{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:20:51Z","timestamp":1789035651993,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jiangsu women and children health hospital","award":["FYRC202017"],"award-info":[{"award-number":["FYRC202017"]}]},{"name":"Jiangsu Province Association of Maternal and Child Health","award":["FYX202303, FYX202431"],"award-info":[{"award-number":["FYX202303, FYX202431"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-02055-2","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T16:40:55Z","timestamp":1747413655000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A risk nomogram for 30-day mortality in Chinese patients with acute pancreatitis using LASSO-logistic regression"],"prefix":"10.1038","volume":"15","author":[{"given":"Ying","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"2055_CR1","doi-asserted-by":"crossref","unstructured":"Anonymous. Working Group IAP\/APA Acute Pancreatitis. Guidelines. IAP\/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 13(4 Suppl 2), e1\u201315. (2013).","DOI":"10.1016\/j.pan.2013.07.063"},{"key":"2055_CR2","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","volume":"156","author":"AF Peery","year":"2019","unstructured":"Peery, A. F. et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018. Gastroenterology 156, 254\u2013272.e11 (2019).","journal-title":"Gastroenterology"},{"key":"2055_CR3","unstructured":"Chen, X. et al. C-reactive protein\/lymphocyte ratio as a prognostic biomarker in acute pancreatitis: A crosssectional study assessing disease severity."},{"issue":"1","key":"2055_CR4","doi-asserted-by":"publisher","first-page":"2194436","DOI":"10.1080\/0886022X.2023.2194436","volume":"45","author":"S Wu","year":"2023","unstructured":"Wu, S. et al. Development and validation of a prediction model for the early occurrence of acute kidney injury in patients with acute pancreatitis. Ren. Fail. 45(1), 2194436 (2023).","journal-title":"Ren. Fail."},{"key":"2055_CR5","doi-asserted-by":"crossref","unstructured":"Iasonos, A. et al. How to build and interpret a nomogram for cancer prognosis. 26(8), 1364\u20131370 (2008).","DOI":"10.1200\/JCO.2007.12.9791"},{"key":"2055_CR6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","volume":"62","author":"PA Banks","year":"2013","unstructured":"Banks, P. A. et al. Classifcation of acute pancreatitis\u20132012: revision of the Atlanta classifcation and defnitions by international consensus. Gut 62, 102\u2013111 (2013).","journal-title":"Gut"},{"issue":"5","key":"2055_CR7","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1097\/SHK.0000000000000982","volume":"49","author":"T Zhang","year":"2018","unstructured":"Zhang, T. et al. Predicting the severity of acute pancreatitis with red cell distribution width at early admission stage. Shock 49(5), 551\u2013555 (2018).","journal-title":"Shock"},{"key":"2055_CR8","doi-asserted-by":"crossref","unstructured":"Kong, W., He, Y., Bao, H., Zhang, W. & Wang, X. Diagnostic value of neutrophil-lymphocyte ratio for predicting the severity of acute pancreatitis: A meta-analysis. Dis. Mark. 2020, 9731854. (2020).","DOI":"10.1155\/2020\/9731854"},{"key":"2055_CR9","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/S1499-3872(17)60007-9","volume":"16","author":"M Kaplan","year":"2017","unstructured":"Kaplan, M. et al. Predictive value of C-reactive protein\/albumin ratio in acute pancreatitis. Hepatobil Pancreat. Dis. Int. 16, 424\u2013430 (2017).","journal-title":"Hepatobil Pancreat. Dis. Int."},{"key":"2055_CR10","doi-asserted-by":"crossref","unstructured":"Wang, J. et al. Association between serum creatinine to albumin ratio and short- and long-term all-cause mortality in patients with acute pancreatitis admitted to the intensive care unit: a retrospective analysis based on the MIMIC-IV database. Front. Immunol. 15, 151373371. (2024).","DOI":"10.3389\/fimmu.2024.1373371"},{"issue":"1","key":"2055_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s12876-024-03331-7","volume":"24","author":"B Huang","year":"2024","unstructured":"Huang, B. et al. Development and validation of a nomogram based on Lasso-logistic regression for predicting splenomegaly secondary to acute pancreatitis. BMC Gastroenterol. 24(1), 281 (2024).","journal-title":"BMC Gastroenterol."},{"issue":"6","key":"2055_CR12","first-page":"528","volume":"24","author":"EM Y\u0131lmaz","year":"2018","unstructured":"Y\u0131lmaz, E. M. & Kandemir, A. Significance of red blood cell distribution width and C-reactive protein\/albumin levels in predicting prognosis of acute pancreatitis. Ulus Travma Acil Cerrahi Derg. 24(6), 528\u2013531 (2018).","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"issue":"1","key":"2055_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.6061\/clinics\/2013(01)RC01","volume":"68","author":"WD Hong","year":"2013","unstructured":"Hong, W. D. et al. Use of an artificial neural network to predict persistent organ failure in patients with acute pancreatitis. Clin. (Sao Paulo). 