{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T21:50:51Z","timestamp":1759614651894,"version":"3.40.5"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82370173"],"award-info":[{"award-number":["82370173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-01730-8","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T03:42:30Z","timestamp":1747366950000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A novel LncRNA risk model for disulfidptosis-related prognosis prediction and response to chemotherapy in acute myeloid leukemia"],"prefix":"10.1038","volume":"15","author":[{"given":"Yihong","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hexiao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Can","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wancheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoxin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"1730_CR1","unstructured":"SEER. Acute Myeloid Leukemia\u2014Cancer Stat Facts. Available from: https:\/\/seer.cancer.gov\/statfacts\/html\/amyl.html"},{"issue":"1","key":"1730_CR2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3324\/haematol.2020.260331","volume":"107","author":"BZ Carter","year":"2022","unstructured":"Carter, B. Z. et al. Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and resensitizes acute myeloid leukemia to BCL-2 Inhibition. Haematologica 107(1), 58\u201376 (2022).","journal-title":"Haematologica"},{"issue":"24","key":"1730_CR3","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1182\/blood.2021014241","volume":"140","author":"M Janssen","year":"2022","unstructured":"Janssen, M. et al. Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1. Blood 140(24), 2594\u20132610 (2022).","journal-title":"Blood"},{"issue":"8","key":"1730_CR4","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1080\/14737140.2019.1652095","volume":"19","author":"RM Shallis","year":"2019","unstructured":"Shallis, R. M., Bewersdorf, J. P., Boddu, P. C. & Zeidan, A. M. Hedgehog pathway inhibition as a therapeutic target in acute myeloid leukemia. Expert Rev. Anticancer Ther. 19(8), 717\u2013729 (2019).","journal-title":"Expert Rev. Anticancer Ther."},{"issue":"9","key":"1730_CR5","first-page":"e44802","volume":"15","author":"AV Tangella","year":"2023","unstructured":"Tangella, A. V., Gajre, A. & Kantheti, V. V. Isocitrate dehydrogenase 1 mutation and Ivosidenib in patients with acute myeloid leukemia: A comprehensive review. Cureus 15(9), e44802 (2023).","journal-title":"Cureus"},{"issue":"6","key":"1730_CR6","doi-asserted-by":"publisher","first-page":"721","DOI":"10.6004\/jnccn.2019.0028","volume":"17","author":"MS Tallman","year":"2019","unstructured":"Tallman, M. S. et al. Acute myeloid leukemia, version 3.2019, NCCN clinical practice guidelines in oncology. J. Natl. Compr. Canc Netw. 17(6), 721\u2013749 (2019).","journal-title":"J. Natl. Compr. Canc Netw."},{"issue":"1","key":"1730_CR7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/wrna.5","volume":"1","author":"LL Chen","year":"2010","unstructured":"Chen, L. L. & Carmichael, G. G. Long noncoding RNAs in mammalian cells: What, where, and why? Wiley Interdiscip Rev. RNA. 1(1), 2\u201321 (2010).","journal-title":"Wiley Interdiscip Rev. RNA"},{"key":"1730_CR8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13045-014-0090-4","volume":"7","author":"G Loewen","year":"2014","unstructured":"Loewen, G., Jayawickramarajah, J., Zhuo, Y. & Shan, B. Functions of LncRNA HOTAIR in lung cancer. J. Hematol. Oncol. 7, 90 (2014).","journal-title":"J. Hematol. Oncol."},{"issue":"2","key":"1730_CR9","doi-asserted-by":"publisher","first-page":"188519","DOI":"10.1016\/j.bbcan.2021.188519","volume":"1875","author":"H Ming","year":"2021","unstructured":"Ming, H., Li, B., Zhou, L., Goel, A. & Huang, C. Long non-coding RNAs and cancer metastasis: Molecular basis and therapeutic implications. Biochim. Biophys. Acta Rev. Cancer 1875(2), 188519 (2021).","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"1730_CR10","doi-asserted-by":"crossref","unstructured":"Nn, P. & Cb, J. Z. T. The hallmarks of cancer metabolism: Still emerging. Cell Metabol. 