{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:59:12Z","timestamp":1761865152631,"version":"build-2065373602"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["ZYGD23016"],"award-info":[{"award-number":["ZYGD23016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Accurate assessment of Ki-67 expression in patients with prostate cancer (PC) is paramount. Therefore, this study aimed to assess the value of integrated Gallium-68(<jats:sup>68<\/jats:sup>Ga)-prostate-Specific membrane antigen-11 (PSMA) Positron Emission Tomography\/Intravoxel Incoherent Motion Magnetic Resonance Imaging (PET\/IVIM MRI) in predicting Ki-67 expression in newly diagnosed PC. A retrospective analysis was conducted on 37 newly diagnosed PC patients who underwent <jats:sup>68<\/jats:sup>Ga-PSMA-11 PET\/MR for staging. Maximum Standardized Uptake Value( SUVmax) and IVIM parameters of lesions were quantified. Patients were stratified into low-risk (Ki-67\u2009&lt;\u20095%) and high-risk groups (Ki-67\u2009&gt;\u20095%). SUVmax and IVIM parameters were compared between the two groups. Of the 37 patients, 29 were categorized as high risk, while 8 were classified as low risk. The high-risk group exhibited significantly higher SUV<jats:sub>max<\/jats:sub> (21.4\u2009\u00b1\u200911.3 vs. 11.2\u2009\u00b1\u20098.5, <jats:italic>P<\/jats:italic>\u2009=\u20090.025) and lower Standard apparent diffusion coefficient (ADC) (0.0011\u2009\u00b1\u20090.00023 vs. 0.0014\u2009\u00b1\u20090.00039, <jats:italic>P<\/jats:italic>\u2009=\u20090.005) compared to the low-risk group. Receiver operating characteristic (ROC) analysis determined optimal cut-off values for predicting high-risk patients as 7.64 for SUV<jats:sub>max<\/jats:sub> (sensitivity: 96.6%, specificity: 59.1%) and 0.0013 for standard ADC (sensitivity: 89.7%, specificity: 52.3%). Integrated assessment of SUVmax and standard ADC using <jats:sup>68<\/jats:sup>Ga-PSMA-11 PET-IVIM MRI may aid in predicting Ki-67 expression, with optimal thresholds of 7.67 for SUVmax and 0.0013 for standard ADC. These findings offer novel insights into evaluating the biological behavior of prostate cancer tumors in patients undergoing PET\/MR imaging.<\/jats:p>","DOI":"10.1038\/s41598-025-02467-0","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T22:13:00Z","timestamp":1751407980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Value of integrated PET-IVIM MRI in predicting Ki-67 expression in newly diagnosed prostate cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"Liu","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yikai","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"2","key":"2467_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1159\/000519007","volume":"89","author":"T Vlajnic","year":"2022","unstructured":"Vlajnic, T. et al. 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The original Article has been corrected.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of West China Hospital of Sichuan University (No.20221295). The informed consent has been waived by the approval committee due to retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22376"}}