{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:17:02Z","timestamp":1787876222649,"version":"build-2784847793"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Sichuan Provincial Administration of TCM","award":["2023MS390"],"award-info":[{"award-number":["2023MS390"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-03833-8","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T06:26:56Z","timestamp":1748327216000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel ribosome biogenesis-related biomarkers and therapeutic targets identified in psoriasis"],"prefix":"10.1038","volume":"15","author":[{"given":"Jinghua","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyun","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingsheng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"3833_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/1744666X.2020.1719833","volume":"16","author":"E Pezzolo","year":"2020","unstructured":"Pezzolo, E. & Naldi, L. Epidemiology of major chronic inflammatory immune-related skin diseases in 2019. Expert Rev. Clin. Immunol. 16, 155\u2013166 (2020).","journal-title":"Expert Rev. Clin. Immunol."},{"key":"3833_CR2","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong, A. W., Read, C. & Pathophysiology Clinical presentation, and treatment of psoriasis: A review. JAMA 323, 1945\u20131960 (2020).","journal-title":"JAMA"},{"key":"3833_CR3","doi-asserted-by":"crossref","unstructured":"Rendon, A. & Sch\u00e4kel, K. Psoriasis pathogenesis and treatment. Int. J. Mol. Sci. 20(6), 1475 (2019).","DOI":"10.3390\/ijms20061475"},{"key":"3833_CR4","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s12016-024-08991-7","volume":"66","author":"I Sieminska","year":"2024","unstructured":"Sieminska, I., Pieniawska, M. & Grzywa, T. M. The immunology of Psoriasis-Current concepts in pathogenesis. Clin. Rev. Allergy Immunol. 66, 164\u2013191 (2024).","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"3833_CR5","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jaad.2016.07.064","volume":"76","author":"J Takeshita","year":"2017","unstructured":"Takeshita, J. et al. Psoriasis and comorbid diseases: epidemiology. J. Am. Acad. Dermatol. 76, 377\u2013390 (2017).","journal-title":"J. Am. Acad. Dermatol."},{"key":"3833_CR6","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41392-021-00728-8","volume":"6","author":"J Kang","year":"2021","unstructured":"Kang, J. et al. Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy. Signal. Transduct. Target. Ther. 6, 323 (2021).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"3833_CR7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41392-022-01285-4","volume":"8","author":"L Jiao","year":"2023","unstructured":"Jiao, L. et al. Ribosome biogenesis in disease: new players and therapeutic targets. Signal. Transduct. Target. Ther. 8, 15 (2023).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"3833_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nrc.2017.104","volume":"18","author":"J Pelletier","year":"2018","unstructured":"Pelletier, J., Thomas, G. & Volarevi\u0107, S. Ribosome biogenesis in cancer: new players and therapeutic avenues. Nat. Rev. Cancer. 18, 51\u201363 (2018).","journal-title":"Nat. Rev. Cancer"},{"key":"3833_CR9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.semcdb.2014.08.004","volume":"36","author":"V Iadevaia","year":"2014","unstructured":"Iadevaia, V., Liu, R. & Proud, C. G. mTORC1 signaling controls multiple steps in ribosome biogenesis. Semin Cell. Dev. Biol. 36, 113\u2013120 (2014).","journal-title":"Semin Cell. Dev. Biol."},{"key":"3833_CR10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/bjd.12271","volume":"169","author":"C Buerger","year":"2013","unstructured":"Buerger, C., Malisiewicz, B., Eiser, A., Hardt, K. & Boehncke, W. H. Mammalian target of Rapamycin and its downstream signalling components are activated in psoriatic skin. Br. J. Dermatol. 169, 156\u2013159 (2013).","journal-title":"Br. J. Dermatol."