{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:14:40Z","timestamp":1790723680332,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-01871-w","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T18:21:55Z","timestamp":1748024515000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Early mobilization in postoperative glioma patients real world impact on recovery and long term prognosis"],"prefix":"10.1038","volume":"15","author":[{"given":"Xiaohang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"1871_CR1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1097\/JNN.0000000000000400","volume":"50","author":"MIJK Snijders","year":"2018","unstructured":"Snijders, M. I. J. K., Teunissen, T. J., de Graeff, S., De Vos, F. & A. & Y. F. Symptom monitoring in glioma patients: development of the Edmonton symptom assessment system glioma module. J. Neurosci. Nurs. 50, 381\u2013387 (2018).","journal-title":"J. Neurosci. Nurs."},{"key":"1871_CR2","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3171\/2014.9.JNS14193","volume":"122","author":"MZ Sun","year":"2015","unstructured":"Sun, M. Z. et al. Survival impact of time to initiation of chemoradiotherapy after resection of newly diagnosed glioblastoma. J. Neurosurg. 122, 1144\u20131150 (2015).","journal-title":"J. Neurosurg."},{"key":"1871_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10143-016-0709-8","volume":"40","author":"NA Bush","year":"2017","unstructured":"Bush, N. A., Chang, S. M. & Berger, M. S. Current and future strategies for treatment of glioma. Neurosurg. Rev. 40, 1\u201314 (2017).","journal-title":"Neurosurg. Rev."},{"key":"1871_CR4","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.1245\/s10434-016-5222-3","volume":"23","author":"F Pessina","year":"2016","unstructured":"Pessina, F. et al. Value of surgical resection in patients with newly diagnosed grade III glioma treated in a multimodal approach: surgery, chemotherapy and radiotherapy. Ann. Surg. Oncol. 23, 3040\u20133046 (2016).","journal-title":"Ann. Surg. Oncol."},{"key":"1871_CR5","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/B978-0-12-802997-8.00012-8","volume":"134","author":"C Jackson","year":"2016","unstructured":"Jackson, C., Westphal, M. & Qui\u00f1ones-Hinojosa, A. Complications of glioma surgery. Handb. Clin. Neurol. 134, 201\u2013218 (2016).","journal-title":"Handb. Clin. Neurol."},{"key":"1871_CR6","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/S0002-9610(02)00866-8","volume":"183","author":"H Kehlet","year":"2002","unstructured":"Kehlet, H. & Wilmore, D. W. Multimodal strategies to improve surgical outcome. Am. J. Surg. 183, 630\u2013641 (2002).","journal-title":"Am. J. Surg."},{"key":"1871_CR7","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1007\/s00464-015-4714-8","volume":"30","author":"TD Martin","year":"2016","unstructured":"Martin, T. D. et al. Newly implemented enhanced recovery pathway positively impacts hospital length of stay. Surg. Endosc. 30, 4019\u20134028 (2016).","journal-title":"Surg. Endosc"},{"key":"1871_CR8","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.otc.2022.07.011","volume":"55","author":"AS Kitchin","year":"2022","unstructured":"Kitchin, A. S. et al. Enhanced recovery after surgery. Otolaryngol Clin North Am. 55, 1271\u20131285 (2022).","journal-title":"Otolaryngol Clin North Am."},{"key":"1871_CR9","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00268-018-4844-y","volume":"43","author":"UO Gustafsson","year":"2019","unstructured":"Gustafsson, U. O. et al. Guidelines for perioperative care in elective colorectal surgery: enhanced recovery after surgery (ERAS(\u00ae)) society recommendations: 2018. World J. Surg. 43, 659\u2013695 (2019).","journal-title":"World J. Surg."