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Students often have irregular day\/night rhythms, which contribute to circadian rhythm disruptions. This open pilot study investigated the feasibility, acceptability, and preliminary effectiveness of a 5-week digital guided self-help intervention in university students with self-reported insomnia. The intervention is based on cognitive behavioural therapy for insomnia with specific emphasis on the biological clock (<jats:italic>\u2018i-Sleep &amp; BioClock\u2019<\/jats:italic>). We assessed feasibility and acceptability. Pre- to post-intervention (7-week) changes in insomnia, depression, anxiety, chronotype, and quality of life were evaluated. Of 101 included students, 81 accessed the platform, 41 initiated the intervention, and 13 completed the intervention. Post-test response was 39%. Students rated the intervention with good acceptability and the platform with excellent usability. Study completers (<jats:italic>n<\/jats:italic>\u2009=\u200939) showed large improvements in insomnia severity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>d<\/jats:italic>\u2009=\u20091.04), and moderate improvements in depression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>d<\/jats:italic>\u2009=\u20090.63), anxiety (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>d<\/jats:italic>\u2009=\u20090.35), and functioning (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>d<\/jats:italic>\u2009=\u20090.56). No significant changes were found in quality of life (<jats:italic>p<\/jats:italic>\u2009=\u20090.07, <jats:italic>d<\/jats:italic>\u2009=\u20090.19). To summarize, the intervention had low uptake but moderate adherence and fairly good acceptability along with important improvements in sleep, mental health, and functioning.<\/jats:p>\n          <jats:p>\n            <jats:bold>Trial registration:<\/jats:bold> ClinicalTrials.gov: NCT05363995.<\/jats:p>","DOI":"10.1038\/s41598-025-04891-8","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T19:02:06Z","timestamp":1751396526000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Open pilot study of a guided digital self-help intervention targeting sleep and the biological clock in university students using a pre-test post-test design"],"prefix":"10.1038","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct05363995","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-7431","authenticated-orcid":false,"given":"Laura M.","family":"Pape","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9343-8842","authenticated-orcid":false,"given":"Niki","family":"Antypa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-335X","authenticated-orcid":false,"given":"Philip","family":"Spinhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6875-2215","authenticated-orcid":false,"given":"Annemieke","family":"van Straten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-5410","authenticated-orcid":false,"given":"Sascha Y.","family":"Struijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Caring Universities Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Struijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Garnefski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Kraaij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elske","family":"Salemink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hurks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilisa","family":"Boffo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Remmerswaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinout","family":"Wiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"van der Heijde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Klinkenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"de Bruijn-Smolders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Nooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"4891_CR1","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1037\/abn0000362","volume":"127","author":"RP Auerbach","year":"2018","unstructured":"Auerbach, R. 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