{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:41:33Z","timestamp":1785498093214,"version":"3.56.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the National Research Council of Thailand (NRCT)  and Faculty of Veterinary Medicine, Kasetsart University.","award":["NRCT5-RGJ63002-039"],"award-info":[{"award-number":["NRCT5-RGJ63002-039"]}]},{"name":"the National Research Council of Thailand (NRCT)  and Faculty of Veterinary Medicine, Kasetsart University.","award":["NRCT5-RGJ63002-039"],"award-info":[{"award-number":["NRCT5-RGJ63002-039"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-03108-2","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T13:25:43Z","timestamp":1748525143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis"],"prefix":"10.1038","volume":"15","author":[{"given":"Wassamon","family":"Moyadee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sittiruk","family":"Roytrakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janthima","family":"Jaresitthikunchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumon","family":"Phaonakrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiattawee","family":"Choowongkomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekkarin","family":"Ploypetch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthasit","family":"Tansakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amonpun","family":"Rattanasrisomporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatuporn","family":"Rattanasrisomporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"3108_CR1","first-page":"157","volume":"53","author":"J Holzworth","year":"1963","unstructured":"Holzworth, J. Some important disorders of cats. Cornell Vet. 53, 157\u2013160 (1963).","journal-title":"Cornell Vet."},{"key":"3108_CR2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jfms.2008.09.008","volume":"11","author":"NC Pedersen","year":"2009","unstructured":"Pedersen, N. C. A review of feline infectious peritonitis virus infection: 1963\u20132008. J. Feline Med. Surg. 11, 225\u2013258 (2009).","journal-title":"J. Feline Med. Surg."},{"key":"3108_CR3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0165-2427(98)00155-X","volume":"65","author":"S Paltrinieri","year":"1998","unstructured":"Paltrinieri, S., Cammarata, M. P., Cammarata, G. & Comazzi, S. Some aspects of humoral and cellular immunity in naturally occurring feline infectious peritonitis. Vet. Immunol. Immunopathol. 65, 205\u2013220 (1998).","journal-title":"Vet. Immunol. Immunopathol."},{"key":"3108_CR4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1177\/1098612X19825701","volume":"21","author":"NC Pedersen","year":"2019","unstructured":"Pedersen, N. C. et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J. Feline Med. Surg. 21, 271\u2013281 (2019).","journal-title":"J. Feline Med. Surg."},{"key":"3108_CR5","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3390\/pathogens11101209","volume":"11","author":"M Roy","year":"2022","unstructured":"Roy, M. et al. Unlicensed molnupiravir is an effective rescue treatment following failure of unlicensed GS-441524-like therapy for cats with suspected feline infectious peritonitis. Pathogens 11, 1209 (2022).","journal-title":"Pathogens"},{"key":"3108_CR6","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1177\/1098612X221118761","volume":"24","author":"V Thayer","year":"2022","unstructured":"Thayer, V. et al. 2022 AAFP\/EveryCat feline infectious peritonitis diagnosis guidelines. J. Feline Med. Surg. 24, 905\u2013933 (2022).","journal-title":"J. Feline Med. Surg."},{"key":"3108_CR7","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.3390\/v15091847","volume":"15","author":"S Tasker","year":"2023","unstructured":"Tasker, S. et al. Feline infectious peritonitis: European advisory board on cat diseases guidelines. Viruses 15, 1847 (2023).","journal-title":"Viruses"},{"key":"3108_CR8","first-page":"19","volume":"11","author":"W Moyadee","year":"2024","unstructured":"Moyadee, W. et al. Feline infectious peritonitis: A comprehensive evaluation of clinical manifestations, laboratory diagnosis, and therapeutic approaches. J. Adv. Vet. Anim. Res. 11, 19 (2024).","journal-title":"J. Adv. Vet. Anim. Res."