34(3). https:\/\/pubmed.ncbi.nlm.nih.gov\/35123658\/ (2022),","DOI":"10.1016\/j.cmet.2022.01.007"},{"issue":"1","key":"1730_CR11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13045-022-01392-3","volume":"15","author":"X Tong","year":"2022","unstructured":"Tong, X. et al. Targeting cell death pathways for cancer therapy: Recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research. J. Hematol. Oncol. 15(1), 174 (2022).","journal-title":"J. Hematol. Oncol."},{"issue":"3","key":"1730_CR12","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","volume":"25","author":"X Liu","year":"2023","unstructured":"Liu, X. et al. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat. Cell. Biol. 25(3), 404\u2013414 (2023).","journal-title":"Nat. Cell. Biol."},{"key":"1730_CR13","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1038\/s41467-021-22164-6","volume":"12","author":"N Jaeger","year":"2021","unstructured":"Jaeger, N. et al. Single-cell analyses of Crohn\u2019s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions. Nat. Commun. 12, 1921 (2021).","journal-title":"Nat. Commun."},{"issue":"1","key":"1730_CR14","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/ncomms3612","volume":"4","author":"K Yoshihara","year":"2013","unstructured":"Yoshihara, K. et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat. Commun. 4(1), 2612 (2013).","journal-title":"Nat. Commun."},{"key":"1730_CR15","doi-asserted-by":"publisher","unstructured":"Chen, B., Khodadoust, M. S., Liu, C. L., Newman, A. M. & Alizadeh, A. A. Profiling tumor infiltrating immune cells with CIBERSORT. In Cancer Systems Biology. Methods in Molecular Biology, vol. 1711, 243\u2013259 (eds. Von Stechow, L.) (Springer, 2018).  http:\/\/link.springer.com\/ (2018). https:\/\/doi.org\/10.1007\/978-1-4939-7493-1_12","DOI":"10.1007\/978-1-4939-7493-1_12"},{"issue":"4","key":"1730_CR16","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","volume":"39","author":"G Bindea","year":"2013","unstructured":"Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39(4), 782\u2013795 (2013).","journal-title":"Immunity"},{"issue":"10147","key":"1730_CR17","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0140-6736(18)31041-9","volume":"392","author":"NJ Short","year":"2018","unstructured":"Short, N. J., Rytting, M. E. & Cortes, J. E. Acute myeloid leukaemia. Lancet 392(10147), 593\u2013606 (2018).","journal-title":"Lancet"},{"issue":"23","key":"1730_CR18","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","volume":"374","author":"E Papaemmanuil","year":"2016","unstructured":"Papaemmanuil, E. et al. Genomic classification and prognosis in acute myeloid leukemia. N. Engl. J. Med. 374(23), 2209\u20132221 (2016).","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"1730_CR19","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1186\/s12967-022-03711-1","volume":"20","author":"ZH Feng","year":"2022","unstructured":"Feng, Z. H. et al. m6A-immune-related LncRNA prognostic signature for predicting immune landscape and prognosis of bladder cancer. J. Transl Med. 20(1), 492 (2022).","journal-title":"J. Transl Med."},{"key":"1730_CR20","doi-asserted-by":"publisher","first-page":"783362","DOI":"10.3389\/fimmu.2021.783362","volume":"12","author":"Z Wu","year":"2021","unstructured":"Wu, Z. et al. Identification and validation of ferroptosis-related LncRNA signatures as a novel prognostic model for colon cancer. Front. Immunol. 12, 783362 (2021).","journal-title":"Front. Immunol."