{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:17:22Z","timestamp":1789471042091,"version":"build-2803163510"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"This study was supported by a gift from the Al Rashid Family."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-04666-1","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T07:02:53Z","timestamp":1749193373000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dysregulation of cell migration by matrix metalloproteinases in geleophysic dysplasia"],"prefix":"10.1038","volume":"15","author":[{"given":"Alejo A.","family":"Morales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Camarena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9Shon","family":"Peart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Smithson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Negron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan E.","family":"Sola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Christina","family":"Brady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherina","family":"Walz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"4666_CR1","unstructured":"Marzin, P. & Cormier-Daire, V. Geleophysic Dysplasia. In GeneReviews\u00ae [Internet] (eds Adam, M. P. et al.) (University of Washington, Seattle)\u00a0(1993\u20132024)."},{"key":"4666_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41436-020-00994-x","volume":"23","author":"P Marzin","year":"2021","unstructured":"Marzin, P. et al. Geleophysic and acromicric dysplasias: natural history, genotype-phenotype correlations, and management guidelines from 38 cases. Genet. Medicine: Official J. Am. Coll. Med. Genet. 23, 331\u2013340 (2021).","journal-title":"Genet. Medicine: Official J. Am. Coll. Med. Genet."},{"key":"4666_CR3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0140-6736(71)92073-3","volume":"2","author":"JW Spranger","year":"1971","unstructured":"Spranger, J. W., Gilbert, E. F., Tuffli, G. A., Rossiter, F. P. & Opitz, J. M. Geleophysic dwarfism\u2013a focal. mucopolysaccharidosis? Lancet (London England). 2, 97\u201398 (1971).","journal-title":"mucopolysaccharidosis? Lancet (London England)"},{"key":"4666_CR4","first-page":"487","volume":"19","author":"J Spranger","year":"1984","unstructured":"Spranger, J., Gilbert, E. F., Arya, S., Hoganson, G. M. I. & Opitz, J. M. Geleophysic Dysplasia 19, 487\u2013499 (1984).","journal-title":"Geleophysic Dysplasia"},{"key":"4666_CR5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/ajmg.1320280522","volume":"3","author":"AH Lipson","year":"1987","unstructured":"Lipson, A. H., Kan, A. E. & Kozlowski, K. Geleophysic dysplasia-acromicric dysplasia with evidence of glycoprotein storage. Am. J. Med. Genet. Suppl. 3, 181\u2013189 (1987).","journal-title":"Am. J. Med. Genet. Suppl."},{"key":"4666_CR6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/ajmg.1320350202","volume":"35","author":"JE Wraith","year":"1990","unstructured":"Wraith, J. E., Bankier, A., Chow, C. W. & Danks, D. M. Sardharwalla I.B. Geleophysic dysplasia. Am. J. Med. Genet. 35, 153\u2013156 (1990).","journal-title":"Am. J. Med. Genet."},{"key":"4666_CR7","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1136\/jmg.2010.087544","volume":"48","author":"S Allali","year":"2011","unstructured":"Allali, S. et al. Molecular screening of ADAMTSL2 gene in 33 patients reveals the genetic heterogeneity of geleophysic dysplasia. J. Med. Genet. 48, 417\u2013421 (2011).","journal-title":"J. Med. Genet."},{"key":"4666_CR8","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/ng.199","volume":"40","author":"C Le Goff","year":"2008","unstructured":"Le Goff, C. et al. Cormier-Daire V. ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat. Genet. 40, 1119\u20131123 (2008).","journal-title":"Nat. Genet."},{"key":"4666_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ajhg.2011.05.012","volume":"89","author":"C Le Goff","year":"2011","unstructured":"Le Goff, C. et al. Cormier-Daire V. Mutations in the TGF\u03b2 binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias. Am. J. Hum. Genet. 89, 7\u201314 (2011).","journal-title":"Am. J. Hum. Genet."},{"key":"4666_CR10","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1136\/jmedgenet-2015-103647","volume":"53","author":"AM McInerney-Leo","year":"2016","unstructured":"McInerney-Leo, A. M. et al. Cormier-Daire V. Mutations in LTBP3 cause acromicric dysplasia and geleophysic dysplasia. J. Med. Genet. 