{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:43:11Z","timestamp":1790790191449,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH040212"],"award-info":[{"award-number":["2022AH040212"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH040212"],"award-info":[{"award-number":["2022AH040212"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH040212"],"award-info":[{"award-number":["2022AH040212"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH040212"],"award-info":[{"award-number":["2022AH040212"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH040212"],"award-info":[{"award-number":["2022AH040212"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH040212"],"award-info":[{"award-number":["2022AH040212"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH040212"],"award-info":[{"award-number":["2022AH040212"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH040212"],"award-info":[{"award-number":["2022AH040212"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH040212"],"award-info":[{"award-number":["2022AH040212"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-04424-3","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T13:43:49Z","timestamp":1748958229000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gender differences in the relationship between hearing and visual impairments, dual sensory impairment, and depression in middle-aged and elderly populations"],"prefix":"10.1038","volume":"15","author":[{"given":"Qiankun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaXue","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"issue":"10278","key":"4424_CR1","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/S0140-6736(21)00516-X","volume":"397","author":"LM Haile","year":"2021","unstructured":"Haile, L. M. et al. Hearing loss prevalence and years lived with disability, 1990\u20132019: Findings from the Global Burden of Disease Study 2019. Lancet 397(10278), 996\u20131009 (2021).","journal-title":"Lancet"},{"issue":"9995","key":"4424_CR2","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","volume":"386","author":"T Vos","year":"2015","unstructured":"Vos, T. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990\u20132013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 386(9995), 743\u2013800 (2015).","journal-title":"Lancet"},{"issue":"12","key":"4424_CR3","doi-asserted-by":"publisher","first-page":"E682","DOI":"10.1016\/S2468-2667(20)30254-1","volume":"5","author":"T Xu","year":"2020","unstructured":"Xu, T. et al. Prevalence and causes of vision loss in China from 1990 to 2019: Findings from the Global Burden of Disease Study 2019. Lancet Public Health 5(12), E682\u2013E691 (2020).","journal-title":"Lancet Public Health"},{"issue":"9","key":"4424_CR4","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1002\/gps.5534","volume":"36","author":"S Pardhan","year":"2021","unstructured":"Pardhan, S. et al. Visual, hearing, and dual sensory impairment are associated with higher depression and anxiety in women. Int. J. Geriatr. Psychiatry 36(9), 1378\u20131385 (2021).","journal-title":"Int. J. Geriatr. Psychiatry"},{"issue":"9","key":"4424_CR5","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1136\/jech-2019-212216","volume":"73","author":"M Ruiz","year":"2019","unstructured":"Ruiz, M. et al. Life course socioeconomic position and incidence of mid-late life depression in China and England: A comparative analysis of CHARLS and ELSA. J. Epidemiol. Commun. Health 73(9), 817\u2013824 (2019).","journal-title":"J. Epidemiol. Commun. Health"},{"key":"4424_CR6","doi-asserted-by":"publisher","first-page":"1656124","DOI":"10.3390\/ijerph192416561","volume":"19","author":"Y Levi-Belz","year":"2022","unstructured":"Levi-Belz, Y. & Birnbaum, S. Depression and suicide ideation among suicide-loss survivors: A six-year longitudinal study. Int. J. Environ. Res. Public Health 19, 1656124 (2022).","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"4424_CR7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.7874\/jao.2023.00213","volume":"28","author":"Y Choi","year":"2024","unstructured":"Choi, Y., Go, J. & Chung, J. W. Association between hearing level and mental health and quality of life in adults aged >\u200940 years. J. Audiol. Otol. 28(1), 52\u201358 (2024).","journal-title":"J. Audiol. Otol."},{"issue":"1","key":"4424_CR8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/ije\/dys203","volume":"43","author":"Y Zhao","year":"2014","unstructured":"Zhao, Y. et al. Cohort profile: The China health and retirement longitudinal study (CHARLS). Int. J. Epidemiol. 43(1), 61\u201368 (2014).","journal-title":"Int. J. Epidemiol."