{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:44:55Z","timestamp":1785793495098,"version":"3.56.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jiangsu Province\u2019s Key Discipline \/ Laboratory of Medicine","award":["No. JSDW202231"],"award-info":[{"award-number":["No. JSDW202231"]}]},{"name":"Xuzhou Medical Key Talent Training Project","award":["No. XWRCHT20210033"],"award-info":[{"award-number":["No. XWRCHT20210033"]}]},{"name":"Key Research and Development Program of Scientific and Technological Innovation in Xuzhou City","award":["No. KC23146"],"award-info":[{"award-number":["No. KC23146"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-01892-5","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T05:19:21Z","timestamp":1748150361000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of intravenous lidocaine on postoperative fatigue syndrome in patients undergoing laparoscopic radical colorectal cancer surgery: a randomized clinical trial"],"prefix":"10.1038","volume":"15","author":[{"given":"Songhai","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghai","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"1892_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41575-022-00726-3","volume":"20","author":"J Huang","year":"2023","unstructured":"Huang, J. et al. Updated epidemiology of Gastrointestinal cancers in East Asia. Nat. Rev. Gastroenterol. Hepatol. 20, 271\u2013287. https:\/\/doi.org\/10.1038\/s41575-022-00726-3 (2023).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"1892_CR2","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.5114\/aoms.2015.56348","volume":"6","author":"J Jane\u017e","year":"2015","unstructured":"Jane\u017e, J., Kora\u0107, T., Kodre, A. R., Jelenc, F. & Ihan, A. Laparoscopically assisted colorectal surgery provides better short-term clinical and inflammatory outcomes compared to open colorectal surgery. Archives Med. Sci. 6, 1217\u20131226. https:\/\/doi.org\/10.5114\/aoms.2015.56348 (2015).","journal-title":"Archives Med. Sci."},{"key":"1892_CR3","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1089\/lap.2018.0708","volume":"29","author":"Q Li","year":"2019","unstructured":"Li, Q. et al. Clinical application of enhanced recovery after surgery in perioperative period of laparoscopic colorectal Cancer surgery. J. Laparoendosc Adv. Surg. Tech. A 29, 178\u2013183. https:\/\/doi.org\/10.1089\/lap.2018.0708 (2019).","journal-title":"J. Laparoendosc Adv. Surg. Tech. A"},{"key":"1892_CR4","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1007\/s00384-022-04285-6","volume":"37","author":"Y Zhang","year":"2022","unstructured":"Zhang, Y., Liu, C., Nistala, K. R. Y. & Chong, C. S. Open versus laparoscopic Hartmann\u2019s procedure: A systematic review and meta-analysis. Int. J. Colorectal Dis. 37, 2421\u20132430. https:\/\/doi.org\/10.1007\/s00384-022-04285-6 (2022).","journal-title":"Int. J. Colorectal Dis."},{"key":"1892_CR5","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.crad.2021.06.002","volume":"76","author":"A Pallan","year":"2021","unstructured":"Pallan, A. et al. Postoperative complications of colorectal cancer. Clin. Radiol. 76, 896\u2013907. https:\/\/doi.org\/10.1016\/j.crad.2021.06.002 (2021).","journal-title":"Clin. Radiol."},{"key":"1892_CR6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jad.2022.06.029","volume":"312","author":"L Zhao","year":"2022","unstructured":"Zhao, L., Zhang, H. & Cheng, H. Effect of a single sub-dose of ketamine on postoperative fatigue syndrome in colorectal cancer patients undergoing radical laparoscopic surgery: A double-blind, pilot study. J. Affect. Disord. 