},{"key":"3108_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12917-017-1147-8","volume":"13","author":"S Felten","year":"2017","unstructured":"Felten, S. et al. Sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction detecting feline coronavirus mutations in effusion and serum\/plasma of cats to diagnose feline infectious peritonitis. BMC Vet. Res. 13, 1\u201311 (2017).","journal-title":"BMC Vet. Res."},{"key":"3108_CR10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3390\/pathogens13040289","volume":"13","author":"P Romanelli","year":"2024","unstructured":"Romanelli, P. et al. Measurement of feline alpha-1 acid glycoprotein in serum and effusion using an ELISA method: Analytical validation and diagnostic role for feline infectious peritonitis. Pathogens 13, 289 (2024).","journal-title":"Pathogens"},{"key":"3108_CR11","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1177\/1098612X16658925","volume":"19","author":"K Hazuchova","year":"2017","unstructured":"Hazuchova, K., Held, S. & Neiger, R. Usefulness of acute phase proteins in differentiating between feline infectious peritonitis and other diseases in cats with body cavity effusions. J. Feline Med. Surg. 19, 809\u2013816 (2017).","journal-title":"J. Feline Med. Surg."},{"key":"3108_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2021.105661","volume":"272","author":"S Meazzi","year":"2021","unstructured":"Meazzi, S. et al. Role of paraoxonase-1 as a diagnostic marker for feline infectious peritonitis. Vet. J. 272, 105661 (2021).","journal-title":"Vet. J."},{"key":"3108_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/vcp.13238","volume":"52","author":"G Rossi","year":"2023","unstructured":"Rossi, G. Acute phase proteins in cats: Diagnostic and prognostic role, future directions, and analytical challenges. Vet. Clin. Pathol. 52, 37\u201349 (2023).","journal-title":"Vet. Clin. Pathol."},{"key":"3108_CR14","doi-asserted-by":"publisher","first-page":"475","DOI":"10.17221\/19\/2016-VETMED","volume":"61","author":"C Tothova","year":"2016","unstructured":"Tothova, C., Nagy, O. & Kovac, G. Serum proteins and their diagnostic utility in veterinary medicine: A review. Vet. Med. 61, 475\u2013496 (2016).","journal-title":"Vet. Med."},{"key":"3108_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/978-3-031-28012-2_8","volume":"1412","author":"ES Mayne","year":"2023","unstructured":"Mayne, E. S., George, J. A. & Louw, S. Assessing biomarkers in viral infection. Adv. Exp. Med. Biol. 1412, 159\u2013173 (2023).","journal-title":"Adv. Exp. Med. Biol."},{"key":"3108_CR16","doi-asserted-by":"publisher","first-page":"4259","DOI":"10.1021\/acs.jproteome.0c00380","volume":"19","author":"M Sperk","year":"2020","unstructured":"Sperk, M. et al. Utility of proteomics in emerging and re-emerging infectious diseases caused by RNA viruses. J. Proteome Res. 19, 4259\u20134274 (2020).","journal-title":"J. Proteome Res."},{"key":"3108_CR17","doi-asserted-by":"publisher","first-page":"840","DOI":"10.3390\/biomedicines12040840","volume":"12","author":"V Urbiola-Salvador","year":"2024","unstructured":"Urbiola-Salvador, V., Lima de Souza, S., Macur, K., Czaplewska, P. & Chen, Z. Plasma proteomics elucidated a protein signature in COVID-19 patients with comorbidities and early-diagnosis biomarkers. Biomedicines 12, 840 (2024).","journal-title":"Biomedicines"},{"key":"3108_CR18","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.tvjl.2015.01.023","volume":"204","author":"E Ferlizza","year":"2015","unstructured":"Ferlizza, E. et al. The effect of chronic kidney disease on the urine proteome in the domestic cat (Felis catus). Vet. J. 204, 73\u201381 (2015).","journal-title":"Vet. J."