53, 457\u2013464 (2016).","journal-title":"J. Med. Genet."},{"key":"4666_CR11","doi-asserted-by":"publisher","first-page":"100504","DOI":"10.1016\/j.ymgmr.2019.100504","volume":"21","author":"P Piccolo","year":"2019","unstructured":"Piccolo, P. et al. Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking. Mol. Genet. Metabolism Rep. 21, 100504 (2019).","journal-title":"Mol. Genet. Metabolism Rep."},{"issue":"3","key":"4666_CR12","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/ajmg.a.62030","volume":"185","author":"J Steinle","year":"2021","unstructured":"Steinle, J., Hossain, W. A., Lovell, S., Veatch, O. J. & Butler, M. G. ADAMTSL2 gene variant in patients with features of autosomal dominant connective tissue disorders. Am. J. Med. Genet. A. 185 (3), 743\u2013752 (2021).","journal-title":"Am. J. Med. Genet. A"},{"key":"4666_CR13","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.matbio.2007.03.003","volume":"26","author":"BH Koo","year":"2007","unstructured":"Koo, B. H. et al. ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis. Matrix Biol. 26, 431\u2013441 (2007).","journal-title":"Matrix Biol."},{"key":"4666_CR14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.matbio.2018.06.002","volume":"71\u201372","author":"TJ Mead","year":"2018","unstructured":"Mead, T. J. & Apte, S. S. ADAMTS proteins in human disorders. Matrix Biology: J. Int. Soc. Matrix Biology. 71\u201372, 225\u2013239 (2018).","journal-title":"Matrix Biology: J. Int. Soc. Matrix Biology"},{"key":"4666_CR15","doi-asserted-by":"publisher","first-page":"15742","DOI":"10.1074\/jbc.RA120.014557","volume":"295","author":"A Zhang","year":"2020","unstructured":"Zhang, A. et al. O-Fucosylation of ADAMTSL2 is required for secretion and is impacted by geleophysic dysplasia-causing mutations. J. Biol. Chem. 295, 15742\u201315753 (2020).","journal-title":"J. Biol. Chem."},{"key":"4666_CR16","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.matbio.2015.05.004","volume":"47","author":"D Hubmacher","year":"2015","unstructured":"Hubmacher, D. & Apte, S. S. ADAMTS proteins as modulators of microfibril formation and function. Matrix Biol. 47, 34\u201343 (2015).","journal-title":"Matrix Biol."},{"key":"4666_CR17","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1096\/fj.201800753RR","volume":"33","author":"L Delhon","year":"2019","unstructured":"Delhon, L. et al. Impairment of chondrogenesis and microfibrillar network in Adamtsl2 deficiency. FASEB J. 33, 2707\u20132718 (2019).","journal-title":"FASEB J."},{"key":"4666_CR18","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1242\/dmm.017046","volume":"8","author":"D Hubmacher","year":"2015","unstructured":"Hubmacher, D., Wang, L. W., Mecham, R. P., Reinhardt, D. P. & Apte, S. S. Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia-18a novel mouse model providing insights into geleophysic dysplasia. Dis. Models Mech. 8, 487\u2013499 (2015).","journal-title":"Dis. Models Mech."},{"key":"4666_CR19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.semcdb.2018.07.016","volume":"89","author":"J Thomson","year":"2019","unstructured":"Thomson, J. et al. Fibrillin microfibrils and elastic fibre proteins: functional interactions and extracellular regulation of growth factors. Semin. Cell Dev. Biol. 89, 109\u2013117 (2019).","journal-title":"Semin. Cell Dev. Biol."},{"key":"4666_CR20","doi-asserted-by":"publisher","first-page":"19757","DOI":"10.1038\/s41598-021-99032-2","volume":"11","author":"KB Rypdal","year":"2021","unstructured":"Rypdal, K. B. et al. The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGF\u03b2 signalling in cardiac fibroblasts. Sci. Rep. 11, 19757 (2021).","journal-title":"Sci. Rep."},{"issue":"3","key":"4666_CR21","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1083\/jcb.200608167","volume":"176","author":"SS Chaudhry","year":"2007","unstructured":"Chaudhry, S. S. et al. Fibrillin-1 regulates the bioavailability of TGFbeta1. J. Cell. Biol. 176 (3), 355\u2013367 (2007).","journal-title":"J. Cell. Biol."},{"key":"4666_CR22","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1083\/jcb.103.6.2499","volume":"103","author":"LY Sakai","year":"1986","unstructured":"Sakai, L. Y., Keene, D. R. & Engvall, E. Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. J. Cell. Biol. 103, 2499\u20132509 (1986).","journal-title":"J. Cell. Biol."