{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:28:39Z","timestamp":1771486119523,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-03429-2","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T08:55:42Z","timestamp":1748422542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between acid-sensing ion channel, ASIC2, and oncogenic \u03b2-catenin signaling in ovarian cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"Tanvi","family":"Joshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagar","family":"Chokshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelise","family":"Wilhite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Howard","family":"Singleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Catranis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Scalici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"3429_CR1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.critrevonc.2006.03.004","volume":"60","author":"N Colombo","year":"2006","unstructured":"Colombo, N. et al. Ovarian cancer. Crit. Rev. Oncol. Hematol. 60, 159\u2013179. https:\/\/doi.org\/10.1016\/j.critrevonc.2006.03.004 (2006).","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"3429_CR2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nrclinonc.2013.5","volume":"10","author":"RL Coleman","year":"2013","unstructured":"Coleman, R. L., Monk, B. J., Sood, A. K. & Herzog, T. J. Latest research and treatment of advanced-stage epithelial ovarian cancer. Nat. Rev. Clin. Oncol. 10, 211\u2013224. https:\/\/doi.org\/10.1038\/nrclinonc.2013.5 (2013).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"3429_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/GCO.0000000000000340","volume":"29","author":"PT Kroeger","year":"2017","unstructured":"Kroeger, P. T. & Drapkin, R. Pathogenesis and heterogeneity of ovarian cancer. Curr. Opin. Obstet. Gynecol. 29, 26\u201334. https:\/\/doi.org\/10.1097\/GCO.0000000000000340 (2017).","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"3429_CR4","doi-asserted-by":"publisher","DOI":"10.4274\/jtgga.galenos.2018.2018.0119","author":"I Nyoman Gede Budiana","year":"2018","unstructured":"Nyoman Gede Budiana, I. Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery. J. Turk.-German Gynecol. Assoc. https:\/\/doi.org\/10.4274\/jtgga.galenos.2018.2018.0119 (2018).","journal-title":"J. Turk.-German Gynecol. Assoc."},{"key":"3429_CR5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1146\/annurev-pathol-020712-163949","volume":"9","author":"NN Nik","year":"2014","unstructured":"Nik, N. N., Vang, R., Shih, I-M. & Kurman, R. J. Origin and pathogenesis of pelvic (Ovarian, tubal, and primary Peritoneal) serous carcinoma. Annu. Rev. Pathol. 9, 27\u201345. https:\/\/doi.org\/10.1146\/annurev-pathol-020712-163949 (2014).","journal-title":"Annu. Rev. Pathol."},{"key":"3429_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41389-020-0243-y","volume":"9","author":"M Kang","year":"2020","unstructured":"Kang, M. et al. Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells. Oncogenesis 9, 1\u201315. https:\/\/doi.org\/10.1038\/s41389-020-0243-y (2020).","journal-title":"Oncogenesis"},{"key":"3429_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.04.543","volume-title":"Is aspirin use associated with a decreased risk of ovarian cancer? A systematic review and meta-analysis of observational studies with dose-response analysis","author":"D Zhang","year":"2016","unstructured":"Zhang, D., Bai, B., Xi, Y., Wang, T. & Zhao, Y. Is aspirin use associated with a decreased risk of ovarian cancer? A systematic review and meta-analysis of observational studies with dose-response analysis (Academic Press Inc., 2016)."},{"key":"3429_CR8","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1007\/s10552-012-0063-2","volume":"23","author":"MA Murphy","year":"2012","unstructured":"Murphy, M. A. et al. Non-steroidal anti-inflammatory drug use and ovarian cancer risk: findings from the NIH-AARP diet and health study and systematic review. Cancer Causes Control. 