68(1), 27\u201331 (2013).","journal-title":"Clin. (Sao Paulo)"},{"key":"2055_CR14","doi-asserted-by":"crossref","unstructured":"Mandalia, A., Wamsteker, E. J. & DiMagno, M. J. Recent advances in understanding and managing acute pancreatitis. F1000Res. 7, F1000 Faculty Rev-959 (2018).","DOI":"10.12688\/f1000research.14244.1"},{"issue":"07","key":"2055_CR15","first-page":"1050","volume":"48","author":"Y Gou","year":"2023","unstructured":"Gou, Y., Yao, L. & Cao, J. Changes in coagulation indices and D-dimer levels in hypertriglyceridemicacute pancreatitis and their value in predicting disease severity. J. Cent. South. University(Medical Science). 48(07), 1050\u20131058 (2023).","journal-title":"J. Cent. South. University(Medical Science)"},{"issue":"10","key":"2055_CR16","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1111\/cts.13378","volume":"15","author":"Y Yang","year":"2022","unstructured":"Yang, Y.  et al. Prolonged activated partial thromboplastin time predicts poor short-term prognosis in patients with acute pancreatitis: a retrospective cohort study. Clin. Transl Sci. 15(10), 2505\u20132513 (2022).","journal-title":"Clin. Transl Sci."},{"issue":"9","key":"2055_CR17","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.hlc.2019.11.013","volume":"29","author":"S Yamaguchi","year":"2020","unstructured":"Yamaguchi, S., Abe, M., Arakaki, T., Arasaki, O. & Shimabukuro, M. Prognostic value of lactate dehydrogenase for mid-term mortality in acute decompensated heart failure: A comparison to established biomarkers and brain natriuretic peptide. Heart Lung Circ. 29(9), 1318\u20131327 (2020).","journal-title":"Heart Lung Circ."},{"key":"2055_CR18","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jcrc.2017.05.001","volume":"41","author":"J Cui","year":"2017","unstructured":"Cui, J. et al. Serum lactate dehydrogenase is predictive of persistent organ failure in acute pancreatitis. J. Crit. Care. 41, 161\u2013165 (2017).","journal-title":"J. Crit. Care"},{"issue":"1","key":"2055_CR19","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12944-023-01984-z","volume":"22","author":"Y Shuanglian","year":"2023","unstructured":"Shuanglian, Y. et al. Establishment and validation of early prediction model for hypertriglyceridemic severe acute pancreatitis. Lipids Health Dis. 22(1), 218 (2023).","journal-title":"Lipids Health Dis."},{"issue":"9607","key":"2055_CR20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0140-6736(08)60107-5","volume":"371","author":"JL Frossard","year":"2008","unstructured":"Frossard, J. L., Steer, M. L. & Pastor, C. M. Acute pancreatitis. Lancet 371(9607), 143\u2013152 (2008).","journal-title":"Lancet"},{"key":"2055_CR21","doi-asserted-by":"publisher","first-page":"279607","DOI":"10.5402\/2011\/279607","volume":"2011","author":"B G\u00fcng\u00f6r","year":"2011","unstructured":"G\u00fcng\u00f6r, B. et al. The predictivity of serum biochemical markers in acute biliary pancreatitis. ISRN Gastroenterol. 2011, 279607 (2011).","journal-title":"ISRN Gastroenterol."},{"key":"2055_CR22","doi-asserted-by":"crossref","unstructured":"Deng, H. et al. Dynamic nomogram for predicting thrombocytopenia in adults with acute pancreatitis. J. Inflamm. Res. 14, 6657\u20136667 (2021).","DOI":"10.2147\/JIR.S339981"},{"issue":"1","key":"2055_CR23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1053\/j.gastro.2009.03.056","volume":"137","author":"BU Wu","year":"2009","unstructured":"Wu, B. U., Johannes, R. S., Sun, X., Conwell, D. L. & Banks, P. A. Early changes in blood Urea nitrogen predict mortality in acute pancreatitis. Gastroenterology 137(1), 129\u2013135 (2009).","journal-title":"Gastroenterology"},{"key":"2055_CR24","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1136\/gut.2008.152702","volume":"57","author":"BU Wu","year":"2008","unstructured":"Wu, B. U. et al. The early prediction of mortality in acute pancreatitis: A large population-based study. Gut 57, 1698\u20131703 (2008).","journal-title":"Gut"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-02055-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-02055-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-02055-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T16:41:00Z","timestamp":1747413660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-02055-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2055"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-02055-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"assertion":[{"value":"4 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University (2023-SR-043). This study protocol complied with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Approval"}},{"value":"The Institutional Review Board of the First Affiliated Hospital of Nanjing Medical University waived the need for informed consent to use anonymized and retrospectively analyzed data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17097"}}