},{"key":"1871_CR10","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.hbpd.2018.12.005","volume":"18","author":"R Mahendran","year":"2019","unstructured":"Mahendran, R., Tewari, M., Dixit, V. K. & Shukla, H. S. Enhanced recovery after surgery protocol enhances early postoperative recovery after pancreaticoduodenectomy. Hepatobiliary Pancreat. Dis. Int. 18, 188\u2013193 (2019).","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"1871_CR11","unstructured":"Wang, Y. et al. Safety and efficacy of a novel neurosurgical enhanced recovery after surgery protocol for elective craniotomy: a prospective randomized controlled trial. J. Neurosurg. 1\u201312 (2018)."},{"key":"1871_CR12","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s00423-021-02345-z","volume":"41","author":"A Palen","year":"2022","unstructured":"Palen, A. et al. Protective peritoneal patch for arteries during pancreatoduodenectomy: good value for money. Langenbeck\u2019s Archives Surg. 41, 377\u2013382 (2022).","journal-title":"Langenbeck\u2019s Archives Surg."},{"key":"1871_CR13","doi-asserted-by":"publisher","unstructured":"Erratum to. Enhanced recovery after surgery\u2122 awake minimally-invasive transforaminal lumbar interbody fusion: 2-dimensional operative video by Hsuan-Kan Chang et al. operative neurosurgery. Oper. Neurosurg.  (Hagerstown) 15, 610 https:\/\/doi.org\/10.1093\/ons\/opy187 (2018).","DOI":"10.1093\/ons\/opy187"},{"key":"1871_CR14","doi-asserted-by":"publisher","first-page":"860257","DOI":"10.3389\/fonc.2022.860257","volume":"12","author":"Y Wang","year":"2022","unstructured":"Wang, Y. et al. Real-world implementation of neurosurgical enhanced recovery after surgery protocol for gliomas in patients undergoing elective craniotomy. Front. Oncol. 12, 860257 (2022).","journal-title":"Front. Oncol."},{"key":"1871_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta21540","volume":"21","author":"P Langhorne","year":"2017","unstructured":"Langhorne, P., Wu, O., Rodgers, H., Ashburn, A. & Bernhardt, J. A very early rehabilitation trial after stroke (AVERT): a phase III, multicentre, randomised controlled trial. Health Technol. Assess. 21, 1\u2013120 (2017).","journal-title":"Health Technol. Assess."},{"key":"1871_CR16","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.6004\/jnccn.2020.0052","volume":"18","author":"LB Nabors","year":"2020","unstructured":"Nabors, L. B. et al. Central nervous system cancers, version 3.2020, NCCN clinical practice guidelines in oncology. J. Natl. Compr. Canc Netw. 18, 1537\u20131570 (2020).","journal-title":"J. Natl. Compr. Canc Netw."},{"key":"1871_CR17","doi-asserted-by":"publisher","first-page":"434","DOI":"10.5935\/0103-507X.20190084","volume":"31","author":"EE Aquim","year":"2019","unstructured":"Aquim, E. E. et al. Brazilian guidelines for early mobilization in intensive care unit. Rev. Bras. Ter. Intensiva. 31, 434\u2013443 (2019).","journal-title":"Rev. Bras. Ter. Intensiva"},{"key":"1871_CR18","doi-asserted-by":"publisher","first-page":"e330","DOI":"10.1016\/S1470-2045(17)30345-5","volume":"18","author":"A Pace","year":"2017","unstructured":"Pace, A. et al. European association for neuro-oncology (EANO) guidelines for palliative care in adults with glioma. Lancet Oncol. 18, e330\u2013e340 (2017).","journal-title":"Lancet Oncol."},{"key":"1871_CR19","unstructured":"Bureau, N. H. C. M. A. Guidelines for the diagnosis and treatment of glioma (2018 edition). Chin. J. Neurosurg. 217\u2013239 (2019)."},{"key":"1871_CR20","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/aas.12651","volume":"60","author":"A Feldheiser","year":"2016","unstructured":"Feldheiser, A. et al. Enhanced recovery after surgery (ERAS) for Gastrointestinal surgery, part 2: consensus statement for anaesthesia practice. Acta Anaesthesiol. Scand. 60, 289\u2013334 (2016).","journal-title":"Acta Anaesthesiol. Scand."