312, 146\u2013151. https:\/\/doi.org\/10.1016\/j.jad.2022.06.029 (2022).","journal-title":"J. Affect. Disord"},{"key":"1892_CR7","doi-asserted-by":"publisher","first-page":"e25849","DOI":"10.1097\/MD.0000000000025849","volume":"100","author":"Q Zheng","year":"2021","unstructured":"Zheng, Q., Wang, R., Shi, Y. & Sun, Q. Effects of acupoint massage combined with relaxation therapy on patients with postoperative fatigue syndrome after lumbar surgery. Med. (Baltim). 100, e25849. https:\/\/doi.org\/10.1097\/MD.0000000000025849 (2021).","journal-title":"Med. (Baltim)."},{"key":"1892_CR8","doi-asserted-by":"publisher","unstructured":"Lin, X. et al. Effects of Esketamine on postoperative fatigue syndrome in patients after laparoscopic resection of gastric carcinoma: A randomized controlled trial. BMC Anesthesiol. 24 https:\/\/doi.org\/10.1186\/s12871-024-02513-w (2024).","DOI":"10.1186\/s12871-024-02513-w"},{"key":"1892_CR9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/gerona\/glp145","volume":"65A","author":"I Bautmans","year":"2009","unstructured":"Bautmans, I., Njemini, R., De Backer, J., De Waele, E. & Mets, T. Surgery-Induced inflammation in relation to age, muscle endurance, and Self-Perceived fatigue. Journals Gerontol. Ser. A: Biol. Sci. Med. Sci. 65A, 266\u2013273. https:\/\/doi.org\/10.1093\/gerona\/glp145 (2009).","journal-title":"Journals Gerontol. Ser. A: Biol. Sci. Med. Sci."},{"key":"1892_CR10","doi-asserted-by":"publisher","unstructured":"Himbert, C. et al. Inflammation- and angiogenesis\u2010related biomarkers are correlated with cancer\u2010related fatigue in colorectal cancer patients: Results from the ColoCare study. Eur. J. Cancer Care. 28 https:\/\/doi.org\/10.1111\/ecc.13055 (2019).","DOI":"10.1111\/ecc.13055"},{"key":"1892_CR11","doi-asserted-by":"publisher","first-page":"652817","DOI":"10.3389\/fnins.2021.652817","volume":"15","author":"S Liu","year":"2021","unstructured":"Liu, S. et al. Inflammation disturbed the Tryptophan catabolites in Hippocampus of Post-operative fatigue syndrome rats via indoleamine 2,3-Dioxygenas enzyme and the improvement effect of ginsenoside Rb1. Front. Neurosci. 15, 652817. https:\/\/doi.org\/10.3389\/fnins.2021.652817 (2021).","journal-title":"Front. Neurosci."},{"key":"1892_CR12","doi-asserted-by":"publisher","first-page":"7315","DOI":"10.1007\/s00520-021-06295-6","volume":"29","author":"G Zhu","year":"2021","unstructured":"Zhu, G. et al. The characteristics and related factors of insomnia among postoperative patients with gastric cancer: A cross-sectional survey. Support. Care Cancer 29, 7315\u20137322. https:\/\/doi.org\/10.1007\/s00520-021-06295-6 (2021).","journal-title":"Support. Care Cancer"},{"key":"1892_CR13","doi-asserted-by":"publisher","unstructured":"Kehlet, H. Enhanced postoperative recovery: Good from Afar, but Far from good? Anaesthesia 75 https:\/\/doi.org\/10.1111\/anae.14860 (2020).","DOI":"10.1111\/anae.14860"},{"key":"1892_CR14","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1097\/ajp.0000000000000697","volume":"35","author":"D Whibley","year":"2019","unstructured":"Whibley, D. et al. Sleep and pain. Clin. J. Pain 35, 544\u2013558. https:\/\/doi.org\/10.1097\/ajp.0000000000000697 (2019).","journal-title":"Clin. J. Pain"},{"key":"1892_CR15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jss.2014.09.041","volume":"194","author":"J Yu","year":"2015","unstructured":"Yu, J. et al. Risk factors for postoperative fatigue after Gastrointestinal surgery. J. Surg. Res. 194, 114\u2013119. https:\/\/doi.org\/10.1016\/j.jss.2014.09.041 (2015).","journal-title":"J. Surg. Res."