},{"key":"4666_CR23","doi-asserted-by":"publisher","first-page":"14763","DOI":"10.1016\/S0021-9258(18)98752-1","volume":"266","author":"LY Sakai","year":"1991","unstructured":"Sakai, L. Y., Keene, D. R., Glanville, R. W. & Bachinger, H. P. Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils. J. Biol. Chem. 266, 14763\u201314770 (1991).","journal-title":"J. Biol. Chem."},{"key":"4666_CR24","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1006\/geno.1993.1350","volume":"17","author":"GM Corson","year":"1993","unstructured":"Corson, G. M., Chalberg, S. C., Dietz, H. C., Charbonneau, N. L. & Sakai, L. Y. Fibrillin binds calcium and is coded by cDNAs that reveal a multidomain structure and alternatively spliced exons at the 5-prime end. Genomics 17, 476\u2013484 (1993).","journal-title":"Genomics"},{"issue":"17","key":"4666_CR25","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1242\/jcs.073437","volume":"123","author":"T Massam-Wu","year":"2010","unstructured":"Massam-Wu, T. et al. Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta. J. Cell. Sci. 123 (17), 3006\u20133018 (2010).","journal-title":"J. Cell. Sci."},{"key":"4666_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.matbio.2022.01.005","volume":"107","author":"MP Lockhart-Cairns","year":"2022","unstructured":"Lockhart-Cairns, M. P. et al. Latent TGF\u03b2 complexes are transglutaminase cross-linked to fibrillin to facilitate TGF\u03b2 activation. Matrix Biol. 107, 24\u201339 (2022).","journal-title":"Matrix Biol."},{"issue":"4","key":"4666_CR27","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/(SICI)1098-1004(1997)10:4<280::AID-HUMU3>3.0.CO;2-L","volume":"10","author":"C Hayward","year":"1997","unstructured":"Hayward, C., Porteous, M. E. & Brock, D. J. Mutation screening of all 65 exons of the fibrillin-1 gene in 60 patients with Marfan syndrome: report of 12 novel mutations. Hum. Mutat. 10 (4), 280\u2013289 (1997).","journal-title":"Hum. Mutat."},{"issue":"3","key":"4666_CR28","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/humu.10249","volume":"22","author":"G Collod-B\u00e9roud","year":"2003","unstructured":"Collod-B\u00e9roud, G. et al. Update of the UMD-FBN1 mutation database and creation of an FBN1 polymorphism database. Hum. Mutat. 22 (3), 199\u2013208 (2003).","journal-title":"Hum. Mutat."},{"key":"4666_CR29","doi-asserted-by":"crossref","unstructured":"Vu, T. H. & Werb, Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 1 14(17), 2123\u20132133 (2000).","DOI":"10.1101\/gad.815400"},{"issue":"3","key":"4666_CR30","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nrm2125","volume":"8","author":"A Page-McCaw","year":"2007","unstructured":"Page-McCaw, A., Ewald, A. J. & Werb, Z. Matrix metalloproteinases and the regulation of tissue remodeling. Nat. Rev. Mol. Cell. Biol. 8 (3), 221\u2013233 (2007).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"12","key":"4666_CR31","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","volume":"15","author":"C Bonnans","year":"2014","unstructured":"Bonnans, C., Chou, J. & Werb, Z. Remodeling the extracellular matrix in development and disease. Nat. Rev. Mol. Cell. Biol. 15 (12), 786\u2013801 (2014).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"18","key":"4666_CR32","doi-asserted-by":"publisher","first-page":"4506","DOI":"10.3390\/ijms20184506","volume":"11","author":"K Juurikka","year":"2019","unstructured":"Juurikka, K., Butler, G. S., Salo, T., Nyberg, P. & \u00c5str\u00f6m, P. The role of MMP8 in cancer: A systematic review. Int. J. Mol. Sci. Sep. 11 (18), 4506 (2019).","journal-title":"Int. J. Mol. Sci. Sep."},{"key":"4666_CR33","doi-asserted-by":"publisher","first-page":"928315","DOI":"10.1155\/2013\/928315","volume":"2013","author":"Q Chen","year":"2013","unstructured":"Chen, Q. et al. Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflamm. 2013, 928315 (2013).","journal-title":"Mediators Inflamm."},{"issue":"6","key":"4666_CR34","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1152\/ajplung.00149.2005","volume":"290","author":"E Lechapt-Zalcman","year":"2006","unstructured":"Lechapt-Zalcman, E. et al. Transforming growth factor-beta1 increases airway wound repair via MMP-2 upregulation: a new pathway for epithelial wound repair? Am. J. Physiol. Lung Cell. Mol. Physiol. 290 (6), 1277\u20131282 (2006).