},{"key":"3108_CR19","first-page":"184","volume":"79","author":"MD Meachem","year":"2015","unstructured":"Meachem, M. D. et al. Comparative proteomic study of plasma in feline pancreatitis and pancreatic carcinoma using 2-dimensional gel electrophoresis to identify diagnostic biomarkers: A pilot study. Can. J. Vet. Res. 79, 184\u2013189 (2015).","journal-title":"Can. J. Vet. Res."},{"key":"3108_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2020.103896","volume":"226","author":"M Liu","year":"2020","unstructured":"Liu, M. et al. Novel biomarkers in cats with congestive heart failure due to primary cardiomyopathy. J. Proteom. 226, 103896 (2020).","journal-title":"J. Proteom."},{"key":"3108_CR21","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1111\/jvim.16743","volume":"37","author":"J Yu","year":"2023","unstructured":"Yu, J. et al. Serum proteome profiles in cats with chronic enteropathies. J. Vet. Intern. Med. 37, 1358\u20131367 (2023).","journal-title":"J. Vet. Intern. Med."},{"key":"3108_CR22","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265\u2013275 (1951).","journal-title":"J. Biol. Chem."},{"key":"3108_CR23","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.1002\/pmic.200500921","volume":"6","author":"C Johansson","year":"2006","unstructured":"Johansson, C. et al. Differential expression analysis of Escherichia coli proteins using a novel software for relative quantitation of LC\u2013MS\/MS data. Proteomics 6, 4475\u20134485 (2006).","journal-title":"Proteomics"},{"key":"3108_CR24","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/rcm.2898","volume":"21","author":"A Thorsell","year":"2007","unstructured":"Thorsell, A., Portelius, E., Blennow, K. & Westman, B. A. Evaluation of sample fractionation using microscale liquid-phase isoelectric focusing on mass spectrometric identification and quantitation of proteins in a SILAC experiment. Rapid Commun. Mass Spectrom. 21, 771\u2013778 (2007).","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"3108_CR25","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2","volume":"20","author":"DN Perkins","year":"1999","unstructured":"Perkins, D. N., Pappin, D. J., Creasy, D. M. & Cottrell, J. S. Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20, 3551\u20133567 (1999).","journal-title":"Electrophoresis"},{"key":"3108_CR26","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1093\/nar\/gkv1277","volume":"44","author":"D Szklarczyk","year":"2016","unstructured":"Szklarczyk, D. et al. STITCH 5: augmenting protein\u2013chemical interaction networks with tissue and affinity data. Nucleic Acids Res. 44, 380\u2013384 (2016).","journal-title":"Nucleic Acids Res."},{"key":"3108_CR27","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12985-023-02273-y","volume":"21","author":"B Dong","year":"2024","unstructured":"Dong, B. et al. Prevalence of natural feline coronavirus infection in domestic cats in Fujian, China. Virol. J. 21, 2 (2024).","journal-title":"Virol. J."},{"key":"3108_CR28","doi-asserted-by":"publisher","first-page":"21641","DOI":"10.1038\/s41598-022-26132-y","volume":"12","author":"S Ploypetch","year":"2022","unstructured":"Ploypetch, S. et al. Utilizing MALDI-TOF MS and LC\u2013MS\/MS to access serum peptidome-based biomarkers in canine oral tumors. Sci. Rep. 12, 21641 (2022).","journal-title":"Sci. Rep."},{"key":"3108_CR29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/14789450.2023.2191845","volume":"20","author":"SN Gajula","year":"2023","unstructured":"Gajula, S. N. et al. LC-MS\/MS: A sensitive and selective analytical technique to detect COVID-19 protein biomarkers in the early disease stage. Expert Rev. Proteom. 20, 5\u201318 (2023).","journal-title":"Expert Rev. Proteom."},{"key":"3108_CR30","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1038\/s41596-021-00566-6","volume":"8","author":"Nakayasu","year":"2021","unstructured":"Nakayasu, et al. Tutorial: Best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation. Nat. Protoc. 8, 3737\u20133760 (2021).","journal-title":"Nat. Protoc."