{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:53:54Z","timestamp":1787003634573,"version":"build-2736575974"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-01797-3","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T16:20:54Z","timestamp":1751386854000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of albumin-based inflammatory markers as diagnostic tools in HELLP syndrome"],"prefix":"10.1038","volume":"15","author":[{"given":"Aziz","family":"K\u0131ndan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara Sarikaya","family":"Kurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilruba Ravza","family":"Nalbant\u00e7\u0131lar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can Ozan","family":"Ulusoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadriye Yakut","family":"Y\u00fccel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"3","key":"1797_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.cnc.2022.04.009","volume":"34","author":"M Adorno","year":"2022","unstructured":"Adorno, M., Maher-Griffiths, C. & Grush Abadie, H. R. HELLP syndrome. Crit. Care Nurs. Clin. North. Am. 34 (3), 277\u2013288 (2022).","journal-title":"Crit. Care Nurs. Clin. North. Am."},{"issue":"9","key":"1797_CR2","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1111\/aogs.13859","volume":"99","author":"O Malmstr\u00f6m","year":"2020","unstructured":"Malmstr\u00f6m, O., H\u00e5berg, S. E. & Morken, N. H. Probability and outcomes of second pregnancy after HELLP syndrome in the first: A population-based registry study. Acta Obstet. Gynecol. Scand. 99 (9), 1206\u20131213 (2020).","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"1797_CR3","doi-asserted-by":"crossref","unstructured":"Wu, N. et al. Albumin, an interesting and functionally diverse protein, varies from \u2018native\u2019 to \u2018effective\u2019 (Review). Mol. Med. Rep. 29(2). (2024).","DOI":"10.3892\/mmr.2023.13147"},{"key":"1797_CR4","doi-asserted-by":"crossref","unstructured":"Choe, H. et al. Accuracy of albumin, Globulin, and Albumin-Globulin ratio for diagnosing periprosthetic joint infection: A systematic review and Meta-Analysis. J. Clin. Med. 12(24). (2023).","DOI":"10.3390\/jcm12247512"},{"key":"1797_CR5","doi-asserted-by":"publisher","first-page":"5501","DOI":"10.2147\/JIR.S335671","volume":"14","author":"Y Chen","year":"2021","unstructured":"Chen, Y. et al. Albumin\/Globulin ratio as Yin-Yang in rheumatoid arthritis and its correlation to Inflamm-Aging cytokines. J. Inflamm. Res. 14, 5501\u20135511 (2021).","journal-title":"J. Inflamm. Res."},{"issue":"1","key":"1797_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1515\/hmbci-2022-0012","volume":"44","author":"N Parasher","year":"2023","unstructured":"Parasher, N. et al. Association of neutrophil gelatinase associated Lipocalin, ischemia modified albumin with uric acid in the etiopathogenesis of preeclampsia. Horm. Mol. Biol. Clin. Investig. 44 (1), 39\u201343 (2023).","journal-title":"Horm. Mol. Biol. Clin. Investig"},{"issue":"11","key":"1797_CR7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.52403\/ijhsr.20211130","volume":"11","author":"C Amadi","year":"2021","unstructured":"Amadi, C. & Amadi, B. Hypoalbuminemia predicts poor pregnancy outcome among cases of HELLP syndrome in Nigeria. Int. J. Health Sci. Res. 11 (11), 252\u2013260 (2021).","journal-title":"Int. J. Health Sci. Res."},{"issue":"4","key":"1797_CR8","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1080\/00325481.2024.2359892","volume":"136","author":"Z Soykan Sert","year":"2024","unstructured":"Soykan Sert, Z. & Bertizlio\u011flu, M. Predictive value of the HALP score for pre-eclampsia with severe features. Postgrad. Med. 136 (4), 468\u2013473 (2024).","journal-title":"Postgrad. Med."},{"issue":"9","key":"1797_CR9","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/S1701-2163(16)35017-4","volume":"33","author":"J Benoit","year":"2011","unstructured":"Benoit, J. & Rey, \u00c9. Preeclampsia: should plasma albumin level be a criterion for severity? J. Obstet. Gynaecol. Can. 33 (9), 922\u2013926 (2011).","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"1797_CR10","doi-asserted-by":"publisher","first-page":"e240","DOI":"10.1097\/01.hjh.0000573076.28399.b1","volume":"37","author":"N Martell-Claros","year":"2019","unstructured":"Martell-Claros, N. et al. Hypoalbuminemia as a risk factor of preeclampsia-eclampsia in high risk pregnancy. J. Hypertens. 37, e240 (2019).","journal-title":"J. Hypertens."