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"4666_CR35","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jsbmb.2015.01.015","volume":"149","author":"L Zhang","year":"2015","unstructured":"Zhang, L. et al. STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration. J. Steroid Biochem. Mol. Biol. 149, 106\u2013117 (2015). 2015.","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"24","key":"4666_CR36","doi-asserted-by":"publisher","first-page":"9739","DOI":"10.3390\/ijms21249739","volume":"21","author":"GA Cabral-Pacheco","year":"2020","unstructured":"Cabral-Pacheco, G. A. et al. The roles of matrix metalloproteinases and their inhibitors in human diseases. Int. J. Mol. Sci. 21 (24), 9739 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"4666_CR37","doi-asserted-by":"crossref","unstructured":"Arpino, V., Brock, M. & Gill, S. E. The role of timps in regulation of extracellular matrix proteolysis. Matrix Biol. 44\u201346,\u00a0247\u201354 (2015).","DOI":"10.1016\/j.matbio.2015.03.005"},{"key":"4666_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.02.005","volume":"147","author":"N Cui","year":"2017","unstructured":"Cui, N., Hu, M. & Khalil, R. A. Biochemical and biological attributes of matrix metalloproteinases. Prog Mol. Biol. Transl Sci. 147, 1\u201373 (2017).","journal-title":"Prog Mol. Biol. Transl Sci."},{"issue":"13","key":"4666_CR39","doi-asserted-by":"publisher","first-page":"10649","DOI":"10.3390\/ijms241310649","volume":"24","author":"S Moli\u00e8re","year":"2023","unstructured":"Moli\u00e8re, S., Jaulin, A., Tomasetto, C. L. & Dali-Youcef, N. Roles of matrix metalloproteinases and their natural inhibitors in metabolism: insights into health and disease. Int. J. Mol. Sci. 24 (13), 10649 (2023).","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"4666_CR40","first-page":"e174417","volume":"9","author":"V Camarena","year":"2024","unstructured":"Camarena, V. et al. ADAMTSL2 mutations determine the phenotypic severity in geleophysic dysplasia. JCI Insight. 9 (5), e174417 (2024).","journal-title":"JCI Insight"},{"issue":"5343","key":"4666_CR41","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/236152a0","volume":"236","author":"T Elsdale","year":"1972","unstructured":"Elsdale, T. & Bard, J. Cellular interactions in mass cultures of human diploid fibroblasts. Nature 236 (5343), 152\u2013155 (1972).","journal-title":"Nature"},{"issue":"6","key":"4666_CR42","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1074\/jbc.M207483200","volume":"278","author":"D Palmieri","year":"2003","unstructured":"Palmieri, D., Poggi, S., Ulivi, V., Casartelli, G. & Manduca, P. Pro-collagen I COOH-terminal trimer induces directional migration and metalloproteinases in breast cancer cells. J. Biol. Chem. 278 (6), 3639\u20133647 (2003).","journal-title":"J. Biol. Chem."},{"issue":"1","key":"4666_CR43","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1189\/jlb.0509361","volume":"87","author":"UA Khatwa","year":"2010","unstructured":"Khatwa, U. A., Kleibrink, B. E., Shapiro, S. D. & Subramaniam, M. MMP-8 promotes polymorphonuclear cell migration through collagen barriers in obliterative bronchiolitis. J. Leukoc. Biol. 87 (1), 69\u201377 (2010).","journal-title":"J. Leukoc. Biol."},{"issue":"44","key":"4666_CR44","doi-asserted-by":"publisher","first-page":"15894","DOI":"10.1523\/JNEUROSCI.3943-11.2011","volume":"31","author":"H Zhang","year":"2011","unstructured":"Zhang, H. et al. Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. J. Neurosci. 31 (44), 15894\u201315903 (2011).","journal-title":"J. Neurosci."},{"key":"4666_CR45","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.3389\/fimmu.2018.01348","volume":"9","author":"S Brilha","year":"2018","unstructured":"Brilha, S. et al. Integrin \u03b12\u03b21 expression regulates matrix Metalloproteinase-1-Dependent bronchial epithelial repair in pulmonary tuberculosis. Front. Immunol. 9, 1348 (2018).","journal-title":"Front. Immunol."