},{"key":"3108_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2023.199059","volume":"326","author":"YY Gao","year":"2023","unstructured":"Gao, Y. Y. An updated review of feline coronavirus: Mind the two biotypes. Virus Res. 326, 199059 (2023).","journal-title":"Virus Res."},{"key":"3108_CR32","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/pathogens9070524","volume":"9","author":"AJ Malbon","year":"2020","unstructured":"Malbon, A. J. et al. The effect of natural feline coronavirus infection on the host immune response: A whole-transcriptome analysis of the mesenteric lymph nodes in cats with and without feline infectious peritonitis. Pathogens 9, 524 (2020).","journal-title":"Pathogens"},{"key":"3108_CR33","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0165-2427(03)00156-9","volume":"9","author":"S Paltrinieri","year":"2003","unstructured":"Paltrinieri, S., Ponti, W., Comazzi, S., Giordano, A. & Poli, G. Shifts in circulating lymphocyte subsets in cats with feline infectious peritonitis (FIP): Pathogenic role and diagnostic relevance. Vet. Immunol. Immunopathol. 9, 141\u2013148 (2003).","journal-title":"Vet. Immunol. Immunopathol."},{"key":"3108_CR34","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.3390\/v13071189","volume":"13","author":"DG Brooks","year":"2021","unstructured":"Brooks, D. G., Tishon, A., Oldstone, M. B. & McGavern, D. B. Prevention of CD8 T cell deletion during chronic viral infection. Viruses 13, 1189 (2021).","journal-title":"Viruses"},{"key":"3108_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114205","volume":"158","author":"JP Liu","year":"2023","unstructured":"Liu, J. P. et al. ATP ion channel P2X purinergic receptors in inflammation response. Biomed. Pharmacother. 158, 114205 (2023).","journal-title":"Biomed. Pharmacother."},{"key":"3108_CR36","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s11302-006-9031-1","volume":"3","author":"JP Hughes","year":"2007","unstructured":"Hughes, J. P., Hatcher, J. P. & Chessell, I. P. The role of P2X 7 in pain and inflammation. Purinergic Signal 3, 163\u2013169 (2007).","journal-title":"Purinergic Signal"},{"key":"3108_CR37","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.ygyno.2007.03.032","volume":"106","author":"X Li","year":"2007","unstructured":"Li, X. et al. Decreased expression of P2X7 in endometrial epithelial pre-cancerous and cancer cells. Gynecol. Oncol. 106, 233\u2013243 (2007).","journal-title":"Gynecol. Oncol."},{"key":"3108_CR38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/MMBR.00055-20","volume":"85","author":"AY Soare","year":"2021","unstructured":"Soare, A. Y. et al. P2RX7 at the host\u2013pathogen interface of infectious diseases. Microbiol. Mol. Biol. 85, 10\u20131128 (2021).","journal-title":"Microbiol. Mol. Biol."},{"key":"3108_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11302-017-9593-0","volume":"14","author":"G Burnstock","year":"2018","unstructured":"Burnstock, G. & Knight, G. E. The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression. Purinergic Signal 14, 1\u20138 (2018).","journal-title":"Purinergic Signal"},{"key":"3108_CR40","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1111\/bph.15009","volume":"177","author":"RA Sophocleous","year":"2020","unstructured":"Sophocleous, R. A. et al. Pharmacological and genetic characterisation of the canine P2X4 receptor. Br. J. Pharmacol. 177, 2812\u20132829 (2020).","journal-title":"Br. J. Pharmacol."},{"key":"3108_CR41","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3389\/fimmu.2020.01179","volume":"11","author":"F Grassi","year":"2020","unstructured":"Grassi, F. The P2X7 receptor as regulator of T cell development and function. Front. Immunol. 11, 1179 (2020).","journal-title":"Front. Immunol."