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However, the results regarding the significance of these associations were conflicting. Thus, the present study aimed to assess whether hysterectomy, menopause, and TL increase the odds of CHD. This case-control study included data from the enrollment phase of the Tabari cohort study (TCS) consisting of 564 cases of CHD and 564 healthy controls. Logistic regression was used to calculate the odds ratio (OR) of CHD in relation to hysterectomy, menopause, and TL status after adjustment for confounders. The univariate logistic regression analysis showed a significantly higher odds of CHD among post-menopausal participants (OR: 5.09, 95%CI 3.92\u20136.61), participants with TL (OR: 1.81, 95%CI 1.41\u20132.32), and women with hysterectomy (OR: 2.43, 95%CI 1.69\u20133.50). However, none of the associations were statistically significant (Hysterectomy: OR: 1.21, 95%CI 0.8\u20131.85; Menopause: OR: 1.43, 95%CI 0.88\u20132.31; TL: OR: 1.01, 95%CI 0.74\u20131.37) in the fully adjusted model (after adjustment for age, diabetes, hypertension, residential area, waist-to-hip ratio, pregnancy number, socio-economic state, occupation, education, and physical activity). Although some models showed significance, none of the reproductive factors showed a significant association with CHD after full adjustment.<\/jats:p>","DOI":"10.1038\/s41598-025-03480-z","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T13:25:42Z","timestamp":1748525142000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case\u2013control study"],"prefix":"10.1038","volume":"15","author":[{"given":"Mehran","family":"Asadi-Aliabadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Moosazadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiarash","family":"Shakeriastani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadmehdi","family":"Pejman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mobina","family":"Gheibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maliheh","family":"Ghasemi Tirtashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erfan","family":"Ghadirzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"3480_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12889-021-10429-0","volume":"21","author":"M Amini","year":"2021","unstructured":"Amini, M., Zayeri, F. & Salehi, M. 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TCS was approved by Mazandaran University of Medical Sciences Ethical Committee (Ethics Approval Code: IR.MAZUMS.REC.95.2524). Written informed consent was obtained from all participants before entering the study. All procedures performed in this study were in accordance with the ethical standards of the Institutional Research Ethics Committee of Mazandaran University of Medical Sciences and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"18906"}}