},{"issue":"11","key":"1730_CR21","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.7150\/jca.23481","volume":"9","author":"XX Li","year":"2018","unstructured":"Li, X. X. et al. Analysis of differential expressions of long non-coding RNAs in nasopharyngeal carcinoma using next-generation deep sequencing. J. Cancer 9(11), 1943\u20131950 (2018).","journal-title":"J. Cancer"},{"key":"1730_CR22","doi-asserted-by":"crossref","unstructured":"Li et al. Identification of long noncoding RNAs as predictors of survival in triple-negative breast cancer based on network analysis. BioMed research international [Internet]. 2020 Mar 3 [cited 2024 Jan 20];2020. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32190687\/","DOI":"10.1155\/2020\/8970340"},{"issue":"7","key":"1730_CR23","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1158\/1078-0432.CCR-19-0674","volume":"26","author":"N Li","year":"2020","unstructured":"Li, N. et al. LncRNA THAP9-AS1 promotes pancreatic ductal adenocarcinoma growth and leads to a poor clinical outcome via a sponging miR-484 and interacting with YAP. Clin. Cancer Res. 26(7), 1736\u20131748 (2020).","journal-title":"Clin. Cancer Res."},{"key":"1730_CR24","doi-asserted-by":"publisher","first-page":"6653","DOI":"10.2147\/OTT.S201832","volume":"12","author":"W Jia","year":"2019","unstructured":"Jia, W. et al. Long noncoding RNA THAP9-AS1 is induced by Helicobacter pylori and promotes cell growth and migration of gastric cancer. Onco Targets Ther. 12, 6653\u20136663 (2019).","journal-title":"Onco Targets Ther."},{"issue":"1","key":"1730_CR25","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1080\/21655979.2021.1933821","volume":"12","author":"J Pan","year":"2021","unstructured":"Pan, J. & Zhao, L. Long non-coding RNA histone deacetylase 4 antisense RNA 1 (HDAC4-AS1) inhibits HDAC4 expression in human ARPE-19 cells with hypoxic stress. Bioengineered 12(1), 2228\u20132237 (2021).","journal-title":"Bioengineered"},{"issue":"4","key":"1730_CR26","doi-asserted-by":"publisher","first-page":"BSR20194444","DOI":"10.1042\/BSR20194444","volume":"40","author":"L Liu","year":"2020","unstructured":"Liu, L. et al. Knockdown of LINC01694 inhibits growth of gallbladder cancer cells via miR-340-5p\/Sox4. Biosci. Rep. 40(4), BSR20194444 (2020).","journal-title":"Biosci. Rep."},{"key":"1730_CR27","doi-asserted-by":"publisher","first-page":"711736","DOI":"10.3389\/fonc.2021.711736","volume":"11","author":"X Li","year":"2021","unstructured":"Li, X. et al. A novel prognostic model based on autophagy-related long non-coding RNAs for clear cell renal cell carcinoma. Front. Oncol. 11, 711736 (2021).","journal-title":"Front. Oncol."},{"issue":"8","key":"1730_CR28","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41591-018-0059-x","volume":"24","author":"G Bajpai","year":"2018","unstructured":"Bajpai, G. et al. The human heart contains distinct macrophage subsets with divergent origins and functions. Nat. Med. 24(8), 1234\u20131245 (2018).","journal-title":"Nat. Med."},{"issue":"7","key":"1730_CR29","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1158\/1078-0432.CCR-19-0674","volume":"26","author":"N Li","year":"2020","unstructured":"Li, N. et al. LncRNA THAP9-AS1 promotes pancreatic ductal adenocarcinoma growth and leads to a poor clinical outcome via sponging miR-484 and interacting with YAP. Clin. Cancer Res. 26(7), 1736\u20131748 (2020).","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"1730_CR30","doi-asserted-by":"publisher","first-page":"e70064","DOI":"10.1002\/cbf.70064","volume":"43","author":"J Du","year":"2025","unstructured":"Du, J., Ji, Q., Dong, L., Wang, L. & Xin, G. HDAC4-AS1\/CTCF transcriptionally represses HDAC4 under stress, whereas HDAC4 inhibits stress\u2010induced syncytiotrophoblast cellular pyroptosis by deacetylating NLRP3 and GSDMD. Cell. Biochem. Function 43(3), e70064 (2025).","journal-title":"Cell. Biochem. Function"},{"issue":"7","key":"1730_CR31","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.21037\/tcr-24-127","volume":"13","author":"J Pan","year":"2024","unstructured":"Pan, J. et al. Identification of a cancer driver gene-associated LncRNA signature for prognostic prediction and immune response evaluation in clear cell renal cell carcinoma. Transl Cancer Res. 13(7), 3418\u20133436 (2024).","journal-title":"Transl Cancer Res."