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Despite this, half of its heritability remains unexplained, with most of the unidentified variants located in non-protein coding regions. Here we performed a genome-wide association study among 52,342 adults screened for CeD, including 465 previously undiagnosed and 361 already diagnosed cases, which mitigated the likely disease misclassification present in previous studies. Genotyping and imputation yielded approximately 24.9\u00a0million variants for analysis. The study identified 15 novel associations (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20095E-08) in 12 loci in addition to all the previously associated loci at lower significance thresholds (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20095E-03). The 5p15.33 locus in the long non-coding RNA gene (\n                    <jats:italic>LINC01019<\/jats:italic>\n                    ) showed the highest potential for a true association with CeD. Notably, variants in 5p15.33 has also been associated with rheumatoid arthritis, suggesting a new shared autoimmune locus.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-04421-6","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T05:17:14Z","timestamp":1749100634000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Population screening of adults identifies novel genetic variants associated with celiac disease"],"prefix":"10.1038","volume":"15","author":[{"given":"Mohammad Sayeef","family":"Alam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Brumpton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Hveem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E. 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Written informed consent was received from all participants. The study was conducted in accordance with principles established by the Declaration of Helsinki..","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"GWASLab -\n                      \n                      . LDSC -\n                      \n                      . GeneCards -\n                      \n                      . dbSNP -\n                      \n                      . Opentargets -\n                      \n                      . eQTL catalogue browser -\n                      \n                      .","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Web resources"}}],"article-number":"19764"}}