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This study evaluates the performance of a novel Swept-Source OCTA device, Intalight DREAM, compared to established systems: Heidelberg Spectralis, Topcon Triton, and Zeiss Cirrus. We assessed acquisition time and microvascular parameters in the superficial (SCP) and deep (DCP) capillary plexuses using the OCTA Vascular Analyser algorithm for standardized image analysis across devices on 30 eyes from 15 healthy participants. In the SCP, DREAM demonstrated a higher median vessel length (47\u00a0\u03bcm) and greater fractal dimension (mean: 1.999) than the other devices, indicating enhanced continuity and network complexity. In the DCP, DREAM showed a smaller foveal avascular zone (median: 0.339\u00a0mm<jats:sup>2<\/jats:sup>) compared to Spectralis (0.51\u00a0mm<jats:sup>2<\/jats:sup>), Triton (0.5935\u00a0mm<jats:sup>2<\/jats:sup>), and Cirrus (0.9145\u00a0mm<jats:sup>2<\/jats:sup>), along with a smaller vessel diameter (median: 23\u00a0\u03bcm) compared to Triton and Cirrus. With a median imaging time of 9.1\u00a0s, DREAM was significantly faster than the Spectralis system (23.3\u00a0s) while providing largely comparable image quality, enhancing patient comfort, and potentially minimizing motion artifacts. These findings suggest that DREAM OCT is a promising tool for deep retinal imaging, with strong potential for clinical application and research.<\/jats:p>","DOI":"10.1038\/s41598-025-04650-9","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T09:13:02Z","timestamp":1750410782000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Quantitative comparison of a novel swept-source optical coherence tomography angiography device with three established systems"],"prefix":"10.1038","volume":"15","author":[{"given":"Michael","family":"Hafner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried G.","family":"Priglinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"von Livonius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian J.","family":"Gerhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"issue":"2","key":"4650_CR1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/eye.2017.181","volume":"32","author":"ACS Tan","year":"2018","unstructured":"Tan, A. 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However, S.G.P. has received previous speaker fees and\/or advisory board honoraria from Novartis Pharma GmbH, Pharm Allergan, Carl Zeiss Meditec AG, BVI, Bayer AG, Alcon Pharma GmbH, Bausch & Lomb (B&L), and Roche AG. S.G.P. also received consulting fees from Roche AG, Carl Zeiss Meditec AG, BVI, and B&L. M.J.G. received speaker fees and\/or advisory board honoraria from Bayer, Janssen, Novartis, Rhythm Pharmaceuticals and Roche. He is consultant for ViGeneron, with all fees paid to LMU Eye Hospital to support research. M.H. and B.L. declare no financial disclosures. All authors confirm that there are no conflicts of interest regarding this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20129"}}