},{"issue":"6117","key":"1730_CR32","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1126\/science.1232227","volume":"339","author":"LM Coussens","year":"2013","unstructured":"Coussens, L. M., Zitvogel, L. & Palucka, A. K. Neutralizing tumor-promoting chronic inflammation: A magic bullet? Science 339(6117), 286\u2013291 (2013).","journal-title":"Science"},{"issue":"12","key":"1730_CR33","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1007\/s00262-013-1487-6","volume":"62","author":"M Santoni","year":"2013","unstructured":"Santoni, M. et al. Emerging role of tumor-associated macrophages as therapeutic targets in patients with metastatic renal cell carcinoma. Cancer Immunol. Immunother. 62(12), 1757\u20131768 (2013).","journal-title":"Cancer Immunol. Immunother"},{"issue":"39","key":"1730_CR34","doi-asserted-by":"publisher","first-page":"20462","DOI":"10.1074\/jbc.M116.750182","volume":"291","author":"G Zhao","year":"2016","unstructured":"Zhao, G. et al. Activation of epidermal growth factor receptor in macrophages mediates feedback Inhibition of M2 polarization and Gastrointestinal tumor cell growth. J. Biol. Chem. 291(39), 20462\u201320472 (2016).","journal-title":"J. Biol. Chem."},{"issue":"8","key":"1730_CR35","doi-asserted-by":"publisher","first-page":"100515","DOI":"10.1016\/j.xcrp.2021.100515","volume":"2","author":"B Sun","year":"2021","unstructured":"Sun, B. The mechanics of fibrillar collagen extracellular matrix. Cell. Rep. Phys. Sci. 2(8), 100515 (2021).","journal-title":"Cell. Rep. Phys. Sci."},{"key":"1730_CR36","doi-asserted-by":"publisher","first-page":"117822341773156","DOI":"10.1177\/1178223417731565","volume":"11","author":"IJ Cohen","year":"2017","unstructured":"Cohen, I. J. & Blasberg, R. Impact of the tumor microenvironment on tumor-Infiltrating lymphocytes: Focus on breast Cancer. Breast Cancer (Auckl) 11, 1178223417731565 (2017).","journal-title":"Breast Cancer (Auckl)"},{"issue":"7440","key":"1730_CR37","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nature11926","volume":"495","author":"A Greenbaum","year":"2013","unstructured":"Greenbaum, A. et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 495(7440), 227\u2013230 (2013).","journal-title":"Nature"},{"issue":"7440","key":"1730_CR38","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature11885","volume":"495","author":"L Ding","year":"2013","unstructured":"Ding, L. & Morrison, S. J. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 495(7440), 231\u2013235 (2013).","journal-title":"Nature"},{"issue":"5","key":"1730_CR39","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s12185-017-2221-5","volume":"105","author":"D Hanekamp","year":"2017","unstructured":"Hanekamp, D., Cloos, J. & Schuurhuis, G. J. Leukemic stem cells: Identification and clinical application. Int. J. Hematol. 105(5), 549\u2013557 (2017).","journal-title":"Int. J. Hematol."},{"issue":"12","key":"1730_CR40","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1002\/gcc.22805","volume":"58","author":"M Chopra","year":"2019","unstructured":"Chopra, M. & Bohlander, S. K. The cell of origin and the leukemia stem cell in acute myeloid leukemia. Genes Chromosomes Cancer 58(12), 850\u2013858 (2019).","journal-title":"Genes Chromosomes Cancer"},{"key":"1730_CR41","doi-asserted-by":"publisher","first-page":"15179","DOI":"10.1038\/srep15179","volume":"5","author":"B Shang","year":"2015","unstructured":"Shang, B., Liu, Y., Jiang, S. & juan, Liu, Y. Prognostic value of tumor-infiltrating FoxP3\u2009+\u2009regulatory T cells in cancers: A systematic review and meta-analysis. Sci. Rep. 5, 15179 (2015).","journal-title":"Sci. Rep."},{"issue":"10","key":"1730_CR42","doi-asserted-by":"publisher","first-page":"5211","DOI":"10.4049\/jimmunol.163.10.5211","volume":"163","author":"J Shimizu","year":"1999","unstructured":"Shimizu, J., Yamazaki, S. & Sakaguchi, S. Induction of tumor immunity by removing CD25\u2009+\u2009CD4\u2009+\u2009T cells: A common basis between tumor immunity and autoimmunity. J. Immunol. 