},{"issue":"34","key":"4666_CR46","doi-asserted-by":"publisher","first-page":"11221","DOI":"10.1021\/bi960618e","volume":"35","author":"G Galazka","year":"1996","unstructured":"Galazka, G., Windsor, L. J., Birkedal-Hansen, H. & Engler, J. A. APMA (4-Aminophenylmercuric Acetate) activation of Stromelysin-1 involves protein interactions in addition to those with Cysteine-75 in the propeptide. Biochemistry 35 (34), 11221\u201311227 (1996).","journal-title":"Biochemistry"},{"issue":"1","key":"4666_CR47","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3390\/pathogens2010105","volume":"2","author":"F Bruschi","year":"2013","unstructured":"Bruschi, F. & Pinto, B. The significance of matrix metalloproteinases in parasitic infections involving the central nervous system. Pathogens 2 (1), 105\u2013129 (2013).","journal-title":"Pathogens"},{"key":"4666_CR48","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/978-1-61779-452-0_15","volume":"814","author":"H Frankowski","year":"2012","unstructured":"Frankowski, H., Gu, Y. H., Heo, J. H., Milner, R. & Del Zoppo, G. J. Use of gel zymography to examine matrix metalloproteinase (gelatinase) expression in brain tissue or in primary glial cultures. Methods Mol. Biol. 814, 221\u2013233 (2012).","journal-title":"Methods Mol. Biol."},{"key":"4666_CR49","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/978-1-4939-6863-3_12","volume":"1579","author":"RB Tajhya","year":"2017","unstructured":"Tajhya, R. B., Patel, R. S. & Beeton, C. Detection of matrix metalloproteinases by zymography. Methods Mol. Biol. 1579, 231\u2013244 (2017).","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"4666_CR50","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/jbmr.4799","volume":"38","author":"D Batkovskyte","year":"2023","unstructured":"Batkovskyte, D. et al. Al-Gazali skeletal dysplasia constitutes the lethal end of ADAMTSL2-Related disorders. J. Bone Min. Res. 38 (5), 692\u2013706 (2023).","journal-title":"J. Bone Min. Res."},{"issue":"9","key":"4666_CR51","doi-asserted-by":"publisher","first-page":"e844","DOI":"10.1002\/mgg3.844","volume":"7","author":"P Piccolo","year":"2019","unstructured":"Piccolo, P. et al. Skin fibroblasts of patients with geleophysic dysplasia due to FBN1 mutations have lysosomal inclusions and Losartan improves their microfibril deposition defect. Mol. Genet. Genomic. 7 (9), e844 (2019).","journal-title":"Mol. Genet. Genomic"},{"issue":"5","key":"4666_CR52","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.bbamcr.2006.07.001","volume":"1773","author":"H Yamaguchi","year":"2007","unstructured":"Yamaguchi, H. & Condeelis, J. Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim. Biophys. Acta. 1773 (5), 642\u2013652 (2007).","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"4666_CR53","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41584-018-0151-0","volume":"15","author":"F Qu","year":"2015","unstructured":"Qu, F., Guilak, F. & Mauck, R. L. Cell migration: implications for repair and regeneration in joint disease. Nat. Rev. Rheumatol. 15 (3), 167\u2013179 (2015).","journal-title":"Nat. Rev. Rheumatol."},{"issue":"12","key":"4666_CR54","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1038\/ni1275","volume":"6","author":"AD Luster","year":"2005","unstructured":"Luster, A. D., Alon, R. & von Andrian, U. H. Immune cell migration in inflammation: present and future therapeutic targets. Nat. Immunol. 6 (12), 1182\u20131190 (2005).","journal-title":"Nat. Immunol."},{"key":"4666_CR55","doi-asserted-by":"crossref","unstructured":"George, R. M., Maldonado-Velez, G. & Firulli, A. B. The heart of the neural crest: cardiac neural crest cells in development and regeneration. Development 147\u00a0(20), (2020).","DOI":"10.1242\/dev.188706"},{"key":"4666_CR56","doi-asserted-by":"crossref","unstructured":"Jiang, H. et al. EZH2 controls epicardial cell migration during heart development. Life Sci. Alliance 6(6), (2023).","DOI":"10.26508\/lsa.202201765"},{"key":"4666_CR57","doi-asserted-by":"crossref","unstructured":"Worku, A. L. et al. Roles of cardiac neural crest cells in cardiovascular development and associated congenital defects-an integrated review. Translational Research in Anatomy\u00a036, In press (2024).","DOI":"10.1016\/j.tria.2024.100304"},{"issue":"1","key":"4666_CR58","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1152\/physrev.00001.2018","volume":"99","author":"JA Whitsett","year":"2019","unstructured":"Whitsett, J. A., Kalin, T. V., Xu, Y. & Kalinichenko, V. V. Building and regenerating the lung cell by cell. Physiol. Rev. 99 (1), 513\u2013554 (2019).","journal-title":"Physiol. Rev."},{"issue":"7","key":"4666_CR59","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.devcel.2024.02.003","volume":"59","author":"M Chioccioli","year":"2024","unstructured":"Chioccioli, M. et al. Stem cell migration drives lung repair in living mice. Dev. Cell. 59 (7), 830\u2013840 (2024).","journal-title":"Dev. Cell."