},{"key":"1892_CR16","doi-asserted-by":"publisher","unstructured":"Machado, P. et al. Effect of exercise training on quality of life after colorectal and lung cancer surgery: A meta-analysis. Cancers 13 https:\/\/doi.org\/10.3390\/cancers13194975 (2021).","DOI":"10.3390\/cancers13194975"},{"key":"1892_CR17","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1093\/asj\/sjx217","volume":"38","author":"EL Bartlett","year":"2018","unstructured":"Bartlett, E. L., Zavlin, D., Friedman, J. D., Abdollahi, A. & Rappaport, N. H. Enhanced recovery after surgery: The plastic surgery paradigm shift. Aesthetic Surg. J. 38, 676\u2013685. https:\/\/doi.org\/10.1093\/asj\/sjx217 (2018).","journal-title":"Aesthetic Surg. J."},{"key":"1892_CR18","doi-asserted-by":"publisher","unstructured":"Castro, I., Carvalho, P., Vale, N., Monjardino, T. & Mour\u00e3o, J. Systemic Anti-Inflammatory effects of intravenous Lidocaine in surgical patients: A systematic review and Meta-Analysis. J. Clin. Med. 12 https:\/\/doi.org\/10.3390\/jcm12113772 (2023).","DOI":"10.3390\/jcm12113772"},{"key":"1892_CR19","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/pm\/pnab210","volume":"23","author":"A Licina","year":"2022","unstructured":"Licina, A. & Silvers, A. Perioperative intravenous Lidocaine infusion for postoperative analgesia in patients undergoing surgery of the spine: Systematic review and Meta-Analysis. Pain Med. (Malden Mass) 23, 45\u201356. https:\/\/doi.org\/10.1093\/pm\/pnab210 (2022).","journal-title":"Pain Med. (Malden Mass)"},{"key":"1892_CR20","doi-asserted-by":"publisher","unstructured":"Hollmann, M. W. & Durieux, M. E. Local anesthetics and the inflammatory response: A new therapeutic indication? Anesthesiology 93, 858\u2013875, (2000). https:\/\/doi.org\/10.1097\/00000542-200009000-00038","DOI":"10.1097\/00000542-200009000-00038"},{"key":"1892_CR21","doi-asserted-by":"publisher","first-page":"26253","DOI":"10.1038\/srep26253","volume":"6","author":"M Kurabe","year":"2016","unstructured":"Kurabe, M., Furue, H. & Kohno, T. Intravenous administration of Lidocaine directly acts on spinal dorsal Horn and produces analgesic effect: An in vivo patch-clamp analysis. Sci. Rep. 6, 26253. https:\/\/doi.org\/10.1038\/srep26253 (2016).","journal-title":"Sci. Rep."},{"key":"1892_CR22","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/iwj.13279","volume":"17","author":"S Wei","year":"2020","unstructured":"Wei, S., Yu-Han, Z., Wei-Wei, J. & Hai, Y. The effects of intravenous Lidocaine on wound pain and Gastrointestinal function recovery after laparoscopic colorectal surgery. Int. Wound J. 17, 351\u2013362. https:\/\/doi.org\/10.1111\/iwj.13279 (2020).","journal-title":"Int. Wound J."},{"key":"1892_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ijsu.2018.01.001","volume":"50","author":"J Li","year":"2018","unstructured":"Li, J., Wang, G., Xu, W., Ding, M. & Yu, W. Efficacy of intravenous Lidocaine on pain relief in patients undergoing laparoscopic cholecystectomy: A meta-analysis from randomized controlled trials. Int. J. Surg. (London England). 50, 137\u2013145. https:\/\/doi.org\/10.1016\/j.ijsu.2018.01.001 (2018).","journal-title":"Int. J. Surg. (London England)"},{"key":"1892_CR24","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.2147\/jpr.S139466","volume":"10","author":"R Staud","year":"2017","unstructured":"Staud, R., Kizer, T. & Robinson, M. E. Muscle injections with Lidocaine improve resting fatigue and pain in patients with chronic fatigue syndrome. J. Pain Res. 10, 1477\u20131486. https:\/\/doi.org\/10.2147\/jpr.S139466 (2017).","journal-title":"J. Pain Res."},{"key":"1892_CR25","doi-asserted-by":"publisher","first-page":"c332","DOI":"10.1136\/bmj.c332","volume":"340","author":"KF Schulz","year":"2010","unstructured":"Schulz, K. F., Altman, D. G. & Moher, D. CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMJ (Clinical Res. ed.). 