23, 1839\u20131852. https:\/\/doi.org\/10.1007\/s10552-012-0063-2 (2012).","journal-title":"Cancer Causes Control"},{"key":"3429_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt431","author":"B Trabert","year":"2014","unstructured":"Trabert, B. et al. Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: A pooled analysis in the ovarian cancer association consortium. J. Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/djt431 (2014).","journal-title":"J. Natl Cancer Inst."},{"key":"3429_CR10","first-page":"3338","volume":"60","author":"WJ Thompson","year":"2000","unstructured":"Thompson, W. J. et al. Exisulind induction of apoptosis involves Guanosine 3\u2032,5\u2032-Cyclic monophosphate phosphodiesterase Inhibition, protein kinase G activation, and attenuated \u03b2-Catenin. Cancer Res. 60, 3338\u20133342 (2000).","journal-title":"Cancer Res."},{"key":"3429_CR11","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13048-022-01050-9","volume":"15","author":"RM Borneman","year":"2022","unstructured":"Borneman, R. M. et al. Phosphodiesterase 10A (PDE10A) as a novel target to suppress \u03b2-catenin and RAS signaling in epithelial ovarian cancer. J. Ovarian Res. 15, 120. https:\/\/doi.org\/10.1186\/s13048-022-01050-9 (2022).","journal-title":"J. Ovarian Res."},{"key":"3429_CR12","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1038\/cdd.2013.90","volume":"20","author":"Y-Z Wang","year":"2013","unstructured":"Wang, Y-Z. et al. Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death. Cell. Death Differ. 20, 1359\u20131369. https:\/\/doi.org\/10.1038\/cdd.2013.90 (2013).","journal-title":"Cell. Death Differ."},{"key":"3429_CR13","doi-asserted-by":"publisher","first-page":"4810","DOI":"10.3390\/ijms22094810","volume":"22","author":"N Ruan","year":"2021","unstructured":"Ruan, N. et al. Acid-Sensing ion channels and mechanosensation. Int. J. Mol. Sci. 22, 4810. https:\/\/doi.org\/10.3390\/ijms22094810 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"3429_CR14","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/gbb.12108","volume":"13","author":"MP Price","year":"2014","unstructured":"Price, M. P. et al. Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli. Genes Brain Behav. 13, 179\u2013194. https:\/\/doi.org\/10.1111\/gbb.12108 (2014).","journal-title":"Genes Brain Behav."},{"key":"3429_CR15","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.2174\/1570159X19666210125151824","volume":"19","author":"M Storozhuk","year":"2017","unstructured":"Storozhuk, M., Cherninskyi, A., Maximyuk, O., Isaev, D. & Krishtal, O. Acid-sensing ion channels: Focus on physiological and some pathological roles in the brain. Curr. Neuropharmacol. 19, 1570\u20131589. https:\/\/doi.org\/10.2174\/1570159X19666210125151824 (2017).","journal-title":"Curr. Neuropharmacol."},{"key":"3429_CR16","doi-asserted-by":"publisher","first-page":"295","DOI":"10.5483\/BMBRep.2013.46.6.121","volume":"46","author":"H-J Kweon","year":"2013","unstructured":"Kweon, H-J. & Suh, B-C. Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation. BMB Rep. 46, 295\u2013304. https:\/\/doi.org\/10.5483\/BMBRep.2013.46.6.121 (2013).","journal-title":"BMB Rep."},{"key":"3429_CR17","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1093\/brain\/awl325","volume":"130","author":"G Pignataro","year":"2007","unstructured":"Pignataro, G., Simon, R. P. & Xiong, Z-G. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain 130, 151\u2013158. https:\/\/doi.org\/10.1093\/brain\/awl325 (2007).","journal-title":"Brain"},{"key":"3429_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ijmm.2022.5150","volume":"50","author":"L Zhang","year":"2022","unstructured":"Zhang, L. et al. Pathology and physiology of acid\u2013sensitive ion channels in the digestive system (Review). Int. J. Mol. Med. 50, 1\u201312. https:\/\/doi.org\/10.3892\/ijmm.2022.5150 (2022).","journal-title":"Int. J. Mol. Med."},{"key":"3429_CR19","doi-asserted-by":"publisher","first-page":"e2806","DOI":"10.1038\/cddis.2017.189","volume":"8","author":"S Zhu","year":"2017","unstructured":"Zhu, S. et al. ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca2+\/RhoA pathway. Cell. Death Dis. 8, e2806\u2013e2806. https:\/\/doi.org\/10.1038\/cddis.2017.189 (2017).","journal-title":"Cell. Death Dis."},{"key":"3429_CR20","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.1038\/onc.2015.477","volume":"35","author":"SC Gupta","year":"2016","unstructured":"Gupta, S. C. et al. Regulation of breast tumorigenesis through acid sensors. Oncogene 35, 4102\u20134111. https:\/\/doi.org\/10.1038\/onc.2015.477 (2016).","journal-title":"Oncogene"},{"key":"3429_CR21","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13046-017-0599-9","volume":"36","author":"Z Zhou","year":"2017","unstructured":"Zhou, Z. et al. The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin\/NFAT1 axis. J. Experimental Clin. Cancer Res. 36, 130. https:\/\/doi.org\/10.1186\/s13046-017-0599-9 (2017).","journal-title":"J. Experimental Clin. Cancer Res."},{"key":"3429_CR22","doi-asserted-by":"publisher","first-page":"C1246","DOI":"10.1152\/ajpcell.00199.2010","volume":"300","author":"N Kapoor","year":"2011","unstructured":"Kapoor, N. et al. Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes. Am. J. Physiology-Cell Physiol. 300, C1246\u2013C1259. https:\/\/doi.org\/10.1152\/ajpcell.00199.2010 (2011).","journal-title":"Am. J. Physiology-Cell Physiol."},{"key":"3429_CR23","doi-asserted-by":"publisher","first-page":"11381","DOI":"10.1073\/pnas.1019711108","volume":"108","author":"S Sharma","year":"2011","unstructured":"Sharma, S. et al. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc. Natl. Acad. Sci. 108, 11381\u201311386. https:\/\/doi.org\/10.1073\/pnas.1019711108 (2011).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"3429_CR24","doi-asserted-by":"publisher","first-page":"3825","DOI":"10.1093\/emboj\/cdg381","volume":"22","author":"T Tomida","year":"2003","unstructured":"Tomida, T., Hirose, K., Takizawa, A., Shibasaki, F. & Iino, M. NFAT functions as a working memory of Ca2\u2009+\u2009signals in decoding Ca2\u2009+\u2009oscillation. EMBO J. 22, 3825\u20133832. https:\/\/doi.org\/10.1093\/emboj\/cdg381 (2003).","journal-title":"EMBO J."},{"key":"3429_CR25","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4161\/org.4.2.5851","volume":"4","author":"Y Komiya","year":"2008","unstructured":"Komiya, Y. & Habas, R. Wnt signal transduction pathways. Organogenesis 4, 68\u201375 (2008).","journal-title":"Organogenesis"},{"key":"3429_CR26","doi-asserted-by":"publisher","first-page":"5353","DOI":"10.18632\/oncotarget.6705","volume":"7","author":"K Lee","year":"2016","unstructured":"Lee, K. et al. \u03b2-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A Inhibition, cGMP elevation, and activation of PKG. Oncotarget 7, 5353\u20135365. https:\/\/doi.org\/10.18632\/oncotarget.6705 (2016).","journal-title":"Oncotarget"},{"key":"3429_CR27","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1158\/1940-6207.CAPR-21-0208","volume":"14","author":"KJ Lee","year":"2021","unstructured":"Lee, K. J. et al. Suppression of Colon tumorigenesis in mutant apc mice by a novel PDE10 inhibitor that reduces oncogenic \u03b2-Catenin. Cancer Prev. Res. (Phila). 14, 995\u20131008. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-21-0208 (2021).","journal-title":"Cancer Prev. Res. (Phila)"},{"key":"3429_CR28","doi-asserted-by":"publisher","first-page":"290","DOI":"10.4331\/wjbc.v6.i4.290","volume":"6","author":"S Rennoll","year":"2015","unstructured":"Rennoll, S. & Yochum, G. Regulation of MYC gene expression by aberrant Wnt\/\u03b2-catenin signaling in colorectal cancer. World J. Biol. Chem. 6, 290\u2013300. https:\/\/doi.org\/10.4331\/wjbc.v6.i4.290 (2015).","journal-title":"World J. Biol. Chem."