},{"key":"1871_CR21","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00268-018-4786-4","volume":"43","author":"DE Low","year":"2019","unstructured":"Low, D. E. et al. Guidelines for perioperative care in esophagectomy: enhanced recovery after surgery (ERAS(\u00ae)) society recommendations. World J. Surg. 43, 299\u2013330 (2019).","journal-title":"World J. Surg."},{"key":"1871_CR22","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1007\/s00464-017-5722-7","volume":"31","author":"JC Carmichael","year":"2017","unstructured":"Carmichael, J. C. et al. Clinical practice guideline for enhanced recovery after colon and rectal surgery from the American society of colon and rectal surgeons (ASCRS) and society of American Gastrointestinal and endoscopic surgeons (SAGES). Surg. Endosc. 31, 3412\u20133436 (2017).","journal-title":"Surg. Endosc"},{"key":"1871_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00268-018-4753-0","volume":"43","author":"KM Elias","year":"2019","unstructured":"Elias, K. M. et al. The reporting on ERAS compliance, outcomes, and elements research (RECOvER) checklist: A joint statement by the ERAS(\u00ae) and ERAS(\u00ae) USA societies. World J. Surg. 43, 1\u20138 (2019).","journal-title":"World J. Surg."},{"key":"1871_CR24","first-page":"164","volume":"29","author":"S Christine","year":"2018","unstructured":"Christine, S.  et al. Nursing guide to management of major symptoms in patients with malignant glioma. Semin. Oncol. Nurs. 29, 164\u2013170 (2018).","journal-title":"Semin. Oncol. Nurs."},{"key":"1871_CR25","first-page":"518","volume":"129","author":"L Miaomiao","year":"2019","unstructured":"Miaomiao, L. Effect of quality nursing measures on patients with brain tumors undergoing operation. World J. Sleep. Med. 129, 518\u2013559 (2019).","journal-title":"World J. Sleep. Med."},{"key":"1871_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.14797\/mdcj-14-2-77","volume":"14","author":"JK Brown","year":"2018","unstructured":"Brown, J. K., Singh, K., Dumitru, R., Chan, E. & Kim, M. P. The benefits of enhanced recovery after surgery programs and their application in cardiothoracic surgery. Methodist Debakey Cardiovasc. J. 14, 77\u201388 (2018).","journal-title":"Methodist Debakey Cardiovasc. J."},{"key":"1871_CR27","first-page":"1","volume":"81","author":"JB John","year":"2020","unstructured":"John, J. B., Hemsley, A., Nunns, M. & McGrath, J. S. Time to make enhanced recovery after surgery the standard. Br. J. Hosp. Med. (Lond). 81, 1\u20134 (2020).","journal-title":"Br. J. Hosp. Med. (Lond)"},{"key":"1871_CR28","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","volume":"185","author":"S Katz","year":"1963","unstructured":"Katz, S., Ford, A. B., Moskowitz, R. W., Jackson, B. A. & Jaffe, M. W. Studies of illness in The aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA 185, 914\u2013919 (1963).","journal-title":"JAMA"},{"key":"1871_CR29","doi-asserted-by":"publisher","first-page":"626400","DOI":"10.3389\/fonc.2020.626400","volume":"10","author":"M Ferro","year":"2020","unstructured":"Ferro, M. et al. Post-operative accelerated-hypofractionated chemoradiation with volumetric modulated Arc therapy and simultaneous integrated boost in glioblastoma: A phase I study (ISIDE-BT-2). Front. Oncol. 10, 626400 (2020).","journal-title":"Front. Oncol."},{"key":"1871_CR30","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1111\/aas.12601","volume":"59","author":"MJ Scott","year":"2015","unstructured":"Scott, M. J. et al. Enhanced recovery after surgery (ERAS) for Gastrointestinal surgery, part 1: pathophysiological considerations. Acta Anaesthesiol. Scand. 59, 1212\u20131231 (2015).","journal-title":"Acta Anaesthesiol. Scand."