340, c332. https:\/\/doi.org\/10.1136\/bmj.c332 (2010).","journal-title":"BMJ (Clinical Res. ed.)"},{"key":"1892_CR26","doi-asserted-by":"publisher","first-page":"e272","DOI":"10.1016\/j.bja.2022.06.033","volume":"130","author":"JH Ma","year":"2023","unstructured":"Ma, J. H. et al. Effect of acute pain on the association between preoperative cognitive impairment and postoperative delirium: A secondary analysis of three trials. Br. J. Anaesth. 130, e272\u2013e280. https:\/\/doi.org\/10.1016\/j.bja.2022.06.033 (2023).","journal-title":"Br. J. Anaesth."},{"key":"1892_CR27","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s11136-018-2068-0","volume":"28","author":"T Nostdahl","year":"2019","unstructured":"Nostdahl, T., Bernklev, T., Fredheim, O. M., Paddison, J. S. & Raeder, J. Defining the cut-off point of clinically significant postoperative fatigue in three common fatigue scales. Qual. Life Res. 28, 991\u20131003. https:\/\/doi.org\/10.1007\/s11136-018-2068-0 (2019).","journal-title":"Qual. Life Res."},{"key":"1892_CR28","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/bjs.1800690721","volume":"69","author":"T Christensen","year":"1982","unstructured":"Christensen, T., Bendix, T. & Kehlet, H. Fatigue and cardiorespiratory function following abdominal surgery. Br. J. Surg. 69, 417\u2013419. https:\/\/doi.org\/10.1002\/bjs.1800690721 (1982).","journal-title":"Br. J. Surg."},{"key":"1892_CR29","doi-asserted-by":"publisher","unstructured":"Lin, X. H. et al. Fatigue and its associated factors in liver transplant recipients in Beijing: A cross-sectional study. BMJ Open. 7 https:\/\/doi.org\/10.1136\/bmjopen-2016-011840 (2017).","DOI":"10.1136\/bmjopen-2016-011840"},{"key":"1892_CR30","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00520-020-05483-0","volume":"29","author":"XY Xu","year":"2021","unstructured":"Xu, X. Y. et al. Risk factors and the utility of three different kinds of prediction models for postoperative fatigue after Gastrointestinal tumor surgery. Supportive Care Cancer: Official J. Multinational Association Supportive Care Cancer. 29, 203\u2013211. https:\/\/doi.org\/10.1007\/s00520-020-05483-0 (2021).","journal-title":"Supportive Care Cancer: Official J. Multinational Association Supportive Care Cancer"},{"key":"1892_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12871-024-02513-w","volume":"24","author":"X Lin","year":"2024","unstructured":"Lin, X. et al. Effects of Esketamine on postoperative fatigue syndrome in patients after laparoscopic resection of gastric carcinoma: a randomized controlled trial. BMC Anesthesiol. 24, 185. https:\/\/doi.org\/10.1186\/s12871-024-02513-w (2024).","journal-title":"BMC Anesthesiol"},{"key":"1892_CR32","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1248\/bpb.b14-00599","volume":"38","author":"WZ Chen","year":"2015","unstructured":"Chen, W. Z. et al. Prevention of postoperative fatigue syndrome in rat model by ginsenoside Rb1 via down-regulation of inflammation along the NMDA receptor pathway in the hippocampus. Biol. Pharm. Bull. 38, 239\u2013247. https:\/\/doi.org\/10.1248\/bpb.b14-00599 (2015).","journal-title":"Biol. Pharm. Bull."},{"key":"1892_CR33","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.jopan.2023.10.022","volume":"39","author":"Y Mo","year":"2024","unstructured":"Mo, Y., Wang, C., Yin, D. & Li, F. Efficacy of dexamethasone in reducing pain and inflammation and accelerating total hip arthroplasty postoperative recovery: A randomized controlled trial. J. Perianesthesia Nursing: Official J. Am. Soc. PeriAnesthesia Nurses. 