},{"key":"3108_CR42","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/pathogens9110893","volume":"9","author":"AJ Malbon","year":"2020","unstructured":"Malbon, A. J. et al. Colony stimulating factors in early feline infectious peritonitis virus infection of monocytes and in end stage feline infectious peritonitis; A combined in vivo and in vitro approach. Pathogens 9, 893 (2020).","journal-title":"Pathogens"},{"key":"3108_CR43","doi-asserted-by":"publisher","first-page":"9434","DOI":"10.3390\/ijms24119434","volume":"24","author":"K Zab\u0142ocki","year":"2023","unstructured":"Zab\u0142ocki, K. & G\u00f3recki, D. C. The role of P2X7 purinoceptors in the pathogenesis and treatment of muscular dystrophies. Int. J. Mol. Sci. 24, 9434 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"3108_CR44","doi-asserted-by":"publisher","first-page":"126","DOI":"10.4049\/jimmunol.2200650","volume":"210","author":"P Muralidhara","year":"2023","unstructured":"Muralidhara, P., Kumar, A., Chaurasia, M. K. & Bansal, K. Topoisomerases in immune cell development and function. J. Immunol. 210, 126\u2013133 (2023).","journal-title":"J. Immunol."},{"key":"3108_CR45","doi-asserted-by":"publisher","first-page":"aad7993","DOI":"10.1126\/science.aad7993","volume":"352","author":"A Rialdi","year":"2016","unstructured":"Rialdi, A. et al. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science 352, aad7993 (2016).","journal-title":"Science"},{"key":"3108_CR46","doi-asserted-by":"publisher","first-page":"2618","DOI":"10.1016\/j.cell.2021.03.051","volume":"184","author":"JS Ho","year":"2021","unstructured":"Ho, J. S. et al. TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation. Cell 184, 2618\u20132632 (2021).","journal-title":"Cell"},{"key":"3108_CR47","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","volume":"20","author":"M Merad","year":"2020","unstructured":"Merad, M. & Martin, J. C. Pathological inflammation in patients with COVID-19: A key role for monocytes and macrophages. Nat. Rev. Immunol. 20, 355\u2013362 (2020).","journal-title":"Nat. Rev. Immunol."},{"key":"3108_CR48","doi-asserted-by":"publisher","first-page":"1776084","DOI":"10.1080\/23723556.2020.1776084","volume":"7","author":"J Pancewicz","year":"2020","unstructured":"Pancewicz, J. A brief overview of clinical significance of novel Notch2 regulators. Mol. Cell. Oncol. 7, 1776084 (2020).","journal-title":"Mol. Cell. Oncol."},{"key":"3108_CR49","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.semcancer.2004.04.011","volume":"14","author":"EM Hansson","year":"2004","unstructured":"Hansson, E. M., Lendahl, U. & Chapman, G. Notch signaling in development and disease. Semin. Cancer Biol. 14, 320\u2013328 (2004).","journal-title":"Semin. Cancer Biol."},{"key":"3108_CR50","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.3390\/ijms25063287","volume":"25","author":"A Di Stefano","year":"2024","unstructured":"Di Stefano, A. et al. Upregulation of notch signaling and cell-differentiation inhibitory transcription factors in stable chronic obstructive pulmonary disease patients. Int. J. Mol. Sci. 25, 3287 (2024).","journal-title":"Int. J. Mol. Sci."},{"key":"3108_CR51","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1016\/j.bcp.2010.07.010","volume":"80","author":"T Quillard","year":"2010","unstructured":"Quillard, T., Devalli\u00e8re, J., Couple, S. & Charreau, B. Inflammation dysregulates Notch signaling in endothelial cells: Implication of Notch2 and Notch4 to endothelial dysfunction. Biochem. Pharmacol. 80, 2032\u20132041 (2010).","journal-title":"Biochem. Pharmacol."},{"key":"3108_CR52","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.virol.2007.02.006","volume":"364","author":"T Takano","year":"2007","unstructured":"Takano, T., Hohdatsu, T., Toda, A., Tanabe, M. & Koyama, H. TNF-alpha, produced by feline infectious peritonitis virus (FIPV)-infected macrophages, upregulates expression of type II FIPV receptor feline aminopeptidase N in feline macrophages. Virology 364, 64\u201372 (2007).","journal-title":"Virology"},{"key":"3108_CR53","doi-asserted-by":"publisher","first-page":"6863","DOI":"10.3390\/ijms14046863","volume":"14","author":"T Quillard","year":"2013","unstructured":"Quillard, T. & Charreau, B. Impact of notch signaling on inflammatory responses in cardiovascular disorders. Int. J. Mol. Sci. 14, 6863\u20136888 (2013).","journal-title":"Int. J. Mol. Sci."