},{"key":"1871_CR31","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/coa.13655","volume":"46","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y., Liu, D., Chen, X., Ma, J. & Song, X. An enhanced recovery programme improves the comfort and outcomes in children with obstructive sleep Apnoea undergoing adenotonsillectomy: A retrospective historical control study. Clin. Otolaryngol. 46, 249\u2013255 (2021).","journal-title":"Clin. Otolaryngol."},{"key":"1871_CR32","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1213\/ANE.0000000000000206","volume":"118","author":"TE Miller","year":"2014","unstructured":"Miller, T. E. et al. Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol. Anesth. Analg. 118, 1052\u20131061 (2014).","journal-title":"Anesth. Analg"},{"key":"1871_CR33","doi-asserted-by":"publisher","first-page":"110575","DOI":"10.1016\/j.jclinane.2021.110575","volume":"76","author":"L Wang","year":"2022","unstructured":"Wang, L. et al. Enhanced recovery after elective craniotomy: A randomized controlled trial. J. Clin. Anesth. 76, 110575 (2022).","journal-title":"J. Clin. Anesth."},{"key":"1871_CR34","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.bja.2021.12.007","volume":"128","author":"C Gillis","year":"2022","unstructured":"Gillis, C., Ljungqvist, O. & Carli, F. Prehabilitation, enhanced recovery after surgery, or both? A narrative review. Br. J. Anaesth. 128, 434\u2013448 (2022).","journal-title":"Br. J. Anaesth."},{"key":"1871_CR35","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s11060-020-03548-y","volume":"148","author":"B Liu","year":"2020","unstructured":"Liu, B. et al. Impact of neurosurgical enhanced recovery after surgery (ERAS) program on health-related quality of life in glioma patients: a secondary analysis of a randomized controlled trial. J. Neurooncol. 148, 555\u2013567 (2020).","journal-title":"J. Neurooncol"},{"key":"1871_CR36","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis, D. N. et al. The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 131, 803\u2013820 (2016).","journal-title":"Acta Neuropathol."},{"key":"1871_CR37","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.cell.2015.12.028","volume":"164","author":"M Ceccarelli","year":"2016","unstructured":"Ceccarelli, M. et al. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell 164, 550\u2013563 (2016).","journal-title":"Cell"},{"key":"1871_CR38","doi-asserted-by":"publisher","first-page":"e23087","DOI":"10.1097\/MD.0000000000023087","volume":"99","author":"K Zhao","year":"2020","unstructured":"Zhao, K. et al. Rehabilitation therapy for patients with glioma: A PRISMA-compliant systematic review and meta-analysis. Med. (Baltim). 99, e23087 (2020).","journal-title":"Med. (Baltim)."},{"key":"1871_CR39","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s11060-021-03828-1","volume":"154","author":"SD van der Linden","year":"2021","unstructured":"van der Linden, S. D. et al. eHealth cognitive rehabilitation for brain tumor patients: results of a randomized controlled trial. J. Neurooncol. 154, 315\u2013326 (2021).","journal-title":"J. Neurooncol"},{"key":"1871_CR40","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11060-017-2738-8","volume":"137","author":"SD van der Linden","year":"2018","unstructured":"van der Linden, S. D., Sitskoorn, M. M., Rutten, G. J. M. & Gehring, K. Feasibility of the evidence-based cognitive telerehabilitation program remind for patients with primary brain tumors. J. Neurooncol. 137, 523\u2013532 (2018).","journal-title":"J. Neurooncol"},{"key":"1871_CR41","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11060-021-03839-y","volume":"155","author":"SE Braun","year":"2021","unstructured":"Braun, S. E. et al. Working memory training for adult glioma patients: a proof-of-concept study. J. Neurooncol. 