},{"key":"1797_CR11","doi-asserted-by":"crossref","unstructured":"Sisti, G., Faraci, A., Silva, J. & Upadhyay, R. Neutrophil-to-Lymphocyte ratio, Platelet-to-Lymphocyte ratio, and routine complete blood count components in HELLP syndrome: A matched case control study. Med. (Kaunas) 55(5). (2019).","DOI":"10.3390\/medicina55050123"},{"issue":"3","key":"1797_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.17772\/gp\/1713","volume":"85","author":"A Yavuzcan","year":"2014","unstructured":"Yavuzcan, A. et al. Mean platelet volume, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in severe preeclampsia. Ginekol. Pol. 85 (3), 197\u2013203 (2014).","journal-title":"Ginekol. Pol."},{"issue":"5","key":"1797_CR13","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1080\/01443615.2021.1986476","volume":"42","author":"E Elmaradny","year":"2022","unstructured":"Elmaradny, E., Alneel, G., Alkhattaf, N., AlGadri, T. & Albriakan, N. Predictive values of combined platelet count, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in preeclampsia. J. Obstet. Gynaecol. 42 (5), 1011\u20131017 (2022).","journal-title":"J. Obstet. Gynaecol."},{"issue":"13","key":"1797_CR14","doi-asserted-by":"publisher","first-page":"e33419","DOI":"10.1097\/MD.0000000000033419","volume":"102","author":"H Ren","year":"2023","unstructured":"Ren, H., Liu, W., Niu, A. & Zhao, X. Fibrinogen to albumin ratio, a novel serum indicator for evaluating the severity of preeclampsia: A single-center retrospective study. Med. (Baltim). 102 (13), e33419 (2023).","journal-title":"Med. (Baltim)."},{"issue":"1","key":"1797_CR15","doi-asserted-by":"publisher","first-page":"2408680","DOI":"10.1080\/01443615.2024.2408680","volume":"44","author":"A Esercan","year":"2024","unstructured":"Esercan, A. & Cindoglu, C. The relationship between early-onset preeclampsia and the prognostic nutritional index and inflammatory markers. J. Obstet. Gynaecol. 44 (1), 2408680 (2024).","journal-title":"J. Obstet. Gynaecol."},{"key":"1797_CR16","doi-asserted-by":"publisher","first-page":"104190","DOI":"10.1016\/j.jri.2023.104190","volume":"162","author":"Z Seyhanli","year":"2024","unstructured":"Seyhanli, Z. et al. The role of first trimester serum inflammatory indexes (NLR, PLR, MLR, SII, SIRI, and PIV) and the \u03b2-hCG to PAPP-A ratio in predicting preeclampsia. J. Reprod. Immunol. 162, 104190 (2024).","journal-title":"J. Reprod. Immunol."},{"key":"1797_CR17","doi-asserted-by":"publisher","first-page":"104126","DOI":"10.1016\/j.jri.2023.104126","volume":"159","author":"G \u0130pek","year":"2023","unstructured":"\u0130pek, G., Tana\u00e7an, A., A\u011fao\u011flu, Z., Peker, A. & \u015eahin, D. Can SIRI or other inflammatory indices predict HELLP syndrome in the first trimester? J. Reprod. Immunol. 159, 104126 (2023).","journal-title":"J. Reprod. Immunol."},{"issue":"2","key":"1797_CR18","doi-asserted-by":"publisher","first-page":"188","DOI":"10.29271\/jcpsp.2021.02.188","volume":"31","author":"HE Tolunay","year":"2021","unstructured":"Tolunay, H. E. et al. Can First-trimester AST to platelet ratio index scores predict HELLP syndrome?? J. Coll. Physicians Surg. Pak. 31 (2), 188\u2013192 (2021).","journal-title":"J. Coll. Physicians Surg. Pak"},{"issue":"12","key":"1797_CR19","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.28982\/josam.1008359","volume":"5","author":"F Bayram","year":"2021","unstructured":"Bayram, F. & Kara\u015fin, S. S. The predictive role of neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and other complete blood count parameters in eclampsia and HELLP syndrome. J. Surg. Med. 5 (12), 1202\u20131205 (2021).","journal-title":"J. Surg. Med."},{"issue":"6","key":"1797_CR20","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.12998\/wjcc.v9.i6.1259","volume":"9","author":"SY Kang","year":"2021","unstructured":"Kang, S. Y., Wang, Y., Zhou, L. P. & Zhang, H. New indicators in evaluation of hemolysis, elevated liver enzymes, and low platelet syndrome: A case-control study. World J. Clin. Cases. 9 (6), 1259\u20131270 (2021).","journal-title":"World J. Clin. Cases"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01797-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01797-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01797-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T16:20:55Z","timestamp":1751386855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01797-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1797"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-01797-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"19 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22125"}}