163(10), 5211\u20135218 (1999).","journal-title":"J. Immunol."},{"issue":"13","key":"1730_CR43","first-page":"3128","volume":"59","author":"S Onizuka","year":"1999","unstructured":"Onizuka, S. et al. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res. 59(13), 3128\u20133133 (1999).","journal-title":"Cancer Res."},{"issue":"2","key":"1730_CR44","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.semcancer.2005.11.005","volume":"16","author":"T Yamaguchi","year":"2006","unstructured":"Yamaguchi, T. & Sakaguchi, S. Regulatory T cells in immune surveillance and treatment of cancer. Semin Cancer Biol. 16(2), 115\u2013123 (2006).","journal-title":"Semin Cancer Biol."},{"issue":"12","key":"1730_CR45","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.1245\/s10434-016-5354-5","volume":"23","author":"K Shigeta","year":"2016","unstructured":"Shigeta, K. et al. High absolute monocyte count predicts poor clinical outcome in patients with castration-resistant prostate cancer treated with docetaxel chemotherapy. Ann. Surg. Oncol. 23(12), 4115\u20134122 (2016).","journal-title":"Ann. Surg. Oncol."},{"issue":"1","key":"1730_CR46","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ygyno.2011.09.034","volume":"124","author":"YY Lee","year":"2012","unstructured":"Lee, Y. Y. et al. Prognostic value of pre-treatment circulating monocyte count in patients with cervical cancer: Comparison with SCC-Ag level. Gynecol. Oncol. 124(1), 92\u201397 (2012).","journal-title":"Gynecol. Oncol."},{"issue":"6","key":"1730_CR47","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.surg.2005.10.009","volume":"139","author":"A Sasaki","year":"2006","unstructured":"Sasaki, A. et al. Prognostic value of preoperative peripheral blood monocyte count in patients with hepatocellular carcinoma. Surgery 139(6), 755\u2013764 (2006).","journal-title":"Surgery"},{"issue":"11","key":"1730_CR48","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.humimm.2010.08.001","volume":"71","author":"P Boros","year":"2010","unstructured":"Boros, P., Ochando, J. C., Chen, S. H. & Bromberg, J. S. Myeloid-derived suppressor cells: Natural regulators for transplant tolerance. Hum. Immunol. 71(11), 1061\u20131066 (2010).","journal-title":"Hum. Immunol."},{"issue":"12","key":"1730_CR49","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1038\/s43018-020-00133-0","volume":"1","author":"I Solomon","year":"2020","unstructured":"Solomon, I. et al. CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity. Nat. Cancer 1(12), 1153\u20131166 (2020).","journal-title":"Nat. Cancer"},{"issue":"1","key":"1730_CR50","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13045-022-01328-x","volume":"15","author":"W Li","year":"2022","unstructured":"Li, W., Wang, F., Guo, R., Bian, Z. & Song, Y. Targeting macrophages in hematological malignancies: Recent advances and future directions. J. Hematol. Oncol. 15(1), 110 (2022).","journal-title":"J. Hematol. Oncol."},{"issue":"12","key":"1730_CR51","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1016\/j.immuni.2024.11.006","volume":"57","author":"CE Faliti","year":"2024","unstructured":"Faliti, C. E. et al. Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis. Immunity 57(12), 2772\u20132789e8 (2024).","journal-title":"Immunity"},{"issue":"10","key":"1730_CR52","doi-asserted-by":"publisher","first-page":"e1011725","DOI":"10.1371\/journal.ppat.1011725","volume":"19","author":"A Malyshkina","year":"2023","unstructured":"Malyshkina, A. et al. Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles. PLoS Pathog. 