},{"issue":"24","key":"4666_CR60","doi-asserted-by":"publisher","first-page":"4149","DOI":"10.1007\/s00018-012-1044-z","volume":"69","author":"H Xiao","year":"2012","unstructured":"Xiao, H., Li, D. X. & Liu, M. Knowledge translation: airway epithelial cell migration and respiratory diseases. Cell. Mol. Life Sci. 69 (24), 4149\u20134162 (2012).","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"4666_CR61","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s41467-019-09067-3","volume":"10","author":"KM Akram","year":"2019","unstructured":"Akram, K. M. et al. Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour. Nat. Commun. 10 (1), 1178 (2019).","journal-title":"Nat. Commun."},{"issue":"1","key":"4666_CR62","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s42003-021-02118-w","volume":"4","author":"CJ Aros","year":"2021","unstructured":"Aros, C. J., Pantoja, C. J. & Gomperts, B. N. Wnt signaling in lung development, regeneration, and disease progression. Commun. Biol. 4 (1), 601 (2021).","journal-title":"Commun. Biol."},{"issue":"3","key":"4666_CR63","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0092-8674(00)81280-5","volume":"84","author":"DA Lauffenburger","year":"1996","unstructured":"Lauffenburger, D. A. & Horwitz, A. F. Cell migration: a physically integrated molecular process. Cell 84 (3), 359\u2013369 (1996).","journal-title":"Cell"},{"issue":"6","key":"4666_CR64","first-page":"380","volume":"28","author":"DJ Tschumperlin","year":"2013","unstructured":"Tschumperlin, D. J. Fibroblasts and the ground they walk on. Physiol. (Bethesda). 28 (6), 380\u2013390 (2013).","journal-title":"Physiol. (Bethesda)"},{"issue":"12","key":"4666_CR65","doi-asserted-by":"publisher","first-page":"a005058","DOI":"10.1101\/cshperspect.a005058","volume":"3","author":"P Lu","year":"2011","unstructured":"Lu, P., Takai, K., Weaver, V. M. & Werb, Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect. Biol. 3 (12), a005058 (2011).","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"4666_CR66","unstructured":"Mecham, R. P. Overview of extracellular matrix. Curr. Protoc. Cell. Biol. Chapter. 10, 10.1.1\u201310.1.16 (2012)."},{"issue":"8 Suppl 1","key":"4666_CR67","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1097\/IJG.0000000000000108","volume":"23","author":"B Yue","year":"2014","unstructured":"Yue, B. Biology of the extracellular matrix: an overview. J. Glaucoma. 23 (8 Suppl 1), S20\u2013S23 (2014).","journal-title":"J. Glaucoma"},{"issue":"20","key":"4666_CR68","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1016\/j.cub.2020.08.020","volume":"30","author":"A Sarkar","year":"2020","unstructured":"Sarkar, A., LeVine, D. N., Kuzmina, N., Zhao, Y. & Wang, X. Cell migration driven by Self-Generated integrin ligand gradient on ligand-Labile surfaces. Curr. Biol. 30 (20), 4022\u20134032 (2020).","journal-title":"Curr. Biol."},{"issue":"6","key":"4666_CR69","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1002\/jcb.22363","volume":"108","author":"P Chen","year":"2009","unstructured":"Chen, P. & Parks, W. C. Role of matrix metalloproteinases in epithelial migration. J. Cell. Biochem. 108 (6), 1233\u20131243 (2009).","journal-title":"J. Cell. Biochem."},{"issue":"36","key":"4666_CR70","doi-asserted-by":"publisher","first-page":"25964","DOI":"10.1074\/jbc.M113.459784","volume":"288","author":"I Herrera","year":"2013","unstructured":"Herrera, I. et al. Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption. J. Biol. Chem. 288 (36), 25964\u201325975 (2013).","journal-title":"J. Biol. Chem."},{"issue":"1","key":"4666_CR71","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3390\/ijms23010146","volume":"23","author":"S Niland","year":"2021","unstructured":"Niland, S., Riscanevo, A. X. & Eble, J. A. Matrix metalloproteinases shape the tumor microenvironment in Cancer progression. Int. J. Mol. Sci. 23 (1), 146 (2021).","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"4666_CR72","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1042\/BST20180363","volume":"47","author":"V Gifford","year":"2019","unstructured":"Gifford, V. & Itoh, Y. MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms. Biochem. Soc. Trans. 47 (3), 811\u2013826 (2019).","journal-title":"Biochem. Soc. Trans."},{"issue":"Suppl B","key":"4666_CR73","doi-asserted-by":"publisher","first-page":"25B","DOI":"10.1016\/S0828-282X(06)70983-7","volume":"22 Suppl B","author":"P Liu","year":"2006","unstructured":"Liu, P., Sun, M. & Sader, S. Matrix metalloproteinases in cardiovascular disease. Can. J. Cardiol. 