155, 25\u201334 (2021).","journal-title":"J. Neurooncol"},{"key":"1871_CR42","doi-asserted-by":"publisher","first-page":"6838","DOI":"10.3390\/jcm12216838","volume":"12","author":"A Pieczy\u0144ska","year":"2023","unstructured":"Pieczy\u0144ska, A. et al. Rehabilitation exercises supported by monitor-augmented reality for patients with high-grade glioma undergoing radiotherapy: results of a randomized clinical trial. J. Clin. Med. 12, 6838 (2023).","journal-title":"J. Clin. Med."},{"key":"1871_CR43","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1097\/PHM.0000000000000192","volume":"94","author":"J Yoon","year":"2015","unstructured":"Yoon, J., Chun, M. H., Lee, S. J. & Kim, B. R. Effect of virtual reality-based rehabilitation on upper-extremity function in patients with brain tumor: controlled trial. Am. J. Phys. Med. Rehabil. 94, 449\u2013459 (2015).","journal-title":"Am. J. Phys. Med. Rehabil"},{"key":"1871_CR44","doi-asserted-by":"publisher","first-page":"726","DOI":"10.5535\/arm.2014.38.6.726","volume":"38","author":"S Yang","year":"2014","unstructured":"Yang, S., Chun, M. H. & Son, Y. R. Effect of virtual reality on cognitive dysfunction in patients with brain tumor. Ann. Rehabil Med. 38, 726\u2013733 (2014).","journal-title":"Ann. Rehabil Med."},{"key":"1871_CR45","doi-asserted-by":"publisher","first-page":"e30985","DOI":"10.2196\/30985","volume":"9","author":"MJ Vinolo Gil","year":"2021","unstructured":"Vinolo Gil, M. J. et al. Augmented reality in physical therapy: systematic review and meta-analysis. JMIR Serious Games. 9, e30985 (2021).","journal-title":"JMIR Serious Games"},{"key":"1871_CR46","doi-asserted-by":"publisher","first-page":"1137516","DOI":"10.3389\/fsurg.2023.1137516","volume":"10","author":"S Spina","year":"2023","unstructured":"Spina, S. et al. Rehabilitation interventions for glioma patients: a mini-review. Front. Surg. 10, 1137516 (2023).","journal-title":"Front. Surg."},{"key":"1871_CR47","doi-asserted-by":"publisher","first-page":"6032","DOI":"10.3390\/jcm12186032","volume":"12","author":"I Zaed","year":"2023","unstructured":"Zaed, I., Marchi, F., Milani, D., Cabrilo, I. & Cardia, A. Role of enhanced recovery after surgery (ERAS) protocol in the management of elderly patients with glioblastoma. J. Clin. Med. 12, 6032 (2023).","journal-title":"J. Clin. Med."},{"key":"1871_CR48","doi-asserted-by":"publisher","first-page":"e30043","DOI":"10.1097\/MD.0000000000030043","volume":"101","author":"B Liu","year":"2022","unstructured":"Liu, B. et al. Neurosurgical enhanced recovery after surgery ERAS for geriatric patients undergoing elective craniotomy: A review. Med. (Baltim). 101, e30043 (2022).","journal-title":"Med. (Baltim)."},{"key":"1871_CR49","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.3171\/2020.10.JNS203160","volume":"135","author":"V Stumpo","year":"2021","unstructured":"Stumpo, V. et al. Enhanced recovery after surgery strategies for elective craniotomy: a systematic review. J. Neurosurg. 135, 1857\u20131881 (2021).","journal-title":"J. Neurosurg."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01871-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01871-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01871-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T19:03:23Z","timestamp":1748027003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01871-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1871"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-01871-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]},"assertion":[{"value":"30 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was complied with the ethical principles the Declaration of Helsinki (2000) of the World Medical Association. The research protocol was ethical clearance by the Institutional Review Board of Zhongnan Hospital of Wuhan University (Approval No. 2019258). Written informed consent was obtained from all participants prior to enrollment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"18032"}}