},{"key":"3833_CR11","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1111\/bjd.13248","volume":"171","author":"MT Ruf","year":"2014","unstructured":"Ruf, M. T., Andreoli, A., Itin, P., Pluschke, G. & Schmid, P. Ribosomal protein S6 is hyperactivated and differentially phosphorylated in epidermal lesions of patients with psoriasis and atopic dermatitis. Br. J. Dermatol. 171, 1533\u20131536 (2014).","journal-title":"Br. J. Dermatol."},{"key":"3833_CR12","doi-asserted-by":"publisher","first-page":"e0231446","DOI":"10.1371\/journal.pone.0231446","volume":"15","author":"S Varma","year":"2020","unstructured":"Varma, S. Blind Estimation and correction of microarray batch effect. PLoS One. 15, e0231446 (2020).","journal-title":"PLoS One"},{"key":"3833_CR13","doi-asserted-by":"crossref","unstructured":"Zang, Y. et al. Genomic hallmarks and therapeutic targets of ribosome biogenesis in cancer. Brief Bioinform. 25(2), bbae023 (2024).","DOI":"10.1093\/bib\/bbae023"},{"key":"3833_CR14","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 9, 559 (2008).","journal-title":"BMC Bioinform."},{"key":"3833_CR15","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).","journal-title":"Nucleic Acids Res."},{"key":"3833_CR16","doi-asserted-by":"publisher","first-page":"W60","DOI":"10.1093\/nar\/gky311","volume":"46","author":"M Franz","year":"2018","unstructured":"Franz, M. et al. GeneMANIA update 2018. Nucleic Acids Res. 46, W60\u2013W64 (2018).","journal-title":"Nucleic Acids Res."},{"key":"3833_CR17","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu, G., Wang, L. G., Han, Y. & He, Q. Y. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16, 284\u2013287 (2012).","journal-title":"OMICS"},{"key":"3833_CR18","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-1-0716-0301-7_11","volume":"2117","author":"G Yu","year":"2020","unstructured":"Yu, G. Gene ontology semantic similarity analysis using gosemsim. Methods Mol. Biol. 2117, 207\u2013215 (2020).","journal-title":"Methods Mol. Biol."},{"key":"3833_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"3833_CR20","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","volume":"26","author":"MD Wilkerson","year":"2010","unstructured":"Wilkerson, M. D. & Hayes, D. N. ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Bioinformatics 26, 1572\u20131573 (2010).","journal-title":"Bioinformatics"},{"key":"3833_CR21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","volume":"1711","author":"B Chen","year":"2018","unstructured":"Chen, B., Khodadoust, M. S., Liu, C. L., Newman, A. M. & Alizadeh, A. A. Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol. Biol. 1711, 243\u2013259 (2018).","journal-title":"Methods Mol. Biol."},{"key":"3833_CR22","doi-asserted-by":"crossref","unstructured":"H\u00e4nzelmann, S., Castelo, R. & Guinney, J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 14, 7 (2013).","DOI":"10.1186\/1471-2105-14-7"},{"key":"3833_CR23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411\u2013420 (2018).","journal-title":"Nat. Biotechnol."},{"key":"3833_CR24","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12964-023-01120-5","volume":"21","author":"G Cao","year":"2023","unstructured":"Cao, G. et al. Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm. Cell. Commun. Signal. 21, 113 (2023).","journal-title":"Cell. Commun. Signal."},{"key":"3833_CR25","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran, D. et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat. Immunol. 20, 163\u2013172 (2019).","journal-title":"Nat. Immunol."},{"key":"3833_CR26","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/j.jaci.2021.04.021","volume":"148","author":"J Kim","year":"2021","unstructured":"Kim, J. et al. Single-cell transcriptomics applied to emigrating cells from psoriasis elucidate pathogenic versus regulatory immune cell subsets. J. Allergy Clin. Immunol. 148, 1281\u20131292 (2021).","journal-title":"J. Allergy Clin. Immunol."