},{"key":"4424_CR9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ajp.2015.08.007","volume":"18","author":"SK Malakouti","year":"2015","unstructured":"Malakouti, S. K. et al. Reliability, validity and factor structure of the CES-D in Iranian elderly. Asian J. Psychiatry 18, 86 (2015).","journal-title":"Asian J. Psychiatry"},{"issue":"12","key":"4424_CR10","doi-asserted-by":"publisher","first-page":"e661","DOI":"10.1016\/S2468-2667(20)30185-7","volume":"5","author":"L Jia","year":"2020","unstructured":"Jia, L. et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: A cross-sectional study. Lancet Public Health 5(12), e661\u2013e671 (2020).","journal-title":"Lancet Public Health"},{"key":"4424_CR11","volume-title":"Influencing factors and policy suggestions of mental health of Chinese elderly-based on 2015 China health and retirement longitudinal study","author":"L Mengqi","year":"2018","unstructured":"Mengqi, L. Influencing factors and policy suggestions of mental health of Chinese elderly-based on 2015 China health and retirement longitudinal study (Admin Zhejiang University, 2018)."},{"key":"4424_CR12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393","volume":"338","author":"JA Sterne","year":"2009","unstructured":"Sterne, J. A. et al. Multiple imputation for missing data in epidemiological and clinical research: Potential and pitfalls. BMJ 338, b2393 (2009).","journal-title":"BMJ"},{"issue":"4","key":"4424_CR13","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.ypmed.2008.06.011","volume":"47","author":"S Harada","year":"2008","unstructured":"Harada, S. et al. Gender difference in the relationships between vision and hearing impairments and negative well-being. Prev. Med. 47(4), 433\u2013437 (2008).","journal-title":"Prev. Med."},{"issue":"1","key":"4424_CR14","doi-asserted-by":"publisher","first-page":"16189","DOI":"10.1038\/s41598-021-95576-5","volume":"11","author":"S Marmamula","year":"2021","unstructured":"Marmamula, S. et al. Depression, combined visual and hearing impairment (dual sensory impairment): A hidden multi-morbidity among the elderly in Residential Care in India. Sci. Rep. 11(1), 16189 (2021).","journal-title":"Sci. Rep."},{"key":"4424_CR15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jad.2022.07.067","volume":"317","author":"NM Armstrong","year":"2022","unstructured":"Armstrong, N. M. et al. Associations of dual sensory impairment with long-term depressive and anxiety symptoms in the United States. J. Affect Disord. 317, 114\u2013122 (2022).","journal-title":"J. Affect Disord."},{"key":"4424_CR16","doi-asserted-by":"publisher","first-page":"101010","DOI":"10.1016\/j.yfrne.2022.101010","volume":"66","author":"M Kundakovic","year":"2022","unstructured":"Kundakovic, M. & Rocks, D. Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms. Front. Neuroendocrinol. 66, 101010 (2022).","journal-title":"Front. Neuroendocrinol."},{"issue":"3","key":"4424_CR17","doi-asserted-by":"publisher","first-page":"197","DOI":"10.5935\/0004-2749.20150051","volume":"78","author":"MV Ribeiro","year":"2015","unstructured":"Ribeiro, M. V. et al. Association between visual impairment and depression in the elderly: A systematic review. Arq. Bras. Oftalmol. 78(3), 197\u2013201 (2015).","journal-title":"Arq. Bras. Oftalmol."},{"key":"4424_CR18","doi-asserted-by":"publisher","first-page":"1281689","DOI":"10.3389\/fpubh.2023.1281689","volume":"11","author":"ZQ Zhang","year":"2023","unstructured":"Zhang, Z. Q. et al. Bidirectional associations between sensorineural hearing loss and depression and anxiety: A meta-analysis. Front Public Health 11, 1281689 (2023).","journal-title":"Front Public Health"},{"issue":"1","key":"4424_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/AUD.0000000000001291","volume":"44","author":"KM Reavis","year":"2023","unstructured":"Reavis, K. M. et al. Sex-linked biology and gender-related research is essential to advancing hearing health. Ear Hear. 44(1), 10\u201327 (2023).","journal-title":"Ear Hear."},{"key":"4424_CR20","doi-asserted-by":"publisher","first-page":"1014143","DOI":"10.1016\/j.bjorl.2024.101414","volume":"90","author":"E Sari","year":"2024","unstructured":"Sari, E. et al. The variations of osseous structure of the \u0131nternal acoustic canal: An anatomical study. Brazil. J. Otorhinolaryngol. 90, 1014143 (2024).","journal-title":"Brazil. J. Otorhinolaryngol."},{"key":"4424_CR21","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.3389\/fnins.2019.01375","volume":"13","author":"B Chakraborti","year":"2020","unstructured":"Chakraborti, B. et al. Gender-specific effect of 5-HT and 5-HIAA on threshold level of behavioral symptoms and sex-bias in prevalence of autism spectrum disorder. Front. Neurosci. 