39, 589\u2013595. https:\/\/doi.org\/10.1016\/j.jopan.2023.10.022 (2024).","journal-title":"J. Perianesthesia Nursing: Official J. Am. Soc. PeriAnesthesia Nurses"},{"key":"1892_CR34","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.bbi.2011.12.007","volume":"26","author":"XS Wang","year":"2012","unstructured":"Wang, X. S. et al. Serum sTNF-R1, IL-6, and the development of fatigue in patients with Gastrointestinal cancer undergoing chemoradiation therapy. Brain Behav. Immun. 26, 699\u2013705. https:\/\/doi.org\/10.1016\/j.bbi.2011.12.007 (2012).","journal-title":"Brain Behav. Immun."},{"key":"1892_CR35","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1002\/acr.22861","volume":"68","author":"A Hodges","year":"2016","unstructured":"Hodges, A. et al. Prevalence and determinants of fatigue following total knee replacement: A longitudinal cohort study. Arthritis Care Res. (Hoboken). 68, 1434\u20131442. https:\/\/doi.org\/10.1002\/acr.22861 (2016).","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"1892_CR36","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.23736\/S0375-9393.20.14358-X","volume":"86","author":"N Mendy","year":"2020","unstructured":"Mendy, N. et al. Postoperative fatigue after day surgery: prevalence and risk factors. A prospective observational study. Minerva Anestesiol. 86, 1269\u20131276. https:\/\/doi.org\/10.23736\/S0375-9393.20.14358-X (2020).","journal-title":"Minerva Anestesiol"},{"key":"1892_CR37","doi-asserted-by":"publisher","unstructured":"Weinberg, L. Pharmacokinetics and pharmacodynamics of Lignocaine: A review. World J. Anesthesiol. 4 https:\/\/doi.org\/10.5313\/wja.v4.i2.17 (2015).","DOI":"10.5313\/wja.v4.i2.17"},{"key":"1892_CR38","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1007\/s40265-018-0955-x","volume":"78","author":"M Beaussier","year":"2018","unstructured":"Beaussier, M., Delbos, A., Maurice-Szamburski, A., Ecoffey, C. & Mercadal, L. Perioperative use of intravenous Lidocaine. Drugs 78, 1229\u20131246. https:\/\/doi.org\/10.1007\/s40265-018-0955-x (2018).","journal-title":"Drugs"},{"key":"1892_CR39","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jss.2010.05.046","volume":"164","author":"T Sammour","year":"2010","unstructured":"Sammour, T., Kahokehr, A., Chan, S., Booth, R. J. & Hill, A. G. The humoral response after laparoscopic versus open colorectal surgery: A meta-analysis. J. Surg. Res. 164, 28\u201337. https:\/\/doi.org\/10.1016\/j.jss.2010.05.046 (2010).","journal-title":"J. Surg. Res."},{"key":"1892_CR40","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1177\/0363546519888450","volume":"48","author":"K Huang","year":"2020","unstructured":"Huang, K., Giddins, G. & Wu, L. D. Platelet-Rich plasma versus corticosteroid injections in the management of elbow epicondylitis and plantar fasciitis: An updated systematic review and Meta-analysis. Am. J. Sports Med. 48, 2572\u20132585. https:\/\/doi.org\/10.1177\/0363546519888450 (2020).","journal-title":"Am. J. Sports Med."},{"key":"1892_CR41","doi-asserted-by":"publisher","first-page":"259","DOI":"10.2165\/11593390-000000000-00000","volume":"11","author":"LR Webster","year":"2011","unstructured":"Webster, L. R., Johnson, F. K., Stauffer, J., Setnik, B. & Ciric, S. Impact of intravenous Naltrexone on intravenous morphine-induced high, drug liking, and euphoric effects in experienced, nondependent male opioid users. Drugs R&D. 11, 259\u2013275. https:\/\/doi.org\/10.2165\/11593390-000000000-00000 (2011).","journal-title":"Drugs R&D"},{"key":"1892_CR42","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bja.2019.06.014","volume":"123","author":"H Hermanns","year":"2019","unstructured":"Hermanns, H. et al. Molecular mechanisms of action of systemic Lidocaine in acute and chronic pain: A narrative review. Br. J. Anaesth. 