},{"key":"3833_CR27","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s13167-023-00327-3","volume":"14","author":"J Liu","year":"2023","unstructured":"Liu, J., Shi, Y. & Zhang, Y. Multi-omics identification of an Immunogenic cell death-related signature for clear cell renal cell carcinoma in the context of 3P medicine and based on a 101-combination machine learning computational framework. Epma J. 14, 275\u2013305 (2023).","journal-title":"Epma J."},{"key":"3833_CR28","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.coisb.2021.03.007","volume":"26","author":"AA Almet","year":"2021","unstructured":"Almet, A. A., Cang, Z., Jin, S. & Nie, Q. The landscape of cell-cell communication through single-cell transcriptomics. Curr. Opin. Syst. Biol. 26, 12\u201323 (2021).","journal-title":"Curr. Opin. Syst. Biol."},{"key":"3833_CR29","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1093\/bioinformatics\/btv313","volume":"31","author":"M Yoo","year":"2015","unstructured":"Yoo, M. et al. DSigDB: drug signatures database for gene set analysis. Bioinformatics 31, 3069\u20133071 (2015).","journal-title":"Bioinformatics"},{"key":"3833_CR30","doi-asserted-by":"publisher","first-page":"D368","DOI":"10.1093\/nar\/gkad1011","volume":"52","author":"M Varadi","year":"2024","unstructured":"Varadi, M. et al. AlphaFold protein structure database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Res. 52, D368\u2013d375 (2024).","journal-title":"Nucleic Acids Res."},{"key":"3833_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s10822-010-9395-8","volume":"25","author":"MA Lill","year":"2011","unstructured":"Lill, M. A. & Danielson, M. L. Computer-aided drug design platform using PyMOL. J. Comput. Aided Mol. Des. 25, 13\u201319 (2011).","journal-title":"J. Comput. Aided Mol. Des."},{"key":"3833_CR32","doi-asserted-by":"crossref","unstructured":"Khoshnevis, S. et al. RNA 2\u2019-O-methylations regulate translation by impacting ribosome dynamics. Proc. Natl. Acad. Sci. U. S. A. 119, e2117334119, (2022).","DOI":"10.1073\/pnas.2117334119"},{"key":"3833_CR33","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/nature12104","volume":"497","author":"AM Anger","year":"2013","unstructured":"Anger, A. M. et al. Structures of the human and Drosophila 80S ribosome. Nature 497, 80\u201385 (2013).","journal-title":"Nature"},{"key":"3833_CR34","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1002\/1873-3468.12682","volume":"591","author":"R Tomecki","year":"2017","unstructured":"Tomecki, R., Sikorski, P. J. & Zakrzewska-Placzek, M. Comparison of preribosomal RNA processing pathways in yeast, plant and human cells - focus on coordinated action of endo- and exoribonucleases. FEBS Lett. 591, 1801\u20131850 (2017).","journal-title":"FEBS Lett."},{"key":"3833_CR35","doi-asserted-by":"publisher","first-page":"6795","DOI":"10.1093\/nar\/gki982","volume":"33","author":"G Schilders","year":"2005","unstructured":"Schilders, G., Raijmakers, R., Raats, J. M. & Pruijn, G. J. MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. Nucleic Acids Res. 33, 6795\u20136804 (2005).","journal-title":"Nucleic Acids Res."},{"key":"3833_CR36","doi-asserted-by":"publisher","first-page":"72375","DOI":"10.18632\/oncotarget.19758","volume":"8","author":"X Yang","year":"2017","unstructured":"Yang, X. et al. Association between MPHOSPH6 gene polymorphisms and IgA nephropathy risk in a Chinese Han population. Oncotarget 8, 72375\u201372380 (2017).","journal-title":"Oncotarget"},{"key":"3833_CR37","doi-asserted-by":"publisher","first-page":"86011","DOI":"10.18632\/oncotarget.20846","volume":"8","author":"Y Zhang","year":"2017","unstructured":"Zhang, Y., Wang, S., Wen, X., Zhang, S. & Yang, Y. Association of ACYP2 and MPHOSPH6 genetic polymorphisms with the risk of hepatocellular carcinoma in chronic hepatitis B virus carriers. Oncotarget 8, 86011\u201386019 (2017).","journal-title":"Oncotarget"},{"key":"3833_CR38","doi-asserted-by":"publisher","first-page":"77233","DOI":"10.18632\/oncotarget.20432","volume":"8","author":"Y Song","year":"2017","unstructured":"Song, Y. et al. Association between TNIP1, MPHOSPH6 and ZNF208 genetic polymorphisms and the coronary artery disease risk in Chinese Han population. Oncotarget 8, 77233\u201377240 (2017).","journal-title":"Oncotarget"},{"key":"3833_CR39","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41389-021-00333-y","volume":"10","author":"HAM Alsheikh","year":"2021","unstructured":"Alsheikh, H. A. M. et al. Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors. Oncogenesis 10, 45 (2021).","journal-title":"Oncogenesis"},{"key":"3833_CR40","doi-asserted-by":"crossref","unstructured":"Chen, Z., Yin, M., Jia, H., Chen, Q. & Zhang, H. ISG20 stimulates anti-tumor immunity via a double-stranded RNA-induced interferon response in ovarian cancer. Front. Immunol. 14, 1176103 (2023).","DOI":"10.3389\/fimmu.2023.1176103"},{"key":"3833_CR41","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.1016\/j.ymthe.2023.07.008","volume":"31","author":"M Jia","year":"2023","unstructured":"Jia, M. et al. Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury. Mol. Ther. 31, 3034\u20133051 (2023).","journal-title":"Mol. Ther."},{"key":"3833_CR42","doi-asserted-by":"publisher","first-page":"2224890","DOI":"10.1080\/0886022X.2023.2224890","volume":"45","author":"T Karasawa","year":"2023","unstructured":"Karasawa, T. et al. Expression of interferon-stimulated gene 20 (ISG20), an antiviral effector protein, in glomerular endothelial cells: possible involvement of ISG20 in lupus nephritis. Ren. Fail. 45, 2224890 (2023).","journal-title":"Ren. Fail."},{"key":"3833_CR43","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1182\/blood.V96.6.2206","volume":"96","author":"SI Hashimoto","year":"2000","unstructured":"Hashimoto, S. I. et al. Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression. Blood 96, 2206\u20132214 (2000).","journal-title":"Blood"},{"key":"3833_CR44","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1046\/j.1365-2133.2001.04376.x","volume":"145","author":"S Reitamo","year":"2001","unstructured":"Reitamo, S. et al. Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial. Br. J. Dermatol. 145, 438\u2013445 (2001).","journal-title":"Br. J. Dermatol."},{"key":"3833_CR45","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1111\/j.1365-2133.2005.06438.x","volume":"152","author":"AD Ormerod","year":"2005","unstructured":"Ormerod, A. D., Shah, S. A., Copeland, P., Omar, G. & Winfield, A. Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial. Br. J. Dermatol. 152, 758\u2013764 (2005).","journal-title":"Br. J. Dermatol."},{"key":"3833_CR46","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1038\/jid.2013.3","volume":"133","author":"A Datta Mitra","year":"2013","unstructured":"Datta Mitra, A. et al. 1\u03b1,25-Dihydroxyvitamin-D3-3-bromoacetate regulates AKT\/mTOR signaling cascades: a therapeutic agent for psoriasis. J. Invest. Dermatol. 133, 1556\u20131564 (2013).","journal-title":"J. Invest. Dermatol."},{"key":"3833_CR47","doi-asserted-by":"publisher","first-page":"147918","DOI":"10.1016\/j.gene.2023.147918","volume":"893","author":"S Liu","year":"2024","unstructured":"Liu, S. et al. Identification of potential biomarkers and infiltrating immune cells from scalp psoriasis. Gene 893, 147918 (2024).","journal-title":"Gene"},{"key":"3833_CR48","doi-asserted-by":"crossref","unstructured":"Popay, T. M. et al. MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1. Elife 10, (2021).","DOI":"10.7554\/eLife.60191"},{"key":"3833_CR49","doi-asserted-by":"publisher","first-page":"4348","DOI":"10.1158\/0008-5472.CAN-18-2718","volume":"79","author":"C Morcelle","year":"2019","unstructured":"Morcelle, C. et al. Oncogenic MYC induces the impaired ribosome biogenesis checkpoint and stabilizes p53 independent of increased ribosome content. Cancer Res. 79, 4348\u20134359 (2019).","journal-title":"Cancer Res."},{"key":"3833_CR50","doi-asserted-by":"crossref","unstructured":"Destefanis, F., Manara, V. & Bellosta, P. Myc as a regulator of ribosome biogenesis and cell competition: A link to Cancer. Int. J. Mol. Sci. 21(11), 4037 (2020).","DOI":"10.3390\/ijms21114037"},{"key":"3833_CR51","doi-asserted-by":"publisher","first-page":"7s","DOI":"10.1111\/1523-1747.ep12505653","volume":"95","author":"LT Elder","year":"1990","unstructured":"Elder, L. T. et al. Growth factor and proto-oncogene expression in psoriasis. J. Invest. Dermatol. 