13, 1375 (2020).","journal-title":"Front. Neurosci."},{"issue":"5","key":"4424_CR22","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1152\/jn.01092.2009","volume":"104","author":"D Rao","year":"2010","unstructured":"Rao, D. et al. Hearing loss alters serotonergic modulation of intrinsic excitability in auditory cortex. J. Neurophysiol. 104(5), 2693\u20132703 (2010).","journal-title":"J. Neurophysiol."},{"issue":"3","key":"4424_CR23","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1007\/s00405-021-06805-6","volume":"279","author":"T Marques","year":"2022","unstructured":"Marques, T., Marques, F. D. & Migu\u00e9is, A. Age-related hearing loss, depression and auditory amplification: A randomized clinical trial. Eur. Arch. Otorhinolaryngol. 279(3), 1317\u20131321 (2022).","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"7","key":"4424_CR24","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/ggi.14413","volume":"22","author":"Z Wang","year":"2022","unstructured":"Wang, Z. et al. Hearing loss, depression and social participation of older adults: Evidence from the China health and retirement longitudinal study. Geriatr. Gerontol. Int. 22(7), 529\u2013535 (2022).","journal-title":"Geriatr. Gerontol. Int."},{"key":"4424_CR25","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1002\/gps.5729","volume":"37","author":"F Jiang","year":"2022","unstructured":"Jiang, F. et al. Relationship between hearing loss and depression symptoms among older adults in China: The mediating role of social isolation and loneliness. Int. J. Geriatric Psychiatry 37, 6 (2022).","journal-title":"Int. J. Geriatric Psychiatry"},{"issue":"5","key":"4424_CR26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3928\/19404921-20190627-01","volume":"12","author":"DV Petrovsky","year":"2019","unstructured":"Petrovsky, D. V. et al. Social engagement, cognition, depression, and comorbidity in nursing home residents with sensory impairment. Res. Gerontol. Nurs. 12(5), 217 (2019).","journal-title":"Res. Gerontol. Nurs."},{"key":"4424_CR27","doi-asserted-by":"publisher","first-page":"20141869","DOI":"10.1001\/jamanetworkopen.2020.14186","volume":"3","author":"H Rong","year":"2020","unstructured":"Rong, H. et al. Association of sensory impairments with cognitive decline and depression among older adults in China. JAMA Netw. Open 3, 20141869 (2020).","journal-title":"JAMA Netw. Open"},{"issue":"1\u20132","key":"4424_CR28","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jad.2007.05.028","volume":"106","author":"K Chou","year":"2008","unstructured":"Chou, K. Combined effect of vision and hearing impairment on depression in older adults: Evidence from the English Longitudinal Study of Ageing. J. Affect. Disord. 106(1\u20132), 191\u2013196 (2008).","journal-title":"J. Affect. Disord."},{"key":"4424_CR29","first-page":"648211","volume":"19","author":"Y Zhang","year":"2022","unstructured":"Zhang, Y. et al. Empirical research on male preference in China: A result of gender imbalance in the seventh population census. Int. J. Environ. Res. Public Health 19, 648211 (2022).","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"4424_CR30","doi-asserted-by":"crossref","unstructured":"Hyde, J. S. Gender Similarities and Differences. In Annual Review of Psychology, S. T. Fiske, Editor. 373\u2013398 (2014).","DOI":"10.1146\/annurev-psych-010213-115057"},{"key":"4424_CR31","first-page":"6","volume":"9","author":"N Utoomprurkporn","year":"2021","unstructured":"Utoomprurkporn, N. et al. Lack of association between audiogram and hearing disability measures in mild cognitive impairment and dementia: What audiogram does not tell you. Healthcare (Basel) 9, 6 (2021).","journal-title":"Healthcare (Basel)"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-04424-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-04424-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-04424-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T13:43:52Z","timestamp":1748958232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-04424-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4424"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-04424-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"8 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"This study involves no data collected from human subjects. We only make use of the publicly available de-identified sample. This paper performed secondary data analysis on survey data which have obtained ethical approval before being fielded and are publicly available.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"19442"}}