123, 335\u2013349. https:\/\/doi.org\/10.1016\/j.bja.2019.06.014 (2019).","journal-title":"Br. J. Anaesth."},{"key":"1892_CR43","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ijsu.2017.07.042","volume":"45","author":"X Song","year":"2017","unstructured":"Song, X., Sun, Y., Zhang, X., Li, T. & Yang, B. Effect of perioperative intravenous Lidocaine infusion on postoperative recovery following laparoscopic Cholecystectomy-A randomized controlled trial. Int. J. Surg. (London England). 45, 8\u201313. https:\/\/doi.org\/10.1016\/j.ijsu.2017.07.042 (2017).","journal-title":"Int. J. Surg. (London England)"},{"key":"1892_CR44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10151-019-1927-1","volume":"23","author":"C Cooke","year":"2019","unstructured":"Cooke, C. et al. Meta-analysis of the effect of perioperative intravenous Lidocaine on return of Gastrointestinal function after colorectal surgery. Tech. Coloproctol. 23, 15\u201324. https:\/\/doi.org\/10.1007\/s10151-019-1927-1 (2019).","journal-title":"Tech. Coloproctol."},{"key":"1892_CR45","doi-asserted-by":"publisher","first-page":"4723","DOI":"10.3892\/etm.2019.7497","volume":"17","author":"T Wang","year":"2019","unstructured":"Wang, T., Liu, H., Sun, J. H., Wang, L. & Zhang, J. Y. Efficacy of intravenous Lidocaine in improving post-operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery. Experimental Therapeutic Med. 17, 4723\u20134729. https:\/\/doi.org\/10.3892\/etm.2019.7497 (2019).","journal-title":"Experimental Therapeutic Med."},{"key":"1892_CR46","doi-asserted-by":"publisher","first-page":"19752","DOI":"10.1038\/s41598-024-70804-w","volume":"14","author":"Y Hu","year":"2024","unstructured":"Hu, Y. et al. Lidocaine and risk of postoperative vomiting in children undergoing tonsillectomy: A randomised clinical trial. Sci. Rep. 14, 19752. https:\/\/doi.org\/10.1038\/s41598-024-70804-w (2024).","journal-title":"Sci. Rep."},{"key":"1892_CR47","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1093\/bja\/aes276","volume":"109","author":"CC Apfel","year":"2012","unstructured":"Apfel, C. C. et al. Evidence-based analysis of risk factors for postoperative nausea and vomiting. Br. J. Anaesth. 109, 742\u2013753. https:\/\/doi.org\/10.1093\/bja\/aes276 (2012).","journal-title":"Br. J. Anaesth."},{"key":"1892_CR48","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1002\/bjs.6375","volume":"95","author":"E Marret","year":"2008","unstructured":"Marret, E., Rolin, M., Beaussier, M. & Bonnet, F. Meta-analysis of intravenous Lidocaine and postoperative recovery after abdominal surgery. Br. J. Surg. 95, 1331\u20131338. https:\/\/doi.org\/10.1002\/bjs.6375 (2008).","journal-title":"Br. J. Surg."},{"key":"1892_CR49","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/anae.15270","volume":"76","author":"I Foo","year":"2021","unstructured":"Foo, I. et al. The use of intravenous Lidocaine for postoperative pain and recovery: International consensus statement on efficacy and safety. Anaesthesia 76, 238\u2013250. https:\/\/doi.org\/10.1111\/anae.15270 (2021).","journal-title":"Anaesthesia"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01892-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01892-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01892-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T05:19:22Z","timestamp":1748150362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-01892-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,25]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1892"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-01892-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,25]]},"assertion":[{"value":"12 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18146"}}