19(10), e1011725 (2023).","journal-title":"PLoS Pathog"},{"issue":"3","key":"1730_CR53","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1517\/13543784.2012.652302","volume":"21","author":"J Joudeh","year":"2012","unstructured":"Joudeh, J. & Claxton, D. Obatoclax mesylate: Pharmacology and potential for therapy of hematological neoplasms. Expert Opin. Investig. Drugs 21(3), 363\u2013373 (2012).","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"4","key":"1730_CR54","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ccell.2019.08.005","volume":"36","author":"R Gui\u00e8ze","year":"2019","unstructured":"Gui\u00e8ze, R. et al. Mitochondrial reprogramming underlies resistance to BCL-2 Inhibition in lymphoid malignancies. Cancer Cell. 36(4), 369\u2013384e13 (2019).","journal-title":"Cancer Cell."},{"issue":"2","key":"1730_CR55","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/nm.3048","volume":"19","author":"AJ Souers","year":"2013","unstructured":"Souers, A. J. et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med. 19(2), 202\u2013208 (2013).","journal-title":"Nat. Med."},{"issue":"9","key":"1730_CR56","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","volume":"68","author":"C Tse","year":"2008","unstructured":"Tse, C. et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 68(9), 3421\u20133428 (2008).","journal-title":"Cancer Res."},{"issue":"3","key":"1730_CR57","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nrclinonc.2013.10","volume":"10","author":"J Rodon","year":"2013","unstructured":"Rodon, J., Dienstmann, R., Serra, V. & Tabernero, J. Development of PI3K inhibitors: Lessons learned from early clinical trials. Nat. Rev. Clin. Oncol. 10(3), 143\u2013153 (2013).","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"18","key":"1730_CR58","doi-asserted-by":"publisher","first-page":"5522","DOI":"10.1021\/jm800295d","volume":"51","author":"AJ Folkes","year":"2008","unstructured":"Folkes, A. J. et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J. Med. Chem. 51(18), 5522\u20135532 (2008).","journal-title":"J. Med. Chem."},{"issue":"7091","key":"1730_CR59","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/nature04694","volume":"441","author":"LC Foukas","year":"2006","unstructured":"Foukas, L. C. et al. Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 441(7091), 366\u2013370 (2006).","journal-title":"Nature"},{"issue":"18","key":"1730_CR60","doi-asserted-by":"publisher","first-page":"8007","DOI":"10.1021\/jm300867c","volume":"55","author":"TP Heffron","year":"2012","unstructured":"Heffron, T. P. et al. The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase \u03b1. J. Med. Chem. 55(18), 8007\u20138020 (2012).","journal-title":"J. Med. Chem."},{"issue":"8","key":"1730_CR61","doi-asserted-by":"publisher","first-page":"e007253","DOI":"10.1136\/jitc-2023-007253","volume":"11","author":"YN Wang","year":"2023","unstructured":"Wang, Y. N. et al. Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response. J. Immunother. Cancer 11(8), e007253 (2023).","journal-title":"J. Immunother. Cancer"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01730-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01730-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01730-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T05:03:21Z","timestamp":1747371801000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01730-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1730"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-01730-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"assertion":[{"value":"19 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our study was approved by the Medical Ethical Committee of Qilu Hospital of Shandong University (KYLL-2018-137) and informed consent was obtained from all participants. All methods were performed in accordance with the relevant guidelines. The research participants have been performed in accordance with the Declaration of Helsinki. And our study did not include any interventional clinical trial.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors agree to the content of the paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16995"}}