95, 7s\u20139s (1990).","journal-title":"J. Invest. Dermatol."},{"key":"3833_CR52","first-page":"145","volume":"8","author":"CK Osterland","year":"1990","unstructured":"Osterland, C. K., Wilkinson, R. D. & St Louis, E. A. Expression of c-myc protein in skin and synovium in psoriasis and psoriatic arthritis. Clin. Exp. Rheumatol. 8, 145\u2013150 (1990).","journal-title":"Clin. Exp. Rheumatol."},{"key":"3833_CR53","doi-asserted-by":"crossref","unstructured":"Liu, G. et al. Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes. Cells 11, (2022).","DOI":"10.3390\/cells11152429"},{"key":"3833_CR54","doi-asserted-by":"publisher","first-page":"153473542110061","DOI":"10.1177\/15347354211006191","volume":"20","author":"HJ Jang","year":"2021","unstructured":"Jang, H. J. et al. Chelidonine induces apoptosis via GADD45a-p53 regulation in human pancreatic Cancer cells. Integr. Cancer Ther. 20, 15347354211006191 (2021).","journal-title":"Integr. Cancer Ther."},{"key":"3833_CR55","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.biopha.2018.08.094","volume":"107","author":"W Liao","year":"2018","unstructured":"Liao, W., He, X., Yi, Z., Xiang, W. & Ding, Y. Chelidonine suppresses LPS-Induced production of inflammatory mediators through the inhibitory of the TLR4\/NF-\u03baB signaling pathway in RAW264.7 macrophages. Biomed. Pharmacother. 107, 1151\u20131159 (2018).","journal-title":"Biomed. Pharmacother"},{"key":"3833_CR56","first-page":"3108","volume":"16","author":"R Herrmann","year":"2018","unstructured":"Herrmann, R., Roller, J., Polednik, C. & Schmidt, M. Effect of chelidonine on growth, invasion, angiogenesis and gene expression in head and neck cancer cell lines. Oncol. Lett. 16, 3108\u20133116 (2018).","journal-title":"Oncol. Lett."},{"key":"3833_CR57","first-page":"s17","volume":"8","author":"W Abramovits","year":"2009","unstructured":"Abramovits, W. Calcitriol 3 Microg\/g ointment: an effective and safe addition to the armamentarium in topical psoriasis therapy. J. Drugs Dermatol. 8, s17\u201322 (2009).","journal-title":"J. Drugs Dermatol."},{"key":"3833_CR58","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s11154-017-9411-6","volume":"18","author":"L Barrea","year":"2017","unstructured":"Barrea, L. et al. Vitamin D and its role in psoriasis: an overview of the dermatologist and nutritionist. Rev. Endocr. Metab. Disord. 18, 195\u2013205 (2017).","journal-title":"Rev. Endocr. Metab. Disord"},{"key":"3833_CR59","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/j.1365-2133.1995.tb00710.x","volume":"132","author":"PC van de Kerkhof","year":"1995","unstructured":"van de Kerkhof, P. C. Biological activity of vitamin D analogues in the skin, with special reference to antipsoriatic mechanisms. Br. J. Dermatol. 132, 675\u2013682 (1995).","journal-title":"Br. J. Dermatol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03833-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03833-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03833-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:03:41Z","timestamp":1748333021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-03833-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3833"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-03833-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,27]]},"assertion":[{"value":"13 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The animal experimental procedures were approved by the Animal Ethics Committee of Sichuan Scientist Biotechnology Co., Ltd. (approval number: SYST-2024-003). The animal experiments described in this study were performed in compliance with the ARRIVE guidelines (\n                      \n                      ). The publicly available human data applied in this study did not require ethical approval, as ethical approval and participant consent were obtained in the original study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"18525"}}