22 Suppl B (Suppl B), 25B\u201330B (2006).","journal-title":"Can. J. Cardiol."},{"issue":"7","key":"4666_CR74","first-page":"1295","volume":"59","author":"G Patrichi","year":"2023","unstructured":"Patrichi, G., Patrichi, A., Satala, C. B. & Sin, A. I. Matrix metalloproteinases and heart Transplantation-A pathophysiological and clinical view. Med. (Kaunas). 59 (7), 1295 (2023).","journal-title":"Med. (Kaunas)"},{"key":"4666_CR75","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13098-021-00727-3","volume":"13","author":"EO Melin","year":"2021","unstructured":"Melin, E. O., Dereke, J. & Hillman, M. Galectin-3, metalloproteinase-2 and cardiovascular disease were independently associated with metalloproteinase-14 in patients with type 1 diabetes: a cross sectional study. Diabetol. Metab. 13, 118 (2021).","journal-title":"Diabetol. Metab."},{"issue":"5","key":"4666_CR76","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1161\/01.RES.0000013290.12884.A3","volume":"90","author":"FG Spinale","year":"2002","unstructured":"Spinale, F. G. Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ. Res. 90 (5), 520\u2013530 (2002).","journal-title":"Circ. Res."},{"key":"4666_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.04.004","volume":"148","author":"AY Hendrix","year":"2017","unstructured":"Hendrix, A. Y. & Kheradmand, F. The role of matrix metalloproteinases in development, repair, and destruction of the lungs. Prog Mol. Biol. Transl Sci. 148, 1\u201329 (2017).","journal-title":"Prog Mol. Biol. Transl Sci."},{"key":"4666_CR78","doi-asserted-by":"publisher","first-page":"1195426","DOI":"10.3389\/fonc.2023.1195426","volume":"13","author":"C Wei","year":"2023","unstructured":"Wei, C. The multifaceted roles of matrix metalloproteinases in lung cancer. Front. Oncol. 13, 1195426 (2023).","journal-title":"Front. Oncol."},{"key":"4666_CR79","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/bs.pmbts.2017.02.001","volume":"147","author":"KY DeLeon-Pennell","year":"2017","unstructured":"DeLeon-Pennell, K. Y., Meschiari, C. A., Jung, M. & Lindsey, M. L. Matrix metalloproteinases in myocardial infarction and heart failure. Prog Mol. Biol. Transl Sci. 147, 75\u2013100 (2017).","journal-title":"Prog Mol. Biol. Transl Sci."},{"key":"4666_CR80","doi-asserted-by":"publisher","first-page":"447","DOI":"10.2741\/1810","volume":"11","author":"PR Brauer","year":"2006","unstructured":"Brauer, P. R. MMPs-role in cardiovascular development and disease. Front. Biosci. 11, 447\u2013478 (2006).","journal-title":"Front. Biosci."},{"issue":"4","key":"4666_CR81","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.1371\/journal.pmed.0050093","volume":"5","author":"IO Rosas","year":"2008","unstructured":"Rosas, I. O. et al. MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS Med. 5 (4), e93 (2008).","journal-title":"PLoS Med."},{"key":"4666_CR82","doi-asserted-by":"publisher","first-page":"121214","DOI":"10.1016\/j.lfs.2022.121214","volume":"313","author":"E Yi","year":"2023","unstructured":"Yi, E. et al. Genetic screening of MMP1 as a potential pathogenic gene in chronic obstructive pulmonary disease. Life Sci. 313, 121214 (2023).","journal-title":"Life Sci."},{"issue":"5","key":"4666_CR83","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1158\/1055-9965.EPI-07-2840","volume":"17","author":"W Sauter","year":"2008","unstructured":"Sauter, W. et al. Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer. Cancer Epidemiol. Biomarkers Prev. 17 (5), 1127\u20131135 (2008).","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"4666_CR84","doi-asserted-by":"publisher","first-page":"107070","DOI":"10.1016\/j.phrs.2024.107070","volume":"200","author":"D Peng","year":"2024","unstructured":"Peng, D. et al. MMP14high macrophages orchestrate progressive pulmonary fibrosis in SR-Ag-induced hypersensitivity pneumonitis. Pharmacol. Res. 200, 107070 (2024).","journal-title":"Pharmacol. Res."},{"issue":"4","key":"4666_CR85","doi-asserted-by":"publisher","first-page":"3786","DOI":"10.3390\/ijms24043786","volume":"24","author":"ME Christopoulou","year":"2023","unstructured":"Christopoulou, M. E., Papakonstantinou, E. & Stolz, D. Matrix metalloproteinases in chronic obstructive pulmonary disease. Int. J. Mol. Sci. 24 (4), 3786 (2023).","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"4666_CR86","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1152\/physrev.00022.2006","volume":"87","author":"KJ Greenlee","year":"2007","unstructured":"Greenlee, K. J., Werb, Z. & Kheradmand, F. Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol. Rev. 87 (1), 69\u201398 (2007).","journal-title":"Physiol. Rev."},{"issue":"38","key":"4666_CR87","doi-asserted-by":"publisher","first-page":"33167","DOI":"10.1074\/jbc.M111.256644","volume":"286","author":"K Zarrabi","year":"2011","unstructured":"Zarrabi, K. et al. Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration. J. Biol. Chem. 286 (38), 33167\u201333177 (2011).","journal-title":"J. Biol. Chem."},{"issue":"9","key":"4666_CR88","doi-asserted-by":"publisher","first-page":"991","DOI":"10.3390\/cells8090991","volume":"8","author":"J Gonzalez-Molina","year":"2019","unstructured":"Gonzalez-Molina, J. et al. MMP14 in sarcoma: A regulator of tumor microenvironment communication in connective tissues. Cells 8 (9), 991 (2019).","journal-title":"Cells"},{"key":"4666_CR89","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.matbio.2025.01.004","volume":"136","author":"S Niland","year":"2025","unstructured":"Niland, S. & Eble, J. A. Decoding the MMP14 integrin link: key player in the secretome landscape. Matrix Biol. 136, 36\u201351 (2025).","journal-title":"Matrix Biol."},{"issue":"9","key":"4666_CR90","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3390\/cells8090984","volume":"8","author":"GB Fields","year":"2019","unstructured":"Fields, G. B. The rebirth of matrix metalloproteinase inhibitors: moving beyond the dogma. Cells 8 (9), 984 (2019).","journal-title":"Cells"},{"key":"4666_CR91","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider, C. A., Rasband, W. S. & Eliceiri, K. W. NIH image to imageJ: 25 years of image analysis. Nat. Methods. 9, 671\u2013675 (2012).","journal-title":"Nat. Methods"},{"key":"4666_CR92","doi-asserted-by":"crossref","unstructured":"Franco-Barraza, J., Beacham, D. A., Amatangelo, M. D. & Cukierman, E. Preparation of extracellular matrices produced by cultured and primary fibroblasts. Curr. Protoc. Cell. Biol. 71, 10.9.1\u201310.9.34 (2016).","DOI":"10.1002\/cpcb.2"},{"key":"4666_CR93","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2012","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15\u201321 (2012).","journal-title":"Bioinformatics"},{"key":"4666_CR94","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","volume":"32","author":"P Ewels","year":"2016","unstructured":"Ewels, P., Magnusson, M., Lundin, S. & K\u00e4ller, M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics 32, 3047\u20133048 (2016).","journal-title":"Bioinformatics"},{"key":"4666_CR95","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/1471-2105-11-422","volume":"11","author":"TJ Hardcastle","year":"2010","unstructured":"Hardcastle, T. J., Kelly, K. A. & baySeq Empirical bayesian methods for identifying differential expression in sequence count data. BMC Bioinform. 11, 422 (2010).","journal-title":"BMC Bioinform."},{"key":"4666_CR96","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated Estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"4666_CR97","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2009","unstructured":"Robinson, M. D., McCarthy, D. J. & Smyth, G. K. EdgeR: a bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139\u2013140 (2009).","journal-title":"Bioinformatics"},{"key":"4666_CR98","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1186\/s12859-018-2486-6","volume":"19","author":"SX Ge","year":"2018","unstructured":"Ge, S. X., Son, E. W. & Yao, R. iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data. BMC Bioinform. 19, 534 (2018).","journal-title":"BMC Bioinform."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-04666-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-04666-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-04666-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T14:02:57Z","timestamp":1749218577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-04666-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":98,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4666"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-04666-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.01.30.635317","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,6]]},"assertion":[{"value":"16 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19970"}}