},{"key":"3429_CR29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0378-1119(03)00633-4","volume":"313","author":"J Xia","year":"2003","unstructured":"Xia, J. et al. Molecular cloning and characterization of human acid sensing ion channel (ASIC)2 gene promoter. Gene 313, 91\u2013101. https:\/\/doi.org\/10.1016\/S0378-1119(03)00633-4 (2003).","journal-title":"Gene"},{"key":"3429_CR30","doi-asserted-by":"publisher","first-page":"e0180147","DOI":"10.1371\/journal.pone.0180147","volume":"12","author":"M Allevato","year":"2017","unstructured":"Allevato, M. et al. Sequence-specific DNA binding by MYC\/MAX to low-affinity non-E-box motifs. PLOS ONE. 12, e0180147. https:\/\/doi.org\/10.1371\/journal.pone.0180147 (2017).","journal-title":"PLOS ONE"},{"key":"3429_CR31","doi-asserted-by":"publisher","first-page":"12394","DOI":"10.1038\/s41598-018-30261-8","volume":"8","author":"D Jia","year":"2018","unstructured":"Jia, D., Nagaoka, Y., Katsumata, M. & Orsulic, S. Inflammation is a key contributor to ovarian cancer cell seeding. Sci. Rep. 8, 12394. https:\/\/doi.org\/10.1038\/s41598-018-30261-8 (2018).","journal-title":"Sci. Rep."},{"key":"3429_CR32","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/cancers10080251","volume":"10","author":"SS Savant","year":"2018","unstructured":"Savant, S. S., Sriramkumar, S. & O\u2019Hagan, H. M. The role of inflammation and inflammatory mediators in the development, progression, metastasis, and chemoresistance of epithelial ovarian Cancer. Cancers 10, 251. https:\/\/doi.org\/10.3390\/cancers10080251 (2018).","journal-title":"Cancers"},{"key":"3429_CR33","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1158\/1055-9965.EPI-09-0976","volume":"19","author":"AE Prizment","year":"2010","unstructured":"Prizment, A. E., Folsom, A. R. & Anderson, K. E. Nonsteroidal Anti-Inflammatory drugs and risk for ovarian and endometrial cancers in the Iowa women\u2019s health study. Cancer Epidemiol. Biomarkers Prev. 19, 435\u2013442. https:\/\/doi.org\/10.1158\/1055-9965.EPI-09-0976 (2010).","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"3429_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.738043","author":"VS Foster","year":"2021","unstructured":"Foster, V. S., Rash, L. D., King, G. F. & Rank, M. M. Acid-sensing ion channels: Expression and function in resident and infiltrating immune cells in the central nervous system. Front. Cell. Neurosci. https:\/\/doi.org\/10.3389\/fncel.2021.738043 (2021).","journal-title":"Front. Cell. Neurosci."},{"key":"3429_CR35","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/wmts.57","volume":"1","author":"Z-G Xiong","year":"2012","unstructured":"Xiong, Z-G. & Xu, T-L. The role of asics in cerebral ischemia. Wiley Interdisciplinary Reviews: Membrane Transp. Signal. 1, 655\u2013662. https:\/\/doi.org\/10.1002\/wmts.57 (2012).","journal-title":"Wiley Interdisciplinary Reviews: Membrane Transp. Signal."},{"key":"3429_CR36","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","volume":"131","author":"DE Clapham","year":"2007","unstructured":"Clapham, D. E. & Calcium Signaling Cell ;131: 1047\u20131058. doi:https:\/\/doi.org\/10.1016\/j.cell.2007.11.028 (2007).","journal-title":"Cell"},{"key":"3429_CR37","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1242\/jcs.03256","volume":"119","author":"J Gwak","year":"2006","unstructured":"Gwak, J. et al. Protein-kinase-C-mediated \u03b2-catenin phosphorylation negatively regulates the Wnt\/\u03b2-catenin pathway. J. Cell Sci. 119, 4702\u20134709. https:\/\/doi.org\/10.1242\/jcs.03256 (2006).","journal-title":"J. Cell Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03429-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03429-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03429-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T08:55:43Z","timestamp":1748422543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03429-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3429"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-03429-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]},"assertion":[{"value":"28 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no potential conflicts of interest. The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18633"}}