1016\/s0140-6736(17)30703-1 (2017).","journal-title":"Lancet"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01596-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01596-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01596-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T12:19:32Z","timestamp":1751372372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01596-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1596"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-01596-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"12 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20425"}}