},{"key":"3108_CR54","doi-asserted-by":"publisher","first-page":"1073672","DOI":"10.3389\/fonc.2022.1073672","volume":"12","author":"N Mesini","year":"2023","unstructured":"Mesini, N. et al. Role of Notch2 pathway in mature B cell malignancies. Front. Oncol. 12, 1073672 (2023).","journal-title":"Front. Oncol."},{"key":"3108_CR55","doi-asserted-by":"publisher","first-page":"8071","DOI":"10.1128\/jvi.70.11.8071-8080.1996","volume":"70","author":"JL Rohn","year":"1996","unstructured":"Rohn, J. L., Lauring, A. S., Linenberger, M. L. & Overbaugh, J. Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma. J. Virol. 70, 8071\u20138080 (1996).","journal-title":"J. Virol."},{"key":"3108_CR56","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1292\/jvms.13-0344","volume":"76","author":"S Watanabe","year":"2014","unstructured":"Watanabe, S. et al. Notch2 transduction by Feline leukemia virus in a naturally infected cat. J. Vet. Med. Sci. 76, 553\u2013557 (2014).","journal-title":"J. Vet. Med. Sci."},{"key":"3108_CR57","first-page":"138","volume":"1806","author":"NP Lee","year":"2010","unstructured":"Lee, N. P., Poon, R. T., Shek, F. H., Ng, I. O. & Luk, J. M. Role of cadherin-17 in oncogenesis and potential therapeutic implications in hepatocellular carcinoma. Biochim. Biophys. Acta 1806, 138\u2013145 (2010).","journal-title":"Biochim. Biophys. Acta"},{"key":"3108_CR58","doi-asserted-by":"publisher","first-page":"262","DOI":"10.4161\/cbt.23299","volume":"14","author":"J Wang","year":"2013","unstructured":"Wang, J. et al. Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NF\u03baB signaling pathway. Cancer Biol. 14, 262\u2013270 (2013).","journal-title":"Cancer Biol."},{"key":"3108_CR59","doi-asserted-by":"publisher","first-page":"3694","DOI":"10.3748\/wjg.v21.i12.3694","volume":"21","author":"ZW Long","year":"2015","unstructured":"Long, Z. W., Zhou, M. L., Fu, J. W., Chu, X. Q. & Wang, Y. N. Association between cadherin-17 expression and pathological characteristics of gastric cancer: a meta-analysis. World J. Gastroenterol. 21, 3694 (2015).","journal-title":"World J. Gastroenterol."},{"key":"3108_CR60","first-page":"1","volume":"16","author":"S Delaney","year":"2024","unstructured":"Delaney, S. et al. Cadherin-17 as a target for the immunoPET of adenocarcinoma. Eur. J. Nucl. Med. Mol. Imaging 16, 1\u201311 (2024).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03108-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03108-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03108-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T14:02:50Z","timestamp":1748527370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03108-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3108"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-03108-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]},"assertion":[{"value":"13 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The work described in this manuscript involved the use of non-experimental (owned) animals. The study received prior ethical approval from the Kasetsart University Institutional Animal Care and Use Committee, Kasetsart University, Bangkok, Thailand, which approved all procedures involving animal use (approval number: ACKU66-VET-019). This study is reported in accordance with ARRIVE guidelines. All methods were conducted in accordance with relevant guidelines and regulations for reporting animal experiments. Blood for proteomic analysis was collected during routine veterinary examinations. Serum samples were obtained from the patients with signed informed consent forms from their owners, and a high standard of care was maintained throughout each examination.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent participate"}}],"article-number":"18899"}}