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Seventy-nine patients with TMD (69 females and 10 males; mean age 45.46\u2009\u00b1\u200914.46 years) were divided into two groups based on the presence or absence of SB: TMD_nonbruxer and TMD_bruxer. Descriptive statistics, correlation analyses, and multivariate stepwise logistic regression were conducted;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 was considered statistically significant. In Cramer\u2019s V, SB was correlated with several clinical and sleep-related factors, including TMJ noise (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.52), TMD pain (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.48), craniomandibular index (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.32), limited mouth opening (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.29), tinnitus (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.29), an increase in the Pittsburgh sleep quality index (PSQI) global score (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.24), and poor sleep quality, defined as a PSQI global score\u2009\u2265\u20095 (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.19) (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). SB was also associated with psychological distress. Regarding hematological factors, elevated levels of cortisol (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.30), adrenocorticotropic hormone (ACTH) (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.34), and cortisol\/ACTH ratio (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.35) were also associated with SB (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The factors associated with an increased likelihood of SB ranked in terms of the odds ratio (OR) were: craniomandibular index (OR\u2009=\u200918.400,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), poor sleep quality with a PSQI global score\u2009\u2265\u20095 (OR\u2009=\u200911.425,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027), depression (OR\u2009=\u20091.189,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014), cortisol\/ACTH ratio (OR\u2009=\u20091.151,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007), anxiety (OR\u2009=\u20091.081,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.040), and adrenocorticotropic hormone (OR\u2009=\u20091.073,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019). Notably, an increase in age was associated with a decreased likelihood of SB (OR\u2009=\u20090.905,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), with a cut-off value of 50 years (AUC\u2009=\u20090.259, 95% CI: 0.149\u20130.368,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024), indicating a significant decrease in bruxism occurrence in individuals aged\u2009\u2265\u200950 years. Further analysis revealed complex interconnections between SB and its predictors. In conclusion, SB in TMD patients was associated with age\u2009&lt;\u200950 years, various clinical factors, such as TMD pain and TMJ noise, poor sleep quality, psychological deterioration, and elevated cortisol and ACTH levels.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-03339-3","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T08:06:34Z","timestamp":1748678794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical, psychological, and hematological factors predicting sleep bruxism in patients with temporomandibular disorders"],"prefix":"10.1038","volume":"15","author":[{"given":"Yeon-Hee","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk","family":"Chon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q-Schick","family":"Auh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merel Charlotte","family":"Verhoeff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lobbezoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"3339_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/ors.12473","volume":"13","author":"FP Kapos","year":"2020","unstructured":"Kapos, F. 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