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One of the main production pathways is the high-energy proton spallation of thorium-based targets, that requires an efficient, nuclide-selective separation method to recover <jats:sup>225<\/jats:sup>Ac from hundreds of co-produced spallation and fission products. The main radioactive contaminant of concern is <jats:sup>227<\/jats:sup>Ac\u00a0 (T<jats:sub>1\/2<\/jats:sub> = 21.8 years), that could preclude extensive medical use if not significantly suppressed. In this work, <jats:sup>225<\/jats:sup>Ac samples were produced by mass separation of radioactive ion beams extracted from proton-irradiated thorium-based targets. The activity of <jats:sup>225<\/jats:sup>Ac and other possible contaminants of the samples were measured using complementary gamma- and alpha-decay spectrometry methods, while <jats:sup>227<\/jats:sup>Ac activity was calculated by performing alpha-decay spectrometry of recoiled progeny from the sample. Using this novel method, accurate measurement of trace <jats:sup>227<\/jats:sup>Ac activity in <jats:sup>225<\/jats:sup>Ac samples was performed much faster than with conventional spectrometry techniques, thanks to its 10,000-fold increase in relative sensitivity. The end of collection activity ratio of <jats:sup>227<\/jats:sup>Ac to <jats:sup>225<\/jats:sup>Ac in two samples from irradiated targets were determined to be <jats:inline-formula>\n              <jats:tex-math>$$2.00(10) \\times 10^{-6}$$<\/jats:tex-math>\n            <\/jats:inline-formula> and <jats:inline-formula>\n              <jats:tex-math>$$2.7(4) \\times 10^{-6}$$<\/jats:tex-math>\n            <\/jats:inline-formula> respectively, three orders of magnitude below the <jats:sup>227<\/jats:sup>Ac activity in <jats:sup>225<\/jats:sup>Ac products obtained through radiochemical separation. The high separation factor of <jats:sup>225<\/jats:sup>Ac over <jats:sup>227<\/jats:sup>Ac suggests the suitability of mass-separated accelerator-based <jats:sup>225<\/jats:sup>Ac for medical use.<\/jats:p>","DOI":"10.1038\/s41598-025-02277-4","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:29:17Z","timestamp":1751448557000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantification of trace 227Ac and other radionuclidic impurities in mass-separated 225Ac samples produced at CERN-MEDICIS"],"prefix":"10.1038","volume":"15","author":[{"given":"Jake D.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Bernerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bruchertseifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Cocolios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Deseyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Duchemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Heines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Keppens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Meurrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf E.","family":"Rossel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Stora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor Van den","family":"Bergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"2277_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fmed.2015.00012","volume":"2","author":"J-P Pouget","year":"2015","unstructured":"Pouget, J.-P., Lozza, C., Deshayes, E., Boudousq, V. & Navarro-Teulon, I. 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